| 1 | TP53BP1, TRIM29
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| TRIM29 is required for efficient recruitment of 53BP1 in response to DNA double-strand breaks in vertebrate cells
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| Wikiniyadhanee R, Lerksuthirat T, Stitchantrakul W, Chitphuk S, Sura T, Dejsuphong D.
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| FEBS Open Bio Oct;10(10):2055-2071. doi: 10.1002/2211-5463.12954. Epub 2020 Aug 31. 2020
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| 2 | AURKA, TP53BP1, TPX2
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| Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function.
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| Byrum AK, Carvajal-Maldonado D, Mudge MC, Valle-Garcia D, Majid MC, Patel R, Sowa ME, Gygi SP, Harper JW, Shi Y, Vindigni A, Mosammaparast N.
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| J Cell Biol 218(2):422-432. doi: 10.1083/jcb.201803003. Epub 2019 Jan 2.
2019
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| 3 | PAXIP1, TP53BP1
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| DNA repair genes PAXIP1 and TP53BP1 expression is associated with breast cancer prognosis.
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| De Gregoriis G, Ramos JA, Fernandes PV, Vignal GM, Brianese RC, Carraro DM, Monteiro AN, Struchiner CJ, Suarez-Kurtz G, Vianna-Jorge R, de Carvalho MA.
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| Cancer Biol Ther 18(6):439-449. doi: 10.1080/15384047.2017.1323590. Epub 2017 May 5.
2017
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| 4 | NUP153, SENP1, TP53BP1
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| Localisation of Nup153 and SENP1 to nuclear pore complexes is required for 53BP1-mediated DNA double-strand break repair.
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| Duheron V, Nilles N, Pecenko S, Martinelli V, Fahrenkrog B.
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| J Cell Sci 130(14):2306-2316. doi: 10.1242/jcs.198390. Epub 2017 Jun 2.
2017
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| 5 | BRCA1, TP53BP1, USP51
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| USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response.
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| Wang Z, Zhang H, Liu J, Cheruiyot A, Lee JH, Ordog T, Lou Z, You Z, Zhang Z.
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| Genes Dev. Apr 15;30(8):946-59. doi: 10.1101/gad.271841.115. 2016
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| 6 | KDM1A, RNF168, TP53BP1
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| Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage.
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| Peng B, Wang J, Hu Y, Zhao H, Hou W, Zhao H, Wang H, Liao J, Xu X.
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| Nucleic Acids Res 43(12):5936-47. doi: 10.1093/nar/gkv528. Epub 2015 May 20.
2015
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| 7 | TP53BP1
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| Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.
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| Carr SM, Munro S, Zalmas LP, Fedorov O, Johansson C, Krojer T, Sagum CA, Bedford MT, Oppermann U, La Thangue NB.
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| Proc Natl Acad Sci U S A 111(31):11341-6. doi: 10.1073/pnas.1403737111. Epub 2014 Jul 21.
2014
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| 8 | TP53BP1
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| Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks.
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| Lee DH, Acharya SS, Kwon M, Drane P, Guan Y, Adelmant G, Kalev P, Shah J, Pellman D, Marto JA, Chowdhury D.
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| Mol Cell 54(3):512-25. doi: 10.1016/j.molcel.2014.03.020. Epub 2014 Apr 3.
2014
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| 9 | TP53BP1, USP28
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| USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism.
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| Knobel PA, Belotserkovskaya R, Galanty Y, Schmidt CK, Jackson SP, Stracker TH.
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| Mol Cell Biol 34(11):2062-74. doi: 10.1128/MCB.00197-14. Epub 2014 Mar 31.
2014
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| 10 | RNF8, TP53BP1
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| Mitosis inhibits DNA double-strand break repair to guard against telomere fusions.
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| Orthwein A, Fradet-Turcotte A, Noordermeer SM, Canny MD, Brun CM, Strecker J, Escribano-Diaz C, Durocher D.
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| Science 344(6180):189-93. doi: 10.1126/science.1248024. Epub 2014 Mar 20.
2014
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| 11 | BRCA1, TP53BP1
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| Double-strand break repair: 53BP1 comes into focus.
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| Panier S, Boulton SJ.
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| Nat Rev Mol Cell Biol 15(1):7-18. doi: 10.1038/nrm3719. Epub 2013 Dec 11. Review.
2014
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| 12 | RNF168, RNF8, TP53BP1
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| Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repair.
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| Hu Y, Wang C, Huang K, Xia F, Parvin JD, Mondal N.
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| PLoS One 9(10):e110522. doi: 10.1371/journal.pone.0110522. eCollection 2014.
2014
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| 13 | TP53BP1, UBE2L3
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| UbcH7 regulates 53BP1 stability and DSB repair.
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| Han X, Zhang L, Chung J, Mayca Pozo F, Tran A, Seachrist DD, Jacobberger JW, Keri RA, Gilmore H, Zhang Y.
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| Proc Natl Acad Sci U S A 111(49):17456-61. doi: 10.1073/pnas.1408538111. Epub 2014 Nov 24.
