| 1 | SBDS, TPP1
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| Shwachman-Diamond Syndrome Protein SBDS Maintains Human Telomeres by Regulating Telomerase Recruitment
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| Liu Y, Liu F, Cao Y, Xu H, Wu Y, Wu S, Liu D, Zhao Y, Songyang Z, Ma W.
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| Cell Rep. Feb 13;22(7):1849-1860. doi: 10.1016/j.celrep.2018.01.057 2018
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| 2 | RFX5, TPP1
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| The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma.
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| Zhao Y, Xie X, Liao W, Zhang H, Cao H, Fei R, Wang X, Wei L, Shao Q, Chen H.
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| Oncol Rep 37(1):289-296. doi: 10.3892/or.2016.5240. Epub 2016 Nov 9.
2017
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| 3 | TPP1
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| Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance.
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| Rajavel M, Orban T, Xu M, Hernandez-Sanchez W, de la Fuente M, Palczewski K, Taylor DJ.
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| Nucleic Acids Res ucleic Acids Res. 2016 Sep 20. pii: gkw846. [Epub ahead of print]
2016
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| 4 | TPP1
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| Shelterin TPP1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirt1 Deacetylase in Chronic Obstructive Pulmonary Disease.
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| Ahmad T, Sundar IK, Tormos AM, Lerner CA, Gerloff J, Yao H, Rahman I.
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| Am J Respir Cell Mol Biol m J Respir Cell Mol Biol. 2016 Aug 25. [Epub ahead of print]
2016
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| 5 | POT1, TERF1, TERF2, TERF2IP, TINF2, TPP1
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| Molecular basis and quantitative assessment of TRF1 and TRF2 protein interactions with TIN2 and Apollo peptides.
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| Kalathiya U, Padariya M, Baginski M.
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| Eur Biophys J ur Biophys J. 2016 Jul 22. [Epub ahead of print]
2016
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| 6 | NEK6, TPP1
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| NEK6-mediated phosphorylation of human TPP1 regulates telomere length through telomerase recruitment.
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| Hirai Y, Tamura M, Otani J, Ishikawa F.
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| Genes Cells 21(8):874-89. doi: 10.1111/gtc.12391. Epub 2016 Jul 11.
2016
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| 7 | TPP1
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| TPP1 Blocks an ATR-Mediated Resection Mechanism at Telomeres.
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| Kibe T, Zimmermann M, de Lange T.
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| Mol Cell 61(2):236-46. doi: 10.1016/j.molcel.2015.12.016. Epub 2016 Jan 14.
2016
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| 8 | SCAAR1, TPP1
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| TPP1 deficiency: Rare cause of isolated childhood-onset progressive ataxia.
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| Dy ME, Sims KB, Friedman J.
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| Neurology 85(14):1259-61. doi: 10.1212/WNL.0000000000001876. Epub 2015 Jul 29. No abstract available. 2015
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| 9 | TERT, TPP1
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| The Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner.
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| Chu TW, D'Souza Y, Autexier C.
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| Mol Cell Biol 36(1):210-22. doi: 10.1128/MCB.00746-15.
2015
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| 10 | TPP1
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| Inherited bone marrow failure associated with germline mutation of ACD, the gene encoding telomere protein TPP1.
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| Guo Y, Kartawinata M, Li J, Pickett HA, Teo J, Kilo T, Barbaro PM, Keating B, Chen Y, Tian L, Al-Odaib A, Reddel RR, Christodoulou J, Xu X, Hakonarson H, Bryan TM.
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| Blood 124(18):2767-74. doi: 10.1182/blood-2014-08-596445. Epub 2014 Sep 9.
2014
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| 11 | TPP1, USP7
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| The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7.
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| Zemp I, Lingner J.
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| J Biol Chem 289(41):28595-606. doi: 10.1074/jbc.M114.596056. Epub 2014 Aug 29.
2014
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| 12 | TPP1
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| Multiple facets of TPP1 in telomere maintenance.
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| Rajavel M, Mullins MR, Taylor DJ.
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| Biochim Biophys Acta 1844(9):1550-9. doi: 10.1016/j.bbapap.2014.04.014. Epub 2014 Apr 26. Review.
2014
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| 13 | SCAAR1, TPP1
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| Autosomal recessive spinocerebellar ataxia 7 (SCAR7) is caused by variants in TPP1, the gene involved in classic late-infantile neuronal ceroid lipofuscinosis 2 disease (CLN2 disease).
