| 1 | IDDHISD, TNPO1, TNPO2
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| TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.
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| Goodman LD, Cope H, Nil Z, Ravenscroft TA, Charng WL, Lu S, Tien AC, Pfundt R, Koolen DA, Haaxma CA, Veenstra-Knol HE, Wassink-Ruiter JSK, Wevers MR, Jones M, Walsh LE, Klee VH, Theunis M, Legius E, Steel D, Barwick KES, Kurian MA, Mohammad SS, Dale RC, Terhal PA, van Binsbergen E, Kirmse B, Robinette B, Cogné B, Isidor B, Grebe TA, Kulch P, Hainline BE, Sapp K, Morava E, Klee EW, Macke EL, Trapane P, Spencer C, Si Y, Begtrup A, Moulton MJ, Dutta D, Kanca O; Undiagnosed Diseases Network, Wangler MF, Yamamoto S, Bellen HJ, Tan QK.
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| Am J Hum Genet Sep 2;108(9):1669-1691. doi: 10.1016/j.ajhg.2021.06.019. Epub 2021 Jul 26. 2021
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| 2 | ARID1A, ARID1B, TNPO1
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| TNPO1-mediated nuclear import of ARID1B promotes tumor growth in ARID1A-deficient gynecologic cancer.
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| Yang B, Chen J, Li X, Zhang X, Hu L, Jiang S, Zhang Z, Teng Y.
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| Cancer Lett. Sep 1;515:14-27. doi: 10.1016/j.canlet.2021.05.016. Epub 2021 May 25 2021
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| 3 | TNPO1
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| Redox-dependent PPARγ/Tnpo1 complex formation enhances PPARγ nuclear localization and signaling
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| Teratani T, Tomita K, Toma-Fukai S, Nakamura Y, Itoh T, Shimizu H, Shiraishi Y, Sugihara N, Higashiyama M, Shimizu T, Inoue I, Takenaka Y, Hokari R, Adachi T, Shimizu T, Miura S, Kanai T
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| Free Radic Biol Med. Aug 20;156:45-56. doi: 10.1016/j.freeradbiomed.2020.06.005. Epub 2020 Jun 15 2020
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| 4 | TNPO1, TNPO3
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| Nonclassical nuclear localization signals mediate nuclear import of CIRBP.
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| Bourgeois B, Hutten S, Gottschalk B, Hofweber M, Richter G, Sternat J, Abou-Ajram C, Göbl C, Leitinger G, Graier WF, Dormann D, Madl T.
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| Proc Natl Acad Sci U S A. Apr 14;117(15):8503-8514. doi: 10.1073/pnas.1918944117. Epub 2020 Mar 31. 2020
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| 5 | HNRNPA1, TNPO1
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| The effect of O-GlcNAcylation on hnRNP A1 translocation and interaction with transportin1
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| Roth S, Khalaila I.
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| Exp Cell Res Jan 1;350(1):210-217. doi: 10.1016/j.yexcr.2016.11.023. Epub 2016 Nov 29. 2017
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| 6 | TNPO1
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| A ternary complex comprising transportin1, Rab8 and the ciliary targeting signal directs proteins to ciliary membranes
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| Madugula V, Lu L.
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| J Cell Sci. Oct 15;129(20):3922-3934. doi: 10.1242/jcs.194019. Epub 2016 Sep 1 2016
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| 7 | TNPO1, YBX1
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| Transportin-1-dependent YB-1 nuclear import.
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| Mordovkina DA, Kim ER, Buldakov IA, Sorokin AV, Eliseeva IA, Lyabin DN, Ovchinnikov LP.
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| Biochem Biophys Res Commun. Nov 25;480(4):629-634. doi: 10.1016/j.bbrc.2016.10.107. Epub 2016 Oct 26 2016
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| 8 | TNPO1, TNPO2
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| Transportin-1 and Transportin-2: protein nuclear import and beyond.
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| Twyffels L, Gueydan C, Kruys V.
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| FEBS Lett. May 21;588(10):1857-68. doi: 10.1016/j.febslet.2014.04.023. Epub 2014 Apr 26. 2014
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| 9 | ALS6, FUS, TNPO1
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| Structural and energetic basis of ALS-causing mutations in the atypical proline-tyrosine nuclear localization signal of the Fused in Sarcoma protein (FUS).
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| Zhang ZC, Chook YM.
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| Proc Natl Acad Sci U S A 109(30):12017-21. doi: 10.1073/pnas.1207247109. Epub 2012 Jul 9.
2012
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| 10 | CD44, TNPO1
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| Transportin regulates nuclear import of CD44.
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| Janiszewska M, De Vito C, Le Bitoux MA, Fusco C, Stamenkovic I.
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| J Biol Chem 285(40):30548-57. Epub 2010 Jul 27.
2010
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| 11 | TNPO1, ZFP36
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| A role for transportin in deposition of TTP to cytoplasmic RNA granules and mRNA decay.
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| Chang WL, Tarn WY.
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| Nucleic Acids Res 37(19):6600-12. Epub 2009 Sep 3.
2009
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| 12 | RANBP1, TNPO1
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| Importin-beta is a GDP-to-GTP exchange factor of Ran: implications for the mechanism of nuclear import.
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| Lonhienne TG, Forwood JK, Marfori M, Robin G, Kobe B, Carroll BJ.
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| J Biol Chem 284(34):22549-58. Epub 2009 Jun 23.PMID: 19549784 2009
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| 13 | CCR2, TNPO1
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| Chemokine receptor CCR2 undergoes transportin1-dependent nuclear translocation.
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| Favre N, Camps M, Arod C, Chabert C, Rommel C, Pasquali C.
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| Proteomics 8(21):4560-76.PMID: 18846510 2008
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| 14 | TNPO1
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| Multiple importins function as nuclear transport receptors for the Rev protein of human immunodeficiency virus type 1.
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| Arnold M, Nath A, Hauber J, Kehlenbach RH.
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| J Biol Chem 281(30):20883-90. Epub 2006 May 16.PMID: 16704975 2006
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| 15 | HNRNPA1, TNPO1, TNPO2
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| Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR.
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| Rebane A, Aab A, Steitz JA.
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| RNA 10(4):590-9.PMID: 15037768 2004
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| 16 | TNPO1, NUP98
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| The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import.
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| Fontoura BM, Blobel G, Yaseen NR.
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| J Biol Chem 275(40):31289-96. 2000
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| 17 | HNRNPA1, TNPO1
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| Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta.
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| Fridell RA, Truant R, Thorne L, Benson RE, Cullen BR.
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| J Cell Sci 110 ( Pt 11):1325-31. 1997
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