1 | TPPP
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| Role of the microtubule-associated TPPP/p25 in Parkinson's and related diseases and its therapeutic potential.
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| Oláh J, Bertrand P, Ovádi J.
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| Expert Rev Proteomics 14(4):301-309. doi: 10.1080/14789450.2017.1304216. Epub 2017 Mar 15.
2017
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2 | TPPP, TPPP2, TPPP3
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| Tubulin Binding and Polymerization Promoting Properties of Tubulin Polymerization Promoting Proteins Are Evolutionarily Conserved.
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| Oláh J, Szénási T, Szabó A, Kovács K, Lőw P, tifanić M, Orosz F.
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| Biochemistry 56(7):1017-1024. doi: 10.1021/acs.biochem.6b00902. Epub 2017 Feb 6.
2017
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3 | TPPP
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| Tubulin Binding and Polymerization Promoting Properties of Tubulin Polymerization Promoting Proteins Are Evolutionarily Conserved.
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| Oláh J, Szénási T, Szabó A, Kovács K, Lőw P, tifanić M, Orosz F.
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| Biochemistry 56(7):1017-1024. doi: 10.1021/acs.biochem.6b00902. Epub 2017 Feb 6.
2017
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4 | TPPP
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| Further evidence for microtubule-independent dimerization of TPPP/p25.
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| Oláh J, Szénási T, Szunyogh S, Szabó A, Lehotzky A, Ovádi J.
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| Sci Rep 7:40594. doi: 10.1038/srep40594.
2017
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5 | SNCA, TPPP
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| Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins.
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| Szénási T, Oláh J, Szabó A, Szunyogh S, Láng A, Perczel A, Lehotzky A, Uversky VN, Ovádi J.
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| Biochim Biophys Acta 1863(1):310-323. doi: 10.1016/j.bbadis.2016.09.017. Epub 2016 Sep 24.
2017
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6 | TPPP
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| Drosophila Ringmaker regulates microtubule stabilization and axonal extension during embryonic development.
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| Mino RE, Rogers SL, Risinger AL, Rohena C, Banerjee S, Bhat MA.
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| J Cell Sci 129(17):3282-94. doi: 10.1242/jcs.187294. Epub 2016 Jul 15.
2016
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7 | BACE1, CDK5, TPPP
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| Enhancement of BACE1 Activity by p25/Cdk5-Mediated Phosphorylation in Alzheimer's Disease.
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| Song WJ, Son MY, Lee HW, Seo H, Kim JH, Chung SH.
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| PLoS One 10(8):e0136950. doi: 10.1371/journal.pone.0136950. eCollection 2015.
2015
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8 | SNCA, TPPP
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| Targeting the interface of the pathological complex of α-synuclein and TPPP/p25.
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| Szunyogh S, Oláh J, Szénási T, Szabó A, Ovádi J.
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| Biochim Biophys Acta 1852(12):2653-61. doi: 10.1016/j.bbadis.2015.09.012. Epub 2015 Sep 25.
2015
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9 | TPPP
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| Self protein-protein interactions are involved in TPPP/p25 mediated microtubule bundling.
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| DeBonis S, Neumann E, Skoufias DA.
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| Sci Rep 5:13242. doi: 10.1038/srep13242.
2015
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10 | TPPP
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| Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome.
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| Lehotzky A, Oláh J, Szunyogh S, Szabó A, Berki T, Ovádi J.
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| Biochim Biophys Acta 1852(1):83-91. doi: 10.1016/j.bbadis.2014.10.015. Epub 2014 Oct 31.
2015
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11 | SNCA, TPPP
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| Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion.
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| Ejlerskov P, Rasmussen I, Nielsen TT, Bergström AL, Tohyama Y, Jensen PH, Vilhardt F.
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| J Biol Chem 288(24):17313-35. doi: 10.1074/jbc.M112.401174. Epub 2013 Apr 29.
2013
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12 | TPPP
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| Tubulin polymerization promoting protein 1 (Tppp1) phosphorylation by Rho-associated coiled-coil kinase (rock) and cyclin-dependent kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell proliferation.