2014
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| 14 | SETX, TP53BP1
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| Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response.
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| Yüce Ö, West SC.
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| Mol Cell Biol 33(2):406-17. doi: 10.1128/MCB.01195-12. Epub 2012 Nov 12.
2013
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| 15 | RNF68, TP53BP1
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| RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.
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| Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R.
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| Proc Natl Acad Sci U S A 110(52):20982-7. doi: 10.1073/pnas.1320302111. Epub 2013 Dec 9.
2013
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| 16 | BRCA1, TP53BP1
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| Differences in 53BP1 and BRCA1 regulation between cycling and non-cycling cells.
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| Croke M, Neumann MA, Grotsky DA, Kreienkamp R, Yaddanapudi SC, Gonzalo S.
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| Cell Cycle 12(23):3629-39. doi: 10.4161/cc.26582. Epub 2013 Oct 2.
2013
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| 17 | TP53BP1
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| 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.
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| Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A.
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| Cell 153(6):1266-80. doi: 10.1016/j.cell.2013.05.023. Epub 2013 May 30.
2013
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| 18 | TP53BP1
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| Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination.
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| Tang J, Cho NW, Cui G, Manion EM, Shanbhag NM, Botuyan MV, Mer G, Greenberg RA.
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| Nat Struct Mol Biol 20(3):317-25. doi: 10.1038/nsmb.2499. Epub 2013 Feb 3.
2013
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| 19 | RIF1, TP53BP1
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| RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.
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| Chapman JR, Barral P, Vannier JB, Borel V, Steger M, Tomas-Loba A, Sartori AA, Adams IR, Batista FD, Boulton SJ.
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| Mol Cell 49(5):858-71. doi: 10.1016/j.molcel.2013.01.002. Epub 2013 Jan 17.
2013
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| 20 | RIF1, TP53BP1
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| 53BP1 regulates DSB repair using Rif1 to control 5' end resection.
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| Zimmermann M, Lottersberger F, Buonomo SB, Sfeir A, de Lange T.
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| Science 339(6120):700-4. doi: 10.1126/science.1231573. Epub 2013 Jan 10.
2013
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| 21 | PAXIP1, RIF1, TP53BP1
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| 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions.
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| Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, Ge K, Alt FW, Fernandez-Capetillo O, Nussenzweig MC, Nussenzweig A.
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| Cell 153(6):1266-80. doi: 10.1016/j.cell.2013.05.023. Epub 2013 May 30.
2013
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| 22 | RNF168, TP53BP1
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| RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.
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| Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R.
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| Proc Natl Acad Sci U S A 110(52):20982-7. doi: 10.1073/pnas.1320302111. Epub 2013 Dec 9.
2013
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| 23 | TP53BP1
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| Role of 53BP1 oligomerization in regulating double-strand break repair.
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| Lottersberger F, Bothmer A, Robbiani DF, Nussenzweig MC, de Lange T.
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| Proc Natl Acad Sci U S A 110(6):2146-51. doi: 10.1073/pnas.1222617110. Epub 2013 Jan 23.
2013
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| 24 | NHEJ1, TBCIM, TP53BP1
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| Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development.
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| Liu X, Jiang W, Dubois RL, Yamamoto K, Wolner Z, Zha S.
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| Proc Natl Acad Sci U S A 109(10):3903-8. doi: 10.1073/pnas.1120160109. Epub 2012 Feb 21.
2012
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| 25 | BRCA1, RNF8, TP53BP1
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| RNF8 regulates assembly of RAD51 at DNA double-strand breaks in the absence of BRCA1 and 53BP1.
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| Nakada S, Yonamine RM, Matsuo K.
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| Cancer Res 72(19):4974-83. doi: 10.1158/0008-5472.CAN-12-1057. Epub 2012 Aug 3.
2012
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| 26 | BRCA1, TP53BP1
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| BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair.
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| Chapman JR, Sossick AJ, Boulton SJ, Jackson SP.
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| J Cell Sci 125(Pt 15):3529-34. Epub 2012 May 2.
2012
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| 27 | TP53BP1
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| 53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response.
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| Martínez P, Flores JM, Blasco MA.
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| J Cell Biol 197(2):283-300. doi: 10.1083/jcb.201110124.
2012
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| 28 | KPNB1, NUP153, TP53BP1
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| Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1.
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| Moudry P, Lukas C, Macurek L, Neumann B, Heriche JK, Pepperkok R, Ellenberg J, Hodny Z, Lukas J, Bartek J.
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| Cell Death Differ 19(5):798-807. doi: 10.1038/cdd.2011.150.
2012
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| 29 | BRCA1, RNF168, TP53BP1
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| RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1.
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| Muñoz MC, Laulier C, Gunn A, Cheng A, Robbiani DF, Nussenzweig A, Stark JM.
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| J Biol Chem 287(48):40618-28. doi: 10.1074/jbc.M112.410951. Epub 2012 Oct 10.
2012
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| 30 | H2AFX, MDC1, NSD2, TP53BP1
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| MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites.
