| 1 | RNF4, TOPORS
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| Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation
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| Liu JCY, Ackermann L, Hoffmann S, Gál Z, Hendriks IA, Jain C, Morlot L, Tatham MH, McLelland GL, Hay RT, Nielsen ML, Brummelkamp T, Haahr P, Mailand N.
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| Nat Struct Mol Biol. Sep;31(9):1355-1367. doi: 10.1038/s41594-024-01294-7. Epub 2024 Apr 22. 2024
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| 2 | JBTS41, TOPORS
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| TOPORS as a novel causal gene for Joubert syndrome.
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| Strong A, Qu HQ, Cullina S, McManus ML, Zackai EH, Glessner J, Kenny EE, Hakonarson H.
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| Am J Med Genet A. Aug;191(8):2156-2163. doi: 10.1002/ajmg.a.63303. Epub 2023 May 25 2023
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| 3 | RAD51, TOPORS
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| TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair.
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| Hariharasudhan G, Jeong SY, Kim MJ, Jung SM, Seo G, Moon JR, Lee S, Chang IY, Kee Y, You HJ, Lee JH.
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| Nucleic Acids Res. Feb 22;50(3):1501-1516. doi: 10.1093/nar/gkac009. 2022
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| 4 | RP31, TOPORS
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| Mutations of TOPORS identified in families with retinitis pigmentosa.
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| He K, Zhou Y, Li N.
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| Ophthalmic Genet. Jun;43(3):371-377. doi: 10.1080/13816810.2022.2039721. Epub 2022 Mar 7. 2022
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| 5 | BANP, TOPORS
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| RING finger protein TOPORS modulates the expression of tumor suppressor SMAR1 in colorectal cancer via the TLR4-TRIF pathway.
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| Firmal P, Shah VK, Pant R, Chattopadhyay S.
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| Mol Oncol. Apr;16(7):1523-1540. doi: 10.1002/1878-0261.13126. Epub 2022 Feb 5. 2022
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| 6 | JBTS41, TOPORS
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| Expanding the genetic landscape of oral-facial-digital syndrome with two novel genes.
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| Strong A, Simone L, Krentz A, Vaccaro C, Watson D, Ron H, Kalish JM, Pedro HF, Zackai EH, Hakonarson H.
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| Am J Med Genet A. Aug;185(8):2409-2416. doi: 10.1002/ajmg.a.62337. Epub 2021 Jun 15. 2021
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| 7 | TOPORS
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| TOPORS, a tumor suppressor protein, contributes to the maintenance of higher-order chromatin architecture.
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| Ji L, Huo X, Zhang Y, Yan Z, Wang Q, Wen B.
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| Biochim Biophys Acta Gene Regul Mech. May;1863(5):194518. doi: 10.1016/j.bbagrm.2020.194518. Epub 2020 Feb 27. 2020
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| 8 | RP31, TOPORS
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| A novel mutation in the dominantly inherited TOPORS gene supports haploinsufficiency as the mechanism of retinitis pigmentosa.
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| Latasiewicz M, Salvetti AP, MacLaren RE.
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| Ophthalmic Genet. Dec;38(6):562-566. doi: 10.1080/13816810.2017.1313994. Epub 2017 Apr 28. 2017
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| 9 | PSMC1, TOPORS
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| TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene.
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| Czub B, Shah AZ, Alfano G, Kruczek PM, Chakarova CF, Bhattacharya SS.
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| PLoS One. Feb 12;11(2):e0148678. doi: 10.1371/journal.pone.0148678. 2016
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| 10 | RP31, TOPORS
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| Genotype and Phenotype Studies in Autosomal Dominant Retinitis Pigmentosa (adRP) of the French Canadian Founder Population.
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| Coussa RG, Chakarova C, Ajlan R, Taha M, Kavalec C, Gomolin J, Khan A, Lopez I, Ren H, Waseem N, Kamenarova K, Bhattacharya SS, Koenekoop RK.
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| Invest Ophthalmol Vis Sci. Dec;56(13):8297-305. doi: 10.1167/iovs.15-17104. 2015
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| 11 | TOPORS
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| TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein.
