| 1 | IGFBP2, TRIB3
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| TRIB3 enhances cell viability during glucose deprivation in HEK293-derived cells by upregulating IGFBP2, a novel nutrient deficiency survival factor.
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| Örd T, Örd D, Adler P, Vilo J, Örd T.
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| Biochim Biophys Acta 1853(10 Pt A):2492-505. doi: 10.1016/j.bbamcr.2015.06.006. Epub 2015 Jun 18.
2015
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| 2 | TRIB3
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| Trib3 is regulated by IL-3 and affects bone marrow-derived mast cell survival and function.
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| Ord T, Ord D, Kuuse S, Plaas M, Ord T.
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| Cell Immunol 280(1):68-75. doi: 10.1016/j.cellimm.2012.11.011. Epub 2012 Nov 30.
2012
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| 3 | TRIB3
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| Regulation of TRIB3 mRNA and protein in breast cancer.
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| Wennemers M, Bussink J, van den Beucken T, Sweep FC, Span PN.
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| PLoS One 7(11):e49439. doi: 10.1371/journal.pone.0049439. Epub 2012 Nov 20.
2012
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| 4 | TRIB3
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| The role of TRB3 in mast cells sensitized with monomeric IgE.
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| Kuo CH, Morohoshi K, Aye CC, Garoon RB, Collins A, Ono SJ.
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| Exp Mol Pathol 93(3):408-15. doi: 10.1016/j.yexmp.2012.09.008. Epub 2012 Sep 21.
2012
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| 5 | APOBEC3A, APOBEC3C, TRIB3
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| Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A.
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| Aynaud MM, Suspène R, Vidalain PO, Mussil B, Guétard D, Tangy F, Wain-Hobson S, Vartanian JP.
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| J Biol Chem 287(46):39182-92. doi: 10.1074/jbc.M112.372722. Epub 2012 Sep 13.
2012
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| 6 | TRIB3
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| Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excess.
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| Liu J, Zhang W, Chuang GC, Hill HS, Tian L, Fu Y, Moellering DR, Garvey WT.
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| Am J Physiol Endocrinol Metab 303(7):E908-16. doi: 10.1152/ajpendo.00663.2011. Epub 2012 Jul 31.
2012
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| 7 | TRIB3
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| The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases.
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| Prudente S, Sesti G, Pandolfi A, Andreozzi F, Consoli A, Trischitta V.
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| Endocr Rev 33(4):526-46. doi: 10.1210/er.2011-1042. Epub 2012 May 10. Review.
2012
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| 8 | CASP3, TRIB3
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| Stress-inducible caspase substrate TRB3 promotes nuclear translocation of procaspase-3.
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| Shimizu K, Takahama S, Endo Y, Sawasaki T.
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| PLoS One 7(8):e42721. doi: 10.1371/journal.pone.0042721. Epub 2012 Aug 9.
2012
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| 9 | SMAD2, SMAD3, SMURF2, TRIB3
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| TRB3 interacts with SMAD3 promoting tumor cell migration and invasion.
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| Hua F, Mu R, Liu J, Xue J, Wang Z, Lin H, Yang H, Chen X, Hu Z.
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| J Cell Sci 124(Pt 19):3235-46. doi: 10.1242/jcs.082875. Epub 2011 Sep 6.
2011
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| 10 | TRIB3
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| TRB3 mediates homocysteine-induced inhibition of endothelial cell proliferation.
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| Zou T, Liu WJ, Li SD, Zhou W, Yang JF, Zou CG.
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| J Cell Physiol 226(11):2782-9. doi: 10.1002/jcp.22554.
2011
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| 11 | TRIB3
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| Tribbles homolog 3 denotes a poor prognosis in breast cancer and is involved in hypoxia response.
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| Wennemers M, Bussink J, Scheijen B, Nagtegaal ID, van Laarhoven HW, Raleigh JA, Varia MA, Heuvel JJ, Rouschop KM, Sweep FC, Span PN.
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| Breast Cancer Res 13(4):R82. doi: 10.1186/bcr2934.
2011
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| 12 | CDC25a, TRIB3
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| Dual mode of regulation of cell division cycle 25 A protein by TRB3.
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| Sakai S, Ohoka N, Onozaki K, Kitagawa M, Nakanishi M, Hayashi H.
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| Biol Pharm Bull 33(7):1112-6.
2010
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| 13 | TRIB3
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| The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.
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| Liew CW, Bochenski J, Kawamori D, Hu J, Leech CA, Wanic K, Malecki M, Warram JH, Qi L, Krolewski AS, Kulkarni RN.
