Citations for
1TPCN2
Ca2+ release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos.
Kelu JJ, Webb SE, Parrington J, Galione A, Miller AL.
Dev Biol 425(2):109-129. doi: 10.1016/j.ydbio.2017.03.031. Epub 2017 Apr 6. 2017
2TPCN2
TPC2 controls pigmentation by regulating melanosome pH and size.
Ambrosio AL, Boyle JA, Aradi AE, Christian KA, Di Pietro SM.
Proc Natl Acad Sci U S A 113(20):5622-7. doi: 10.1073/pnas.1600108113. Epub 2016 May 2. 2016
3TPCN1, TPCN2
Exploring the biophysical evidence that mammalian two-pore channels are NAADP-activated calcium-permeable channels.
Pitt SJ, Reilly-O'Donnell B, Sitsapesan R.
J Physiol 594(15):4171-9. doi: 10.1113/JP270936. Epub 2016 Mar 31. Review. 2016
4TPCN1, TPCN2
The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca˛⁺ dynamics and insulin secretion.
Cane MC, Parrington J, Rorsman P, Galione A, Rutter GA.
Cell Calcium 59(1):32-40. doi: 10.1016/j.ceca.2015.12.004. Epub 2015 Dec 23. 2016
5TPCN1, TPCN2
Endolysosomal two-pore channels regulate autophagy in cardiomyocytes.
García-Rúa V, Feijóo-Bandín S, Rodríguez-Penas D, Mosquera-Leal A, Abu-Assi E, Beiras A, María Seoane L, Lear P, Parrington J, Portolés M, Roselló-Lletí E, Rivera M, Gualillo O, Parra V, Hill JA, Rothermel B, González-Juanatey JR, Lago F.
J Physiol 594(11):3061-77. doi: 10.1113/JP271332. Epub 2016 Feb 4. 2016
6TPCN2
TPC2 mediates new mechanisms of platelet dense granule membrane dynamics through regulation of Ca2+ release.
Ambrosio AL, Boyle JA, Di Pietro SM.
Mol Biol Cell 26(18):3263-74. doi: 10.1091/mbc.E15-01-0058. Epub 2015 Jul 22. 2015
7TPCN1, TPCN2
Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.
Lear PV, González-Touceda D, Porteiro Couto B, Viańo P, Guymer V, Remzova E, Tunn R, Chalasani A, García-Caballero T, Hargreaves IP, Tynan PW, Christian HC, Nogueiras R, Parrington J, Diéguez C.
Endocrinology 156(3):975-86. doi: 10.1210/en.2014-1766. Epub 2014 Dec 29. 2015
8TPCN2
Lysosomal two-pore channel subtype 2 (TPC2) regulates skeletal muscle autophagic signaling.
Lin PH, Duann P, Komazaki S, Park KH, Li H, Sun M, Sermersheim M, Gumpper K, Parrington J, Galione A, Evans AM, Zhu MX, Ma J.
J Biol Chem 290(6):3377-89. doi: 10.1074/jbc.M114.608471. Epub 2014 Dec 5. 2015
9TPCN1, TPCN2
Function and dysfunction of two-pore channels.
Patel S.
Sci Signal 8(384):re7. doi: 10.1126/scisignal.aab3314. Review. 2015
10TPCN1, TPCN2
TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.
Ruas M, Chuang KT, Davis LC, Al-Douri A, Tynan PW, Tunn R, Teboul L, Galione A, Parrington J.
Mol Cell Biol 34(21):3981-92. doi: 10.1128/MCB.00113-14. Epub 2014 Aug 18. 2014
11TPCN2
Two pore channel 2 differentially modulates neural differentiation of mouse embryonic stem cells.
Zhang ZH, Lu YY, Yue J.
PLoS One 8(6):e66077. doi: 10.1371/journal.pone.0066077. Print 2013. 2013
12HAX1, TPCN1, TPCN2
Hax-1 identified as a two-pore channel (TPC)-binding protein
Lam AK, Galione A, Lai FA, Zissimopoulos S.
FEBS Lett. Nov 29;587(23):3782-6. doi: 10.1016/j.febslet.2013.10.031. Epub 2013 Nov 1. 2013
13TPCN2
Identification of two-pore channel 2 as a novel regulator of osteoclastogenesis.
Notomi T, Ezura Y, Noda M.
J Biol Chem 287(42):35057-64. doi: 10.1074/jbc.M111.328930. Epub 2012 Jul 25. 2012
14TPCN1, TPCN2
Two-pore channel 2 (TPC2) modulates store-operated Ca(2+) entry.
López J, Dionisio N, Berna-Erro A, Galán C, Salido GM, Rosado JA.
Biochim Biophys Acta 1823(10):1976-83. doi: 10.1016/j.bbamcr.2012.08.002. 2012
15TPCN1, TPCN2
TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.
Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H.
Cell 151(2):372-83. doi: 10.1016/j.cell.2012.08.036. 2012
16TPCN2
Characterization of two-pore channel 2 (TPCN2)-mediated Ca2+ currents in isolated lysosomes.
Schieder M, Rötzer K, Brüggemann A, Biel M, Wahl-Schott CA.
J Biol Chem. 285(28):21219-22. 2010
17TPCN2
TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+.
Pitt SJ, Funnell TM, Sitsapesan M, Venturi E, Rietdorf K, Ruas M, Ganesan A, Gosain R, Churchill GC, Zhu MX, Parrington J, Galione A, Sitsapesan R.
J Biol Chem 285(45):35039-46. Epub 2010 Aug 18. 2010
18TPCN1, TPCN2
NAADP mobilizes calcium from acidic organelles through two-pore channels.
Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX.
Nature 459(7246):596-600. Epub 2009 Apr 22. 2009
19TPCN2
The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores.
Zong X, Schieder M, Cuny H, Fenske S, Gruner C, Rötzer K, Griesbeck O, Harz H, Biel M, Wahl-Schott C.
Pflugers Arch 458(5):891-9. Epub 2009 Jun 26. 2009
20ASIP, TPCN2, MC1R, TYRP1
Two newly identified genetic determinants of pigmentation in Europeans.
Sulem P, Gudbjartsson DF, Stacey SN, Helgason A, Rafnar T, Jakobsdottir M, Steinberg S, Gudjonsson SA, Palsson A, Thorleifsson G, P‡lsson S, Sigurgeirsson B, Thorisdottir K, Ragnarsson R, Benediktsdottir KR, Aben KK, Vermeulen SH, Goldstein AM, Tucker MA, Kiemeney LA, Olafsson JH, Gulcher J, Kong A, Thorsteinsdottir U, Stefansson K.
Nat Genet 40(7):835-7. Epub 2008 May 18. 2008