| 1 | RGS5, TNFRSF1A
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| RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling.
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| Yin S, Ma XY, Sun YF, Yin YQ, Long Y, Zhao CL, Ma JW, Li S, Hu Y, Li MT, Hu G, Zhou JW.
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| Neuroinflammation. Sep 6;20(1):203. doi: 10.1186/s12974-023-02884-w. 2023
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| 2 | RIPK1, TNFRSF1A, TRADD
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| TRADD regulates perinatal development and adulthood survival in mice lacking RIPK1 and RIPK3.
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| Dowling JP, Alsabbagh M, Del Casale C, Liu ZG, Zhang J.
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| Nat Commun 10(1):705. doi: 10.1038/s41467-019-08584-5.
2019
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| 3 | LYPLA2, TNFRSF1A
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| Palmitoylation is required for TNF-R1 signaling.
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| Zingler P, Särchen V, Glatter T, Caning L, Saggau C, Kathayat RS, Dickinson BC, Adam D, Schneider-Brachert W, Schütze S, Fritsch J.
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| Cell Commun Signal. Aug 5;17(1):90. doi: 10.1186/s12964-019-0405-8. 2019
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| 4 | HACE, TNFRSF1A, TRAF2
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| The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.
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| Tortola L, Nitsch R, Bertrand MJM, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, Hanada T, Takahashi N, Kernbauer E, Demiröz D, Lang M, Superti-Furga G, Decker T, Pichler A, Ikeda F, Kroemer G, Vandenabeele P, Sorensen PH, Penninger JM.
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| Cell Rep 15(7):1481-1492. doi: 10.1016/j.celrep.2016.04.032. Epub 2016 May 5.
2016
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| 5 | RIPK1, TNFRSF1A, TRADD
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| Death domain complex of the TNFR-1, TRADD, and RIP1 proteins for death-inducing signaling.
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| Park YH, Jeong MS, Jang SB.
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| Biochem Biophys Res Commun 443(4):1155-61. doi: 10.1016/j.bbrc.2013.12.068. Epub 2013 Dec 19.
2014
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| 6 | TNFRSF1A, TNFRSF1B, TRAF2
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| Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression.
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| Chandrasekharan UM, Dechert L, Davidson UI, Waitkus M, Mavrakis L, Lyons K, Beach JR, Li X, Egelhoff TT, Fox PL, DiCorleto PE.
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| Sci Signal 6(284):ra60. doi: 10.1126/scisignal.2003743.
2013
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| 7 | TNFRSF1A, TNFRSF1B
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| Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-β autocrine signaling to promote monocyte recruitment.
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| Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN.
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| Immunity 38(5):1025-37. doi: 10.1016/j.immuni.2013.01.012. Epub 2013 Apr 25.
2013
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| 8 | TNFRSF1A, TNFRSF1B
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| Circulating levels of TNF receptor II are prognostic for patients with peripheral T-cell non-Hodgkin lymphoma.
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| Heemann C, Kreuz M, Stoller I, Schoof N, von Bonin F, Ziepert M, Löffler M, Jung W, Pfreundschuh M, Trümper L, Kube D.
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| Clin Cancer Res 18(13):3637-47. doi: 10.1158/1078-0432.CCR-11-3299. Epub 2012 May 9.
2012
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| 9 | ADAM17, TNFRSF1A
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| The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress.
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| Rzymski T, Petry A, Kračun D, Rieß F, Pike L, Harris AL, Görlach A.
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| Oncogene 31(31):3621-34. doi: 10.1038/onc.2011.522. Epub 2011 Nov 21.
2012
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| 10 | IGFBP5, TNFRSF1A
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| Insulin-like growth factor-binding protein-5 (IGFBP-5) inhibits TNF-α-induced NF-κB activity by binding to TNFR1.
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| Hwang JR, Huh JH, Lee Y, Lee SI, Rho SB, Lee JH.
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| Biochem Biophys Res Commun 405(4):545-51. Epub 2011 Jan 21.
