Citations for
1PGR, STAT5A, TNFSF11
Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells.
Obr AE, Grimm SL, Bishop KA, Pike JW, Lydon JP, Edwards DP.
Mol Endocrinol 27(11):1808-24. doi: 10.1210/me.2013-1077. Epub 2013 Sep 6. 2013
2EGR2, TNFSF11
Early growth response 2 negatively modulates osteoclast differentiation through upregulation of Id helix-loop-helix proteins.
Kim HJ, Hong JM, Yoon KA, Kim N, Cho DW, Choi JY, Lee IK, Kim SY.
Bone 51(4):643-50. doi: 10.1016/j.bone.2012.07.015. Epub 2012 Jul 26. 2012
3OPTB2, TNFSF11
A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF.
Douni E, Rinotas V, Makrinou E, Zwerina J, Penninger JM, Eliopoulos E, Schett G, Kollias G.
Hum Mol Genet 21(4):784-98. doi: 10.1093/hmg/ddr510. Epub 2011 Nov 7. 2012
4ICAM1, TNFSF11
RANKL increases migration of human lung cancer cells through intercellular adhesion molecule-1 up-regulation.
Chen LM, Kuo CH, Lai TY, Lin YM, Su CC, Hsu HH, Tsai FJ, Tsai CH, Huang CY, Tang CH.
J Cell Biochem 112(3):933-41. doi: 10.1002/jcb.23009. 2011
5NFATC1, TNFSF11
NFATC1 promotes epicardium-derived cell invasion into myocardium.
Combs MD, Braitsch CM, Lange AW, James JF, Yutzey KE.
Development 138(9):1747-57. Epub 2011 Mar 29. 2011
6ACP5, NFATC1, OSCAR, TNFSF11
RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation.
Kim JH, Kim K, Youn BU, Jin HM, Kim JY, Moon JB, Ko A, Seo SB, Lee KY, Kim N.
Biochem J 436(2):253-62. 2011
7TNFRSF11B, TNFSF11
Expression of RANKL/OPG during bone remodeling in vivo.
Tanaka H, Mine T, Ogasa H, Taguchi T, Liang CT.
Biochem Biophys Res Commun. 411(4):690-4. 2011
8TNFSF11
Evidence for osteocyte regulation of bone homeostasis through RANKL expression.
Nakashima T, Hayashi M, Fukunaga T, Kurata K, Oh-Hora M, Feng JQ, Bonewald LF, Kodama T, Wutz A, Wagner EF, Penninger JM, Takayanagi H.
Nat Med 17(10):1231-4. doi: 10.1038/nm.2452. 2011
9RAB27A, RAB27B, TNFSF11
Rab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic cells.
Kariya Y, Honma M, Hanamura A, Aoki S, Ninomiya T, Nakamichi Y, Udagawa N, Suzuki H.
J Bone Miner Res 26(4):689-703. doi: 10.1002/jbmr.268. 2011
10SERPINF1, TNFSF11
PEDF regulates osteoclasts via osteoprotegerin and RANKL.
Akiyama T, Dass CR, Shinoda Y, Kawano H, Tanaka S, Choong PF.
Biochem Biophys Res Commun 391(1):789-94. Epub 2009 Nov 27.PMID: 19945427 2010
11ESR1, ESR2, LRP4, LRP5, SOST, TNFRSF11A, TNFRSF11B, TNFSF11, VDR, WLS
Genetics of osteoporosis: accelerating pace in gene identification and validation.
Li WF, Hou SX, Yu B, Li MM, Férec C, Chen JM.
Hum Genet 127(3):249-85. Epub 2009 Dec 12. Review.PMID: 20101412 2010
12TNFSF11
Camurati-engelmann disease: Unique variant featuring a novel mutation in TGFβ1 encoding transforming growth factor beta 1 and a missense change in TNFSF11 encoding RANK ligand.
Whyte MP, Totty WG, Novack DV, Zhang X, Wenkert D, Mumm S.
J Bone Miner Res Bone Miner Res. 2010 Nov 4. [Epub ahead of print]PMID: 21053311 2010
13TNFRSF11A, TNFSF11
Expression pattern of receptor activator of NFκB (RANK) in a series of primary solid tumors and related bone metastases.
