| 1 | PLK1, RAD51, TOPBP1
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| TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.
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| Moudry P, Watanabe K, Wolanin KM, Bartkova J, Wassing IE, Watanabe S, Strauss R, Troelsgaard Pedersen R, Oestergaard VH, Lisby M, Andújar-Sánchez M, Maya-Mendoza A, Esashi F, Lukas J, Bartek J.
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| J Cell Biol 212(3):281-8. doi: 10.1083/jcb.201507042.
2016
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| 2 | TOPBP1, WDR18
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| WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling.
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| Yan S, Willis J.
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| Biochem Biophys Res Commun 431(3):466-71. doi: 10.1016/j.bbrc.2012.12.144. Epub 2013 Jan 16.
2013
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| 3 | ATR, TICRR, TOPBP1
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| Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response.
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| Hassan BH, Lindsey-Boltz LA, Kemp MG, Sancar A.
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| J Biol Chem 288(26):18903-10. doi: 10.1074/jbc.M113.475517. Epub 2013 May 21.
2013
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| 4 | ATM, ATR, NBN, TOPBP1
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| NBS1 directly activates ATR independently of MRE11 and TOPBP1.
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| Kobayashi M, Hayashi N, Takata M, Yamamoto K.
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| Genes Cells 18(3):238-46. doi: 10.1111/gtc.12031. Epub 2013 Feb 1.
2013
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| 5 | BLM, TOPBP1
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| TopBP1 controls BLM protein level to maintain genome stability.
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| Wang J, Chen J, Gong Z.
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| Mol Cell 52(5):667-78. doi: 10.1016/j.molcel.2013.10.012. Epub 2013 Nov 14.
2013
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| 6 | NONO, SFPQ, TOPBP1
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| Proteomic identification of PSF and p54(nrb) as TopBP1-interacting proteins.
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| Kuhnert A, Schmidt U, Monajembashi S, Franke C, Schlott B, Grosse F, Greulich KO, Saluz HP, Hänel F.
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| J Cell Biochem 113(5):1744-53. doi: 10.1002/jcb.24045.
2012
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| 7 | TOPBP1
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| Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1.
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| Rappas M, Oliver AW, Pearl LH.
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| Nucleic Acids Res 39(1):313-24. Epub 2010 Aug 19.
2011
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| 8 | BRIP1, TOPBP1
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| Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control.
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| Leung CC, Gong Z, Chen J, Glover JN.
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| J Biol Chem 286(6):4292-301. Epub 2010 Dec 2.
2011
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| 9 | TOPBP1
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| TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells.
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| Jeon Y, Ko E, Lee KY, Ko MJ, Park SY, Kang J, Jeon CH, Lee H, Hwang DS.
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| J Biol Chem 286(7):5414-22. Epub 2010 Dec 13.
2011
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| 10 | TOPBP1
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| Human TopBP1 localization to the mitotic centrosome mediates mitotic progression.
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| Bang SW, Ko MJ, Kang S, Kim GS, Kang D, Lee J, Hwang DS.
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| Exp Cell Res 317(7):994-1004. Epub 2011 Feb 1.
2011
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| 11 | TICRR, TOPBP1
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| Treslin collaborates with TopBP1 in triggering the initiation of DNA replication.
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| Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG.
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| Cell 140(3):349-59. Epub 2010 Jan 28.PMID: 20116089 2010
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| 12 | BRIP1, TOPBP1
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| BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control.
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| Gong Z, Kim JE, Leung CC, Glover JN, Chen J.
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| Mol Cell 37(3):438-46.PMID: 20159562 2010
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| 13 | ATR, CHEK1, FANCM, SMC1A, TOPBP1
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| ATR activation and replication fork restart are defective in FANCM-deficient cells.
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| Schwab RA, Blackford AN, Niedzwiedz W.
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| EMBO J 29(4):806-18. Epub 2010 Jan 7.PMID: 20057355 2010
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| 14 | TICRR, TOPBP1
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| A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.
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| Sansam CL, Cruz NM, Danielian PS, Amsterdam A, Lau ML, Hopkins N, Lees JA.
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| Genes Dev 24(2):183-94.PMID: 20080954 2010
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| 15 | TOPBP1, TP53BP1
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| TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.
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| Cescutti R, Negrini S, Kohzaki M, Halazonetis TD.
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| EMBO J 29(21):3723-32. Epub 2010 Sep 24.
2010
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| 16 | RAD9A, TOPBP1
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| Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition.
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| Greer Card DA, Sierant ML, Davey S.
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| J Biol Chem 285(20):15653-61. Epub 2010 Mar 21. 2010
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| 17 | ATR, CLK2, TOPBP1
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| HCLK2 is required for activity of the DNA damage response kinase ATR.
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| Danielsen JM, Larsen DH, Schou KB, Freire R, Falck J, Bartek J, Lukas J.
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| J Biol Chem 284(7):4140-7. Epub 2008 Dec 19. 2009
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| 18 | TOPBP1, TP53
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| Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer.
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| Liu K, Bellam N, Lin HY, Wang B, Stockard CR, Grizzle WE, Lin WC.
