Citations for
1TNNT1, TNNT2, TNNT3
TNNT1, TNNT2, and TNNT3: Isoform genes, regulation, and structure-function relationships.
Wei B, Jin JP.
Gene 582(1):1-13. doi: 10.1016/j.gene.2016.01.006. Epub 2016 Jan 13. Review. 2016
2NPPB, TNNT2
Troponin T, N-terminal pro-B-type natriuretic peptide, and incidence of stroke: the atherosclerosis risk in communities study.
Folsom AR, Nambi V, Bell EJ, Oluleye OW, Gottesman RF, Lutsey PL, Huxley RR, Ballantyne CM.
Stroke 44(4):961-7. doi: 10.1161/STROKEAHA.111.000173. Epub 2013 Mar 7. 2013
3TNNT2
Cardiac troponin T, a sarcomeric AKAP, tethers protein kinase A at the myofilaments.
Sumandea CA, Garcia-Cazarin ML, Bozio CH, Sievert GA, Balke CW, Sumandea MP.
J Biol Chem 286(1):530-41. Epub 2010 Nov 5. 2011
4RCM3, TNNT2
Fetal cardiac troponin isoforms rescue the increased Ca2+ sensitivity produced by a novel double deletion in cardiac troponin T linked to restrictive cardiomyopathy: a clinical, genetic, and functional approach.
Pinto JR, Yang SW, Hitz MP, Parvatiyar MS, Jones MA, Liang J, Kokta V, Talajic M, Tremblay N, Jaeggi M, Andelfinger G, Potter JD.
J Biol Chem 286(23):20901-12. Epub 2011 Apr 18. 2011
5TNNT2
Phosphorylation, but not alternative splicing or proteolytic degradation, is conserved in human and mouse cardiac troponin T.
Zhang J, Zhang H, Ayaz-Guner S, Chen YC, Dong X, Xu Q, Ge Y.
Biochemistry 50(27):6081-92. Epub 2011 Jun 15. 2011
6MYBPC3, MYH7, TNNT2
The role of sarcomere gene mutations in patients with idiopathic dilated cardiomyopathy.
Møller DV, Andersen PS, Hedley P, Ersbøll MK, Bundgaard H, Moolman-Smook J, Christiansen M, Køber L.
Eur J Hum Genet 17(10):1241-9. Epub 2009 Mar 18.PMID: 19293840 2009
7TNNT2, RCM3
A troponin T mutation that causes infantile restrictive cardiomyopathy increases Ca2+ sensitivity of force development and impairs the inhibitory properties of troponin.
Pinto JR, Parvatiyar MS, Jones MA, Liang J, Potter JD.
J Biol Chem 283(4):2156-66. Epub 2007 Nov 21. 2008
8ACTC1, CMH1, CMH11, CMH4, MYBPC3, MYH7, MYL2, MYL3, PRKAG2, TNNI3, TNNT2, TPM1
Shared genetic causes of cardiac hypertrophy in children and adults.
Morita H, Rehm HL, Menesses A, McDonough B, Roberts AE, Kucherlapati R, Towbin JA, Seidman JG, Seidman CE.
N Engl J Med 358(18):1899-908. Epub 2008 Apr 9. 2008
9TNNC2, TNNI2, TNNT2
Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle.
Moran CM, Garriock RJ, Miller MK, Heimark RL, Gregorio CC, Krieg PA.
Cell Motil Cytoskeleton 65(8):652-61. 2008
10TNNT2
Relationships of N-terminal pro-B-natriuretic peptide and cardiac troponin T to left ventricular mass and function and mortality in asymptomatic hemodialysis patients.
Satyan S, Light RP, Agarwal R.
Am J Kidney Dis 50(6):1009-19. 2007
11TNNT2, CMD1D
Characterization of troponin T dilated cardiomyopathy mutations in the fetal troponin isoform.
Venkatraman G, Gomes AV, Kerrick WG, Potter JD.
J Biol Chem 280(18):17584-92. Epub 2004 Dec 28. 2005
12TNNT2, CMD1D
Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype.
Mirza M, Marston S, Willott R, Ashley C, Mogensen J, McKenna W, Robinson P, Redwood C, Watkins H.
J Biol Chem 280(31):28498-506. Epub 2005 May 27. 2005
13TNNC2, TNNI2, TNNT2
Structural basis for Ca2+-regulated muscle relaxation at interaction sites of troponin with actin and tropomyosin.
Murakami K, Yumoto F, Ohki SY, Yasunaga T, Tanokura M, Wakabayashi T.
J Mol Biol 352(1):178-201. 2005
14TNNT2, CMD1D, CMH2
The role of a common TNNT2 polymorphism in cardiac hypertrophy.
Komamura K, Iwai N, Kokame K, Yasumura Y, Kim J, Yamagishi M, Morisaki T, Kimura A, Tomoike H, Kitakaze M, Miyatake K.
J Hum Genet 49(3):129-33. Epub 2004 Feb 24. 2004
15TNNT2
The slow skeletal muscle troponin T gene is expressed in developing and diseased human heart.
Barton PJ, Felkin LE, Koban MU, Cullen ME, Brand NJ, Dhoot GK.
Mol Cell Biochem 263(1-2):91-7. 2004
16TNNT2
Cardiac troponin T is essential in sarcomere assembly and cardiac contractility.
Sehnert AJ, Huq A, Weinstein BM, Walker C, Fishman M, Stainier DY.
