Citations for
1TNFRSF10A, TNFRSF10B, TNFSF10, TNK2
Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death.
Linderoth E, Pilia G, Mahajan NP, Ferby I.
J Biol Chem 288(46):32922-31. doi: 10.1074/jbc.M113.481507. Epub 2013 Oct 1. 2013
2TNFRSF10B
Death receptor 5 signaling promotes hepatocyte lipoapoptosis.
Cazanave SC, Mott JL, Bronk SF, Werneburg NW, Fingas CD, Meng XW, Finnberg N, El-Deiry WS, Kaufmann SH, Gores GJ.
J Biol Chem 286(45):39336-48. doi: 10.1074/jbc.M111.280420. Epub 2011 Sep 22. 2011
3TNFRSF10A, TNFRSF10B, TNFSF10
Post-translational modification of TRAIL receptor type 1 on various tumor cells and the susceptibility of tumors to TRAIL-induced apoptosis.
Lin Z, Jin A, Ozawa T, Tajiri K, Obata T, Ishida I, Jin F, Kishi H, Muraguchi A.
Biochem Biophys Res Commun 395(2):251-7. Epub 2010 Apr 2.PMID: 20363213 2010
4TNFRSF10A, TNFRSF10B, TNFSF10
TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5.
Lemke J, Noack A, Adam D, Tchikov V, Bertsch U, Röder C, Schütze S, Wajant H, Kalthoff H, Trauzold A.
J Mol Med 88(7):729-40. Epub 2010 Mar 31.PMID: 20354842 2010
5BECN1, TNFRSF10B
Upregulation of Beclin-1 expression and phosphorylation of Bcl-2 and p53 are involved in the JNK-mediated autophagic cell death.
Park KJ, Lee SH, Lee CH, Jang JY, Chung J, Kwon MH, Kim YS.
Biochem Biophys Res Commun 382(4):726-9. Epub 2009 Mar 24. 2009
6TNFRSF10A, TNFRSF10B
TRAIL-induced apoptosis and expression of death receptor TRAIL-R1 and TRAIL-R2 in bladder cancer cells.
Szliszka E, Mazur B, Zydowicz G, Czuba ZP, Król W.
Folia Histochem Cytobiol 47(4):579-85.PMID: 20430723 2009
7TNFRSF10A, TNFRSF10B, TNFSF10
TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumors.
Oikonomou E, Kosmidou V, Katseli A, Kothonidis K, Mourtzoukou D, Kontogeorgos G, Andera L, Zografos G, Pintzas A.
Int J Cancer 125(9):2127-35.PMID: 19637313 2009
8TNFRSF10A, TNFRSF10B, TNFSF10
TRAIL receptor mediates inflammatory cytokine release in an NF-kappaB-dependent manner.
Tang W, Wang W, Zhang Y, Liu S, Liu Y, Zheng D.
Cell Res 19(6):758-67.PMID: 19434100 2009
9TNFRSF10B, TNFS10
Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease.
Takeda K, Kojima Y, Ikejima K, Harada K, Yamashina S, Okumura K, Aoyama T, Frese S, Ikeda H, Haynes NM, Cretney E, Yagita H, Sueyoshi N, Sato N, Nakanuma Y, Smyth MJ, Okumura K.
Proc Natl Acad Sci U S A 105(31):10895-900. Epub 2008 Jul 30. 2008
10TNFRSF10B
Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines.
Kouhara J, Yoshida T, Nakata S, Horinaka M, Wakada M, Ueda Y, Yamagishi H, Sakai T.
Int J Oncol 30(3):679-87. 2007
11TNFRSF10B
TRAIL-receptor expression is an independent prognostic factor for survival in patients with a primary glioblastoma multiforme.
Kuijlen JM, Mooij JJ, Platteel I, Hoving EW, van der Graaf WT, Span MM, Hollema H, den Dunnen WF.
