| 1 | SPAG6, TNFSF10
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| SPAG6 regulates cell apoptosis through the TRAIL signal pathway in myelodysplastic syndromes.
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| Li X, Yang B, Wang L, Chen L, Luo X, Liu L.
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| Oncol Rep May;37(5):2839-2846. doi: 10.3892/or.2017.5540. Epub 2017 Mar 31 2017
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| 2 | CTSD, TNFSF10
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| Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL.
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| Jancekova B, Ondrouskova E, Knopfova L, Smarda J, Benes P.
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| Tumour Biol 37(8):10685-96. doi: 10.1007/s13277-016-4958-5. Epub 2016 Feb 11.
2016
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| 3 | FGF2, TNFSF10, VEGFA
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| Comparative Evaluation of TRAIL, FGF-2 and VEGF-A-Induced Angiogenesis In Vitro and In Vivo.
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| Cartland SP, Genner SW, Zahoor A, Kavurma MM.
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| Int J Mol Sci 17(12). pii: E2025.
2016
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| 4 | CASP8, TNFSF10
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| Correlation between TRAIL and caspase-8 expression and their relationship with cell proliferation and apoptosis in human osteosarcoma.
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| Ning X, Shang XW, Zhuang Y, Liu M, Yang H, Zhang H, Huang MZ.
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| Genet Mol Res 15(4). doi: 10.4238/gmr15048876.
2016
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| 5 | BIRC3, PACS2, TNFSF10, bIRC2
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| Cellular inhibitor of apoptosis (cIAP)-mediated ubiquitination of phosphofurin acidic cluster sorting protein 2 (PACS-2) negatively regulates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity.
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| Guicciardi ME, Werneburg NW, Bronk SF, Franke A, Yagita H, Thomas G, Gores GJ.
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| PLoS One 9(3):e92124. doi: 10.1371/journal.pone.0092124. eCollection 2014.
2014
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| 6 | TNFRSF10A, TNFRSF10B, TNFSF10, TNK2
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| Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death.
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| Linderoth E, Pilia G, Mahajan NP, Ferby I.
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| J Biol Chem 288(46):32922-31. doi: 10.1074/jbc.M113.481507. Epub 2013 Oct 1.
2013
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| 7 | HSPB1, MAP3K4, SH3KBP1, TNFSF10
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| TRAIL/MEKK4/p38/HSP27/Akt survival network is biphasically modulated by the Src/CIN85/c-Cbl complex.
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| Kim J, Kang D, Sun BK, Kim JH, Song JJ.
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| Cell Signal 25(1):372-9. doi: 10.1016/j.cellsig.2012.10.010. Epub 2012 Oct 23.
2013
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| 8 | TNFSF10, WEE1
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| WEE1 inhibition sensitizes basal breast cancer cells to TRAIL-induced apoptosis.
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| Garimella SV, Rocca A, Lipkowitz S.
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| Mol Cancer Res 10(1):75-85. Epub 2011 Nov 23.
2012
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| 9 | PPP3R1, TNFSF10
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| The calcineurin B subunit induces TNF-related apoptosis-inducing ligand (TRAIL) expression via CD11b-NF-κB pathway in RAW264.7 macrophages.
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| Su Z, Xin S, Xu L, Cheng J, Guo J, Li L, Wei Q.
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| Biochem Biophys Res Commun 417(2):777-83. doi: 10.1016/j.bbrc.2011.12.034. Epub 2011 Dec 16.
2012
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| 10 | TNFSF10, TRADD
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| TRADD is critical for resistance to TRAIL-induced cell death through NF-κB activation.
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| Kim JY, Lee JY, Kim DG, Koo GB, Yu JW, Kim YS.
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| FEBS Lett 585(14):2144-50. Epub 2011 May 27.
2011
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| 11 | TNFSF10, TRADD
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| The role of TRADD in TRAIL-induced apoptosis and signaling.
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| Cao X, Pobezinskaya YL, Morgan MJ, Liu ZG.
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| FASEB J 25(4):1353-8. Epub 2010 Dec 27.
2011
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| 12 | PPARG, SERPINF1, TNFSF10
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| Pigment epithelium-derived factor (PEDF) promotes tumor cell death by inducing macrophage membrane tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
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| Ho TC, Chen SL, Shih SC, Chang SJ, Yang SL, Hsieh JW, Cheng HC, Chen LJ, Tsao YP.
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| J Biol Chem 286(41):35943-54. doi: 10.1074/jbc.M111.266064. Epub 2011 Aug 16.
2011
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| 13 | BECN1, BIRC5, TNFSF10
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| Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis.
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| Niu TK, Cheng Y, Ren X, Yang JM.
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| FEBS Lett 584(16):3519-24. Epub 2010 Jul 16.
