Citations for
1PLK1, RAD51, TOPBP1
TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity.
Moudry P, Watanabe K, Wolanin KM, Bartkova J, Wassing IE, Watanabe S, Strauss R, Troelsgaard Pedersen R, Oestergaard VH, Lisby M, Andújar-Sánchez M, Maya-Mendoza A, Esashi F, Lukas J, Bartek J.
J Cell Biol 212(3):281-8. doi: 10.1083/jcb.201507042. 2016
2TOPBP1, WDR18
WD40-repeat protein WDR18 collaborates with TopBP1 to facilitate DNA damage checkpoint signaling.
Yan S, Willis J.
Biochem Biophys Res Commun 431(3):466-71. doi: 10.1016/j.bbrc.2012.12.144. Epub 2013 Jan 16. 2013
3ATR, TICRR, TOPBP1
Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response.
Hassan BH, Lindsey-Boltz LA, Kemp MG, Sancar A.
J Biol Chem 288(26):18903-10. doi: 10.1074/jbc.M113.475517. Epub 2013 May 21. 2013
4ATM, ATR, NBN, TOPBP1
NBS1 directly activates ATR independently of MRE11 and TOPBP1.
Kobayashi M, Hayashi N, Takata M, Yamamoto K.
Genes Cells 18(3):238-46. doi: 10.1111/gtc.12031. Epub 2013 Feb 1. 2013
5BLM, TOPBP1
TopBP1 controls BLM protein level to maintain genome stability.
Wang J, Chen J, Gong Z.
Mol Cell 52(5):667-78. doi: 10.1016/j.molcel.2013.10.012. Epub 2013 Nov 14. 2013
6NONO, SFPQ, TOPBP1
Proteomic identification of PSF and p54(nrb) as TopBP1-interacting proteins.
Kuhnert A, Schmidt U, Monajembashi S, Franke C, Schlott B, Grosse F, Greulich KO, Saluz HP, Hänel F.
J Cell Biochem 113(5):1744-53. doi: 10.1002/jcb.24045. 2012
7TOPBP1
Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1.
Rappas M, Oliver AW, Pearl LH.
Nucleic Acids Res 39(1):313-24. Epub 2010 Aug 19. 2011
8BRIP1, TOPBP1
Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control.
Leung CC, Gong Z, Chen J, Glover JN.
J Biol Chem 286(6):4292-301. Epub 2010 Dec 2. 2011
9TOPBP1
TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells.
Jeon Y, Ko E, Lee KY, Ko MJ, Park SY, Kang J, Jeon CH, Lee H, Hwang DS.
J Biol Chem 286(7):5414-22. Epub 2010 Dec 13. 2011
10TOPBP1
Human TopBP1 localization to the mitotic centrosome mediates mitotic progression.
Bang SW, Ko MJ, Kang S, Kim GS, Kang D, Lee J, Hwang DS.
Exp Cell Res 317(7):994-1004. Epub 2011 Feb 1. 2011
11TICRR, TOPBP1
Treslin collaborates with TopBP1 in triggering the initiation of DNA replication.
Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG.
Cell 140(3):349-59. Epub 2010 Jan 28.PMID: 20116089 2010
12BRIP1, TOPBP1
BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control.
Gong Z, Kim JE, Leung CC, Glover JN, Chen J.
Mol Cell 37(3):438-46.PMID: 20159562 2010
13ATR, CHEK1, FANCM, SMC1A, TOPBP1
ATR activation and replication fork restart are defective in FANCM-deficient cells.
Schwab RA, Blackford AN, Niedzwiedz W.
EMBO J 29(4):806-18. Epub 2010 Jan 7.PMID: 20057355 2010
14TICRR, TOPBP1
A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.
Sansam CL, Cruz NM, Danielian PS, Amsterdam A, Lau ML, Hopkins N, Lees JA.
Genes Dev 24(2):183-94.PMID: 20080954 2010
15TOPBP1, TP53BP1
TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.
Cescutti R, Negrini S, Kohzaki M, Halazonetis TD.
EMBO J 29(21):3723-32. Epub 2010 Sep 24. 2010
16RAD9A, TOPBP1
Rad9A is required for G2 decatenation checkpoint and to prevent endoreduplication in response to topoisomerase II inhibition.
Greer Card DA, Sierant ML, Davey S.
J Biol Chem 285(20):15653-61. Epub 2010 Mar 21. 2010
17ATR, CLK2, TOPBP1
HCLK2 is required for activity of the DNA damage response kinase ATR.
Danielsen JM, Larsen DH, Schou KB, Freire R, Falck J, Bartek J, Lukas J.
J Biol Chem 284(7):4140-7. Epub 2008 Dec 19. 2009
18TOPBP1, TP53
Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer.
Liu K, Bellam N, Lin HY, Wang B, Stockard CR, Grizzle WE, Lin WC.