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| Sun Y, Almomani R, Breedveld GJ, Santen GW, Aten E, Lefeber DJ, Hoff JI, Brusse E, Verheijen FW, Verdijk RM, Kriek M, Oostra B, Breuning MH, Losekoot M, den Dunnen JT, van de Warrenburg BP, Maat-Kievit AJ.
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| Hum Mutat 34(5):706-13. doi: 10.1002/humu.22292. Epub 2013 Mar 11.
2013
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| 14 | AKT1, TPP1
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| Akt regulates TPP1 homodimerization and telomere protection.
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| Han X, Liu D, Zhang Y, Li Y, Lu W, Chen J, Songyang Z.
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| Aging Cell 12(6):1091-9. doi: 10.1111/acel.12137. Epub 2013 Aug 11.
2013
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| 15 | TPP1
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| Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment.
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| Zhang Y, Chen LY, Han X, Xie W, Kim H, Yang D, Liu D, Songyang Z.
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| Proc Natl Acad Sci U S A 110(14):5457-62. doi: 10.1073/pnas.1217733110. Epub 2013 Mar 18.
2013
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| 16 | TPP1
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| TPP1 OB-fold domain controls telomere maintenance by recruiting telomerase to chromosome ends.
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| Zhong FL, Batista LF, Freund A, Pech MF, Venteicher AS, Artandi SE.
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| Cell 150(3):481-94. doi: 10.1016/j.cell.2012.07.012.
2012
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| 17 | TINF2, TPP1
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| Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control.
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| Chen LY, Zhang Y, Zhang Q, Li H, Luo Z, Fang H, Kim SH, Qin L, Yotnda P, Xu J, Tu BP, Bai Y, Songyang Z.
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| Mol Cell 47(6):839-50. doi: 10.1016/j.molcel.2012.07.002. Epub 2012 Aug 9.
2012
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| 18 | TPP1
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| The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.
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| Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR.
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| Nature 492(7428):285-9. doi: 10.1038/nature11648. Epub 2012 Oct 24.
2012
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| 19 | POT1, TINF2, TPP1
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| Telomere protection by TPP1/POT1 requires tethering to TIN2.
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| Takai KK, Kibe T, Donigian JR, Frescas D, de Lange T.
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| Mol Cell 44(4):647-59. doi: 10.1016/j.molcel.2011.08.043.
2011
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| 20 | RNF8, TPP1
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| The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection.
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| Rai R, Li JM, Zheng H, Lok GT, Deng Y, Huen MS, Chen J, Jin J, Chang S.
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| Nat Struct Mol Biol 18(12):1400-7. doi: 10.1038/nsmb.2172.
2011
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| 21 | CLN2, TPP1
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| Glial fibrillary acidic protein is elevated in the lysosomal storage disease classical late-infantile neuronal ceroid lipofuscinosis, but is not a component of the storage material.
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| Xu S, Sleat DE, Jadot M, Lobel P.
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| Biochem J 428(3):355-62.PMID: 20370715 2010
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| 22 | TPP1
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| Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner.
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| Autefage H, Albinet V, Garcia V, Berges H, Nicolau ML, Therville N, Altié MF, Caillaud C, Levade T, Andrieu-Abadie N.
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| J Biol Chem 284(17):11507-16. Epub 2009 Feb 26.
2009
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| 23 | CLN2, TPP1
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| Late-infantile neuronal ceroid lipofuscinosis (CLN2/Jansky-Bielschowsky type) in Oman.
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| Koul R, Al-Futaisi A, Ganesh A, Rangnath Bushnarmuth S.
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| J Child Neurol 22(5):555-9.
2007
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| 24 | CLN2, TPP1
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| Mutations in classical late infantile neuronal ceroid lipofuscinosis disrupt transport of tripeptidyl-peptidase I to lysosomes.
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| Steinfeld R, Steinke HB, Isbrandt D, Kohlschutter A, Gartner J.
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| Hum Mol Genet 13(20):2483-91. Epub 2004 Aug 18. 2004
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| 25 | CLN2, TPP1
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| The lysosomal degradation of neuromedin B is dependent on tripeptidyl peptidase-I: evidence for the impairment of neuropeptide degradation in late-infantile neuronal ceroid lipofuscinosis.
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| Kopan S, Sivasubramaniam U, Warburton MJ.
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| Biochem Biophys Res Commun 319(1):58-65. 2004
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| 26 | CLN2, CLN6, TPP1
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| Mutations in a novel CLN6-encoded transmembrane protein cause variant neuronal ceroid lipofuscinosis in man and mouse.