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| Mol Cell Biol 29(10):2673-93. Epub 2009 Mar 16.PMID: 19289498 2009
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| 19 | TOPBP1, ZBTB17
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| Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1.
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| Herold S, Hock A, Herkert B, Berns K, Mullenders J, Beijersbergen R, Bernards R, Eilers M.
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| EMBO J 27(21):2851-61. Epub 2008 Oct 16.
2008
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| 20 | TOPBP1, TREX1
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| Dpb11 activates the Mec1-Ddc2 complex.
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| Mordes DA, Nam EA, Cortez D.
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| Proc Natl Acad Sci U S A 105(48):18730-4. Epub 2008 Nov 21.
2008
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| 21 | CDC45, TOPBP1
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| Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein.
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| Schmidt U, Wollmann Y, Franke C, Grosse F, Saluz HP, Hänel F.
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| Biochem J 409(1):169-77.PMID: 17887956 2008
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| 22 | ATR, ATRIP, TOPBP1
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| TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.
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| Mordes DA, Glick GG, Zhao R, Cortez D.
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| Genes Dev 22(11):1478-89.PMID: 18519640 2008
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| 23 | TOPBP1
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| Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition.
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| Jeon Y, Lee KY, Ko MJ, Lee YS, Kang S, Hwang DS.
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| J Biol Chem 282(20):14882-90. Epub 2007 Feb 10. 2007
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| 24 | TOPBP1
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| Identification of a common polymorphism in the TopBP1 gene associated with hereditary susceptibility to breast and ovarian cancer.
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| Karppinen SM, Erkko H, Reini K, Pospiech H, Heikkinen K, Rapakko K, Syväoja JE, Winqvist R.
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| Eur J Cancer 42(15):2647-52. Epub 2006 Aug 23.
2006
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| 25 | TOPBP1, ATR
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| TopBP1 activates the ATR-ATRIP complex.
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| Kumagai A, Lee J, Yoo HY, Dunphy WG.
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| Cell 124(5):943-55. 2006
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| 26 | TOPBP1, EGR1
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| The transcription factor Egr-1 is a regulator of the human TopBP1 gene.
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| Usskilat C, Skerka C, Saluz HP, Hanel F.
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| Gene 380(2):144-50. Epub 2006 Jun 8. 2006
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| 27 | TOPBP1
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| TopBP1 contains a transcriptional activation domain suppressed by two adjacent BRCT domains.
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| Wright RH, Dornan ES, Donaldson MM, Morgan IM.
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| Biochem J 400(3):573-82. 2006
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| 28 | ATR, ATRIP, TOPBP1
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| TopBP1 activates the ATR-ATRIP complex.
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| Kumagai A, Lee J, Yoo HY, Dunphy WG.
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| Cell 124(5):943-55.
2006
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| 29 | TOPBP1, ABL1
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| Identification of TopBP1 as a c-Abl-interacting protein and a repressor for c-Abl expression.
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| Zeng L, Hu Y, Li B.
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| J Biol Chem 280(32):29374-80. Epub 2005 Jun 16. 2005
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| 30 | E2F1, TOPBP1
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| Regulation of E2F1 by BRCT domain-containing protein TopBP1.
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| Liu K, Lin FT, Ruppert JM, Lin WC.
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| Mol Cell Biol 23(9):3287-304. 2003
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| 31 | TOPBP1
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| Negative regulation of the mammalian UV response by Myc through association with Miz-1.
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| Herold S, Wanzel M, Beuger V, Frohme C, Beul D, Hillukkala T, Syvaoja J, Saluz HP, Haenel F, Eilers M.
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| Mol Cell 10(3):509-21. 2002
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| 32 | TOPBP1
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| A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.
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| Yamane K, Wu X, Chen J.
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| Mol Cell Biol 22(2):555-66. 2002
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| 33 | TOPBP1
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| BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.
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| Makiniemi M, Hillukkala T, Tuusa J, Reini K, Vaara M, Huang D, Pospiech H, Majuri I, Westerling T, Makela TP, Syvaoja JE.
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| J Biol Chem 276(32):30399-406. Epub 2001 Jun 6. 2001
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| 34 | TOPBP1
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| A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator.
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| Yamane K, Kawabata M, Tsuruo T.
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| Eur J Biochem 250(3):794-9. 1997
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| 35 | ANKS1A, BCL2L2, DCUN1D4, DHX38, DHX38, DVL3, EDEM1, FAM38A, FIG4, GCN1L1, HSPH1, IHPK1, KIAA0232, KIAA0240, KIAA0247, LARP4B, LPGAT1, LRRC8B, MFN2, MRPS27, NCSTN, NUP205, PHF15, PHF16, PHYHIP, PIEZO1, PUM2, RAPGEF5, RGP1, RIMS3, RNF10, RTF1, RUBCN, SNX19, SPOCK2, STAB1, TATDN2, TBC1D5, TIAF1, TM9SF4, TOPBP1, WAPL, WASF1, ZNF516, ZNF516, ZNF592
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| Prediction of the coding sequences of unidentified human genes. VI. the coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
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| Nagase T, et al.
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| DNA Res 3 : 321-329,341-54. 1996
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