| 1 | BARD1, BRCA1, TOP2B
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| BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ.
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| Bunch H, Jeong J, Kang K, Jo DS, Cong ATQ, Kim D, Kim D, Cho DH, Lee YM, Chen BPC, Schellenberg MJ, Calderwood SK.
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| Open Biol. Oct;11(10):210221. doi: 10.1098/rsob.210221. Epub 2021 Oct 6. 2021
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| 2 | NR4A2, TOP2B
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| Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons.
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| Heng X, Jin G, Zhang X, Yang D, Zhu M, Fu S, Li X, Le W.
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| Mol Neurodegener 7:4. doi: 10.1186/1750-1326-7-4.
2012
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| 3 | TOP2B
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| Topoisomerase IIβ regulates base excision repair capacity of neurons.
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| Gupta KP, Swain U, Rao KS, Kondapi AK.
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| Mech Ageing Dev 133(4):203-13. doi: 10.1016/j.mad.2012.03.010. Epub 2012 Mar 17.
2012
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| 4 | TOP1MT, TOP2B, TOP3A
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| Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism.
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| Douarre C, Sourbier C, Dalla Rosa I, Brata Das B, Redon CE, Zhang H, Neckers L, Pommier Y.
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| PLoS One 7(7):e41094. doi: 10.1371/journal.pone.0041094. Epub 2012 Jul 20.
2012
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| 5 | TOP2B
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| Topoisomerase IIbeta is required for lamina-specific targeting of retinal ganglion cell axons and dendrites.
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| Nevin LM, Xiao T, Staub W, Baier H.
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| Development 138(12):2457-65. doi: 10.1242/dev.060335.
2011
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| 6 | PARP1, PARP2, TOP2B
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| Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.
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| Meyer-Ficca ML, Lonchar JD, Ihara M, Meistrich ML, Austin CA, Meyer RG.
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| Biol Reprod 84(5):900-9. doi: 10.1095/biolreprod.110.090035. Epub 2011 Jan 12.
2011
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| 7 | PARP1, TOP2B, XRCC6
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| Topoisomerase IIβ associates with Ku70 and PARP-1 during double strand break repair of DNA in neurons.
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| Mandraju R, Chekuri A, Bhaskar C, Duning K, Kremerskothen J, Kondapi AK.
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| Arch Biochem Biophys 516(2):128-37. doi: 10.1016/j.abb.2011.09.017. Epub 2011 Oct 10.
2011
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| 8 | TOP2B
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| The function of DNA topoisomerase IIβ in neuronal development.
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| Heng X, Le WD.
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| Neurosci Bull 26(5):411-6. doi: 10.1007/s12264-010-0625-9. Review.
2010
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| 9 | HNRNPU, TOP2B
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| Regulation of DNA Topoisomerase IIbeta through RNA-dependent association with heterogeneous nuclear ribonucleoprotein U (hnRNP U).
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| Kawano S, Miyaji M, Ichiyasu S, Tsutsui KM, Tsutsui K.
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| J Biol Chem 285(34):26451-60. doi: 10.1074/jbc.M110.112979. Epub 2010 Jun 16.
2010
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| 10 | TOP2B
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| Topoisomerase IIbeta activates a subset of neuronal genes that are repressed in AT-rich genomic environment.
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| Sano K, Miyaji-Yamaguchi M, Tsutsui KM, Tsutsui K.
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| PLoS One 3(12):e4103. doi: 10.1371/journal.pone.0004103. Epub 2008 Dec 31.
2008
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| 11 | TOP2A, TOP2B
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| C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo.
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| Linka RM, Porter AC, Volkov A, Mielke C, Boege F, Christensen MO.
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| Nucleic Acids Res 35(11):3810-22. Epub 2007 May 25.
2007
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| 12 | TOP2B
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| Role of DNA topoisomerase IIbeta in neurite outgrowth.
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| Nur-E-Kamal A, Meiners S, Ahmed I, Azarova A, Lin CP, Lyu YL, Liu LF.
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| Brain Res 1154:50-60. Epub 2007 Apr 19.
2007
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| 13 | TOP2B
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| Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest.
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| Chikamori K, Hill JE, Grabowski DR, Zarkhin E, Grozav AG, Vaziri SA, Wang J, Gudkov AV, Rybicki LR, Bukowski RM, Yen A, Tanimoto M, Ganapathi MK, Ganapathi R.
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| Leukemia 20(10):1809-18. Epub 2006 Aug 17. 2006
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| 14 | TOP2B
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| Role of topoisomerase IIbeta in the expression of developmentally regulated genes.
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| Lyu YL, Lin CP, Azarova AM, Cai L, Wang JC, Liu LF.
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| Mol Cell Biol 26(21):7929-41. Epub 2006 Aug 21.
2006
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| 15 | TOP2B
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| A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.
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| Ju BG, Lunyak VV, Perissi V, Garcia-Bassets I, Rose DW, Glass CK, Rosenfeld MG.
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| Science 312(5781):1798-802. Erratum in: Science. 2011 May 6;332(6030):664.
2006
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| 16 | TOP2A, TOP2B
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| Functional compatibility between isoform alpha and beta of type II DNA topoisomerase.
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| Sakaguchi A, Kikuchi A.
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| J Cell Sci 117(Pt 7):1047-54.
2004
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| 17 | TOP2A, TOP2B
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| Molecular cloning and characterization of the human topoisomerase IIalpha and IIbeta genes: evidence for isoform evolution through gene duplication.
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| Sng JH, et al.
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| Biochim Biophys Acta 1444(3):395-406. 1999
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| 18 | TOP2A, TOP2B
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| Structural organization of the human TOP2A and TOP2B genes.
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| Lang AJ, Mirski SE, Cummings HJ, Yu Q, Gerlach JH, Cole SP.
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| Gene 221 : 255-266. 1998
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| 19 | TOP2B
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| Cloning and characterization of the 5'-flanking sequence for the human DNA topoisomerase II beta gene.
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| Ng SW, Liu Y, Schnipper LE.
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| Gene 203(2):113-9. 1997
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| 20 | TOP2A, TOP2B
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| Topoisomerase IIalpha and topoisomerase IIbeta genes: characterization and mapping to human chromosomes 17 and 3, respectively.
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| Tan KB, et al.
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| Cancer Res 52 : 231-234. 1992
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| 21 | TOP2A, TOP2B
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| Amplification of the topoisomerase II alpha gene in a non-small cell lung cancer cell line and characterisation of polymorphisms at the human topoisomerase II alpha and beta loci in normal tissue.
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| Keith WN, et al.
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| Genes Chromosomes Cancer 4 : 169-175. 1992
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| 22 | TOP2B
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| Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24.
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| Jenkins JR, et al.
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| Nucleic Acids Res 20 : 5587-5592. 1992
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| 23 | TOP2A, TOP2B
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| Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form o human topoisomerase II.
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| Lee MS, et al.
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| J Mol Biol 223 : 837-843. 1992
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