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| Schofield AV, Gamell C, Suryadinata R, Sarcevic B, Bernard O.
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| J Biol Chem 288(11):7907-17. doi: 10.1074/jbc.M112.441048. Epub 2013 Jan 25.
2013
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13 | TPPP
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| Tubulin polymerization promoting protein 1 (TPPP1) increases β-catenin expression through inhibition of HDAC6 activity in U2OS osteosarcoma cells
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| Schofield AV, Gamell C, Bernard O.
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| Biochem Biophys Res Commun. Jul 12;436(4):571-7. doi: 10.1016/j.bbrc.2013.05.076. Epub 2013 May 29 2013
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14 | LIMK1, LIMK2, TPPP
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| TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation.
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| Heng YW, Lim HH, Mina T, Utomo P, Zhong S, Lim CT, Koh CG.
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| J Cell Sci 125(Pt 6):1579-90. doi: 10.1242/jcs.096818. Epub 2012 Feb 10.
2012
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15 | TPPP
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| A new myelin protein, TPPP/p25, reduced in demyelinated lesions is enriched in cerebrospinal fluid of multiple sclerosis.
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| Vincze O, Oláh J, Zádori D, Klivényi P, Vécsei L, Ovádi J.
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| Biochem Biophys Res Commun 409(1):137-41. Epub 2011 May 1.
2011
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16 | HDAC6, TPPP
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| TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6.
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| Tokési N, Lehotzky A, Horváth I, Szabó B, Oláh J, Lau P, Ovádi J.
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| J Biol Chem 285(23):17896-906. Epub 2010 Mar 22.PMID: 20308065 2010
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17 | TPPP, TPPP2, TPPP3
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| TPPP orthologs are ciliary proteins.
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| Orosz F, Ovádi J.
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| FEBS Lett 582(27):3757-64. Epub 2008 Oct 16.
2008
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18 | AHRR, BRD9, CEP72, CLPTM1L, EXOC3, SLC6A3, SLC9A3, TPPP, TRIP13, ZDHHC11
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| Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer.
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| Kang JU, Koo SH, Kwon KC, Park JW, Kim JM.
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| Cancer Genet Cytogenet 182(1):1-11.PMID: 18328944 2008
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19 | TPPP
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| The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules.
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| Acevedo K, Li R, Soo P, Suryadinata R, Sarcevic B, Valova VA, Graham ME, Robinson PJ, Bernard O.
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| Exp Cell Res 313(20):4091-106.
2007
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20 | TPPP, ZDHHC11
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| Gain of 5p15.33 is associated with progression of bladder cancer.
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| Yamamoto Y, Chochi Y, Matsuyama H, Eguchi S, Kawauchi S, Furuya T, Oga A, Kang JJ, Naito K, Sasaki K.
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| Oncology 72(1-2):132-8. Epub 2007 Nov 15.PMID: 18025801 2007
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21 | GAPDH, TPPP
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| Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies.
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| Oláh J, Tokési N, Vincze O, Horváth I, Lehotzky A, Erdei A, Szájli E, Medzihradszky KF, Orosz F, Kovács GG, Ovádi J.
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| FEBS Lett 580(25):5807-14. Epub 2006 Sep 27. 2006
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22 | TPPP, TPPP2, TPPP3
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| Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions.
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| Vincze O, Tokesi N, Olah J, Hlavanda E, Zotter A, Horvath I, Lehotzky A, Tirian L, Medzihradszky KF, Kovacs J, Orosz F, Ovadi J.
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| Biochemistry 45(46):13818-26. 2006
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23 | TPPP
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| TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation.
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| Tirian L, Hlavanda E, Olah J, Horvath I, Orosz F, Szabo B, Kovacs J, Szabad J, Ovadi J.
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| Proc Natl Acad Sci U S A 100(24):13976-81. Epub 2003 Nov 17. 2003
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24 | TPPP
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| A novel human gene whose product shares significant homology with the bovine brain-specific protein p25 on chromosome 5p15.3.
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| Seki N, Hattori A, Sugano S, Suzuki Y, Nakagawara A, Muramatsu M, Hori T,Saito T.
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| J Hum Genet 44(2):121-2. 1999
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