Citations for
1TRIM21
Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.
Dickson C, Fletcher AJ, Vaysburd M, Yang JC, Mallery DL, Zeng J, Johnson CM, McLaughlin SH, Skehel M, Maslen S, Cruickshank J, Huguenin-Dezot N, Chin JW, Neuhaus D, James LC.
Elife 7. pii: e32660. doi: 10.7554/eLife.32660. 2018
2SALL1, SALL4, TRIM21
Sal-like 4 protein levels in breast cancer cells are post-translationally down-regulated by tripartite motif-containing 21.
Itou J, Li W, Ito S, Tanaka S, Matsumoto Y, Sato F, Toi M.
J Biol Chem 293(17):6556-6564. doi: 10.1074/jbc.RA117.000245. Epub 2018 Mar 6. 2018
3TRIM21
Dysfunction of TRIM21 in interferon signature of systemic lupus erythematosus.
Kamiyama R, Yoshimi R, Takeno M, Iribe Y, Tsukahara T, Kishimoto D, Kunishita Y, Sugiyama Y, Tsuchida N, Nakano H, Minegishi K, Tamura M, Asami Y, Kirino Y, Ishigatsubo Y, Ozato K, Nakajima H.
Mod Rheumatol od Rheumatol. 2018 Feb 23:1-11. doi: 10.1080/14397595.2018.1436028. [Epub ahead of print] 2018
4TRIM21
Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content.
Brauner S, Jiang X, Thorlacius GE, Lundberg AM, Östberg T, Yan ZQ, Kuchroo VK, Hansson GK, Wahren-Herlenius M.
Cardiovasc Res 114(1):158-167. doi: 10.1093/cvr/cvx181. 2018
5PAWR, TRIM21
TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells.
Nguyen JQ, Irby RB.
Cancer Biol Ther 18(1):16-25. doi: 10.1080/15384047.2016.1252880. Epub 2016 Nov 10. 2017
6IFI35, NMI, TRIM21
Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response.
Das A, Dinh PX, Pattnaik AK.
Virology 485:383-392. doi: 10.1016/j.virol.2015.08.013. [Epub ahead of print] 2015
7MEFV, TRIM21
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.
Kimura T, Jain A, Choi SW, Mandell MA, Schroder K, Johansen T, Deretic V.
J Cell Biol 210(6):973-89. 2015
8TRIM21
Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21.
Fletcher AJ, Mallery DL, Watkinson RE, Dickson CF, James LC.
Proc Natl Acad Sci U S A 112(32):10014-9. doi: 10.1073/pnas.1507534112. Epub 2015 Jul 6. 2015
9IRF5, TLR7, TRIM21
TRIpartite motif 21 (TRIM21) differentially regulates the stability of interferon regulatory factor 5 (IRF5) isoforms.
Lazzari E, Korczeniewska J, Ní Gabhann J, Smith S, Barnes BJ, Jefferies CA.
PLoS One 9(8):e103609. doi: 10.1371/journal.pone.0103609. eCollection 2014. 2014
10TRIM21
Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors.
Sjöstrand M, Ambrosi A, Brauner S, Sullivan J, Malin S, Kuchroo VK, Espinosa A, Wahren-Herlenius M.
J Immunol 191(7):3753-63. doi: 10.4049/jimmunol.1202341. Epub 2013 Aug 23. 2013
11DDX41, TRIM21
The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA.
Zhang Z, Bao M, Lu N, Weng L, Yuan B, Liu YJ.
Nat Immunol 14(2):172-8. doi: 10.1038/ni.2492. Epub 2012 Dec 9. 2013
12TRIM21, VCP
AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization.
Hauler F, Mallery DL, McEwan WA, Bidgood SR, James LC.
Proc Natl Acad Sci U S A 109(48):19733-8. doi: 10.1073/pnas.1210659109. Epub 2012 Oct 22. 2012
13FADD, TRIM21
Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon production.
Young JA, Sermwittayawong D, Kim HJ, Nandu S, An N, Erdjument-Bromage H, Tempst P, Coscoy L, Winoto A.
J Biol Chem 286(8):6521-31. Epub 2010 Dec 23. 2011
14TRIM21
Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21).
Mallery DL, McEwan WA, Bidgood SR, Towers GJ, Johnson CM, James LC.
Proc Natl Acad Sci U S A 107(46):19985-90. Epub 2010 Nov 2. 2010
15TRIM21
Downregulation of active IKK beta by Ro52-mediated autophagy.
Niida M, Tanaka M, Kamitani T.
Mol Immunol 47(14):2378-87. Epub 2010 Jun 2. 2010
16TRIM21
Dynamic movements of Ro52 cytoplasmic bodies along microtubules.
Tanaka M, Tanji K, Niida M, Kamitani T.
Histochem Cell Biol 133(3):273-84. Epub 2009 Dec 16. 2010
17TRIM21
Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts.
Yoshimi R, Chang TH, Wang H, Atsumi T, Morse HC 3rd, Ozato K.
J Immunol 182(12):7527-38. 2009
18TRIM21
TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response.
