| 1 | TNNT1, TNNT2, TNNT3
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| TNNT1, TNNT2, and TNNT3: Isoform genes, regulation, and structure-function relationships.
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| Wei B, Jin JP.
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| Gene 582(1):1-13. doi: 10.1016/j.gene.2016.01.006. Epub 2016 Jan 13. Review.
2016
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| 2 | NPPB, TNNT2
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| Troponin T, N-terminal pro-B-type natriuretic peptide, and incidence of stroke: the atherosclerosis risk in communities study.
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| Folsom AR, Nambi V, Bell EJ, Oluleye OW, Gottesman RF, Lutsey PL, Huxley RR, Ballantyne CM.
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| Stroke 44(4):961-7. doi: 10.1161/STROKEAHA.111.000173. Epub 2013 Mar 7.
2013
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| 3 | TNNT2
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| Cardiac troponin T, a sarcomeric AKAP, tethers protein kinase A at the myofilaments.
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| Sumandea CA, Garcia-Cazarin ML, Bozio CH, Sievert GA, Balke CW, Sumandea MP.
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| J Biol Chem 286(1):530-41. Epub 2010 Nov 5.
2011
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| 4 | RCM3, TNNT2
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| Fetal cardiac troponin isoforms rescue the increased Ca2+ sensitivity produced by a novel double deletion in cardiac troponin T linked to restrictive cardiomyopathy: a clinical, genetic, and functional approach.
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| Pinto JR, Yang SW, Hitz MP, Parvatiyar MS, Jones MA, Liang J, Kokta V, Talajic M, Tremblay N, Jaeggi M, Andelfinger G, Potter JD.
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| J Biol Chem 286(23):20901-12. Epub 2011 Apr 18.
2011
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| 5 | TNNT2
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| Phosphorylation, but not alternative splicing or proteolytic degradation, is conserved in human and mouse cardiac troponin T.
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| Zhang J, Zhang H, Ayaz-Guner S, Chen YC, Dong X, Xu Q, Ge Y.
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| Biochemistry 50(27):6081-92. Epub 2011 Jun 15.
2011
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| 6 | MYBPC3, MYH7, TNNT2
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| The role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy.
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| Møller DV, Andersen PS, Hedley P, Ersbøll MK, Bundgaard H, Moolman-Smook J, Christiansen M, Køber L.
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| Eur J Hum Genet 17(10):1241-9. Epub 2009 Mar 18.PMID: 19293840 2009
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| 7 | TNNT2, RCM3
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| A troponin T mutation that causes infantile restrictive cardiomyopathy increases Ca2+ sensitivity of force development and impairs the inhibitory properties of troponin.
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| Pinto JR, Parvatiyar MS, Jones MA, Liang J, Potter JD.
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| J Biol Chem 283(4):2156-66. Epub 2007 Nov 21. 2008
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| 8 | ACTC1, CFMH4, CMH1, CMH11, MYBPC3, MYH7, MYL2, MYL3, PRKAG2, TNNI3, TNNT2, TPM1
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| Shared genetic causes of cardiac hypertrophy in children and adults.
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| Morita H, Rehm HL, Menesses A, McDonough B, Roberts AE, Kucherlapati R, Towbin JA, Seidman JG, Seidman CE.
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| N Engl J Med 358(18):1899-908. Epub 2008 Apr 9. 2008
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| 9 | TNNC2, TNNI2, TNNT2
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| Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle.
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| Moran CM, Garriock RJ, Miller MK, Heimark RL, Gregorio CC, Krieg PA.
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| Cell Motil Cytoskeleton 65(8):652-61. 2008
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| 10 | TNNT2
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| Relationships of N-terminal pro-B-natriuretic peptide and cardiac troponin T to left ventricular mass and function and mortality in asymptomatic hemodialysis patients.
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| Satyan S, Light RP, Agarwal R.