2011
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| 11 | TNFRSF1A
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| TNF receptor-1 is required for the formation of splenic compartments during adult, but not embryonic life.
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| Milićević NM, Klaperski K, Nohroudi K, Milićević Ž, Bieber K, Baraniec B, Blessenohl M, Kalies K, Ware CF, Westermann J.
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| J Immunol 186(3):1486-94. Epub 2010 Dec 27.
2011
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| 12 | TNFRSF1A, TNFRSF1B
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| A TNF receptor 2 selective agonist rescues human neurons from oxidative stress-induced cell death.
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| Fischer R, Maier O, Siegemund M, Wajant H, Scheurich P, Pfizenmaier K.
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| PLoS One 6(11):e27621. doi: 10.1371/journal.pone.0027621. Epub 2011 Nov 14.
2011
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| 13 | NDN, TNFRSF1A
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| Necdin protects embryonic motoneurons from programmed cell death.
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| Aebischer J, Sturny R, Andrieu D, Rieusset A, Schaller F, Geib S, Raoul C, Muscatelli F.
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| PLoS One 6(9):e23764. doi: 10.1371/journal.pone.0023764. Epub 2011 Sep 2.
2011
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| 14 | IL32, TNFRSF1A
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| Inflammatory cytokines IL-32 and IL-17 have common signaling intermediates despite differential dependence on TNF-receptor 1.
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| Turner-Brannen E, Choi KY, Arsenault R, El-Gabalawy H, Napper S, Mookherjee N.
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| J Immunol 186(12):7127-35. doi: 10.4049/jimmunol.1002306. Epub 2011 May 20.
2011
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| 15 | EED, NSMAF, SMPD2, SMPD3, TNFRSF1A
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| The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase.
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| Philipp S, Puchert M, Adam-Klages S, Tchikov V, Winoto-Morbach S, Mathieu S, Deerberg A, Kolker L, Marchesini N, Kabelitz D, Hannun YA, Schütze S, Adam D.
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| Proc Natl Acad Sci U S A 107(3):1112-7. Epub 2009 Dec 28.PMID: 20080539 2010
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| 16 | TNFRSF1A, TRAF2, TRPC4AP
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| TNF receptor-1 (TNF-R1) ubiquitous scaffolding and signaling protein interacts with TNF-R1 and TRAF2 via an N-terminal docking interface.
|
| Terry Powers JL, Mace KE, Parfrey H, Lee SJ, Zhang G, Riches DW.
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| Biochemistry 49(36):7821-9.
2010
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| 17 | IGFBP5, TNFRSF1A
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| Biological characterization and structure based prediction of insulin-like growth factor binding protein-5.
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| Sung M, Jeong MS, Jang SB.
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| Biochem Biophys Res Commun 403(2):230-6. Epub 2010 Nov 11. 2010
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| 18 | TNFRSF1A
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| Targeting of tumor necrosis factor receptor 1 to low density plasma membrane domains in human endothelial cells.
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| D'Alessio A, Kluger MS, Li JH, Al-Lamki R, Bradley JR, Pober JS.
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| J Biol Chem 285(31):23868-79. Epub 2010 May 28.
2010
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| 19 | TNFRSF1A, TRAPS
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| Role of the R92Q TNFRSF1A mutation in patients with familial Mediterranean fever.
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| Marek-Yagel D, Berkun Y, Padeh S, Lidar M, Shinar Y, Bar-Joseph I, Reznik-Wolf H, Langevitz P, Livneh A, Pras E.
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| Arthritis Care Res (Hoboken) 62(9):1294-8.
2010
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| 20 | TNFRSF1A
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| TNFRI is a positive T-cell costimulatory molecule important for the timing of cytokine responses.
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| Evangelidou M, Tseveleki V, Vamvakas SS, Probert L.
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| Immunol Cell Biol 88(5):586-95. Epub 2010 Mar 9.
