Citations for
1RAC1, TRIO
Opposite Modulation of RAC1 by Mutations in TRIO Is Associated with Distinct, Domain-Specific Neurodevelopmental Disorders.
Barbosa S, Greville-Heygate S, Bonnet M, Godwin A, Fagotto-Kaufmann C, Kajava AV, Laouteouet D, Mawby R, Wai HA, Dingemans AJM, Hehir-Kwa J, Willems M, Capri Y, Mehta SG, Cox H, Goudie D, Vansenne F, Turnpenny P, Vincent M, Cogné B, Lesca G, Hertecant J, Rodriguez D, Keren B, Burglen L, Gérard M, Putoux A; C4RCD Research Group, Cantagrel V, Siquier-Pernet K, Rio M, Banka S, Sarkar A, Steeves M, Parker M, Clement E, Moutton S, Tran Mau-Them F, Piton A, de Vries BBA, Guille M, Debant A, Schmidt S, Baralle D.
Am J Hum Genet. Mar 5;106(3):338-355. doi: 10.1016/j.ajhg.2020.01.018. Epub 2020 Feb 27 2020
2CDH2, TRIO
N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability.
Kruse K, Lee QS, Sun Y, Klomp J, Yang X, Huang F, Sun MY, Zhao S, Hong Z, Vogel SM, Shin JW, Leckband DE, Tai LM, Malik AB, Komarova YA.
J Cell Biol 218(1):299-316. doi: 10.1083/jcb.201802076. Epub 2018 Nov 21. 2019
3MRD44, TRIO
TRIO loss of function is associated with mild intellectual disability and affects dendritic branching and synapse function.
Ba W, Yan Y, Reijnders MR, Schuurs-Hoeijmakers JH, Feenstra I, Bongers EM, Bosch DG, De Leeuw N, Pfundt R, Gilissen C, De Vries PF, Veltman JA, Hoischen A, Mefford HC, Eichler EE, Vissers LE, Nadif Kasri N, De Vries BB.
Hum Mol Genet 25(5):892-902. doi: 10.1093/hmg/ddv618. Epub 2015 Dec 31. 2016
4MRD44, TRIO
Mutations specific to the Rac-GEF domain of TRIO cause intellectual disability and microcephaly.
Pengelly RJ, Greville-Heygate S, Schmidt S, Seaby EG, Jabalameli MR, Mehta SG, Parker MJ, Goudie D, Fagotto-Kaufmann C, Mercer C; DDD Study,, Debant A, Ennis S, Baralle D.
J Med Genet Med Genet. 2016 Jul 14. pii: jmedgenet-2016-103942. doi: 10.1136/jmedgenet-2016-103942. [Epub ahead of print] 2016
5BSN, PCLO, TRIO
Trio, a Rho Family GEF, Interacts with the Presynaptic Active Zone Proteins Piccolo and Bassoon.
Terry-Lorenzo RT, Torres VI, Wagh D, Galaz J, Swanson SK, Florens L, Washburn MP, Waites CL, Gundelfinger ED, Reimer RJ, Garner CC.
PLoS One 11(12):e0167535. doi: 10.1371/journal.pone.0167535. eCollection 2016. 2016
6CDH5, RAC1, TRIO
A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1.
Timmerman I, Heemskerk N, Kroon J, Schaefer A, van Rijssel J, Hoogenboezem M, van Unen J, Goedhart J, Gadella TW Jr, Yin T, Wu Y, Huveneers S, van Buul JD.
J Cell Sci 128(16):3041-54. doi: 10.1242/jcs.168674. Epub 2015 Jun 26. Erratum in: J Cell Sci. 2015 Sep 15;128(18):3514. 2015
7RAC1, RHOA, TRIO
Identification of a mitotic Rac-GEF, Trio, that counteracts MgcRacGAP function during cytokinesis.
Cannet A, Schmidt S, Delaval B, Debant A.
Mol Biol Cell 25(25):4063-71. doi: 10.1091/mbc.E14-06-1153. Epub 2014 Oct 29. 2014
8NAV1, RAC1, RHOG, TRIO
Dynamic microtubules catalyze formation of navigator-TRIO complexes to regulate neurite extension.
van Haren J, Boudeau J, Schmidt S, Basu S, Liu Z, Lammers D, Demmers J, Benhari J, Grosveld F, Debant A, Galjart N.
