| 1 | TPCN1, TPCN2
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| Exploring the biophysical evidence that mammalian two-pore channels are NAADP-activated calcium-permeable channels.
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| Pitt SJ, Reilly-O'Donnell B, Sitsapesan R.
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| J Physiol 594(15):4171-9. doi: 10.1113/JP270936. Epub 2016 Mar 31. Review.
2016
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| 2 | TPCN1, TPCN2
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| The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca²⁺ dynamics and insulin secretion.
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| Cane MC, Parrington J, Rorsman P, Galione A, Rutter GA.
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| Cell Calcium 59(1):32-40. doi: 10.1016/j.ceca.2015.12.004. Epub 2015 Dec 23.
2016
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| 3 | TPCN1, TPCN2
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| Endolysosomal two-pore channels regulate autophagy in cardiomyocytes.
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| García-Rúa V, Feijóo-Bandín S, Rodríguez-Penas D, Mosquera-Leal A, Abu-Assi E, Beiras A, María Seoane L, Lear P, Parrington J, Portolés M, Roselló-Lletí E, Rivera M, Gualillo O, Parra V, Hill JA, Rothermel B, González-Juanatey JR, Lago F.
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| J Physiol 594(11):3061-77. doi: 10.1113/JP271332. Epub 2016 Feb 4.
2016
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| 4 | TPCN1, TPCN2
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| Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.
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| Lear PV, González-Touceda D, Porteiro Couto B, Viaño P, Guymer V, Remzova E, Tunn R, Chalasani A, García-Caballero T, Hargreaves IP, Tynan PW, Christian HC, Nogueiras R, Parrington J, Diéguez C.
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| Endocrinology 156(3):975-86. doi: 10.1210/en.2014-1766. Epub 2014 Dec 29.
2015
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| 5 | TPCN1, TPCN2
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| Function and dysfunction of two-pore channels.
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| Patel S.
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| Sci Signal 8(384):re7. doi: 10.1126/scisignal.aab3314. Review.
2015
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| 6 | TPCN1
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| Two-pore channel 1 interacts with citron kinase, regulating completion of cytokinesis.
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| Horton JS, Wakano CT, Speck M, Stokes AJ.
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| Channels (Austin) 9(1):21-9. doi: 10.4161/19336950.2014.978676.
2015
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| 7 | TPCN1, TPCN2
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| TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.
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| Ruas M, Chuang KT, Davis LC, Al-Douri A, Tynan PW, Tunn R, Teboul L, Galione A, Parrington J.
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| Mol Cell Biol 34(21):3981-92. doi: 10.1128/MCB.00113-14. Epub 2014 Aug 18.
2014
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| 8 | TPCN1
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| Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+.
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| Pitt SJ, Lam AK, Rietdorf K, Galione A, Sitsapesan R.
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| Sci Signal 7(326):ra46. doi: 10.1126/scisignal.2004854.
2014
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| 9 | TPCN1
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| The voltage-gated sodium channel TPC1 confers endolysosomal excitability.
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| Cang C, Bekele B, Ren D.
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| Nat Chem Biol 10(6):463-9. doi: 10.1038/nchembio.1522. Epub 2014 Apr 28.
2014
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| 10 | HAX1, TPCN1, TPCN2
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| Hax-1 identified as a two-pore channel (TPC)-binding protein
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| Lam AK, Galione A, Lai FA, Zissimopoulos S.
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| FEBS Lett. Nov 29;587(23):3782-6. doi: 10.1016/j.febslet.2013.10.031. Epub 2013 Nov 1. 2013
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| 11 | TPCN1, TPCN2
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| Two-pore channel 2 (TPC2) modulates store-operated Ca(2+) entry.
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| López J, Dionisio N, Berna-Erro A, Galán C, Salido GM, Rosado JA.
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| Biochim Biophys Acta 1823(10):1976-83. doi: 10.1016/j.bbamcr.2012.08.002.
2012
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| 12 | TPCN1, TPCN2
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| TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.
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| Wang X, Zhang X, Dong XP, Samie M, Li X, Cheng X, Goschka A, Shen D, Zhou Y, Harlow J, Zhu MX, Clapham DE, Ren D, Xu H.
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| Cell 151(2):372-83. doi: 10.1016/j.cell.2012.08.036.
2012
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| 13 | MCOLN1, TPCN1
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| Transient receptor potential mucolipin 1 (TRPML1) and two-pore channels are functionally independent organellar ion channels.
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| Yamaguchi S, Jha A, Li Q, Soyombo AA, Dickinson GD, Churamani D, Brailoiu E, Patel S, Muallem S.
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| J Biol Chem 286(26):22934-42. doi: 10.1074/jbc.M110.210930. Epub 2011 May 3.
2011
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| 14 | TPCN1, TPCN2
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| NAADP mobilizes calcium from acidic organelles through two-pore channels.
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| Calcraft PJ, Ruas M, Pan Z, Cheng X, Arredouani A, Hao X, Tang J, Rietdorf K, Teboul L, Chuang KT, Lin P, Xiao R, Wang C, Zhu Y, Lin Y, Wyatt CN, Parrington J, Ma J, Evans AM, Galione A, Zhu MX.
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| Nature 459(7246):596-600. Epub 2009 Apr 22.
2009
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| 15 | TPCN1
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| Molecular cloning of a novel form (two-repeat) protein related to voltage-gated sodium and calcium channels.
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| Ishibashi K, Suzuki M, Imai M.
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| Biochem Biophys Res Commun 270(2):370-6. 2000
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| 16 | AARS2, ADAMTSL3, AHRR, AMIGO1, ANKFY1, ARHGAP31, ARID1A, ARID1B, ASAP1, ASB1, BACE1, BIRC6, BRPF3, C14orf118, CASKIN2, CCPG1, CD2BP2, CNOT6, COG6, CPAMD8, DCDC2, DLG3, ERBIN, ERGIC1, FAM190B, FAM63B, FBXO40, FILIP1, FSTL5, FZR1, GALNTL1, GATAD2B, GDA, GMEB2, GNPTAB, GRID1, GRIPAP1, HECTD1, HEG1, HHATL, INTU, IPO9, ISY1, KCNH3, KIAA1143, KIAA1161, KIAA1191, KIAA1217, KIAA1274, LCHN, LMBR1L, LRFN2, LRRC47, MACF1, MAP7D1, MIER2, MTA3, MYO5B, MYOF, NDFIP2, NDRG2, NELFB, NLGN4X, NLN, OGDHL, PAIP2B, PAK7, PECR, PLEKHG1, PLEKHH1, PNKD, PNMAL2, PPP1R9A, PRDM10, REXO1, RIMKLB, RNF150, SGPL1, SHROOM4, SLC39A10, SLC45A4, SRGAP2, STK36, SULF2, TBC1D24, TLE4, TMCC3, TPCN1, TRMT6, TTC7A, TTC7B, USP31, ZBTB47, ZC4H2, ZNF295, ZNF490, ZNF644, ZNF777
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| Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.
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| Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O.
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| DNA Res 6(5):329-36. 1999
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