Santini D, Perrone G, Roato I, Godio L, Pantano F, Grasso D, Russo A, Vincenzi B, Elisabetta Fratto M, Sabbatini R, Pepa CD, Porta C, Del Greco A, Schiavon G, Berruti A, Tomasino RM, Papotti M, Papapietro N, Onetti Muda A, Denaro V, Tonini G.
J Cell Physiol Cell Physiol. 2010 Sep 20. [Epub ahead of print]PMID: 20857484 2010
14TNFSF11
Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.
Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, Penninger JM.
Nature. 468(7320):98-102. 2010
15TNFSF11
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesis.
Gonzalez-Suarez E, Jacob AP, Jones J, Miller R, Roudier-Meyer MP, Erwert R, Pinkas J, Branstetter D, Dougall WC.
Nature. 468(7320):103-7. 2010
16CKB, PARP1, TNFSF11
RANKL up-regulates brain-type creatine kinase via poly(ADP-ribose) polymerase-1 during osteoclastogenesis.
Chen J, Sun Y, Mao X, Liu Q, Wu H, Chen Y.
J Biol Chem 285(47):36315-21. Epub 2010 Sep 13. 2010
17CARD9, DNMT3A, ERAP2, FUT2, PTGER4, TNFSF11
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panés J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D'Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M.
Nat Genet 42(12):1118-25. 2010
18CTSK, NFATC1, TNFSF11
Identification of NFAT binding sites that mediate stimulation of cathepsin K promoter activity by RANK ligand.
Balkan W, Martinez AF, Fernandez I, Rodriguez MA, Pang M, Troen BR.
Gene 446(2):90-8. Epub 2009 Jun 27. 2009
19TNFSF11
Central control of fever and female body temperature by RANKL/RANK.
Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, Trichereau J, Paolino M, Qadri F, Plehm R, Klaere S, Komnenovic V, Mimata H, Yoshimatsu H, Takahashi N, von Haeseler A, Bader M, Kilic SS, Ueta Y, Pifl C, Narumiya S, Penninger JM.
Nature. 462(7272):505-9. 2009
20E2F1, TNFSF11
Transcriptional regulation of human RANK ligand gene expression by E2F1.
Hu Y, Sun M, Nadiminty N, Lou W, Pinder E, Gao AC.
Biochem Biophys Res Commun 370(3):440-4. Epub 2008 Mar 31. 2008
21TNFSF11, VEGFC
VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism.
Zhang Q, Guo R, Lu Y, Zhao L, Zhou Q, Schwarz EM, Huang J, Chen D, Jin ZG, Boyce BF, Xing L.
J Biol Chem 283(19):13491-9. Epub 2008 Mar 20. 2008
22OSCAR, TNFSF11, USF1, USF2
Upstream stimulatory factors regulate OSCAR gene expression in RANKL-mediated osteoclast differentiation.
Kim JH, Kim K, Jin HM, Youn BU, Song I, Choi HS, Kim N.
J Mol Biol 383(3):502-11. Epub 2008 Aug 22.PMID: 18762192 2008
23TNFRSF11A, TNFSF11
Functions of RANKL/RANK/OPG in bone modeling and remodeling.
Boyce BF, Xing L.
Arch Biochem Biophys 473(2):139-46. Epub 2008 Mar 25. Review.PMID: 18395508 2008
24CALCA, CALCRL, TNFSF11
Expression of the calcitonin receptor, calcitonin receptor-like receptor, and receptor activity modifying proteins during osteoclast differentiation.
Granholm S, Lundberg P, Lerner UH.
J Cell Biochem 104(3):920-33. doi: 10.1002/jcb.21674. 2008
25GPR68, NFATC1, RGS18, TNFSF11
RGS18 acts as a negative regulator of osteoclastogenesis by modulating the acid-sensing OGR1/NFAT signaling pathway.
Iwai K, Koike M, Ohshima S, Miyatake K, Uchiyama Y, Saeki Y, Ishii M.
J Bone Miner Res 22(10):1612-20. 2007
26TNFSF11,TRAF6
TRAF6 ubiquitin ligase is essential for RANKL signaling and osteoclast differentiation.
Lamothe B, Webster WK, Gopinathan A, Besse A, Campos AD, Darnay BG.
Biochem Biophys Res Commun 359(4):1044-9. Epub 2007 Jun 11. 2007
27OPTB2, TNFSF11
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.