Curr Biol 24(15):1778-85. doi: 10.1016/j.cub.2014.06.037. Epub 2014 Jul 24. 2014
9ANKRD26, GPS2, HMMR, TRIO
ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells.
Liu XF, Bera TK, Kahue C, Escobar T, Fei Z, Raciti GA, Pastan I.
PLoS One 7(5):e38130. doi: 10.1371/journal.pone.0038130. Epub 2012 May 30. 2012
10ICAM1, RAC1, RHOG, TRIO
The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation.
van Rijssel J, Kroon J, Hoogenboezem M, van Alphen FP, de Jong RJ, Kostadinova E, Geerts D, Hordijk PL, van Buul JD.
Mol Biol Cell 23(15):2831-44. doi: 10.1091/mbc.E11-11-0907. Epub 2012 Jun 13. 2012
11TRIO
The N-terminal DH-PH domain of Trio induces cell spreading and migration by regulating lamellipodia dynamics in a Rac1-dependent fashion.
van Rijssel J, Hoogenboezem M, Wester L, Hordijk PL, Van Buul JD.
PLoS One 7(1):e29912. doi: 10.1371/journal.pone.0029912. Epub 2012 Jan 6. 2012
12ARHGAP32, BCAR1, PPFIA4, PTPRS, TRIO
Receptor tyrosine phosphatase sigma (RPTPσ) regulates, p250GAP, a novel substrate that attenuates Rac signaling.
Chagnon MJ, Wu CL, Nakazawa T, Yamamoto T, Noda M, Blanchetot C, Tremblay ML.
Cell Signal 22(11):1626-33. Epub 2010 Jun 12. 2010
13CEP68, TRIO, TRIOBP
Changing modified regions in the genome in hematopoietic stem cell differentiation.
Hamada T, Murasawa S, Yokoyama A, Hayashi S, Kobayashi Y, Asahara T.
Biochem Biophys Res Commun 381(2):135-8. Epub 2008 Nov 24.PMID: 19032947 2009
14TRIO
Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain.
Rojas RJ, Yohe ME, Gershburg S, Kawano T, Kozasa T, Sondek J.
J Biol Chem 282(40):29201-10. Epub 2007 Jul 2. 2007
15TRIO
The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation.
Chhatriwala MK, Betts L, Worthylake DK, Sondek J.
J Mol Biol 368(5):1307-20. Epub 2007 Feb 22. 2007
16TRIO
Tgat, a Rho-specific guanine nucleotide exchange factor, activates NF-kappaB via physical association with IkappaB kinase complexes.
Yamada K, Moriuchi R, Mori T, Okazaki E, Kohno T, Nagayasu T, Matsuyama T, Katamine S.
Biochem Biophys Res Commun 355(1):269-74. Epub 2007 Feb 2. 2007
17TRIO, NKD2, IRX2
Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas.
Adamowicz M, Radlwimmer B, Rieker RJ, Mertens D, Schwarzbach M, Schraml P, Benner A, Lichter P, Mechtersheimer G, Joos S.
Genes Chromosomes Cancer 45(9):829-38. 2006
18TRIO
Identification of novel neuronal isoforms of the Rho-GEF Trio.
Portales-Casamar E, Briançon-Marjollet A, Fromont S, Triboulet R, Debant A.
Biol Cell 98(3):183-93. 2006
19TRIO
TRIO amplification and abundant mRNA expression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer.
Zheng M, Simon R, Mirlacher M, Maurer R, Gasser T, Forster T, Diener PA, Mihatsch MJ, Sauter G, Schraml P.
Am J Pathol 165(1):63-9. 2004
20TRIO
Assignment of TRIO, the Trio gene (PTPRF interacting) to human chromosome bands 5p 15.1-->p 14 by in situ hybridization.
Taviaux S, Diriong S, Bellanger JM, Streuli M, Debant A.
Cytogenet Cell Genet 76(1-2):107-8. 1997
21CTNND2, TRIO, CDCS
A high-resolution physical and transcript map of the Cri du Chat region of human chromosome 5p.
Church DM, Yang J, Bocian M, Shiang R, Wasmuth JJ.
Genome Res 7(8):787-801. 1997
22TRIO
The multidomain protein trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.
Debant A, et al.
Proc Natl Acad Sci U S A 93 : 5466-5471. 1996