Nat Genet 31(1):106-10. 2002
17TPM1, TNNT2, MYBPC3, MYH7
Novel mutations in sarcomeric protein genes in dilated cardiomyopathy.
Daehmlow S, Erdmann J, Knueppel T, Gille C, Froemmel C, Hummel M, Hetzer R, Regitz-Zagrosek V.
Biochem Biophys Res Commun 298(1):116-20. 2002
18CMH2, TNNT2
Novel cardiac troponin T mutation as a cause of familial dilated cardiomyopathy
Li D, Czernuszewicz GZ, Gonzalez O, Tapscott T, Karibe A, Durand JB, Brugada R, Hill R, Gregoritch JM, Anderson JL, Quinones M, Bachinski LL, Roberts R.
Circulation 104(18):2188-93. 2001
19TNNT2, CMD1D
Novel cardiac troponin T mutation as a cause of familial dilated cardiomyopathy.
Li D, Czernuszewicz GZ, Gonzalez O, Tapscott T, Karibe A, Durand JB, Brugada R, Hill R, Gregoritch JM, Anderson JL, Quinones M, Bachinski LL, Roberts R.
Circulation 104(18):2188-93. 2001
20TNNT2
Functional consequences of the deletion mutation deltaGlu160 in human cardiac troponin T.
Harada K, Takahashi-Yanaga F, Minakami R, Morimoto S, Ohtsuki I.
J Biochem (Tokyo) 127(2):263-8. 2000
21CMH2, TNNT2
Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy.
Szczesna D, Zhang R, Zhao J, Jones M, Guzman G, Potter JD.
J Biol Chem 275(1):624-30. 2000
22CMH2, TNNT2
Homozygous mutation in cardiac troponin T: implications for hypertrophic cardiomyopathy.
Ho CY, Lever HM, DeSanctis R, Farver CF, Seidman JG, Seidman CE.
Circulation 102(16):1950-5. 2000
23TNNI1, TNNI3, TNNT1, TNNT2
Close physical linkage of human troponin genes: organization, sequence, and expression of the locus encoding cardiac troponin I and slow skeletal troponin T.
Barton PJ, et al.
Genomics 57(1):102-9 1999
24CMH2, TNNT2
Effects of missense mutations Phe110Ile and Glu244Asp in human cardiac troponin T on force generation in skinned cardiac muscle fibers.
Nakaura H, Yanaga F, Ohtsuki I, Morimoto S.
J Biochem (Tokyo) 126(3):457-60 1999
25TNNT2
A new mutation of the cardiac troponin T gene causing familial hypertrophic cardiomyopathy without left ventricular hypertrophy.
Varnava A, Baboonian C, Davison F, de Cruz L, Elliott PM, Davies MJ, McKenna WJ.
Heart 82(5):621-4 1999
26TNNT2
Genomic organisation, alternative splicing and polymorphisms of the human cardiac troponin T gene.
Farza H, et al.
J Mol Cell Cardiol 30 : 1247-1253. 1998
27CMH2, TNNT2
Patients with familial hypertrophic cardiomyopathy caused by a Phe110Ile missense mutation in the cardiac troponin T gene have variable cardiac morphologies and a favorable prognosis.
Anan R, Shono H, Kisanuki A, Arima S, Nakao S, Tanaka H.
Circulation 98 : 391-397. 1998
28CMH2, TNNT2
Sudden death due to troponin T mutations.
Moolman JC, et al.
J Am Coll Cardiol 29 : 549-555. 1997
29CMH2, TNNT2
Novel missense mutation in cardiac troponin T gene found in Japanese patient with hypertrophic cardiomyopathy.
Nakajima-Taniguchi C, et al.
J Mol Cell Cardiol 29 : 839-843. 1997
30CMH2, TNNT2
Expression of a mutant (Arg92Gln) human cardiac troponin T, known to cause hypertrophic cardiomyopathy, impairs adult cardiac myocyte contractility.
Marian AJ, Zhao G, Seta Y, Roberts R, Yu QT.
Circ Res 81(1):76-85. 1997
31ELF3, TNNI1, TNNT2
A novel epithelial-expressed ETS gene, ELF3 : human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer.
Tymms MJ, Ng AY, Thomas RS, Schutte BC, Zhou J, Eyre HJ, Sutherland GR, Seth A, Rosenberg M, Papas T, Debouck C, Kola I.
Oncogene 15(20):2449-62. 1997
32CMH2, TNNT2
Expression and functional assessment of a truncated cardiac troponin T that causes hypertrophic cardiomyopathy. Evidence for a dominant negative action.
Watkins H, et al.
J Clin Invest 98 : 2456-2461. 1996
33CMH2, TNNT2
Codon 102 of the cardiac troponin T gene is a putative hot spot for mutations in familial hypertrophic cardiomyopathy.
Forissier JF, et al.
Circulation 94 : 3069-3073. 1996
34TNNT2
Molecular cloning of human cardiac troponin T isoforms : expression in developing and failing heart.
Townsend PJ, et al.
J Mol Cell Cardiol 27 : 2223-2236. 1995
35TNNT2
Human cardiac troponin T : identification of fetal isoforms and assignment of the TNNT2 locus to chromosome 1q.
Townsend PJ, et al.
Genomics 21 : 311-316. 1994
36TNNT2
Molecular cloning and developmental expression of human cardiac troponinT.
Mesnard L, et al.
FEBS Lett 328 : 139-144. 1993