Citations for
1MAP3K5, TNFAIP3
The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis.
Zhang P, Wang PX, Zhao LP, Zhang X, Ji YX, Zhang XJ, Fang C, Lu YX, Yang X, Gao MM, Zhang Y, Tian S, Zhu XY, Gong J, Ma XL, Li F, Wang Z, Huang Z, She ZG, Li H.
Nat Med 24(1):84-94. doi: 10.1038/nm.4453. Epub 2017 Dec 11. 2018
2ESRRA, TNFAIP3
Orphan Nuclear Receptor ERRα Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation.
Yuk JM, Kim TS, Kim SY, Lee HM, Han J, Dufour CR, Kim JK, Jin HS, Yang CS, Park KS, Lee CH, Kim JM, Kweon GR, Choi HS, Vanacker JM, Moore DD, Giguère V, Jo EK.
Immunity Jul 21;43(1):80-91. doi: 10.1016/j.immuni.2015.07.003 2015
3KCNIP3, TNFAIP3
The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation.
Tiruppathi C, Soni D, Wang DM, Xue J, Singh V, Thippegowda PB, Cheppudira BP, Mishra RK, Debroy A, Qian Z, Bachmaier K, Zhao YY, Christman JW, Vogel SM, Ma A, Malik AB.
Nat Immunol 15(3):239-47. doi: 10.1038/ni.2823. Epub 2014 Feb 2. 2014
4SMAD6, TNFAIP3, TRAF6
Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6.
Jung SM, Lee JH, Park J, Oh YS, Lee SK, Park JS, Lee YS, Kim JH, Lee JY, Bae YS, Koo SH, Kim SJ, Park SH.
Nat Commun 4:2562. doi: 10.1038/ncomms3562. 2013
5ASH1L, TNFAIP3
Histone methyltransferase Ash1l suppresses interleukin-6 production and inflammatory autoimmune diseases by inducing the ubiquitin-editing enzyme A20.
Xia M, Liu J, Wu X, Liu S, Li G, Han C, Song L, Li Z, Wang Q, Wang J, Xu T, Cao X.
Immunity 39(3):470-81. doi: 10.1016/j.immuni.2013.08.016. Epub 2013 Sep 5. 2013
6CCDC50, TNFAIP3
Ymer acts as a multifunctional regulator in nuclear factor-κB and Fas signaling pathways.
Tsukiyama T, Matsuda-Tsukiyama M, Bohgaki M, Terai S, Tanaka S, Hatakeyama S.
Mol Med 18:587-97. doi: 10.2119/molmed.2011.00435. 2012
7RNF11, TNFAIP3
RNF11 modulates microglia activation through NF-κB signalling cascade.
Dalal NV, Pranski EL, Tansey MG, Lah JJ, Levey AI, Betarbet RS.
Neurosci Lett 528(2):174-9. doi: 10.1016/j.neulet.2012.08.060. Epub 2012 Sep 11. 2012
8TNFAIP3
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.
Adrianto I, Wen F, Templeton A, Wiley G, King JB, Lessard CJ, Bates JS, Hu Y, Kelly JA, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks, Anaya JM, Bae SC, Bang SY, Boackle SA, Brown EE, Petri MA, Gallant C, Ramsey-Goldman R, Reveille JD, Vila LM, Criswell LA, Edberg JC, Freedman BI, Gregersen PK, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Park SY, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Moser KL, Webb CF, Humphrey MB, Montgomery CG, Gaffney PM.
Nat Genet 43(3):253-8. Epub 2011 Feb 20. 2011
9TNFAIP3
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis.
Matmati M, Jacques P, Maelfait J, Verheugen E, Kool M, Sze M, Geboes L, Louagie E, Mc Guire C, Vereecke L, Chu Y, Boon L, Staelens S, Matthys P, Lambrecht BN, Schmidt-Supprian M, Pasparakis M, Elewaut D, Beyaert R, van Loo G.
Nat Genet 43(9):908-12. doi: 10.1038/ng.874. 2011
10TAX1BP1, TNFAIP3, TNIP1
ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.
Gao L, Coope H, Grant S, Ma A, Ley SC, Harhaj EW.
J Biol Chem 286(42):36592-602. doi: 10.1074/jbc.M111.283762. Epub 2011 Sep 1. 2011
11TNFAIP3
The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.
Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, Ma A.
Immunity 33(2):181-91. Epub 2010 Aug 12.PMID: 20705491 2010
12TNFAIP3
Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population.
Kawasaki A, Ito I, Ito S, Hayashi T, Goto D, Matsumoto I, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N.
J Biomed Biotechnol 2010:207578. Epub 2010 May 27.PMID: 20617138 2010
13TNFAIP3
Expression, biological activities and mechanisms of action of A20 (TNFAIP3).
Verstrepen L, Verhelst K, van Loo G, Carpentier I, Ley SC, Beyaert R.
Biochem Pharmacol iochem Pharmacol. 2010 Jul 3. [Epub ahead of print]PMID: 20599425 2010
14IRF7, TNFAIP3
The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7.
Ning S, Pagano JS.
J Virol 84(12):6130-8. Epub 2010 Apr 14.PMID: 20392859 2010
15TNFAIP3
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling.
Bosanac I, Wertz IE, Pan B, Yu C, Kusam S, Lam C, Phu L, Phung Q, Maurer B, Arnott D, Kirkpatrick DS, Dixit VM, Hymowitz SG.