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| Gao H, Boustany RM, Espinola JA, Cotman SL, Srinidhi L, Antonellis KA, Gillis T, Qin X, Liu S, Donahue LR, Bronson RT, Faust JR, Stout D, Haines JL, Lerner TJ, MacDonald ME.
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| Am J Hum Genet 70(2):324-35. 2002
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| 27 | CLN1, CLN2, TPP1
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| Neuronal ceroid lipofuscinoses caused by defects in soluble lysosomal enzymes (CLN1 and CLN2).
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| Hofmann SL, Atashband A, Cho SK, Das AK, Gupta P, Lu JY.
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| Curr Mol Med 2(5):423-37. Review. 2002
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| 28 | CLN2, TPP1
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| Distribution and development of CLN2 protein, the late-infantile neuronal ceroid lipofuscinosis gene product.
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| Kurachi Y, Oka A, Itoh M, Mizuguchi M, Hayashi M, Takashima S.
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| Acta Neuropathol (Berl) 102(1):20-6. 2001
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| 29 | CLN1, CLN2, CLN3, TPP1
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| Neural and extraneural expression of the neuronal ceroid lipofuscinoses genes CLN1, CLN2, and CLN3: functional implications for CLN3.
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| Chattopadhyay S, Pearce DA.
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| Mol Genet Metab 71(1-2):207-11. 2000
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| 30 | CLN1, CLN2, PPT1, TPP1
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| Developmental changes in the expression of neuronal ceroid lipofuscinoses-linked proteins.
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| Suopanki J, Partanen S, Ezaki J, Baumann M, Kominami E, Tyynela J.
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| Mol Genet Metab 71(1-2):190-4. 2000
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| 31 | CLN2, TPP1
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| Tripeptidyl-peptidase I is apparently the CLN2 protein absent in classical late-infantile neuronal ceroid lipofuscinosis.
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| Rawlings ND, et al.
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| Biochim Biophys Acta 1429(2):496-500. 1999
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| 32 | CLN2, TPP1
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| Reevaluation of neuronal ceroid lipofuscinoses: atypical juvenile onset may Be the result of CLN2 mutations.
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| Wisniewski KE, et al.
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| Mol Genet Metab 66(4):248-52. 1999
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| 33 | CLN2, TPP1
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| Mutational analysis of the defective protease in classic late-infantile neuronal ceroid lipofuscinosis, a neurodegenerative lysosomal storage disorder.
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| Sleat DE, et al.
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| Am J Hum Genet 64(6):1511-23. 1999
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| 34 | CLN2, CLN2, TPP1
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| Late infantile neuronal ceroid lipofuscinosis is due to splicing mutations in the CLN2 gene.
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| Hartikainen JM, et al.
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| Mol Genet Metab 67(2):162-8. 1999
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| 35 | CLN1, CLN2, CLN3, CLN5, PPT1, TPP1
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| Molecular basis of the neuronal ceroid lipofuscinoses: Mutations in CLN1, CLN2, CLN3, and CLN5.
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| Mole SE, et al.
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| Hum Mutat 14(3):199-215 1999
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| 36 | CLN2,ILK, CLN2, TAF10, TPP1
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| Structural organization and sequence of CLN2, the defective gene in classical late infantile neuronal ceroid lipofuscinosis.
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| Liu CG, Sleat DE, Donnelly RJ, Lobel P.
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| Genomics 50 : 206-212. 1998
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| 37 | CLN2, TPP1
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| Two common mutations in the CLN2 gene underlie late infantile neuronal ceroid lipofuscinosis.
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| Zhong N, et al.
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| Clin Genet 54 : 234-238. 1998
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| 38 | CLN2, TPP1
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| The expression of late infantile neuronal ceroid lipofuscinosis (CLN2) gene product in human brains.
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| Oka A, et al.
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| Neurosci Lett 257 : 113-115. 1998
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| 39 | CLN2, CLN6, TPP1
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| Loci for classical and a variant late infantile neuronal ceroid lipofuscinosis map to chromosomes 11p15 and 15q21-23.
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| Sharp JD, et al.
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| Hum Mol Genet 6 : 591-595. 1997
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| 40 | CLN2, TPP1
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| Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis.
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| Sleat DE, Donnelly RJ, Lackland H, Liu CG, Sohar I, Pullarkat RK, Lobel P.
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| Science 277(5333):1802-5. 1997
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| 41 | TPP1
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| Purification and characterization of a tripeptidyl peptidase I from human osteoclastomas: evidence for its role in bone resorption.
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| Page AE, Fuller K, Chambers TJ, Warburton MJ.
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| Arch Biochem Biophys 306(2):354-9.
1993
|