Citations for
1CD180, TLR4
RP105 ameliorates hypoxia̸reoxygenation injury in cardiac microvascular endothelial cells by suppressing TLR4̸MAPKs̸NF-κB signaling.
Guo X, Jiang H, Chen J, Zhang BF, Hu Q, Yang S, Yang J, Zhang J.
Int J Mol Med 42(1):505-513. doi: 10.3892/ijmm.2018.3621. Epub 2018 Apr 16. 2018
2CAMP, TLR4, TLR9
Cathelicidin modulates synthesis of Toll-like Receptors (TLRs) 4 and 9 in colonic epithelium.
Marin M, Holani R, Shah CB, Odeón A, Cobo ER.
Mol Immunol 91:249-258. doi: 10.1016/j.molimm.2017.09.011. Epub 2017 Oct 5. 2017
3CAV1, TLR4, ZNRF1
The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation.
Lee CY, Lai TY, Tsai MK, Chang YC, Ho YH, Yu IS, Yeh TW, Chou CC, Lin YS, Lawrence T, Hsu LC.
Nat Commun 8:15502. doi: 10.1038/ncomms15502. 2017
4CSF3, SFI1, TLR1, TLR2, TLR4
GM-CSF Down-Regulates TLR Expression via the Transcription Factor PU.1 in Human Monocytes.
Sadeghi K, Wisgrill L, Wessely I, Diesner SC, Schüller S, Dürr C, Heinle A, Sachet M, Pollak A, Förster-Waldl E, Spittler A.
PLoS One 11(10):e0162667. doi: 10.1371/journal.pone.0162667. 2016
5TIRAP, TLR2, TLR4, TLR6
Differential adapter recruitment by TLR2 co-receptors.
Piao W, Ru LW, Toshchakov VY.
Pathog Dis 74(5). pii: ftw043. doi: 10.1093/femspd/ftw043. Epub 2016 May 4. 2016
6TLR4, TLR7
Quantitative Evaluation of BAFF, HMGB1, TLR 4 AND TLR 7 Expression in Patients with Relapsing Remitting Multiple Sclerosis.
Hamid KM, Nejati A, Shoja Z, Mollaei-Kandelousd Y, Doosti R, Mirshafiey A, Tafakhori A, Sahraian MA, Marashi SM.
Iran J Allergy Asthma Immunol 15(1):75-81. 2016
7IFNB1, IL10, SYK, TLR4
Syk negatively regulates TLR4-mediated IFNβ and IL-10 production and promotes inflammatory responses in dendritic cells.
Yin H, Zhou H, Kang Y, Zhang X, Duan X, Alnabhan R, Liang S, Scott DA, Lamont RJ, Shang J, Wang H.
Biochim Biophys Acta 1860(3):588-98. doi: 10.1016/j.bbagen.2015.12.012. Epub 2015 Dec 17. 2016
8CD14, S100A9, TLR4
CD14 Is a Co-Receptor for TLR4 in the S100A9-Induced Pro-Inflammatory Response in Monocytes.
He Z, Riva M, Björk P, Swärd K, Mörgelin M, Leanderson T, Ivars F.
PLoS One 11(5):e0156377. doi: 10.1371/journal.pone.0156377. eCollection 2016. 2016
9THBD, TLR4
Thrombomodulin promotes diabetic wound healing by regulating toll-like receptor 4 expression.
Cheng TL, Lai CH, Chen PK, Cho CF, Hsu YY, Wang KC, Lin WL, Chang BI, Liu SK, Wu YT, Hsu CK, Shi GY, Wu HL.
J Invest Dermatol 135(6):1668-75. doi: 10.1038/jid.2015.32. Epub 2015 Feb 4. 2015
10HAVCR2, IRF3, TLR4
Tim-3 promotes intestinal homeostasis in DSS colitis by inhibiting M1 polarization of macrophages.
Jiang X, Yu J, Shi Q, Xiao Y, Wang W, Chen G, Zhao Z, Wang R, Xiao H, Hou C, Feng J, Ma Y, Shen B, Wang L, Li Y, Han G.
Clin Immunol 160(2):328-35. doi: 10.1016/j.clim.2015.07.008. Epub 2015 Jul 21. 2015
11LY96, TLR4
Amniotic Fluid Soluble Myeloid Differentiation-2 (sMD-2) as Regulator of Intra-amniotic Inflammation in Infection-induced Preterm Birth.