Mol Cell 40(4):548-57. 2010
16TNFAIP3
Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis.
Bowes J, Lawrence R, Eyre S, Panoutsopoulou K, Orozco G, Elliott KS, Ke X, Morris AP; UKRAG, Thomson W, Worthington J, Barton A, Zeggini E.
Hum Genet 128(6):627-33. Epub 2010 Sep 18. 2010
17RNF11, TNFAIP3
Expression, biological activities and mechanisms of action of A20 (TNFAIP3).
Verstrepen L, Verhelst K, van Loo G, Carpentier I, Ley SC, Beyaert R.
Biochem Pharmacol 80(12):2009-20. doi: 10.1016/j.bcp.2010.06.044. Epub 2010 Jul 3. Review. 2010
18TAX1BP1, TNFAIP3
TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases.
Parvatiyar K, Barber GN, Harhaj EW.
J Biol Chem 285(20):14999-5009. doi: 10.1074/jbc.M110.109819. Epub 2010 Mar 19. 2010
19BANK1, BLK, FCGR2A, FCGR3A, HLA-DR2, HLA-DR3, IRAK1, IRF5, ITGAM, PDCD1, PTPN22, PXK, TNFAIP3, TREX1, XKR6
Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies.
Harley IT, Kaufman KM, Langefeld CD, Harley JB, Kelly JA.
Nat Rev Genet 10(5):285-90. 2009
20ITCH, RIPK1, RNF11, TAX1BP1, TNFAIP3
The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.
Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW.
EMBO J 28(5):513-22. Epub 2009 Jan 8. 2009
21TNFAIP3
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
Graham RR, Cotsapas C, Davies L, Hackett R, Lessard CJ, Leon JM, Burtt NP, Guiducci C, Parkin M, Gates C, Plenge RM, Behrens TW, Wither JE, Rioux JD, Fortin PR, Graham DC, Wong AK, Vyse TJ, Daly MJ, Altshuler D, Moser KL, Gaffney PM.
Nat Genet at Genet. 2008 Aug 1. [Epub ahead of print] 2008
22TNFAIP3
Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.
Musone SL, Taylor KE, Lu TT, Nititham J, Ferreira RC, Ortmann W, Shifrin N, Petri MA, Ilyas Kamboh M, Manzi S, Seldin MF, Gregersen PK, Behrens TW, Ma A, Kwok PY, Criswell LA.
Nat Genet at Genet. 2008 Aug 1. [Epub ahead of print] 2008
23TNFAIP3
TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma.
Honma K, Tsuzuki S, Nakagawa M, Karnan S, Aizawa Y, Kim WS, Kim YD, Ko YH, Seto M.
Genes Chromosomes Cancer 47(1):1-7. 2008
24BCL10, CARD10, TNFAIP3
A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-kappaB.
Stilo R, Varricchio E, Liguoro D, Leonardi A, Vito P.
J Cell Sci 121(Pt 8):1165-71. Epub 2008 Mar 18. 2008
25TNFAIP3
Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling.
Li L, Hailey DW, Soetandyo N, Li W, Lippincott-Schwartz J, Shu HB, Ye Y.
Biochim Biophys Acta 1783(6):1140-9. Epub 2008 Feb 19.PMID: 18329387 2008
26CCDC50, TNFAIP3
Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain.
Bohgaki M, Tsukiyama T, Nakajima A, Maruyama S, Watanabe M, Koike T, Hatakeyama S.
Biochim Biophys Acta 1783(5):826-37. Epub 2007 Oct 4. 2008
27TNFAIP3, TAX1BP1, TRAF6, IRAK1
Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.
Shembade N, Harhaj NS, Liebl DJ, Harhaj EW.
EMBO J 26(17):3910-22. Epub 2007 Aug 16. 2007
28TNFAIP3, OLIG3
Rheumatoid arthritis association at 6q23.
Thomson W, Barton A, Ke X, Eyre S, Hinks A, Bowes J, Donn R, Symmons D, Hider S, Bruce IN; Wellcome Trust Case Control Consortium, Wilson AG, Marinou I, Morgan A, Emery P; YEAR Consortium, Carter A, Steer S, Hocking L, Reid DM, Wordsworth P, Harrison P, Strachan D, Worthington J.
Nat Genet 39(12):1431-3. Epub 2007 Nov 4. 2007
29TAX1BP1, TNFAIP3
Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.
Shembade N, Harhaj NS, Liebl DJ, Harhaj EW.
EMBO J 26(17):3910-22. Epub 2007 Aug 16. 2007
30TNFAIP3
The promyelocytic leukemia protein represses A20-mediated transcription.
Wu WS, Xu ZX, Chang KS.
J Biol Chem 277(35):31734-9. 2002
31TNFAIP3
Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice.
Lee EG, Boone DL, Chai S, Libby SL, Chien M, Lodolce JP, Ma A.
Science 289(5488):2350-4. 2000
32TNFAIP3
A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism.
Cooper JT, Stroka DM, Brostjan C, Palmetshofer A, Bach FH, Ferran C.
J Biol Chem 271(30):18068-73. 1996
33TNFAIP3
The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.
Song HY, Rothe M, Goeddel DV.
Proc Natl Acad Sci U S A 93(13):6721-5. 1996
34TNFAIP3
The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.
Opipari AW Jr, et al.
J Biol Chem 265(25):14705-8 1990
35TNFAIP3
Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin.
Dixit VM, et al.
J Biol Chem 265(5):2973-8 1990