Sobacchi C, Frattini A, Guerrini MM, Abinun M, Pangrazio A, Susani L, Bredius R, Mancini G, Cant A, Bishop N, Grabowski P, Del Fattore A, Messina C, Errigo G, Coxon FP, Scott DI, Teti A, Rogers MJ, Vezzoni P, Villa A, Helfrich MH.
Nat Genet 39(8):960-2. Epub 2007 Jul 15. 2007
28CCL20, CCR6, TNFSF11
CCL20 chemokine induces both osteoblast proliferation and osteoclast differentiation: Increased levels of CCL20 are expressed in subchondral bone tissue of rheumatoid arthritis patients.
Lisignoli G, Piacentini A, Cristino S, Grassi F, Cavallo C, Cattini L, Tonnarelli B, Manferdini C, Facchini A.
J Cell Physiol 210(3):798-806. 2007
29TNFRSF11A, TNFRSF11B, TNFSF11
Receptor activator of nuclear factor-kappaB ligand (RANKL) directly modulates the gene expression profile of RANK-positive Saos-2 human osteosarcoma cells.
Mori K, Berreur M, Blanchard F, Chevalier C, Guisle-Marsollier I, Masson M, Rédini F, Heymann D.
Oncol Rep 18(6):1365-71. 2007
30TNFRSF11B, TNFSF11, TNFRSF11A
Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men.
Hsu YH, Niu T, Terwedow HA, Xu X, Feng Y, Li Z, Brain JD, Rosen CJ, Laird N, Xu X.
Hum Genet 118(5):568-77. Epub 2005 Oct 26. 2006
31TNFSF11
Regulation of cancer cell migration and bone metastasis by RANKL.
Jones DH, Nakashima T, Sanchez OH, Kozieradzki I, Komarova SV, Sarosi I, Morony S, Rubin E, Sarao R, Hojilla CV, Komnenovic V, Kong YY, Schreiber M, Dixon SJ, Sims SM, Khokha R, Wada T, Penninger JM.
Nature 440(7084):692-6. 2006
32TNFSF11, TNFRSF11A
Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells.
Loser K, Mehling A, Loeser S, Apelt J, Kuhn A, Grabbe S, Schwarz T, Penninger JM, Beissert S.
Nat Med 12(12):1372-9. Epub 2006 Dec 3. 2006
33NFATC1, TNFSF11, CTSK
NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K.
Lange AW, Yutzey KE.
Dev Biol 292(2):407-17. 2006
34TNFSF11, NFATC1
RANK-L induces the expression of NFATc1, but not of NFkappaB subunits during osteoclast formation.
Zhu LL, Zaidi S, Moonga BS, Troen BR, Sun L.
Biochem Biophys Res Commun 326(1):131-5. 2005
35ANXA2,TNFSF11
Annexin II stimulates RANKL expression through MAPK.
Li F, Chung H, Reddy SV, Lu G, Kurihara N, Zhao AZ, Roodman GD.
J Bone Miner Res 20(7):1161-7. Epub 2005 Feb 14. 2005
36RASA4, TNFSF11
Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.
Hikita A, Kadono Y, Chikuda H, Fukuda A, Wakeyama H, Yasuda H, Nakamura K, Oda H, Miyazaki T, Tanaka S.
J Biol Chem 280(50):41700-6. Epub 2005 Oct 18. 2005
37TNFSF11, TNFRSF11B
The RANKL/OPG system and bone mineral density in patients with chronic liver disease.
Moschen AR, Kaser A, Stadlmann S, Millonig G, Kaser S, Muhllechner P, Habior A, Graziadei I, Vogel W, Tilg H.
J Hepatol 43(6):973-83. Epub 2005 Jul 5. 2005
38TNFSF11
Lynch CC, Hikosaka A, Acuff HB, Martin MD, Kawai N, Singh RK, Vargo-Gogola TC, Begtrup JL, Peterson TE, Fingleton B, Shirai T, Matrisian LM, Futakuchi M.
Cancer Res. 7(5):485-96. 2005
39TNFSF11, TYROBP, CSF1, OSCAR
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis.
Koga T, Inui M, Inoue K, Kim S, Suematsu A, Kobayashi E, Iwata T, Ohnishi H, Matozaki T, Kodama T, Taniguchi T, Takayanagi H, Takai T.
Nature 428(6984):758-63. 2004
40TNFSF11
Expression and function of RANK in human monocyte chemotaxis.
