| 1 | CD40, TNFSF12, TRAF2
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| TWEAK inhibits TRAF2-mediated CD40 signaling by destabilization of CD40 signaling complexes.
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| Salzmann S, Lang I, Rosenthal A, Schäfer V, Weisenberger D, Carmona Arana JA, Trebing J, Siegmund D, Neumann M, Wajant H.
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| J Immunol 191(5):2308-18. doi: 10.4049/jimmunol.1202899. Epub 2013 Aug 5.
2013
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| 2 | BIRC3, NFKB1, TNFSF12
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| TWEAK and cIAP1 regulate myoblast fusion through the noncanonical NF-κB signaling pathway.
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| Enwere EK, Holbrook J, Lejmi-Mrad R, Vineham J, Timusk K, Sivaraj B, Isaac M, Uehling D, Al-awar R, LaCasse E, Korneluk RG.
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| Sci Signal 5(246):ra75. doi: 10.1126/scisignal.2003086.
2012
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| 3 | TNF, TNFSF12
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| The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB.
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| Moreno JA, Izquierdo MC, Sanchez-Niño MD, Suárez-Alvarez B, Lopez-Larrea C, Jakubowski A, Blanco J, Ramirez R, Selgas R, Ruiz-Ortega M, Egido J, Ortiz A, Sanz AB.
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| J Am Soc Nephrol 22(7):1315-25. Epub 2011 Jun 30.
2011
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| 4 | TNFRSF12A, TNFSF12
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| Full-length, membrane-anchored TWEAK can function as a juxtacrine signaling molecule and activate the NF-kappaB pathway.
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| Brown SA, Ghosh A, Winkles JA.
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| J Biol Chem 285(23):17432-41. Epub 2010 Apr 12.PMID: 20385556 2010
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| 5 | TNFRSF12A, TNFSF12
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| Proinflammatory effect of TWEAK/Fn14 interaction in human retinal pigment epithelial cells.
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| Ebihara N, Nakayama M, Tokura T, Iwatsu M, Ushio H, Murakami A.
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| Curr Eye Res 34(10):836-44.PMID: 19895311 2009
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| 6 | TNFSF12
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| Urinary TWEAK as a biomarker of lupus nephritis: a multicenter cohort study.
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| Schwartz N, Rubinstein T, Burkly LC, Collins CE, Blanco I, Su L, Hojaili B, Mackay M, Aranow C, Stohl W, Rovin BH, Michaelson JS, Putterman C.
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| Arthritis Res Ther 11(5):R143. Epub 2009 Sep 28.PMID: 19785730 2009
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| 7 | TNFSF12
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| Considering TWEAK as a target for therapy in renal and vascular injury.
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| Ortiz A, Sanz AB, Muñoz García B, Moreno JA, Sánchez Niño MD, Martín-Ventura JL, Egido J, Blanco-Colio LM.
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| Cytokine Growth Factor Rev 20(3):251-8. Epub 2009 May 30. Review.PMID: 19482507 2009
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| 8 | TNFRSF12A, TNFSF12
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| TWEAK promotes ovarian cancer cell metastasis via NF-kappaB pathway activation and VEGF expression.
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| Dai L, Gu L, Ding C, Qiu L, Di W.
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| Cancer Lett 283(2):159-67. Epub 2009 Apr 23.PMID: 19398263 2009
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| 9 | TNFRSF12A, TNFSF12
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| A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure.
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| Jain M, Jakubowski A, Cui L, Shi J, Su L, Bauer M, Guan J, Lim CC, Naito Y, Thompson JS, Sam F, Ambrose C, Parr M, Crowell T, Lincecum JM, Wang MZ, Hsu YM, Zheng TS, Michaelson JS, Liao R, Burkly LC.
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| Circulation 119(15):2058-68. Epub 2009 Apr 6.PMID: 19349318 2009
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| 10 | TNFSF12
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| Soluble TWEAK is markedly elevated in hemophagocytic lymphohistiocytosis.
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| Nagasawa M, Yi Z, Imashuku S, Nonoyama S, Ogawa K, Okumura K, Mizutani S.
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| Am J Hematol 83(3):222-5.PMID: 17918252 2008
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| 11 | TNFRSF12A, TNFSF12
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| Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis.
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| Dogra C, Hall SL, Wedhas N, Linkhart TA, Kumar A.
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| J Biol Chem 282(20):15000-10. Epub 2007 Mar 22. 2007
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| 12 | TNFRSF12A, TNFSF12
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| Age-dependent effects of TWEAK/Fn14 receptor activation on neural progenitor cells.
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| Hamill CA, Michaelson JS, Hahm K, Burkly LC, Kessler JA.
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| J Neurosci Res 85(16):3535-44.PMID: 17803219 2007
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| 13 | TNFRSF12A, TNFSF12
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| TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration.
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| Girgenrath M, Weng S, Kostek CA, Browning B, Wang M, Brown SA, Winkles JA, Michaelson JS, Allaire N, Schneider P, Scott ML, Hsu YM, Yagita H, Flavell RA, Miller JB, Burkly LC, Zheng TS.
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| EMBO J 25(24):5826-39. Epub 2006 Nov 23.
2006
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| 14 | TNFSF12, TNFRSF12A
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| The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL/BCL-W expression.
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| Tran NL, McDonough WS, Savitch BA, Sawyer TF, Winkles JA, Berens ME.
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| J Biol Chem 280(5):3483-92. Epub 2004 Dec 16. 2005
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| 15 | TNFSF12
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| TWEAK attenuates the transition from innate to adaptive immunity.
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| Maecker H, Varfolomeev E, Kischkel F, Lawrence D, LeBlanc H, Lee W, Hurst S, Danilenko D, Li J, Filvaroff E, Yang B, Daniel D, Ashkenazi A.
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| Cell 123(5):931-44. 2005
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| 16 | TNFSF12
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| Functional expression of TWEAK in human hepatocellular carcinoma: possible implication in cell proliferation and tumor angiogenesis.
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| Kawakita T, Shiraki K, Yamanaka Y, Yamaguchi Y, Saitou Y, Enokimura N, Yamamoto N, Okano H, Sugimoto K, Murata K, Nakano T.
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| Biochem Biophys Res Commun 318(3):726-33. 2004
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| 17 | TNFRSF12A , TNFSF12
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| TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor.
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| Polek TC, Talpaz M, Darnay BG, Spivak-Kroizman T.
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| J Biol Chem 278(34):32317-23. Epub 2003 Jun 6. 2003
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| 18 | ALOX12, ATP1B2, CD68, CHD3, CHRNB1, EIF4A1, FGF11, FXR2, GUCY2D, KDM6B, NEUROD2, SHBG, TNFSF12, TNFSF13, TP53
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| Physical Map of 17p13 and the Genes Adjacent to p53.
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| Cousin P, Billotte J, Chaubert P, Shaw P.
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| Genomics 63(1):60-68. 2000
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| 19 | TNFSF12
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| TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis.
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| Chicheportiche Y, et al.
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| J Biol Chem 272 : 32401-32410. 1997
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