2010
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| 21 | TNFRSF1A, TRAPS
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| TNF receptor-associated periodic syndrome (TRAPS): a new cause of joint destruction?
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| Schoindre Y, Feydy A, Giraudet-Lequintrec JS, Kahan A, Allanore Y.
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| Joint Bone Spine 76(5):567-9. Epub 2009 Sep 30.
2009
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| 22 | TNFRSF1A
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| Apoptotic mechanisms in fulminant hepatic failure: potential therapeutic target.
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| Singhal S, Jain S, Kohaar I, Singla M, Gondal R, Kar P.
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| Appl Immunohistochem Mol Morphol 17(4):282-5.
2009
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| 23 | TNFRSF1A
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| Tumor necrosis factor receptor 1 induces interleukin-6 upregulation through NF-kappaB in a rat neuropathic pain model.
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| Lee KM, Jeon SM, Cho HJ.
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| Eur J Pain 13(8):794-806. Epub 2008 Oct 19.
2009
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| 24 | TNFRSF1A, TNFRSF1B
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| Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis.
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| Secher T, Vasseur V, Poisson DM, Mitchell JA, Cunha FQ, Alves-Filho JC, Ryffel B.
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| J Immunol 182(12):7855-64. doi: 10.4049/jimmunol.0804008.
2009
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| 25 | TNFRSF1A, TNFRSF1B
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| Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1-TNFR2 cooperation.
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| Wicovsky A, Henkler F, Salzmann S, Scheurich P, Kneitz C, Wajant H.
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| Oncogene 28(15):1769-81. doi: 10.1038/onc.2009.29. Epub 2009 Mar 16. Erratum in: Oncogene. 2009 Aug 20;28(33):3008.
2009
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| 26 | TNFRSF1A
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| TNFR1 promoter -329G/T polymorphism results in allele-specific repression of TNFR1 expression.
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| Kim S, Moon SM, Kim YS, Kim JJ, Ryu HJ, Kim YJ, Choi JW, Park HS, Kim DG, Shin HD, Rutherford MS, Oh B, Lee JK.
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| Biochem Biophys Res Commun 368(2):395-401. Epub 2008 Feb 1. 2008
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| 27 | ERAP1, RBMX, TNFRSF1A
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| An association between RBMX, a heterogeneous nuclear ribonucleoprotein, and ARTS-1 regulates extracellular TNFR1 release.
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| Adamik B, Islam A, Rouhani FN, Hawari FI, Zhang J, Levine SJ.
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| Biochem Biophys Res Commun 371(3):505-9. Epub 2008 Apr 28. 2008
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| 28 | FMF, MEFV, TNFRSF1A, TRAPS
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| Overlap syndrome between FMF and TRAPS in a patient carrying MEFV and TNFRSF1A mutations.
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| Granel B, Serratrice J, Dodé C, Grateau G, Disdier P, Weiller PJ.
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| Clin Exp Rheumatol 25(4 Suppl 45):S93-5.PMID: 17949559 2007
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| 29 | CF, SCNN1B, SCNN1G, TNFRSF1A
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| The TNFalpha receptor TNFRSF1A and genes encoding the amiloride-sensitive sodium channel ENaC as modulators in cystic fibrosis.
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| Stanke F, Becker T, Cuppens H, Kumar V, Cassiman JJ, Jansen S, Radojkovic D, Siebert B, Yarden J, Ussery DW, Wienker TF, Tummler B.
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| Hum Genet 119(3):331-43. Epub 2006 Feb 4. 2006
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| 30 | TNFRSF1A,TRAPS
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| Mutation of the extracellular domain of tumour necrosis factor receptor 1 causes reduced NF-kappaB activation due to decreased surface expression.
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| Siebert S, Fielding CA, Williams BD, Brennan P.
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| FEBS Lett 579(23):5193-8. 2005
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| 31 | TNFRSF1A
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| Release of full-length 55-kDa TNF receptor 1 in exosome-like vesicles: a mechanism for generation of soluble cytokine receptors.