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| Am J Kidney Dis 50(6):1009-19. 2007
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| 11 | TNNT2, CMD1D
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| Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform.
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| Venkatraman G, Gomes AV, Kerrick WG, Potter JD.
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| J Biol Chem 280(18):17584-92. Epub 2004 Dec 28. 2005
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| 12 | TNNT2, CMD1D
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| Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype.
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| Mirza M, Marston S, Willott R, Ashley C, Mogensen J, McKenna W, Robinson P, Redwood C, Watkins H.
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| J Biol Chem 280(31):28498-506. Epub 2005 May 27. 2005
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| 13 | TNNC2, TNNI2, TNNT2
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| Structural basis for Ca2+-regulated muscle relaxation at interaction sites of troponin with actin and tropomyosin.
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| Murakami K, Yumoto F, Ohki SY, Yasunaga T, Tanokura M, Wakabayashi T.
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| J Mol Biol 352(1):178-201.
2005
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| 14 | TNNT2, CMD1D, CMH2
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| The role of a common TNNT2 polymorphism in cardiac hypertrophy.
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| Komamura K, Iwai N, Kokame K, Yasumura Y, Kim J, Yamagishi M, Morisaki T, Kimura A, Tomoike H, Kitakaze M, Miyatake K.
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| J Hum Genet 49(3):129-33. Epub 2004 Feb 24. 2004
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| 15 | TNNT2
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| The slow skeletal muscle troponin T gene is expressed in developing and diseased human heart.
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| Barton PJ, Felkin LE, Koban MU, Cullen ME, Brand NJ, Dhoot GK.
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| Mol Cell Biochem 263(1-2):91-7. 2004
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| 16 | TNNT2
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| Cardiac troponin T is essential in sarcomere assembly and cardiac contractility.
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| Sehnert AJ, Huq A, Weinstein BM, Walker C, Fishman M, Stainier DY.
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| Nat Genet 31(1):106-10. 2002
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| 17 | TPM1, TNNT2, MYBPC3, MYH7
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| Novel mutations in sarcomeric protein genes in dilated cardiomyopathy.
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| Daehmlow S, Erdmann J, Knueppel T, Gille C, Froemmel C, Hummel M, Hetzer R, Regitz-Zagrosek V.
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| Biochem Biophys Res Commun 298(1):116-20. 2002
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| 18 | CMH2, TNNT2
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| Novel cardiac troponin T mutation as a cause of familial dilated cardiomyopathy
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| Li D, Czernuszewicz GZ, Gonzalez O, Tapscott T, Karibe A, Durand JB, Brugada R, Hill R, Gregoritch JM, Anderson JL, Quinones M, Bachinski LL, Roberts R.
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| Circulation 104(18):2188-93. 2001
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| 19 | TNNT2, CMD1D
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| Novel cardiac troponin T mutation as a cause of familial dilated cardiomyopathy.
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| Li D, Czernuszewicz GZ, Gonzalez O, Tapscott T, Karibe A, Durand JB, Brugada R, Hill R, Gregoritch JM, Anderson JL, Quinones M, Bachinski LL, Roberts R.
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| Circulation 104(18):2188-93. 2001
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| 20 | TNNT2
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| Functional consequences of the deletion mutation deltaGlu160 in human cardiac troponin T.
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| Harada K, Takahashi-Yanaga F, Minakami R, Morimoto S, Ohtsuki I.
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| J Biochem (Tokyo) 127(2):263-8. 2000
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| 21 | CMH2, TNNT2
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| Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy.
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| Szczesna D, Zhang R, Zhao J, Jones M, Guzman G, Potter JD.
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| J Biol Chem 275(1):624-30. 2000
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| 22 | CMH2, TNNT2
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| Homozygous mutation in cardiac troponin T: implications for hypertrophic cardiomyopathy.
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| Ho CY, Lever HM, DeSanctis R, Farver CF, Seidman JG, Seidman CE.
