| 1 | DEE100, DEL1Q41, DISP1, FBXO28, TP53BP2, WDR26
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| A novel FBXO28 frameshift mutation in a child with developmental delay, dysmorphic features, and intractable epilepsy: A second gene that may contribute to the 1q41-q42 deletion phenotype.
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| Balak C, Belnap N, Ramsey K, Joss S, Devriendt K, Naymik M, Jepsen W, Siniard AL, Szelinger S, Parker ME, Richholt R, Izatt T, LaFleur M, Terraf P, Llaci L, De Both M, Piras IS, Rangasamy S, Schrauwen I, Craig DW, Huentelman M, Narayanan V.
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| Am J Med Genet A. Jul;176(7):1549-1558. doi: 10.1002/ajmg.a.38712. 2018
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| 2 | TP53BP2
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| STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression.
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| Turnquist C, Wang Y, Severson DT, Zhong S, Sun B, Ma J, Constaninescu SN, Ansorge O, Stolp HB, Molnár Z, Szele FG, Lu X.
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| Proc Natl Acad Sci U S A 111(27):9834-9. doi: 10.1073/pnas.1407898111. Epub 2014 Jun 23.
2014
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| 3 | SIAH2, TP53BP2
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| Siah2 regulates tight junction integrity and cell polarity through control of ASPP2 stability.
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| Kim H, Claps G, Möller A, Bowtell D, Lu X, Ronai ZA.
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| Oncogene 33(15):2004-10. doi: 10.1038/onc.2013.149. Epub 2013 May 6.
2014
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| 4 | TP53BP2
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| N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence.
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| Wang Z, Liu Y, Takahashi M, Van Hook K, Kampa-Schittenhelm KM, Sheppard BC, Sears RC, Stork PJ, Lopez CD.
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| Proc Natl Acad Sci U S A 110(1):312-7. doi: 10.1073/pnas.1201514110. Epub 2012 Dec 17.
2013
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| 5 | TP53BP2
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| Regulation of ASPP2 interaction with p53 core domain by an intramolecular autoinhibitory mechanism.
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| Rotem-Bamberger S, Katz C, Friedler A.
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| PLoS One 8(3):e58470. doi: 10.1371/journal.pone.0058470. Epub 2013 Mar 5.
2013
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| 6 | HRAS, TP53BP2
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| Autophagic activity dictates the cellular response to oncogenic RAS.
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| Wang Y, Wang XD, Lapi E, Sullivan A, Jia W, He YW, Ratnayaka I, Zhong S, Goldin RD, Goemans CG, Tolkovsky AM, Lu X.
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| Proc Natl Acad Sci U S A 109(33):13325-30. doi: 10.1073/pnas.1120193109. Epub 2012 Jul 30.
2012
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| 7 | PPP1CA, TAZ, TP53BP2
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| PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ.
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| Liu CY, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei QY, Guan KL.
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| J Biol Chem 286(7):5558-66. doi: 10.1074/jbc.M110.194019. Epub 2010 Dec 28.
2011
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| 8 | PARD3, TP53BP2
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| ASPP2 regulates epithelial cell polarity through the PAR complex.
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| Cong W, Hirose T, Harita Y, Yamashita A, Mizuno K, Hirano H, Ohno S.
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| Curr Biol 20(15):1408-14. doi: 10.1016/j.cub.2010.06.024. Epub 2010 Jul 8. 2010
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| 9 | DDX42, TP53BP2
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| The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis.
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| Uhlmann-Schiffler H, Kiermayer S, Stahl H.
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| Oncogene 28(20):2065-73. Epub 2009 Apr 20.
2009
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| 10 | PPP1R13B, TP53, TP53BP2, TP63, TP73
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| Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.
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| Patel S, George R, Autore F, Fraternali F, Ladbury JE, Nikolova PV.
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| Nucleic Acids Res 36(16):5139-51. Epub 2008 Aug 2.
2008
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| 11 | BCL2, TP53BP2
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| Molecular basis of the interaction between the antiapoptotic Bcl-2 family proteins and the proapoptotic protein ASPP2.
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| Katz C, Benyamini H, Rotem S, Lebendiker M, Danieli T, Iosub A, Refaely H, Dines M, Bronner V, Bravman T, Shalev DE, Rüdiger S, Friedler A.
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| Proc Natl Acad Sci U S A 105(34):12277-82. Epub 2008 Aug 21.
2008
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| 12 | PPP1R13B, PPP1R13L, TP53BP2
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| Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73.
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| Robinson RA, Lu X, Jones EY, Siebold C.
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| Structure 16(2):259-68.
2008
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| 13 | PPP1R13B, TP53BP2
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| Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold.
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| Tidow H, Andreeva A, Rutherford TJ, Fersht AR.
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| J Mol Biol 371(4):948-58. Epub 2007 May 13. 2007
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| 14 | PPP1R13B, PPP1R13L, TP53BP2
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| ASPP: a new family of oncogenes and tumour suppressor genes.
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| Sullivan A, Lu X.
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| Br J Cancer 96(2):196-200. Epub 2007 Jan 9. Review.
2007
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| 15 | TP53BP2
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| ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth.
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| Vives V, Su J, Zhong S, Ratnayaka I, Slee E, Goldin R, Lu X.
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| Genes Dev 20(10):1262-7. 2006
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| 16 | PPP1R13B, TP53BP2
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| Downregulated mRNA expression of ASPP and the hypermethylation of the 5'-untranslated region in cancer cell lines retaining wild-type p53.
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| Liu ZJ, Lu X, Zhang Y, Zhong S, Gu SZ, Zhang XB, Yang X, Xin HM.
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| FEBS Lett 579(7):1587-90. 2005
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| 17 | TP53BP2
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| TP53BP2 locus is associated with gastric cancer susceptibility.
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| Ju H, Lee KA, Yang M, Kim HJ, Kang CP, Sohn TS, Rhee JC, Kang C, Kim JW.
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| Int J Cancer 117(6):957-60. 2005
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| 18 | E2F1, PPP1R13B, TP53BP2
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| ASPP1 and ASPP2 are new transcriptional targets of E2F.
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| Fogal V, Kartasheva NN, Trigiante G, Llanos S, Yap D, Vousden KH, Lu X.
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| Cell Death Differ 12(4):369-76. 2005
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| 19 | PPP1R13B, TP53BP2
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| ASPP proteins specifically stimulate the apoptotic function of p53.
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| Samuels-Lev Y, O'Connor DJ, Bergamaschi D, Trigiante G, Hsieh JK, Zhong S, Campargue I, Naumovski L, Crook T, Lu X.
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| Mol Cell 8(4):781-94. 2001
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| 20 | TP53BP1, TP53BP2
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| Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53 BP2.
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| Iwabuchi K, et al.
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| J Biol Chem 273 : 26061-26068. 1998
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| 21 | TP53BP2
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| Assignment of p53 binding protein (TP53BP2) to human chromosome band 1q42.1 by in situ hybridization.
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| Yang JP, Ono T, Sonta S, Kawabe T, Okamoto T.
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| Cytogenet Cell Genet 78(1):61-2. 1997
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| 22 | TP53BP2
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| The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M.
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| Naumovski L, Cleary ML.
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| Mol Cell Biol 16(7):3884-92. 1996
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| 23 | TP53BP1, TP53BP2
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| Two cellular proteins that bind to wild-type but not mutant p53.
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| Iwabuchi K, et al.
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| Proc Natl Acad Sci U S A 91 : 6098-6102. 1994
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