2010
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| 14 | GLI3, TNFRSF10A, TNFSF10
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| GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosis.
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| Kurita S, Mott JL, Almada LL, Bronk SF, Werneburg NW, Sun SY, Roberts LR, Fernandez-Zapico ME, Gores GJ.
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| Oncogene 29(34):4848-58. Epub 2010 Jun 21. 2010
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| 15 | TNFRSF10A, TNFRSF10B, TNFSF10
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| Post-translational modification of TRAIL receptor type 1 on various tumor cells and the susceptibility of tumors to TRAIL-induced apoptosis.
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| Lin Z, Jin A, Ozawa T, Tajiri K, Obata T, Ishida I, Jin F, Kishi H, Muraguchi A.
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| Biochem Biophys Res Commun 395(2):251-7. Epub 2010 Apr 2.PMID: 20363213 2010
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| 16 | TNFRSF10A, TNFRSF10B, TNFSF10
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| TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5.
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| Lemke J, Noack A, Adam D, Tchikov V, Bertsch U, Röder C, Schütze S, Wajant H, Kalthoff H, Trauzold A.
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| J Mol Med 88(7):729-40. Epub 2010 Mar 31.PMID: 20354842 2010
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| 17 | CASP4, TNFSF10
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| TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4.
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| Mao ZG, Jiang CC, Yang F, Thorne RF, Hersey P, Zhang XD.
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| Apoptosis 15(10):1211-22. doi: 10.1007/s10495-010-0513-9.
2010
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| 18 | HOMER1, TNFSF10
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| Homer1 regulates the susceptibility to TRAIL.
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| Shin JN, Piya S, Yun CW, Seol DW, Seo YW, Moon AR, Kim TH.
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| Exp Cell Res 315(13):2249-55. Epub 2009 Apr 17.PMID: 19376111 2009
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| 19 | TNFRSF10A, TNFRSF10B, TNFSF10
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| TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumors.
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| Oikonomou E, Kosmidou V, Katseli A, Kothonidis K, Mourtzoukou D, Kontogeorgos G, Andera L, Zografos G, Pintzas A.
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| Int J Cancer 125(9):2127-35.PMID: 19637313 2009
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| 20 | TNFRSF10A, TNFRSF10B, TNFSF10
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| TRAIL receptor mediates inflammatory cytokine release in an NF-kappaB-dependent manner.
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| Tang W, Wang W, Zhang Y, Liu S, Liu Y, Zheng D.
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| Cell Res 19(6):758-67.PMID: 19434100 2009
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| 21 | PLSCR3, TNFSF10
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| Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3.
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| Ndebele K, Gona P, Jin TG, Benhaga N, Chalah A, Degli-Esposti M, Khosravi-Far R.
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| Apoptosis 13(7):845-56.PMID: 18491232 2008
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| 22 | CFLAR, TNFSF10
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| cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes.
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| Wachter T, Sprick M, Hausmann D, Kerstan A, McPherson K, Stassi G, Brocker EB, Walczak H, Leverkus M.
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| J Biol Chem 279(51):52824-34. Epub 2004 Sep 30. 2004
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| 23 | TNFSF10, CCL25, IFI30, EGR1
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| Egr-1 target genes in human endothelial cells identified by microarray analysis.
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| Fu M, Zhu X, Zhang J, Liang J, Lin Y, Zhao L, Ehrengruber MU, Chen YE.
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| Gene 315:33-41. 2003
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| 24 | DAP3, TNFSF10, DAPK3
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| TRAIL-induced apoptosis is independent of the mitochondrial apoptosis mediator DAP3.
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| Berger T, Kretzler M.
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| Biochem Biophys Res Commun 297(4):880-4. 2002
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| 25 | TNFSF10
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| APO2L/TRAIL expression in human brain tumors.
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| Nakamura M, Rieger J, Weller M, Kim J, Kleihues P, Ohgaki H.
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| Acta Neuropathol (Berl) 99(1):1-6. 2000
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| 26 | TNFSF10
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| Genomic organization and transcriptional regulation of human Apo2/TRAIL gene.
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| Gong B, Almasan A.
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| Biochem Biophys Res Commun 278(3):747-52. 2000
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| 27 | TNFSF10
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| APO2 ligand : a novel lethal weapon against maligant glioma?
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| Rieger J, et al.
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| FEBS Lett 427 : 124-128. 1998
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| 28 | TNFSF10
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| Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.
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| Pitti RM, et al.
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| J Biol Chem 271 : 12687-12690. 1996
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| 29 | TNFSF10
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| Identification and characterization of a new member of the TNF family that induces apoptosis.
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| Wiley SR, et al.
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| Immunity 3 : 673-682. 1995
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