Dulay AT, Buhimschi CS, Zhao G, Oliver EA, Abdel-Razeq SS, Shook LL, Bahtiyar MO, Buhimschi IA.
Am J Reprod Immunol 73(6):507-21. doi: 10.1111/aji.12362. Epub 2015 Jan 21. 2015
12HMGB1, LY96, TLR4
MD-2 is required for disulfide HMGB1-dependent TLR4 signaling.
Yang H, Wang H, Ju Z, Ragab AA, Lundbäck P, Long W, Valdes-Ferrer SI, He M, Pribis JP, Li J, Lu B, Gero D, Szabo C, Antoine DJ, Harris HE, Golenbock DT, Meng J, Roth J, Chavan SS, Andersson U, Billiar TR, Tracey KJ, Al-Abed Y.
J Exp Med 212(1):5-14. doi: 10.1084/jem.20141318. Epub 2015 Jan 5. 2015
13PRG4, TLR2, TLR4
The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid.
Alquraini A, Garguilo S, D'Souza G, Zhang LX, Schmidt TA, Jay GD, Elsaid KA.
Arthritis Res Ther 17:353. doi: 10.1186/s13075-015-0877-x. 2015
14IL10, IL12A, MAP2K1, TLR4
MEK1 dependent and independent ERK activation regulates IL-10 and IL-12 production in bone marrow derived macrophages.
Bouhamdan M, Bauerfeld C, Talreja J, Beuret L, Charron J, Samavati L.
Cell Signal 27(10):2068-76. doi: 10.1016/j.cellsig.2015.07.015. Epub 2015 Jul 21. 2015
15TICAM1, TLR3, TLR4
Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation.
Hu W, Jain A, Gao Y, Dozmorov IM, Mandraju R, Wakeland EK, Pasare C.
Proc Natl Acad Sci U S A 112(45):13994-9. doi: 10.1073/pnas.1510760112. Epub 2015 Oct 27. 2015
16TLR3, TLR4, TRIM38
TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms.
Hu MM, Xie XQ, Yang Q, Liao CY, Ye W, Lin H, Shu HB.
J Immunol 195(9):4415-25. doi: 10.4049/jimmunol.1500859. Epub 2015 Sep 21. 2015
17TICAM1, TLR3, TLR4, WDFY1
WDFY1 mediates TLR3/4 signaling by recruiting TRIF.
Hu YH, Zhang Y, Jiang LQ, Wang S, Lei CQ, Sun MS, Shu HB, Liu Y.
EMBO Rep 16(4):447-55. doi: 10.15252/embr.201439637. Epub 2015 Mar 3. 2015
18TICAM1, TICAM2, TLR4
Phosphatase PTPN4 preferentially inhibits TRIF-dependent TLR4 pathway by dephosphorylating TRAM.
Huai W, Song H, Wang L, Li B, Zhao J, Han L, Gao C, Jiang G, Zhang L, Zhao W.
J Immunol 194(9):4458-65. doi: 10.4049/jimmunol.1402183. Epub 2015 Mar 30. 2015
19TICAM1, TICAM2, TLR4
Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2.
Funami K, Matsumoto M, Enokizono Y, Ishii N, Tatematsu M, Oshiumi H, Inagaki F, Seya T.
J Immunol 195(9):4456-65. doi: 10.4049/jimmunol.1402628. Epub 2015 Sep 25. 2015
20ANXA2, TICAM1, TICAM2, TLR4
Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2.
Funami K, Matsumoto M, Enokizono Y, Ishii N, Tatematsu M, Oshiumi H, Inagaki F, Seya T.
J Immunol 195(9):4456-65. doi: 10.4049/jimmunol.1402628. Epub 2015 Sep 25. 2015
21ANPEP, TLR4
CD13 restricts TLR4 endocytic signal transduction in inflammation.
Ghosh M, Subramani J, Rahman MM, Shapiro LH.
J Immunol 194(9):4466-76. doi: 10.4049/jimmunol.1403133. Epub 2015 Mar 23. 2015
22HSPD1, TLR4
Heat shock protein 60 stimulates the migration of vascular smooth muscle cells via Toll-like receptor 4 and ERK MAPK activation.
Zhao Y, Zhang C, Wei X, Li P, Cui Y, Qin Y, Wei X, Jin M, Kohama K, Gao Y.