Mol Cell Biol 29(10):2673-93. Epub 2009 Mar 16.PMID: 19289498 2009
19TOPBP1, ZBTB17
Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1.
Herold S, Hock A, Herkert B, Berns K, Mullenders J, Beijersbergen R, Bernards R, Eilers M.
EMBO J 27(21):2851-61. Epub 2008 Oct 16. 2008
20TOPBP1, TREX1
Dpb11 activates the Mec1-Ddc2 complex.
Mordes DA, Nam EA, Cortez D.
Proc Natl Acad Sci U S A 105(48):18730-4. Epub 2008 Nov 21. 2008
21CDC45, TOPBP1
Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein.
Schmidt U, Wollmann Y, Franke C, Grosse F, Saluz HP, Hänel F.
Biochem J 409(1):169-77.PMID: 17887956 2008
22ATR, ATRIP, TOPBP1
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.
Mordes DA, Glick GG, Zhao R, Cortez D.
Genes Dev 22(11):1478-89.PMID: 18519640 2008
23TOPBP1
Human TopBP1 participates in cyclin E/CDK2 activation and preinitiation complex assembly during G1/S transition.
Jeon Y, Lee KY, Ko MJ, Lee YS, Kang S, Hwang DS.
J Biol Chem 282(20):14882-90. Epub 2007 Feb 10. 2007
24TOPBP1
Identification of a common polymorphism in the TopBP1 gene associated with hereditary susceptibility to breast and ovarian cancer.
Karppinen SM, Erkko H, Reini K, Pospiech H, Heikkinen K, Rapakko K, Syväoja JE, Winqvist R.
Eur J Cancer 42(15):2647-52. Epub 2006 Aug 23. 2006
25TOPBP1, ATR
TopBP1 activates the ATR-ATRIP complex.
Kumagai A, Lee J, Yoo HY, Dunphy WG.
Cell 124(5):943-55. 2006
26TOPBP1, EGR1
The transcription factor Egr-1 is a regulator of the human TopBP1 gene.
Usskilat C, Skerka C, Saluz HP, Hanel F.
Gene 380(2):144-50. Epub 2006 Jun 8. 2006
27TOPBP1
TopBP1 contains a transcriptional activation domain suppressed by two adjacent BRCT domains.
Wright RH, Dornan ES, Donaldson MM, Morgan IM.
Biochem J 400(3):573-82. 2006
28ATR, ATRIP, TOPBP1
TopBP1 activates the ATR-ATRIP complex.
Kumagai A, Lee J, Yoo HY, Dunphy WG.
Cell 124(5):943-55. 2006
29TOPBP1, ABL1
Identification of TopBP1 as a c-Abl-interacting protein and a repressor for c-Abl expression.
Zeng L, Hu Y, Li B.
J Biol Chem 280(32):29374-80. Epub 2005 Jun 16. 2005
30E2F1, TOPBP1
Regulation of E2F1 by BRCT domain-containing protein TopBP1.
Liu K, Lin FT, Ruppert JM, Lin WC.
Mol Cell Biol 23(9):3287-304. 2003
31TOPBP1
Negative regulation of the mammalian UV response by Myc through association with Miz-1.
Herold S, Wanzel M, Beuger V, Frohme C, Beul D, Hillukkala T, Syvaoja J, Saluz HP, Haenel F, Eilers M.
Mol Cell 10(3):509-21. 2002
32TOPBP1
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival.
Yamane K, Wu X, Chen J.
Mol Cell Biol 22(2):555-66. 2002
33TOPBP1
BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.
Makiniemi M, Hillukkala T, Tuusa J, Reini K, Vaara M, Huang D, Pospiech H, Majuri I, Westerling T, Makela TP, Syvaoja JE.
J Biol Chem 276(32):30399-406. Epub 2001 Jun 6. 2001
34TOPBP1
A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator.
Yamane K, Kawabata M, Tsuruo T.
Eur J Biochem 250(3):794-9. 1997
35ANKS1A, BCL2L2, DCUN1D4, DHX38, DHX38, DVL3, EDEM1, FAM38A, FIG4, GCN1L1, HSPH1, IHPK1, KIAA0232, KIAA0240, KIAA0247, LARP4B, LPGAT1, LRRC8B, MFN2, MRPS27, NCSTN, NUP205, PHF15, PHF16, PHYHIP, PIEZO1, PUM2, RAPGEF5, RGP1, RIMS3, RNF10, RTF1, RUBCN, SNX19, SPOCK2, STAB1, TATDN2, TBC1D5, TIAF1, TM9SF4, TOPBP1, WAPL, WASF1, ZNF516, ZNF516, ZNF592
Prediction of the coding sequences of unidentified human genes. VI. the coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
Nagase T, et al.
DNA Res 3 : 321-329,341-54. 1996