1 | TRIM21
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| Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.
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| Dickson C, Fletcher AJ, Vaysburd M, Yang JC, Mallery DL, Zeng J, Johnson CM, McLaughlin SH, Skehel M, Maslen S, Cruickshank J, Huguenin-Dezot N, Chin JW, Neuhaus D, James LC.
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| Elife 7. pii: e32660. doi: 10.7554/eLife.32660.
2018
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2 | SALL1, SALL4, TRIM21
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| Sal-like 4 protein levels in breast cancer cells are post-translationally down-regulated by tripartite motif-containing 21.
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| Itou J, Li W, Ito S, Tanaka S, Matsumoto Y, Sato F, Toi M.
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| J Biol Chem 293(17):6556-6564. doi: 10.1074/jbc.RA117.000245. Epub 2018 Mar 6.
2018
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3 | TRIM21
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| Dysfunction of TRIM21 in interferon signature of systemic lupus erythematosus.
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| Kamiyama R, Yoshimi R, Takeno M, Iribe Y, Tsukahara T, Kishimoto D, Kunishita Y, Sugiyama Y, Tsuchida N, Nakano H, Minegishi K, Tamura M, Asami Y, Kirino Y, Ishigatsubo Y, Ozato K, Nakajima H.
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| Mod Rheumatol od Rheumatol. 2018 Feb 23:1-11. doi: 10.1080/14397595.2018.1436028. [Epub ahead of print]
2018
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4 | TRIM21
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| Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content.
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| Brauner S, Jiang X, Thorlacius GE, Lundberg AM, Östberg T, Yan ZQ, Kuchroo VK, Hansson GK, Wahren-Herlenius M.
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| Cardiovasc Res 114(1):158-167. doi: 10.1093/cvr/cvx181.
2018
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5 | PAWR, TRIM21
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| TRIM21 is a novel regulator of Par-4 in colon and pancreatic cancer cells.
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| Nguyen JQ, Irby RB.
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| Cancer Biol Ther 18(1):16-25. doi: 10.1080/15384047.2016.1252880. Epub 2016 Nov 10.
2017
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6 | IFI35, NMI, TRIM21
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| Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response.
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| Das A, Dinh PX, Pattnaik AK.
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| Virology 485:383-392. doi: 10.1016/j.virol.2015.08.013. [Epub ahead of print]
2015
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7 | MEFV, TRIM21
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| TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.
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| Kimura T, Jain A, Choi SW, Mandell MA, Schroder K, Johansen T, Deretic V.
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| J Cell Biol 210(6):973-89.
2015
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8 | TRIM21
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| Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21.
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| Fletcher AJ, Mallery DL, Watkinson RE, Dickson CF, James LC.
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| Proc Natl Acad Sci U S A 112(32):10014-9. doi: 10.1073/pnas.1507534112. Epub 2015 Jul 6.
2015
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9 | IRF5, TLR7, TRIM21
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| TRIpartite motif 21 (TRIM21) differentially regulates the stability of interferon regulatory factor 5 (IRF5) isoforms.
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| Lazzari E, Korczeniewska J, Ní Gabhann J, Smith S, Barnes BJ, Jefferies CA.
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| PLoS One 9(8):e103609. doi: 10.1371/journal.pone.0103609. eCollection 2014.
2014
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10 | TRIM21
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| Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors.
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| Sjöstrand M, Ambrosi A, Brauner S, Sullivan J, Malin S, Kuchroo VK, Espinosa A, Wahren-Herlenius M.
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| J Immunol 191(7):3753-63. doi: 10.4049/jimmunol.1202341. Epub 2013 Aug 23.
2013
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11 | DDX41, TRIM21
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| The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA.
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| Zhang Z, Bao M, Lu N, Weng L, Yuan B, Liu YJ.
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| Nat Immunol 14(2):172-8. doi: 10.1038/ni.2492. Epub 2012 Dec 9.
2013
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12 | TRIM21, VCP
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| AAA ATPase p97/VCP is essential for TRIM21-mediated virus neutralization.
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| Hauler F, Mallery DL, McEwan WA, Bidgood SR, James LC.
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| Proc Natl Acad Sci U S A 109(48):19733-8. doi: 10.1073/pnas.1210659109. Epub 2012 Oct 22.
2012
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13 | FADD, TRIM21
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| Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon production.
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| Young JA, Sermwittayawong D, Kim HJ, Nandu S, An N, Erdjument-Bromage H, Tempst P, Coscoy L, Winoto A.
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| J Biol Chem 286(8):6521-31. Epub 2010 Dec 23.
2011
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14 | TRIM21
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| Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21).
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| Mallery DL, McEwan WA, Bidgood SR, Towers GJ, Johnson CM, James LC.
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| Proc Natl Acad Sci U S A 107(46):19985-90. Epub 2010 Nov 2.
2010
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15 | TRIM21
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| Downregulation of active IKK beta by Ro52-mediated autophagy.
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| Niida M, Tanaka M, Kamitani T.
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| Mol Immunol 47(14):2378-87. Epub 2010 Jun 2.
2010
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16 | TRIM21
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| Dynamic movements of Ro52 cytoplasmic bodies along microtubules.
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| Tanaka M, Tanji K, Niida M, Kamitani T.
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| Histochem Cell Biol 133(3):273-84. Epub 2009 Dec 16.
2010
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17 | TRIM21
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| Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts.
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| Yoshimi R, Chang TH, Wang H, Atsumi T, Morse HC 3rd, Ozato K.
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| J Immunol 182(12):7527-38.
2009
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18 | TRIM21
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| TRIM21 is essential to sustain IFN regulatory factor 3 activation during antiviral response.