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| Circulation 102(16):1950-5. 2000
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| 23 | TNNI1, TNNI3, TNNT1, TNNT2
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| Close physical linkage of human troponin genes: organization, sequence, and expression of the locus encoding cardiac troponin I and slow skeletal troponin T.
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| Barton PJ, et al.
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| Genomics 57(1):102-9 1999
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| 24 | CMH2, TNNT2
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| Effects of missense mutations Phe110Ile and Glu244Asp in human cardiac troponin T on force generation in skinned cardiac muscle fibers.
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| Nakaura H, Yanaga F, Ohtsuki I, Morimoto S.
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| J Biochem (Tokyo) 126(3):457-60 1999
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| 25 | TNNT2
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| A new mutation of the cardiac troponin T gene causing familial hypertrophic cardiomyopathy without left ventricular hypertrophy.
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| Varnava A, Baboonian C, Davison F, de Cruz L, Elliott PM, Davies MJ, McKenna WJ.
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| Heart 82(5):621-4 1999
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| 26 | TNNT2
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| Genomic organisation, alternative splicing and polymorphisms of the human cardiac troponin T gene.
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| Farza H, et al.
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| J Mol Cell Cardiol 30 : 1247-1253. 1998
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| 27 | CMH2, TNNT2
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| Patients with familial hypertrophic cardiomyopathy caused by a Phe110Ile missense mutation in the cardiac troponin T gene have variable cardiac morphologies and a favorable prognosis.
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| Anan R, Shono H, Kisanuki A, Arima S, Nakao S, Tanaka H.
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| Circulation 98 : 391-397. 1998
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| 28 | CMH2, TNNT2
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| Sudden death due to troponin T mutations.
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| Moolman JC, et al.
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| J Am Coll Cardiol 29 : 549-555. 1997
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| 29 | CMH2, TNNT2
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| Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy.
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| Nakajima-Taniguchi C, et al.
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| J Mol Cell Cardiol 29 : 839-843. 1997
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| 30 | CMH2, TNNT2
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| Expression of a mutant (Arg92Gln) human cardiac troponin T, known to cause hypertrophic cardiomyopathy, impairs adult cardiac myocyte contractility.
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| Marian AJ, Zhao G, Seta Y, Roberts R, Yu QT.
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| Circ Res 81(1):76-85. 1997
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| 31 | ELF3, TNNI1, TNNT2
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| A novel epithelial-expressed ETS gene, ELF3 : human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer.
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| Tymms MJ, Ng AY, Thomas RS, Schutte BC, Zhou J, Eyre HJ, Sutherland GR, Seth A, Rosenberg M, Papas T, Debouck C, Kola I.
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| Oncogene 15(20):2449-62. 1997
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| 32 | CMH2, TNNT2
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| Expression and functional assessment of a truncated cardiac troponin T that causes hypertrophic cardiomyopathy. Evidence for a dominant negative action.
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| Watkins H, et al.
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| J Clin Invest 98 : 2456-2461. 1996
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| 33 | CMH2, TNNT2
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| Codon 102 of the cardiac troponin T gene is a putative hot spot for mutations in familial hypertrophic cardiomyopathy.
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| Forissier JF, et al.
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| Circulation 94 : 3069-3073. 1996
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| 34 | TNNT2
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| Molecular cloning of human cardiac troponin T isoforms : expression in developing and failing heart.
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| Townsend PJ, et al.
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| J Mol Cell Cardiol 27 : 2223-2236. 1995
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| 35 | TNNT2
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| Human cardiac troponin T : identification of fetal isoforms and assignment of the TNNT2 locus to chromosome 1q.
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| Townsend PJ, et al.
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| Genomics 21 : 311-316. 1994
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| 36 | TNNT2
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| Molecular cloning and developmental expression of human cardiac troponinT.
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| Mesnard L, et al.
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| FEBS Lett 328 : 139-144. 1993
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