Sci Rep 5:15352. doi: 10.1038/srep15352. 2015
23CD14, TLR4
LPS receptor subunits have antagonistic roles in epithelial apoptosis and colonic carcinogenesis.
Kuo WT, Lee TC, Yang HY, Chen CY, Au YC, Lu YZ, Wu LL, Wei SC, Ni YH, Lin BR, Chen Y, Tsai YH, Kung JT, Sheu F, Lin LW, Yu LC.
Cell Death Differ 22(10):1590-604. doi: 10.1038/cdd.2014.240. Epub 2015 Jan 30. 2015
24HMGN1, TLR4
The Alarmin HMGN1 contributes to antitumor immunity and is a potent immunoadjuvant.
Wei F, Yang D, Tewary P, Li Y, Li S, Chen X, Howard OM, Bustin M, Oppenheim JJ.
Cancer Res 74(21):5989-98. doi: 10.1158/0008-5472.CAN-13-2042. Epub 2014 Sep 9. 2014
25CASP8, TLR4, TNFAIP8L2
A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-8.
Li XM, Su JR, Yan SP, Cheng ZL, Yang TT, Zhu Q.
Cancer Biomark 14(4):233-40. doi: 10.3233/CBM-140402. 2014
26ITGAM, TLR4
TLR4-mediated expression of Mac-1 in monocytes plays a pivotal role in monocyte adhesion to vascular endothelium.
Lee SJ, Choi EK, Seo KW, Bae JU, Park SY, Kim CD.
PLoS One 9(8):e104588. doi: 10.1371/journal.pone.0104588. eCollection 2014. 2014
27CD14, CD33, TLR4
Negative regulation of Toll-like receptor-4 signaling through the binding of glycosylphosphatidylinositol-anchored glycoprotein, CD14, with the sialic acid-binding lectin, CD33.
Ishida A, Akita K, Mori Y, Tanida S, Toda M, Inoue M, Nakada H.
J Biol Chem 289(36):25341-50. doi: 10.1074/jbc.M113.523480. Epub 2014 Jul 24. 2014
28TLR4
Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal.
Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A.
J Biol Chem 288(21):15326-41. doi: 10.1074/jbc.M112.448712. Epub 2013 Apr 9. 2013
29IL10, MYD88, TLR4
Interleukin-10 activates Toll-like receptor 4 and requires MyD88 for cardiomyocyte survival.
Bagchi AK, Sharma A, Dhingra S, Lehenbauer Ludke AR, Al-Shudiefat AA, Singal PK.
Cytokine 61(1):304-14. doi: 10.1016/j.cyto.2012.10.013. Epub 2012 Nov 8. 2013
30LY96, TLR4
MD-2-dependent human Toll-like receptor 4 monoclonal antibodies detect extracellular association of Toll-like receptor 4 with extrinsic soluble MD-2 on the cell surface.
Tsukamoto H, Ihara H, Ito R, Ukai I, Suzuki N, Kimoto M, Tomioka Y, Ikeda Y.
Biochem Biophys Res Commun 440(1):31-6. doi: 10.1016/j.bbrc.2013.09.004. Epub 2013 Sep 8. 2013
31SIK1, SIK3, TAB2, TLR4, TRAF6
Salt-inducible kinases 1 and 3 negatively regulate Toll-like receptor 4-mediated signal.
Yong Kim S, Jeong S, Chah KH, Jung E, Baek KH, Kim ST, Shim JH, Chun E, Lee KY.
Mol Endocrinol 27(11):1958-68. doi: 10.1210/me.2013-1240. Epub 2013 Sep 23. 2013
32TLR3, TLR4, USP25
Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3.
Zhong B, Liu X, Wang X, Liu X, Li H, Darnay BG, Lin X, Sun SC, Dong C.
Sci Signal 6(275):ra35. doi: 10.1126/scisignal.2003708. 2013
33CD180, TLR2, TLR4
RP105 involved in activation of mouse macrophages via TLR2 and TLR4 signaling.
Liu B, Zhang N, Liu Z, Fu Y, Feng S, Wang S, Cao Y, Li D, Liang D, Li F, Song X, Yang Z.
Mol Cell Biochem 378(1-2):183-93. doi: 10.1007/s11010-013-1609-7. Epub 2013 Mar 13. 2013
34TLR4
Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation.
Reynolds JM, Martinez GJ, Chung Y, Dong C.
