Citations for
1TPPP
Role of the microtubule-associated TPPP/p25 in Parkinson's and related diseases and its therapeutic potential.
Oláh J, Bertrand P, Ovádi J.
Expert Rev Proteomics 14(4):301-309. doi: 10.1080/14789450.2017.1304216. Epub 2017 Mar 15. 2017
2TPPP, TPPP2, TPPP3
Tubulin Binding and Polymerization Promoting Properties of Tubulin Polymerization Promoting Proteins Are Evolutionarily Conserved.
Oláh J, Szénási T, Szabó A, Kovács K, Lőw P, Štifanić M, Orosz F.
Biochemistry 56(7):1017-1024. doi: 10.1021/acs.biochem.6b00902. Epub 2017 Feb 6. 2017
3TPPP
Tubulin Binding and Polymerization Promoting Properties of Tubulin Polymerization Promoting Proteins Are Evolutionarily Conserved.
Oláh J, Szénási T, Szabó A, Kovács K, Lőw P, Štifanić M, Orosz F.
Biochemistry 56(7):1017-1024. doi: 10.1021/acs.biochem.6b00902. Epub 2017 Feb 6. 2017
4TPPP
Further evidence for microtubule-independent dimerization of TPPP/p25.
Oláh J, Szénási T, Szunyogh S, Szabó A, Lehotzky A, Ovádi J.
Sci Rep 7:40594. doi: 10.1038/srep40594. 2017
5SNCA, TPPP
Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins.
Szénási T, Oláh J, Szabó A, Szunyogh S, Láng A, Perczel A, Lehotzky A, Uversky VN, Ovádi J.
Biochim Biophys Acta 1863(1):310-323. doi: 10.1016/j.bbadis.2016.09.017. Epub 2016 Sep 24. 2017
6TPPP
Drosophila Ringmaker regulates microtubule stabilization and axonal extension during embryonic development.
Mino RE, Rogers SL, Risinger AL, Rohena C, Banerjee S, Bhat MA.
J Cell Sci 129(17):3282-94. doi: 10.1242/jcs.187294. Epub 2016 Jul 15. 2016
7BACE1, CDK5, TPPP
Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease.
Song WJ, Son MY, Lee HW, Seo H, Kim JH, Chung SH.
PLoS One 10(8):e0136950. doi: 10.1371/journal.pone.0136950. eCollection 2015. 2015
8SNCA, TPPP
Targeting the interface of the pathological complex of α-synuclein and TPPP/p25.
Szunyogh S, Oláh J, Szénási T, Szabó A, Ovádi J.
Biochim Biophys Acta 1852(12):2653-61. doi: 10.1016/j.bbadis.2015.09.012. Epub 2015 Sep 25. 2015
9TPPP
Self protein-protein interactions are involved in TPPP/p25 mediated microtubule bundling.
DeBonis S, Neumann E, Skoufias DA.
Sci Rep 5:13242. doi: 10.1038/srep13242. 2015
10TPPP
Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome.
Lehotzky A, Oláh J, Szunyogh S, Szabó A, Berki T, Ovádi J.
Biochim Biophys Acta 1852(1):83-91. doi: 10.1016/j.bbadis.2014.10.015. Epub 2014 Oct 31. 2015
11SNCA, TPPP
Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion.
Ejlerskov P, Rasmussen I, Nielsen TT, Bergström AL, Tohyama Y, Jensen PH, Vilhardt F.
J Biol Chem 288(24):17313-35. doi: 10.1074/jbc.M112.401174. Epub 2013 Apr 29. 2013
12TPPP
Tubulin polymerization promoting protein 1 (Tppp1) phosphorylation by Rho-associated coiled-coil kinase (rock) and cyclin-dependent kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell proliferation.
Schofield AV, Gamell C, Suryadinata R, Sarcevic B, Bernard O.
J Biol Chem 288(11):7907-17. doi: 10.1074/jbc.M112.441048. Epub 2013 Jan 25. 2013
13TPPP
Tubulin polymerization promoting protein 1 (TPPP1) increases β-catenin expression through inhibition of HDAC6 activity in U2OS osteosarcoma cells
Schofield AV, Gamell C, Bernard O.
Biochem Biophys Res Commun. Jul 12;436(4):571-7. doi: 10.1016/j.bbrc.2013.05.076. Epub 2013 May 29 2013
14LIMK1, LIMK2, TPPP
TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation.
Heng YW, Lim HH, Mina T, Utomo P, Zhong S, Lim CT, Koh CG.
J Cell Sci 125(Pt 6):1579-90. doi: 10.1242/jcs.096818. Epub 2012 Feb 10. 2012
15TPPP
A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis.
Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J.
Biochem Biophys Res Commun 409(1):137-41. Epub 2011 May 1. 2011
16HDAC6, TPPP
TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6.
Tokési N, Lehotzky A, Horváth I, Szabó B, Oláh J, Lau P, Ovádi J.
J Biol Chem 285(23):17896-906. Epub 2010 Mar 22.PMID: 20308065 2010
17TPPP, TPPP2, TPPP3
TPPP orthologs are ciliary proteins.
Orosz F, Ovádi J.
FEBS Lett 582(27):3757-64. Epub 2008 Oct 16. 2008
18AHRR, BRD9, CEP72, CLPTM1L, EXOC3, SLC6A3, SLC9A3, TPPP, TRIP13, ZDHHC11
Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer.
Kang JU, Koo SH, Kwon KC, Park JW, Kim JM.
Cancer Genet Cytogenet 182(1):1-11.PMID: 18328944 2008
19TPPP
The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules.
Acevedo K, Li R, Soo P, Suryadinata R, Sarcevic B, Valova VA, Graham ME, Robinson PJ, Bernard O.
Exp Cell Res 313(20):4091-106. 2007
20TPPP, ZDHHC11
Gain of 5p15.33 is associated with progression of bladder cancer.
Yamamoto Y, Chochi Y, Matsuyama H, Eguchi S, Kawauchi S, Furuya T, Oga A, Kang JJ, Naito K, Sasaki K.
Oncology 72(1-2):132-8. Epub 2007 Nov 15.PMID: 18025801 2007
21GAPDH, TPPP
Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies.
Oláh J, Tokési N, Vincze O, Horváth I, Lehotzky A, Erdei A, Szájli E, Medzihradszky KF, Orosz F, Kovács GG, Ovádi J.
FEBS Lett 580(25):5807-14. Epub 2006 Sep 27. 2006
22TPPP, TPPP2, TPPP3
Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions.
Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J.
Biochemistry 45(46):13818-26. 2006
23TPPP
TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation.
Tirian L, Hlavanda E, Olah J, Horvath I, Orosz F, Szabo B, Kovacs J, Szabad J, Ovadi J.
Proc Natl Acad Sci U S A 100(24):13976-81. Epub 2003 Nov 17. 2003
24TPPP
A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3.
Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, Hori T,Saito T.
J Hum Genet 44(2):121-2. 1999