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| J Clin Invest 120(8):2876-88. doi: 10.1172/JCI36849. Epub 2010 Jul 1.
2010
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| 14 | TRIB3
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| Tribbles homologue 3 (TRIB3) and the insulin-resistance genes in type 2 diabetes.
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| Beguinot F.
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| Diabetologia 53(9):1831-4. doi: 10.1007/s00125-010-1824-7. Epub 2010 Jun 22. No abstract available.
2010
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| 15 | FZR1, TRIB3
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| Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3.
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| Ohoka N, Sakai S, Onozaki K, Nakanishi M, Hayashi H.
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| Biochem Biophys Res Commun 392(3):289-94. doi: 10.1016/j.bbrc.2009.12.175. Epub 2010 Jan 11.
2010
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| 16 | TRIB3
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| Association of TRB3 gene Q84R polymorphism with type 2 diabetes mellitus in Chinese population.
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| Shi Z, Liu J, Guo Q, Ma X, Shen L, Xu S, Gao H, Yuan X, Zhang J.
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| Endocrine ndocrine. 2009 Mar 17. [Epub ahead of print] 2009
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| 17 | TRIB3
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| The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes.
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| Prudente S, Scarpelli D, Chandalia M, Zhang YY, Morini E, Del Guerra S, Perticone F, Li R, Powers C, Andreozzi F, Marchetti P, Dallapiccola B, Abate N, Doria A, Sesti G, Trischitta V.
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| J Clin Endocrinol Metab 94(1):190-6. Epub 2008 Nov 4.
2009
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| 18 | TRIB3
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| Human TRB3 is upregulated in stressed cells by the induction of translationally efficient mRNA containing a truncated 5'-UTR.
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| Ord T, Ord D, Kõivomägi M, Juhkam K, Ord T.
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| Gene 444(1-2):24-32. Epub 2009 Jun 6.
2009
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| 19 | TRIB3
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| TRB3 suppresses adipocyte differentiation by negatively regulating PPARgamma transcriptional activity.
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| Takahashi Y, Ohoka N, Hayashi H, Sato R.
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| J Lipid Res 49(4):880-92. Epub 2008 Jan 10.
2008
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| 20 | SIAH1, TRIB3
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| E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3.
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| Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F.
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| Cell Signal 20(5):942-8. Epub 2008 Jan 24.PMID: 18276110 2008
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| 21 | ATF4, TRIB3
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| TRB3 protects cells against the growth inhibitory and cytotoxic effect of ATF4.
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| Ord D, Meerits K, Ord T.
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| Exp Cell Res 313(16):3556-67. Epub 2007 Jul 25.PMID: 17707795 2007
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| 22 | TRIB3
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| Tribbles: novel regulators of cell function; evolutionary aspects.
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| Hegedus Z, Czibula A, Kiss-Toth E.
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| Cell Mol Life Sci 63(14):1632-41. Review.
2006
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| 23 | TRIB3
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| Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions.
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| Ord D, Ord T.
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| Biochem Biophys Res Commun 330(1):210-8. 2005
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| 24 | TRIB3, DDIT3, ATF4
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| TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.
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| Ohoka N, Yoshii S, Hattori T, Onozaki K, Hayashi H.
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| EMBO J 24(6):1243-55. Epub 2005 Mar 10. 2005
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| 25 | TRIB1, TRIB2, TRIB3
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| Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.
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| Kiss-Toth E, Bagstaff SM, Sung HY, Jozsa V, Dempsey C, Caunt JC, Oxley KM, Wyllie DH, Polgar T, Harte M, O'neill LA, Qwarnstrom EE, Dower SK.
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| J Biol Chem 279(41):42703-8. Epub 2004 Aug 6. 2004
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| 26 | PPARA, PPARGC1A, TRIB3
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| PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.
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| Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M.
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| Nat Med 10(5):530-4. Epub 2004 Apr 25. 2004
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| 27 | TRIB3
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| SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia.
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| Bowers AJ, Scully S, Boylan JF.
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| Oncogene 22(18):2823-35. 2003
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| 28 | TRIB3
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| TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver.
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| Du K, Herzig S, Kulkarni RN, Montminy M.
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| Science 300(5625):1574-7. 2003
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| 29 | TRIB3
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| SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.
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| Wu M, Xu LG, Zhai Z, Shu HB.
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| J Biol Chem 278(29):27072-9. Epub 2003 May 7. 2003
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