Proc Natl Acad Sci U S A 109(32):13064-9. doi: 10.1073/pnas.1120585109. Epub 2012 Jul 23. 2012
35CNPY3, CNPY4, TLR1, TLR10, TLR2, TLR4, TLR6
Cell surface trafficking of TLR1 is differentially regulated by the chaperones PRAT4A and PRAT4B.
Hart BE, Tapping RI.
J Biol Chem 287(20):16550-62. doi: 10.1074/jbc.M112.342717. Epub 2012 Mar 23. 2012
36LY96, TLR4
Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2.
Ohto U, Fukase K, Miyake K, Shimizu T.
Proc Natl Acad Sci U S A 109(19):7421-6. doi: 10.1073/pnas.1201193109. Epub 2012 Apr 24. 2012
37CD74, MIF, TLR4
CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer.
Zheng YX, Yang M, Rong TT, Yuan XL, Ma YH, Wang ZH, Shen LS, Cui L.
World J Gastroenterol 18(18):2253-61. doi: 10.3748/wjg.v18.i18.2253. 2012
38HSP90B1, HSPA5, TLR4
Chaperone insufficiency links TLR4 protein signaling to endoplasmic reticulum stress.
Coope A, Milanski M, Arruda AP, Ignacio-Souza LM, Saad MJ, Anhê GF, Velloso LA.
J Biol Chem 287(19):15580-9. doi: 10.1074/jbc.M111.315218. Epub 2012 Mar 16. 2012
39BBC3, LGR5, TLR4
Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis.
Neal MD, Sodhi CP, Jia H, Dyer M, Egan CE, Yazji I, Good M, Afrazi A, Marino R, Slagle D, Ma C, Branca MF, Prindle T Jr, Grant Z, Ozolek J, Hackam DJ.
J Biol Chem 287(44):37296-308. doi: 10.1074/jbc.M112.375881. Epub 2012 Sep 6. 2012
40TLR1, TLR2, TLR3, TLR4, TLR5
Age-related changes in expression and function of Toll-like receptors in human skin.
Iram N, Mildner M, Prior M, Petzelbauer P, Fiala C, Hacker S, Schöppl A, Tschachler E, Elbe-Bürger A.
Development 139(22):4210-9. doi: 10.1242/dev.083477. Epub 2012 Oct 3. 2012
41LRRFIP2, TLR4, TOR1AIP2, UBD
Modification of the inflammatory mediator LRRFIP2 by the ubiquitin-like protein FAT10 inhibits its activity during cellular response to LPS.
Buchsbaum S, Bercovich B, Ziv T, Ciechanover A.
Biochem Biophys Res Commun 428(1):11-6. doi: 10.1016/j.bbrc.2012.09.110. Epub 2012 Oct 1. 2012
42TLR4, TOLLIP
Expression and localization of TLR4 and its negative regulator Tollip in the placenta of early-onset and late-onset preeclampsia.
Zhang L, Yang H.
Hypertens Pregnancy 31(2):218-27. doi: 10.3109/10641955.2011.642434. 2012
43CD180, TLR4
The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells.
Nagai Y, Yanagibashi T, Watanabe Y, Ikutani M, Kariyone A, Ohta S, Hirai Y, Kimoto M, Miyake K, Takatsu K.
Int Immunol 24(6):389-400. doi: 10.1093/intimm/dxs040. Epub 2012 Feb 21. 2012
44PRDX1, TLR4
Peroxiredoxin 1 controls prostate cancer growth through Toll-like receptor 4-dependent regulation of tumor vasculature.
Riddell JR, Bshara W, Moser MT, Spernyak JA, Foster BA, Gollnick SO.
Cancer Res 71(5):1637-46. Epub 2011 Feb 22. 2011
45KCNJ3, TLR4
Kir3.1 channel is functionally involved in TLR4-mediated signaling.
Jo HY, Kim SY, Lee S, Jeong S, Kim SJ, Kang TM, Lee KY.
Biochem Biophys Res Commun 407(4):687-91. Epub 2011 Mar 21. 2011
46TLR4
TLR4 activates NF-κB in human ovarian granulosa tumor cells.
Woods DC, White YA, Dau C, Johnson AL.
Biochem Biophys Res Commun 409(4):675-80. Epub 2011 May 17. 2011
47TLR4
The role of TLR4 activation in photoreceptor mitochondrial oxidative stress.
Ko MK, Saraswathy S, Parikh JG, Rao NA.
Invest Ophthalmol Vis Sci. 52(8):5824-35. 2011
48NLRP3, TLR4
The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3.
