Citations for
1SPAG6, TNFSF10
SPAG6 regulates cell apoptosis through the TRAIL signal pathway in myelodysplastic syndromes.
Li X, Yang B, Wang L, Chen L, Luo X, Liu L.
Oncol Rep May;37(5):2839-2846. doi: 10.3892/or.2017.5540. Epub 2017 Mar 31 2017
2CTSD, TNFSF10
Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL.
Jancekova B, Ondrouskova E, Knopfova L, Smarda J, Benes P.
Tumour Biol 37(8):10685-96. doi: 10.1007/s13277-016-4958-5. Epub 2016 Feb 11. 2016
3FGF2, TNFSF10, VEGFA
Comparative Evaluation of TRAIL, FGF-2 and VEGF-A-Induced Angiogenesis In Vitro and In Vivo.
Cartland SP, Genner SW, Zahoor A, Kavurma MM.
Int J Mol Sci 17(12). pii: E2025. 2016
4CASP8, TNFSF10
Correlation between TRAIL and caspase-8 expression and their relationship with cell proliferation and apoptosis in human osteosarcoma.
Ning X, Shang XW, Zhuang Y, Liu M, Yang H, Zhang H, Huang MZ.
Genet Mol Res 15(4). doi: 10.4238/gmr15048876. 2016
5BIRC3, PACS2, TNFSF10, bIRC2
Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity.
Guicciardi ME, Werneburg NW, Bronk SF, Franke A, Yagita H, Thomas G, Gores GJ.
PLoS One 9(3):e92124. doi: 10.1371/journal.pone.0092124. eCollection 2014. 2014
6TNFRSF10A, TNFRSF10B, TNFSF10, TNK2
Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death.
Linderoth E, Pilia G, Mahajan NP, Ferby I.
J Biol Chem 288(46):32922-31. doi: 10.1074/jbc.M113.481507. Epub 2013 Oct 1. 2013
7HSPB1, MAP3K4, SH3KBP1, TNFSF10
TRAIL/MEKK4/p38/HSP27/Akt survival network is biphasically modulated by the Src/CIN85/c-Cbl complex.
Kim J, Kang D, Sun BK, Kim JH, Song JJ.
Cell Signal 25(1):372-9. doi: 10.1016/j.cellsig.2012.10.010. Epub 2012 Oct 23. 2013
8TNFSF10, WEE1
WEE1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis.
Garimella SV, Rocca A, Lipkowitz S.
Mol Cancer Res 10(1):75-85. Epub 2011 Nov 23. 2012
9PPP3R1, TNFSF10
The calcineurin B subunit induces TNF-related apoptosis-inducing ligand (TRAIL) expression via CD11b-NF-κB pathway in RAW264.7 macrophages.
Su Z, Xin S, Xu L, Cheng J, Guo J, Li L, Wei Q.
Biochem Biophys Res Commun 417(2):777-83. doi: 10.1016/j.bbrc.2011.12.034. Epub 2011 Dec 16. 2012
10TNFSF10, TRADD
TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation.
Kim JY, Lee JY, Kim DG, Koo GB, Yu JW, Kim YS.
FEBS Lett 585(14):2144-50. Epub 2011 May 27. 2011
11TNFSF10, TRADD
The role of TRADD in TRAIL-induced apoptosis and signaling.
Cao X, Pobezinskaya YL, Morgan MJ, Liu ZG.
FASEB J 25(4):1353-8. Epub 2010 Dec 27. 2011
12PPARG, SERPINF1, TNFSF10
Pigment epithelium-derived factor (PEDF) promotes tumor cell death by inducing macrophage membrane tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Ho TC, Chen SL, Shih SC, Chang SJ, Yang SL, Hsieh JW, Cheng HC, Chen LJ, Tsao YP.
J Biol Chem 286(41):35943-54. doi: 10.1074/jbc.M111.266064. Epub 2011 Aug 16. 2011
13BECN1, BIRC5, TNFSF10
Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis.
Niu TK, Cheng Y, Ren X, Yang JM.
FEBS Lett 584(16):3519-24. Epub 2010 Jul 16. 2010
14GLI3, TNFRSF10A, TNFSF10
GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosis.