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| Pei H, Zhang L, Luo K, Qin Y, Chesi M, Fei F, Bergsagel PL, Wang L, You Z, Lou Z.
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| Nature 470(7332):124-8. 2011
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| 31 | TP53BP1
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| 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress.
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| Lukas C, Savic V, Bekker-Jensen S, Doil C, Neumann B, Pedersen RS, Grøfte M, Chan KL, Hickson ID, Bartek J, Lukas J.
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| Nat Cell Biol 13(3):243-53. Epub 2011 Feb 13.
2011
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| 32 | CTSL, TP53BP1
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| A new pathway that regulates 53BP1 stability implicates cathepsin L and vitamin D in DNA repair.
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| Gonzalez-Suarez I, Redwood AB, Grotsky DA, Neumann MA, Cheng EH, Stewart CL, Dusso A, Gonzalo S.
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| EMBO J 30(16):3383-96. doi: 10.1038/emboj.2011.225. 2011
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| 33 | RNF168, RNF8, TP53BP1
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| The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination.
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| Ramachandran S, Chahwan R, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A.
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| Proc Natl Acad Sci U S A 107(2):809-14. Epub 2009 Dec 22.PMID: 20080757 2010
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| 34 | MDC1, RNF168, RNF8, TP53BP1, TRIM28
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| 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.
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| Noon AT, Shibata A, Rief N, Löbrich M, Stewart GS, Jeggo PA, Goodarzi AA.
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| Nat Cell Biol 12(2):177-84. Epub 2010 Jan 17.PMID: 20081839 2010
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| 35 | BRCA1, LIG4, TP53BP1
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| 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.
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| Bunting SF, Callén E, Wong N, Chen HT, Polato F, Gunn A, Bothmer A, Feldhahn N, Fernandez-Capetillo O, Cao L, Xu X, Deng CX, Finkel T, Nussenzweig M, Stark JM, Nussenzweig A.
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| Cell 141(2):243-54. Epub 2010 Apr 1.
2010
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| 36 | H2AFX, PARP1, TP53BP1
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| Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.
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| Orsburn B, Escudero B, Prakash M, Gesheva S, Liu G, Huso DL, Franco S.
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| Mol Cell Biol 30(10):2341-52. Epub 2010 Mar 15.PMID: 20231360 2010
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| 37 | TOPBP1, TP53BP1
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| TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.
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| Cescutti R, Negrini S, Kohzaki M, Halazonetis TD.
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| EMBO J 29(21):3723-32. Epub 2010 Sep 24.
2010
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| 38 | ATM, ATR, TP53BP1
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| Telomeres avoid end detection by severing the checkpoint signal transduction pathway.
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| Carneiro T, Khair L, Reis CC, Borges V, Moser BA, Nakamura TM, Ferreira MG.
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| Nature 467(7312):228-32. 2010
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| 39 | ATM, MRE11, RAD50, TP53BP1
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| 53BP1 promotes ATM activity through direct interactions with the MRN complex.
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| Lee JH, Goodarzi AA, Jeggo PA, Paull TT.
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| EMBO J 29(3):574-85. doi: 10.1038/emboj.2009.372. Epub 2009 Dec 10.
2010
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| 40 | RAD18, TP53BP1
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| RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1.
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| Watanabe K, Iwabuchi K, Sun J, Tsuji Y, Tani T, Tokunaga K, Date T, Hashimoto M, Yamaizumi M, Tateishi S.
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| Nucleic Acids Res 37(7):2176-93. Epub 2009 Feb 19.
2009
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| 41 | PAXIP1, RNF8, TP53BP1
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| PTIP regulates 53BP1 and SMC1 at the DNA damage sites.
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| Wu J, Prindle MJ, Dressler GR, Yu X.
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| J Biol Chem 284(27):18078-84. Epub 2009 May 4.PMID: 19414588 2009
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| 42 | TP53BP1
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| RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage.
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| Sakasai R, Tibbetts R.
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| J Biol Chem 283(20):13549-55. Epub 2008 Mar 12.
2008
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| 43 | RIDIS, TP53BP1
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| RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling.
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| Stewart GS, Stankovic T, Byrd PJ, Wechsler T, Miller ES, Huissoon A, Drayson MT, West SC, Elledge SJ, Taylor AM.
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| Proc Natl Acad Sci U S A 104(43):16910-5. Epub 2007 Oct 16. 2007
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| 44 | TP53BP1
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| Subcellular localization and mechanisms of nucleocytoplasmic distribution of p202, an interferon-inducible candidate for lupus susceptibility.
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| Choubey D, Pramanik R, Xin H.
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| FEBS Lett 553(3):245-9. 2003
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| 45 | TP53BP1, TP53BP2
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| Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53 BP2.
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| Iwabuchi K, et al.
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| J Biol Chem 273 : 26061-26068. 1998
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| 46 | TP53BP1, TP53BP2
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| Two cellular proteins that bind to wild-type but not mutant p53.
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| Iwabuchi K, et al.
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| Proc Natl Acad Sci U S A 91 : 6098-6102. 1994
|