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| Yang K, Shi HX, Liu XY, Shan YF, Wei B, Chen S, Wang C.
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| J Immunol 182(6):3782-92.
2009
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19 | TRIM21
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| TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.
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| Keeble AH, Khan Z, Forster A, James LC.
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| Proc Natl Acad Sci U S A 105(16):6045-50. Epub 2008 Apr 17. 2008
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20 | FMF, MEFV, MID1, MID2, PML, TRIM10, TRIM11, TRIM13, TRIM15, TRIM17, TRIM2, TRIM21, TRIM22, TRIM23, TRIM24, TRIM25, TRIM26, TRIM27, TRIM28, TRIM3, TRIM31, TRIM32, TRIM33, TRIM34, TRIM35, TRIM36, TRIM37, TRIM38, TRIM39, TRIM4, TRIM40, TRIM41, TRIM42, TRIM43, TRIM45, TRIM46, TRIM47, TRIM48, TRIM49, TRIM5, TRIM50, TRIM52, TRIM53, TRIM54, TRIM55, TRIM56, TRIM58, TRIM59, TRIM6, TRIM60, TRIM61, TRIM62, TRIM63, TRIM64, TRIM65, TRIM67, TRIM68, TRIM69, TRIM7, TRIM71, TRIM72, TRIM73, TRIM74, TRIM75, TRIM8, TRIM9, TRIML1
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| TRIM family proteins and their emerging roles in innate immunity.
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| Ozato K, Shin DM, Chang TH, Morse HC 3rd.
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| Nat Rev Immunol 8(11):849-60. Review. 2008
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21 | TRIM21
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| TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved.
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| Keeble AH, Khan Z, Forster A, James LC.
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| Proc Natl Acad Sci U S A 105(16):6045-50. Epub 2008 Apr 17.
2008
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22 | TRIM21, UBE2D1, UBE2E1
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| The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide.
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| Espinosa A, Oke V, Elfving A, Nyberg F, Covacu R, Wahren-Herlenius M.
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| Exp Cell Res 314(20):3605-13. Epub 2008 Sep 25.
2008
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23 | FMF, MEFV, TRIM21, TRIM5
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| Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function.
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| James LC, Keeble AH, Khan Z, Rhodes DA, Trowsdale J.
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| Proc Natl Acad Sci U S A 104(15):6200-5. Epub 2007 Mar 30. 2007
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24 | MEFV, TRIM21
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| Structure of the PRYSPRY-domain: implications for autoinflammatory diseases.
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| Grutter C, Briand C, Capitani G, Mittl PR, Papin S, Tschopp J, Grutter MG.
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| FEBS Lett 580(1):99-106. Epub 2005 Dec 9. 2006
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25 | TRIM21
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| The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death.
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| Espinosa A, Zhou W, Ek M, Hedlund M, Brauner S, Popovic K, Horvath L, Wallerskog T, Oukka M, Nyberg F, Kuchroo VK, Wahren-Herlenius M.
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| J Immunol 176(10):6277-85. 2006
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26 | TRIM21, USP4
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| Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity.
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| Wada K, Tanji K, Kamitani T.
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| Biochem Biophys Res Commun 339(3):731-6. 2006
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27 | TRIM21
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| The Ro52/SS-A autoantigen has elevated expression at the brain microvasculature.
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| Shusta EV, Li JY, Boado RJ, Pardridge WM.
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| Neuroreport 14(14):1861-5. 2003
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28 | TRIM21
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| Leucine zipper domain of 52 kDa SS-A/Ro promotes protein dimer formation and inhibits in vitro transcription activity.
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| Wang D, Buyon JP, Yang Z, Di Donato F, Miranda-Carus ME, Chan EK.
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| Biochim Biophys Acta 1568(2):155-61. 2001
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29 | TRIM21
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| Characterization of DNA binding properties and sequence specificity of the human 52 kDa Ro/SS-A (Ro52) zinc finger protein.
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| Frank MB.
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| Biochem Biophys Res Commun 259(3):665-70 1999
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30 | TRIM21
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| The nuclear autoantigen La/SS-B: mapping and sequencing of the gene and the three retropseudogenes.
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| Grolz D, Bartsch H, Troster H, Bachmann M.
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| Gene 191(1):23-9. 1997
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31 | TRIM21
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| 52-kD SS-A/Ro: genomic structure and identification of an alternatively spliced transcript encoding a novel leucine zipper-minus autoantigen expressed in fetal and adult heart.
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| Chan EK, Di Donato F, Hamel JC, Tseng CE, Buyon JP.
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| J Exp Med 182(4):983-92.
1995
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32 | TRIM21
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| The location of a disease-associated polymorphism and genomic structure of the human 52-kDa Ro/SSA locus (SSA1).
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| Tsugu H, et al.
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| Genomics 24 : 541-548. 1994
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33 | TRIM21
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| The mapping of human 52-kD Ro/SSA autoantigen gene to human chromosome II, and its polymorphisms.
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| Frank MB, et al.
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| Am J Hum Genet 52 : 183-191. 1993
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34 | RO60, TRIM21
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| Protein Heterogeneity in the human Ro/SSA ribonucleoproteins.
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| Itoh K, et al.
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| J Clin Invest 87 : 177-186. 1991
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35 | TRIM21
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| Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen.
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| Chan EKL, et al.
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| J Clin Invest 87 : 68-76. 1991
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36 | CALR, TRIM21
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| Ro/SS-A and the pathogenic significance of its antibodies.
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| McCauliffe DP, Lux FA, Lieu TS, Sanz I, Hanke J, Newkirk MM, Siciliano MJ, Sontheimer RD, Capra JD.
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| J Autoimmunity 2(4):375-81. 1989
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