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| Hawari FI, Rouhani FN, Cui X, Yu ZX, Buckley C, Kaler M, Levine SJ.
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| Proc Natl Acad Sci U S A 101(5):1297-302. Epub 2004 Jan 26. 2004
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| 32 | TNFRSF1A
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| Polymorphism R92Q of the tumour necrosis factor receptor 1 gene is associated with myocardial infarction and carotid intima-media thickness--the ECTIM, AXA, EVA and GENIC Studies.
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| Poirier O, Nicaud V, Gariepy J, Courbon D, Elbaz A, Morrison C, Kee F, Evans A, Arveiler D, Ducimetiere P, Amarenco P, Cambien F.
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| Eur J Hum Genet 12(3):213-9. 2004
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| 33 | TNFRSF1A, TRAPS
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| Tumour necrosis factor receptor-associated periodic syndrome with a novel mutation in the TNFRSF1A gene in a Japanese family.
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| Kusuhara K, Nomura A, Nakao F, Hara T.
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| Eur J Pediatr 163(1):30-2. Epub 2003 Nov 11. 2004
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| 34 | HIDS, MVK, MVKD, TNFRSF1A, TRAPS
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| Molecular analysis of the MVK and TNFRSF1A genes in patients with a clinical presentation typical of the hyperimmunoglobulinemia D with periodic fever syndrome: a low-penetrance TNFRSF1A variant in a heterozygous MVK carrier possibly influences the phenotype of hyperimmunoglobulinemia D with periodic fever syndrome or vice versa.
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| Stojanov S, Lohse P, Lohse P, Hoffmann F, Renner ED, Zellerer S, Kery A, Shin YS, Haas D, Hoffmann GF, Belohradsky BH.
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| Arthritis Rheum 50(6):1951-8. 2004
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| 35 | TNFRSF1A
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| Novel mutations in TNFRSF1A in patients with typical tumor necrosis factor receptor-associated periodic syndrome and with systemic lupus erythematosus in Japanese.
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| Horiuchi T, Tsukamoto H, Mitoma H, Miyagawa H, Tamimoto Y, Yoshizawa S, Harada M, Hayashi K, Hashimura C, Oribe M, Okamura S.
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| Int J Mol Med 14(5):813-8. 2004
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| 36 | BRE, TNFRSF1A
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| A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway.
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| Li Q, Ching AK, Chan BC, Chow SK, Lim PL, Ho TC, Ip WK, Wong CK, Lam CW, Lee KK, Chan JY, Chui YL.
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| J Biol Chem 279(50):52106-16. Epub 2004 Oct 1. 2004
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| 37 | BIRC2, TNFRSF1A, TRADD, TRAF2
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| TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2.
|
| Li X, Yang Y, Ashwell JD.
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| Nature 416(6878):345-7. 2002
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| 38 | TNFRSF1A, TRAPS
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| An Israeli Arab patient with a de novo TNFRSF1A mutation causing tumor necrosis factor receptor-associated periodic syndrome.
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| Aganna E, Zeharia A, Hitman GA, Basel-Vanagaite L, Allotey RA, Booth DR, Hawkins PN, Thacker C, Syndercombe-Court D, McDermott MF.
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| Arthritis Rheum 46(1):245-9. 2002
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| 39 | TNFRSF1A, TRAPS
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| Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) in a Dutch family: evidence for a TNFRSF1A mutation with reduced penetrance.
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| Aganna E, Aksentijevich I, Hitman GA, Kastner DL, Hoepelman AI, Posma FD, Zweers EJ, McDermott MF.
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| Eur J Hum Genet 9(1):63-6. 2001
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| 40 | TNFRSF1A, TRAPS
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| The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers.
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| Aksentijevich I, Galon J, Soares M, Mansfield E, Hull K, Oh HH, Goldbach-Mansky R, Dean J, Athreya B, Reginato AJ, Henrickson M, Pons-Estel B, O'Shea JJ, Kastner DL.