Tannahill GM, O'Neill LA.
FEBS Lett 585(11):1568-72. Epub 2011 May 6. Review. 2011
49HSPA14, TLR4
Toll-like receptor 4 (TLR4) is essential for Hsp70-like protein 1 (HSP70L1) to activate dendritic cells and induce Th1 response.
Fang H, Wu Y, Huang X, Wang W, Ang B, Cao X, Wan T.
J Biol Chem 286(35):30393-400. Epub 2011 Jul 5. 2011
50TLR3, TLR4, TRIL
Toll-like receptor 3 (TLR3) signaling requires TLR4 Interactor with leucine-rich REPeats (TRIL).
Carpenter S, Wochal P, Dunne A, O'Neill LA.
J Biol Chem 286(44):38795-804. doi: 10.1074/jbc.M111.255893. Epub 2011 Sep 12. 2011
51LY96, TLR4
Myeloid differentiation protein 2 silencing decreases LPS-induced cytokine production and TLR4/MyD88 pathway activity in alveolar macrophages.
Ren W, Hu L, Hua F, Jin J, Wang Y, Zhu L.
Immunol Lett 141(1):94-101. doi: 10.1016/j.imlet.2011.07.010. Epub 2011 Aug 9. 2011
52HMGB1, TLR4
A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release.
Yang H, Hreggvidsdottir HS, Palmblad K, Wang H, Ochani M, Li J, Lu B, Chavan S, Rosas-Ballina M, Al-Abed Y, Akira S, Bierhaus A, Erlandsson-Harris H, Andersson U, Tracey KJ.
Proc Natl Acad Sci U S A 107(26):11942-7. Epub 2010 Jun 14.PMID: 20547845 2010
53TLR4
Toll-like receptor 4 mediates lipopolysaccharide-induced muscle catabolism via coordinate activation of ubiquitin-proteasome and autophagy-lysosome pathways.
Doyle A, Zhang G, Abdel Fattah EA, Tony Eissa N, Li YP.
FASEB J ASEB J. 2010 Sep 8. [Epub ahead of print]PMID: 20826541 2010
54TLR4
Abrogation of TLR4 and CD14 Expression and Signaling in Human Adrenocortical Tumors.
Kanczkowski W, Tymoszuk P, Ehrhart-Bornstein M, Wirth MP, Zacharowski K, Bornstein SR.
J Clin Endocrinol Metab Clin Endocrinol Metab. 2010 Sep 8. [Epub ahead of print]PMID: 20826579 2010
55TLR4
TLR4 and Insulin Resistance.
Kim JJ, Sears DD.
Gastroenterol Res Pract 2010. pii: 212563. Epub 2010 Aug 10.PMID: 20814545 2010
56MYD88, TLR4
High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer.
Wang EL, Qian ZR, Nakasono M, Tanahashi T, Yoshimoto K, Bando Y, Kudo E, Shimada M, Sano T.
Br J Cancer 102(5):908-15. Epub 2010 Feb 9.PMID: 20145615 2010
57FOXO1, TLR4
FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages.
Fan W, Morinaga H, Kim JJ, Bae E, Spann NJ, Heinz S, Glass CK, Olefsky JM.
EMBO J 29(24):4223-36. Epub 2010 Nov 2. 2010
58LY96, MYD88, TLR2, TLR4
Human neonatal peripheral blood leukocytes demonstrate pathogen-specific coordinate expression of TLR2, TLR4/MD2, and MyD88 during bacterial infection in vivo.
Zhang JP, Yang Y, Levy O, Chen C.
Pediatr Res 68(6):479-83. doi: 10.1203/PDR.0b013e3181f90810. 2010
59LY96, TLR4
Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling.
Gray P, Michelsen KS, Sirois CM, Lowe E, Shimada K, Crother TR, Chen S, Brikos C, Bulut Y, Latz E, Underhill D, Arditi M.
J Immunol 184(11):6359-66. doi: 10.4049/jimmunol.0903543. Epub 2010 Apr 30. 2010
60LY96, TLR4
MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation.
Meng J, Lien E, Golenbock DT.
J Biol Chem 285(12):8695-702. doi: 10.1074/jbc.M109.075127. Epub 2009 Dec 15. 2010
61TLR1, TLR10, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9
Expression analysis of the Toll-like receptors in human peripheral blood mononuclear cells.