J Neurooncol 78(2):161-71. Epub 2006 Mar 17. 2006
12TNFRSF10B
Extensive regions of the FADD death domain are required for binding to the TRAIL receptor DR5.
Thomas LR, Bender LM, Morgan MJ, Thorburn A.
Cell Death Differ 13(1):160-2. No abstract available. 2006
13EHF, TNFRSF10B
ESE-3 transcription factor is involved in the expression of death receptor (DR)-5 through putative Ets sites.
Lim JH, Cho JY, Park YB, Park JW, Kwon TK.
Biochem Biophys Res Commun 350(3):736-41. Epub 2006 Sep 28. 2006
14TNFRSF10B
Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes.
Rubio-Moscardo F, Blesa D, Mestre C, Siebert R, Balasas T, Benito A, Rosenwald A, Climent J, Martinez JI, Schilhabel M, Karran EL, Gesk S, Esteller M, deLeeuw R, Staudt LM, Fernandez-Luna JL, Pinkel D, Dyer MJ, Martinez-Climent JA.
Blood 106(9):3214-22. Epub 2005 Jul 28. 2005
15TNFRSF10B
Functional expression of TRAIL and TRAIL-R2 during human megakaryocytic development.
Melloni E, Secchiero P, Celeghini C, Campioni D, Grill V, Guidotti L, Zauli G.
J Cell Physiol 204(3):975-82. 2005
16TNFRSF10B
Luteolin induces apoptosis via death receptor 5 upregulation in human malignant tumor cells.
Horinaka M, Yoshida T, Shiraishi T, Nakata S, Wakada M, Nakanishi R, Nishino H, Matsui H, Sakai T.
Oncogene 24(48):7180-9. 2005
17FADD, TNFRSF10B
Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling.
McDonald ER 3rd, Chui PC, Martelli PF, Dicker DT, El-Deiry WS.
J Biol Chem 276(18):14939-45. 2001
18TNFRSF10B
Promoter structure and transcription initiation sites of the human death receptor 5/TRAIL-R2 gene
Yoshida T, Maeda A, Tani N, Sakai T.
FEBS Lett 507(3):381-5. 2001
19TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D
Homozygous deletion of the death receptor DR4 gene in a nasopharyngeal cancer cell line is associated with TRAIL resistance.
Ozoren N, Fisher MJ, Kim K, Liu CX, Genin A, Shifman Y, Dicker DT, Spinner NB, Lisitsyn NA, El-Deiry WS.
Int J Oncol 16(5):917-25. 2000
20TNFRSF10B
Rare loss-of-function mutation of a death receptor gene in head and neck cancer.
Pai SI, Wu GS, Ozoren N, Wu L, Jen J, Sidransky D, El-Deiry WS.
Cancer Res 58 : 3513-3518. 1998
21TNFRSF10B, TSG8D
Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas.
Arai T, et al.
Cancer Lett 133(2):197-204. 1998
22TNFRSF10B
KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene.
Wu GS, Burns TF, McDonald ER 3rd, Jiang W, Meng R, Krantz ID, Kao G, Gan DD, Zhou JY, Muschel R, Hamilton SR, Spinner NB, Markowitz S, Wu G, el-Deiry WS.
Nat Genet 17(2):141-3. No abstract available. 1997
23TNFRSF10A, TNFRSF10B, TNFRSF10C
Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.
MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM, Alnemri ES.
J Biol Chem 272(41):25417-20. 1997
24TNFRSF10A, TNFRSF10B
TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.
Schneider P, Thome M, Burns K, Bodmer JL, Hofmann K, Kataoka T, Holler N, Tschopp J.
Immunity 7(6):831-6. 1997
25TNFRSF10B
TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL.
Screaton GR, et al.
Curr Biol 7 : 693-696. 1997
26TNFRSF10B
TRAIL-R2 : a novel apoptosis-mediating receptor for TRAIL.
Walczak H, et al.
EMBO J 16 : 5386-5397. 1997