Kurita S, Mott JL, Almada LL, Bronk SF, Werneburg NW, Sun SY, Roberts LR, Fernandez-Zapico ME, Gores GJ.
Oncogene 29(34):4848-58. Epub 2010 Jun 21. 2010
15TNFRSF10A, TNFRSF10B, TNFSF10
Post-translational modification of TRAIL receptor type 1 on various tumor cells and the susceptibility of tumors to TRAIL-induced apoptosis.
Lin Z, Jin A, Ozawa T, Tajiri K, Obata T, Ishida I, Jin F, Kishi H, Muraguchi A.
Biochem Biophys Res Commun 395(2):251-7. Epub 2010 Apr 2.PMID: 20363213 2010
16TNFRSF10A, TNFRSF10B, TNFSF10
TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5.
Lemke J, Noack A, Adam D, Tchikov V, Bertsch U, Röder C, Schütze S, Wajant H, Kalthoff H, Trauzold A.
J Mol Med 88(7):729-40. Epub 2010 Mar 31.PMID: 20354842 2010
17CASP4, TNFSF10
TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4.
Mao ZG, Jiang CC, Yang F, Thorne RF, Hersey P, Zhang XD.
Apoptosis 15(10):1211-22. doi: 10.1007/s10495-010-0513-9. 2010
18HOMER1, TNFSF10
Homer1 regulates the susceptibility to TRAIL.
Shin JN, Piya S, Yun CW, Seol DW, Seo YW, Moon AR, Kim TH.
Exp Cell Res 315(13):2249-55. Epub 2009 Apr 17.PMID: 19376111 2009
19TNFRSF10A, TNFRSF10B, TNFSF10
TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumors.
Oikonomou E, Kosmidou V, Katseli A, Kothonidis K, Mourtzoukou D, Kontogeorgos G, Andera L, Zografos G, Pintzas A.
Int J Cancer 125(9):2127-35.PMID: 19637313 2009
20TNFRSF10A, TNFRSF10B, TNFSF10
TRAIL receptor mediates inflammatory cytokine release in an NF-kappaB-dependent manner.
Tang W, Wang W, Zhang Y, Liu S, Liu Y, Zheng D.
Cell Res 19(6):758-67.PMID: 19434100 2009
21PLSCR3, TNFSF10
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3.
Ndebele K, Gona P, Jin TG, Benhaga N, Chalah A, Degli-Esposti M, Khosravi-Far R.
Apoptosis 13(7):845-56.PMID: 18491232 2008
22CFLAR, TNFSF10
cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes.
Wachter T, Sprick M, Hausmann D, Kerstan A, McPherson K, Stassi G, Brocker EB, Walczak H, Leverkus M.
J Biol Chem 279(51):52824-34. Epub 2004 Sep 30. 2004
23TNFSF10, CCL25, IFI30, EGR1
Egr-1 target genes in human endothelial cells identified by microarray analysis.
Fu M, Zhu X, Zhang J, Liang J, Lin Y, Zhao L, Ehrengruber MU, Chen YE.
Gene 315:33-41. 2003
24DAP3, TNFSF10, DAPK3
TRAIL-induced apoptosis is independent of the mitochondrial apoptosis mediator DAP3.
Berger T, Kretzler M.
Biochem Biophys Res Commun 297(4):880-4. 2002
25TNFSF10
APO2L/TRAIL expression in human brain tumors.
Nakamura M, Rieger J, Weller M, Kim J, Kleihues P, Ohgaki H.
Acta Neuropathol (Berl) 99(1):1-6. 2000
26TNFSF10
Genomic organization and transcriptional regulation of human Apo2/TRAIL gene.
Gong B, Almasan A.
Biochem Biophys Res Commun 278(3):747-52. 2000
27TNFSF10
APO2 ligand : a novel lethal weapon against maligant glioma?
Rieger J, et al.
FEBS Lett 427 : 124-128. 1998
28TNFSF10
Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.
Pitti RM, et al.
J Biol Chem 271 : 12687-12690. 1996
29TNFSF10
Identification and characterization of a new member of the TNF family that induces apoptosis.
Wiley SR, et al.
Immunity 3 : 673-682. 1995