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| Am J Hum Genet 69(2):301-14. 2001
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| 41 | TNFRSF1A, TRAPS
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| Autosomal-dominant periodic fever with AA amyloidosis: Novel mutation in tumor necrosis factor receptor 1 gene Rapid Communication.
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| Jadoul M, Dode C, Cosyns JP, Abramowicz D, Georges B, Delpech M, Pirson Y.
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| Kidney Int 59(5):1677-82. 2001
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| 42 | TNFRSF1A, TRAPS
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| Periodic fever (TRAPS) caused by mutations in the TNFalpha receptor 1 (TNFRSF1A) gene of three German patients.
|
| Rosen-Wolff A, Kreth HW, Hofmann S, Hohne K, Heubner G, Mobius D, Zintl F, Gahr M, Roesler J.
|
| Eur J Haematol 67(2):105-9. 2001
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| 43 | TRAPS, TNFRSF1A
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| A novel missense mutation (C30S) in the gene encoding tumor necrosis factor receptor 1 linked to autosomal-dominant recurrent fever with localized myositis in a French family.
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| Dode C, Papo T, Fieschi C, Pecheux C, Dion E, Picard F, Godeau P, Bienvenu J, Piette JC, Delpech M, Grateau G.
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| Arthritis Rheum 43(7):1535-42. 2000
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| 44 | TRAPS, TNFRSF1A
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| Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.
|
| McDermott MF, et al.
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| Cell 97(1):133-44. 1999
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| 45 | NSMAF, SMPD1, TNFRSF1A
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| Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor.
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| Adam-Klages S, Schwandner R, Adam D, Kreder D, Bernardo K, Kronke M.
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| J Leukoc Biol 63(6):678-82. Review 1998
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| 46 | TNFRSF1A
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| A novel cytoplasmic domain of the p55 tumor necrosis factor receptor initiates the neutral sphingomyelinase pathway.
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| Adam D, Wiegmann K, Adam-Klages S, Ruff A, Kronke M.
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| J Biol Chem 271(24):14617-22 1996
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| 47 | NSMAF, TNFRSF1A
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| FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase.
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| Adam-Klages S, Adam D, Wiegmann K, Struve S, Kolanus W, Schneider-Mergener J, Kronke M.
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| Cell 86(6):937-47. 1996
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| 48 | TNFRSF1A
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| A novel domain within the 55 kd TNF receptor signals cell death.
|
| Tartaglia LA, et al.
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| Cell 74 : 845-853. 1993
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| 49 | TNFRSF1A
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| Structure of the human TNF receptor 1 (p60) gene (TNFR1) and localization to chromosome 12p13.
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| Fuchs P, et al.
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| Genomics 13 : 219-224. 1992
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| 50 | IL1A, IL6, IL8, TNFRSF1A
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| Heterogeneity among human nasopharyngeal carcinoma cell lines for inflammatory cytokines mRNA expression levels.
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| Mahe Y, Hirose K, Clausse B, Chouaib S, Tursz T, Mariame B.
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| Biochem Biophys Res Commun 187(1):121-6. 1992
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| 51 | TNFRSF1A
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| The gene for the type 1 tumor necrosis factor receptor (TNF-R1) is localized on band 12p13.
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| DerrŽ J, et al.
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| Hum Genet 87 : 231-233. 1991
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| 52 | TNFRSF1A, TNFRSF1B
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| Chromosomal location of the human tumor necrosis factor receptor genes.
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| Baker E, et al.
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| Cytogenet Cell Genet 57 : 117-118. 1991
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| 53 | TNFRSF1A, TNFRSF1B
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| Tumor necrosis factor receptors genes, TNFR1 and TNFR2, on human chromosomes 12 and 1.
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| Milatovich A, et al.
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| Somat Cell Mol Genet 17 : 519-523. 1991
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| 54 | TNFRSF1A
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| Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein.
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| Himmler A, et al.
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| DNA Cell Biol 9 : 705-715. 1990
|