Citations for
TNK2 gene amplification is a novel predictor of a poor prognosis in patients with gastric cancer.
Shinmura K, Kiyose S, Nagura K, Igarashi H, Inoue Y, Nakamura S, Maeda M, Baba M, Konno H, Sugimura H.
J Surg Oncol 109(3):189-97. doi: 10.1002/jso.23482. Epub 2013 Oct 31. 2014
Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death.
Linderoth E, Pilia G, Mahajan NP, Ferby I.
J Biol Chem 288(46):32922-31. doi: 10.1074/jbc.M113.481507. Epub 2013 Oct 1. 2013
Mutations in TNK2 in severe autosomal recessive infantile onset epilepsy.
Hitomi Y, Heinzen EL, Donatello S, Dahl HH, Damiano JA, McMahon JM, Berkovic SF, Scheffer IE, Legros B, Rai M, Weckhuysen S, Suls A, De Jonghe P, Pandolfo M, Goldstein DB, Van Bogaert P, Depondt C.
Ann Neurol 74(3):496-501. doi: 10.1002/ana.23934. Epub 2013 Sep 4. 2013
SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation.
Buchwald M, Pietschmann K, Brand P, Günther A, Mahajan NP, Heinzel T, Krämer OH.
Oncogene 32(41):4913-20. doi: 10.1038/onc.2012.515. Epub 2012 Dec 3. 2013
The activation mechanism of ACK1 (activated Cdc42-associated tyrosine kinase 1).
Lin Q, Wang J, Childress C, Yang W.
Biochem J 445(2):255-64. doi: 10.1042/BJ20111575. 2012
The Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation.
Chan W, Sit ST, Manser E.
Biochem J 435(2):355-64. doi: 10.1042/BJ20102156. 2011
Shepherding AKT and androgen receptor by Ack1 tyrosine kinase.
Mahajan K, Mahajan NP.
J Cell Physiol 224(2):327-33. doi: 10.1002/jcp.22162. Review. 2010
Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1.
Prieto-Echagüe V, Gucwa A, Craddock BP, Brown DA, Miller WT.
J Biol Chem 285(14):10605-15. doi: 10.1074/jbc.M109.060459. Epub 2010 Jan 28. 2010
Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.
Pao-Chun L, Chan PM, Chan W, Manser E.
J Biol Chem 284(50):34954-63. doi: 10.1074/jbc.M109.072660. Epub 2009 Oct 8. 2009
Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.
Chan W, Tian R, Lee YF, Sit ST, Lim L, Manser E.
J Biol Chem 284(12):8185-94. doi: 10.1074/jbc.M806877200. Epub 2009 Jan 14. 2009
Nephrocystin-1 interacts directly with Ack1 and is expressed in human collecting duct.
Eley L, Moochhala SH, Simms R, Hildebrandt F, Sayer JA.
Biochem Biophys Res Commun 371(4):877-82. Epub 2008 May 12. 2008
Activated Cdc42-associated kinase Ack1 promotes prostate cancer progression via androgen receptor tyrosine phosphorylation.
Mahajan NP, Liu Y, Majumder S, Warren MR, Parker CE, Mohler JL, Earp HS, Whang YE.
Proc Natl Acad Sci U S A. 104(20):8438-43. Epub 2007 May 9. 2007
Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1.
van der Horst EH, Degenhardt YY, Strelow A, Slavin A, Chinn L, Orf J, Rong M, Li S, See LH, Nguyen KQ, Hoey T, Wesche H, Powers S.
Proc Natl Acad Sci U S A 102(44):15901-6. Epub 2005 Oct 24. 2005
14SNX9, TNK2
SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1.
Yeow-Fong L, Lim L, Manser E.
FEBS Lett 579(22):5040-8. 2005
Cdc42-dependent nuclear translocation of non-receptor tyrosine kinase, ACK.
Ahmed I, Calle Y, Sayed MA, Kamal JM, Rengaswamy P, Manser E, Meiners S, Nur-E-Kamal A.
Biochem Biophys Res Commun 314(2):571-9. 2004
Identification of the region in Cdc42 that confers the binding specificity to activated Cdc42-associated kinase.
Gu Y, Lin Q, Childress C, Yang W.
J Biol Chem 279(29):30507-13. Epub 2004 May 03. 2004
Biochemical properties of the Cdc42-associated tyrosine kinase ACK1. Substrate specificity, authphosphorylation, and interaction with Hck.
Yokoyama N, Miller WT.
J Biol Chem 278(48):47713-23. Epub 2003 Sep 22. 2003
A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42.
Manser E, Leung T, Salihuddin H, Tan L, Lim L.
Nature 363(6427):364-7. 1993