Mosheimer BA, Kaneider NC, Feistritzer C, Sturn DH, Wiedermann CJ.
Arthritis Rheum. 50(7):2309-16. 2004
41TNFSF11
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta.
Takayanagi H, Kim S, Matsuo K, Suzuki H, Suzuki T, Sato K, Yokochi T, Oda H, Nakamura K, Ida N, Wagner EF, Taniguchi T.
Nature 416(6882):744-9. 2002
42TNFSF11, CALCA, TNFRSF11B
Isolation of human osteoclasts formed in vitro: hormonal effects on the bone-resorbing activity of human osteoclasts.
Kudo O, Sabokbar A, Pocock A, Itonaga I, Athanasou NA.
Calcif Tissue Int 71(6):539-46. Epub 2002 Sep 18. 2002
43TNFSF11
RANKL induces formation of avian osteoclasts from macrophages but not from macrophage polykaryons.
Boissy P, Destaing O, Jurdic P.
Biochem Biophys Res Commun 288(2):340-6. 2001
44TNFSF11
The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development.
Fata JE, Kong YY, Li J, Sasaki T, Irie-Sasaki J, Moorehead RA, Elliott R, Scully S, Voura EB, Lacey DL, Boyle WJ, Khokha R, Penninger JM.
Cell 103(1):41-50. 2000
45TNFSF11
Cancer cells responsible for humoral hypercalcemia express mRNA encoding a secreted form of ODF/TRANCE that induces osteoclast formation.
Nagai M, Kyakumoto S, Sato N.
Biochem Biophys Res Commun 269(2):532-6. 2000
46FOS, FOSL1, TNFSF11
Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation.
Matsuo K, Owens JM, Tonko M, Elliott C, Chambers TJ, Wagner EF.
Nat Genet 24(2):184-7. 2000
47TNFSF11
Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene.
Kim N, Odgren PR, Kim DK, Marks SC Jr, Choi Y.
Proc Natl Acad Sci U S A. 97(20):10905-10. 2000
48TNFSF11
Prostaglandin E2 cooperates with TRANCE in osteoclast induction from hemopoietic precursors: synergistic activation of differentiation, cell spreading, and fusion.
Wani MR, et al.
Endocrinology 140(4):1927-35. 1999
49TNFSF11
A new member of tumor necrosis factor ligand family, ODF/OPGL/TRANCE/RANKL, regulates osteoclast differentiation and function.
Takahashi N, et al.
Biochem Biophys Res Commun 256(3):449-55. 1999
50IL1B, TNFRSF11B, TNFSF11
Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells.
Hofbauer LC, Lacey DL, Dunstan CR, Spelsberg TC, Riggs BL, Khosla S.
Bone 25(3):255-9 1999
51SRC, TNFSF11, TRAF6
TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src.
Wong BR, Besser D, Kim N, Arron JR, Vologodskaia M, Hanafusa H, Choi Y.
Mol Cell 4(6):1041-9 1999
52TNFSF11
Localization of RANKL (receptor activator of NFkappaB ligand) mRNA and protein in skeletal and extraskeletal tissues.
Kartsogiannis V, Zhou H, Horwood NJ, Thomas RJ, Hards DK, Quinn JM, Niforas P, Ng KW, Martin TJ, Gillespie MT.
Bone 25(5):525-34 1999
53TNFSF11
Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand.
Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S, Wong T, Campagnuolo G, Moran E, Bogoch ER, Van G, Nguyen LT, Ohashi PS, Lacey DL, Fish E, Boyle WJ, Penninger JM.
Nature 402(6759):304-9 1999
54TNFSF11
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ.
Cell 93(2):165-76 1998
55TNFRSF11B, TNFSF11
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL.
Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T.
Proc Natl Acad Sci U S A. 95(7):3597-602. 1998
56TNFRSF11A, TNFSF11
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
Anderson DM, Maraskovsky E, Billingsley WL, Dougall WC, Tometsko ME, Roux ER, Teepe MC, DuBose RF, Cosman D, Galibert L.
Nature 390(6656):175-9. 1997
57TNFSF11
TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells.
Wong BR, Rho J, Arron J, Robinson E, Orlinick J, Chao M, Kalachikov S, Cayani E, Bartlett FS 3rd, Frankel WN, Lee SY, Choi Y.
J Biol Chem 272(40):25190-4. 1997