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| Chakarova CF, Khanna H, Shah AZ, Patil SB, Sedmak T, Murga-Zamalloa CA, Papaioannou MG, Nagel-Wolfrum K, Lopez I, Munro P, Cheetham M, Koenekoop RK, Rios RM, Matter K, Wolfrum U, Swaroop A, Bhattacharya SS.
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| Hum Mol Genet 20(5):975-87. Epub 2010 Dec 15.
2011
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| 12 | TOPORS
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| Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.
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| Marshall H, Bhaumik M, Aviv H, Moore D, Yao M, Dutta J, Rahim H, Gounder M, Ganesan S, Saleem A, Rubin E.
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| BMC Mol Biol 11:31.
2010
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| 13 | PLK1, TOPORS
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| Plk1 phosphorylation of Topors is involved in its degradation.
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| Yang X, Li H, Deng A, Liu X.
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| Mol Biol Rep 37(6):3023-8. Epub 2009 Oct 11. 2010
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| 14 | RP31, TOPORS
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| Autosomal dominant pericentral retinal dystrophy caused by a novel missense mutation in the TOPORS gene.
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| Selmer KK, Grøndahl J, Riise R, Brandal K, Braaten O, Bragadottir R, Undlien DE.
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| Acta Ophthalmol 88(3):323-8. Epub 2009 Jan 30.
2010
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| 15 | PLK1, TOPORS
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| Plk1-mediated phosphorylation of Topors regulates p53 stability.
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| Yang X, Li H, Zhou Z, Wang WH, Deng A, Andrisani O, Liu X.
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| J Biol Chem 284(28):18588-92. Epub 2009 May 27.
2009
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| 16 | TOPORS, NKX3.1
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| Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1.
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| Guan B, Pungaliya P, Li X, Uquillas C, Mutton LN, Rubin EH, Bieberich CJ.
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| J Biol Chem 283(8):4834-40. Epub 2007 Dec 12. 2008
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| 17 | RP31, TOPORS
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| Mutations in the TOPORS gene cause 1% of autosomal dominant retinitis pigmentosa.
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| Bowne SJ, Sullivan LS, Gire AI, Birch DG, Hughbanks-Wheaton D, Heckenlively JR, Daiger SP.
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| Mol Vis 14:922-7.
2008
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| 18 | TOPORS
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| Identification of phosphorylation sites of TOPORS and a role for serine 98 in the regulation of ubiquitin but not SUMO E3 ligase activity.
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| Park HJ, Zheng H, Kulkarni D, Kerrigan J, Pungaliya P, Saleem A, Rubin EH.
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| Biochemistry 47(52):13887-96.
2008
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| 19 | TOPORS
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| The E3 ligase Topors induces the accumulation of polysumoylated forms of DNA topoisomerase I in vitro and in vivo.
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| Hammer E, Heilbronn R, Weger S.
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| FEBS Lett 581(28):5418-24. Epub 2007 Oct 30. 2007
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| 20 | TOPORS
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| Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy.
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| Chakarova CF, Papaioannou MG, Khanna H, Lopez I, Waseem N, Shah A, Theis T, Friedman J, Maubaret C, Bujakowska K, Veraitch B, Abd El-Aziz MM, Prescott de Q, Parapuram SK, Bickmore WA, Munro PM, Gal A, Hamel CP, Marigo V, Ponting CP, Wissinger B, Zrenner E, Matter K, Swaroop A, Koenekoop RK, Bhattacharya SS.
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| Am J Hum Genet 81(5):1098-103. Epub 2007 Sep 26. 2007
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| 21 | TOPORS
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| TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins.
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| Pungaliya P, Kulkarni D, Park HJ, Marshall H, Zheng H, Lackland H, Saleem A, Rubin EH.
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| J Proteome Res 6(10):3918-23. Epub 2007 Sep 6. 2007
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| 22 | TOPORS
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| Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence.
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| Chu D, Kakazu N, Gorrin-Rivas MJ, Lu HP, Kawata M, Abe T, Ueda K, Adachi Y.
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| J Biol Chem 276(17):14004-13. 2001
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