Yang K, Shi HX, Liu XY, Shan YF, Wei B, Chen S, Wang C.
J Immunol 182(6):3782-92. 2009
19TRIM21
TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.
Keeble AH, Khan Z, Forster A, James LC.
Proc Natl Acad Sci U S A 105(16):6045-50. Epub 2008 Apr 17. 2008
20FMF, MEFV, MID1, MID2, PML, TRIM10, TRIM11, TRIM13, TRIM15, TRIM17, TRIM2, TRIM21, TRIM22, TRIM23, TRIM24, TRIM25, TRIM26, TRIM27, TRIM28, TRIM3, TRIM31, TRIM32, TRIM33, TRIM34, TRIM35, TRIM36, TRIM37, TRIM38, TRIM39, TRIM4, TRIM40, TRIM41, TRIM42, TRIM43, TRIM45, TRIM46, TRIM47, TRIM48, TRIM49, TRIM5, TRIM50, TRIM52, TRIM53, TRIM54, TRIM55, TRIM56, TRIM58, TRIM59, TRIM6, TRIM60, TRIM61, TRIM62, TRIM63, TRIM64, TRIM65, TRIM67, TRIM68, TRIM69, TRIM7, TRIM71, TRIM72, TRIM73, TRIM74, TRIM75, TRIM8, TRIM9, TRIML1
TRIM family proteins and their emerging roles in innate immunity.
Ozato K, Shin DM, Chang TH, Morse HC 3rd.
Nat Rev Immunol 8(11):849-60. Review. 2008
21TRIM21
TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.
Keeble AH, Khan Z, Forster A, James LC.
Proc Natl Acad Sci U S A 105(16):6045-50. Epub 2008 Apr 17. 2008
22TRIM21, UBE2D1, UBE2E1
The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide.
Espinosa A, Oke V, Elfving A, Nyberg F, Covacu R, Wahren-Herlenius M.
Exp Cell Res 314(20):3605-13. Epub 2008 Sep 25. 2008
23FMF, MEFV, TRIM21, TRIM5
Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function.
James LC, Keeble AH, Khan Z, Rhodes DA, Trowsdale J.
Proc Natl Acad Sci U S A 104(15):6200-5. Epub 2007 Mar 30. 2007
24MEFV, TRIM21
Structure of the PRYSPRY-domain: implications for autoinflammatory diseases.
Grutter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grutter MG.
FEBS Lett 580(1):99-106. Epub 2005 Dec 9. 2006
25TRIM21
The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death.
Espinosa A, Zhou W, Ek M, Hedlund M, Brauner S, Popovic K, Horvath L, Wallerskog T, Oukka M, Nyberg F, Kuchroo VK, Wahren-Herlenius M.
J Immunol 176(10):6277-85. 2006
26TRIM21, USP4
Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity.
Wada K, Tanji K, Kamitani T.
Biochem Biophys Res Commun 339(3):731-6. 2006
27TRIM21
The Ro52/SS-A autoantigen has elevated expression at the brain microvasculature.
Shusta EV, Li JY, Boado RJ, Pardridge WM.
Neuroreport 14(14):1861-5. 2003
28TRIM21
Leucine zipper domain of 52 kDa SS-A/Ro promotes protein dimer formation and inhibits in vitro transcription activity.
Wang D, Buyon JP, Yang Z, Di Donato F, Miranda-Carus ME, Chan EK.
Biochim Biophys Acta 1568(2):155-61. 2001
29TRIM21
Characterization of DNA binding properties and sequence specificity of the human 52 kDa Ro/SS-A (Ro52) zinc finger protein.
Frank MB.
Biochem Biophys Res Commun 259(3):665-70 1999
30TRIM21
The nuclear autoantigen La/SS-B: mapping and sequencing of the gene and the three retropseudogenes.
Grolz D, Bartsch H, Troster H, Bachmann M.
Gene 191(1):23-9. 1997
31TRIM21
52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart.
Chan EK, Di Donato F, Hamel JC, Tseng CE, Buyon JP.
J Exp Med 182(4):983-92. 1995
32TRIM21
The location of a disease-associated polymorphism and genomic structure of the human 52-kDa Ro/SSA locus (SSA1).
Tsugu H, et al.
Genomics 24 : 541-548. 1994
33TRIM21
The mapping of human 52-kD Ro/SSA autoantigen gene to human chromosome II, and its polymorphisms.
Frank MB, et al.
Am J Hum Genet 52 : 183-191. 1993
34RO60, TRIM21
Protein Heterogeneity in the human Ro/SSA ribonucleoproteins.
Itoh K, et al.
J Clin Invest 87 : 177-186. 1991
35TRIM21
Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen.
Chan EKL, et al.
J Clin Invest 87 : 68-76. 1991
36CALR, TRIM21
Ro/SS-A and the pathogenic significance of its antibodies.
McCauliffe DP, Lux FA, Lieu TS, Sanz I, Hanke J, Newkirk MM, Siciliano MJ, Sontheimer RD, Capra JD.
J Autoimmunity 2(4):375-81. 1989