Siednienko J, Miggin SM.
Methods Mol Biol 517:3-14.PMID: 19378036 2009
62CXCL10, TLR4
CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling.
Schulthess FT, Paroni F, Sauter NS, Shu L, Ribaux P, Haataja L, Strieter RM, Oberholzer J, King CC, Maedler K.
Cell Metab 9(2):125-39.PMID: 19187771 2009
63IFNGR1, NOS2, TLR4
NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans.
Velez DR, Hulme WF, Myers JL, Weinberg JB, Levesque MC, Stryjewski ME, Abbate E, Estevan R, Patillo SG, Gilbert JR, Hamilton CD, Scott WK.
Hum Genet 126(5):643-53. Epub 2009 Jul 3.PMID: 19575238 2009
64TLR4, ZNF160
Epigenetic regulation of TLR4 gene expression in intestinal epithelial cells for the maintenance of intestinal homeostasis.
Takahashi K, Sugi Y, Hosono A, Kaminogawa S.
J Immunol 183(10):6522-9. Epub 2009 Oct 21. 2009
65TLR4
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex.
Park BS, Song DH, Kim HM, Choi BS, Lee H, Lee JO.
Nature. 458(7242):1191-5. 2009
66TLR4
Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9.
Yu N, Zhang S, Zuo F, Kang K, Guan M, Xiang L.
J Dermatol Sci. 56(2):113-20. 2009
67LY96, TLR4
Mutational analysis of Cys(88) of Toll-like receptor 4 highlights the critical role of MD-2 in cell surface receptor expression.
Nishitani C, Takahashi M, Mitsuzawa H, Shimizu T, Ariki S, Matsushima N, Kuroki Y.
Int Immunol 21(8):925-34. doi: 10.1093/intimm/dxp059. Epub 2009 Jun 25. 2009
68LY96, TLR4
Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin.
Resman N, Vasl J, Oblak A, Pristovsek P, Gioannini TL, Weiss JP, Jerala R.
J Biol Chem 284(22):15052-60. doi: 10.1074/jbc.M901429200. Epub 2009 Mar 24. 2009
69LY96, TLR4
A single amino acid of toll-like receptor 4 that is pivotal for its signal transduction and subcellular localization.
Yanagimoto S, Tatsuno K, Okugawa S, Kitazawa T, Tsukada K, Koike K, Kodama T, Kimura S, Shibasaki Y, Ota Y.
J Biol Chem 284(6):3513-20. doi: 10.1074/jbc.M803086200. Epub 2008 Dec 8. 2009
70LY96, TLR4
Soluble MD2 increases TLR4 levels on the epithelial cell surface.
Lauer S, Kunde YA, Apodaca TA, Goldstein B, Hong-Geller E.
Cell Immunol 255(1-2):8-16. doi: 10.1016/j.cellimm.2008.08.009. Epub 2008 Oct 9. 2009
71S1PR1, S1PR3, TLR4
TLR4 and S1P receptors cooperate to enhance inflammatory cytokine production in human gingival epithelial cells.
Eskan MA, Rose BG, Benakanakere MR, Zeng Q, Fujioka D, Martin MH, Lee MJ, Kinane DF.
Eur J Immunol 38(4):1138-47.PMID: 18395849 2008
72TLR4
Functional Toll-like receptor 4 mutations modulate the response to fibrinogen.
Hodgkinson CP, Patel K, Ye S.
Thromb Haemost 100(2):301-7.PMID: 18690351 2008
73LY96, TLR4
Increased release of sMD-2 during human endotoxemia and sepsis: a role for endothelial cells.
Wolfs TG, Dunn-Siegrist I, van't Veer C, Hodin CM, Germeraad WT, van Zoelen MA, van Suylen RJ, Peutz-Kootstra CJ, Elson G, Pugin J, Buurman WA.
Mol Immunol 45(11):3268-77. doi: 10.1016/j.molimm.2008.02.014. Epub 2008 Apr 1. 2008
74LY96, TLR4
MD-2 controls bacterial lipopolysaccharide hyporesponsiveness in human intestinal epithelial cells.
Lenoir C, Sapin C, Broquet AH, Jouniaux AM, Bardin S, Gasnereau I, Thomas G, Seksik P, Trugnan G, Masliah J, Bachelet M.
Life Sci 82(9-10):519-28. doi: 10.1016/j.lfs.2007.12.007. Epub 2007 Dec 17. 2008
75TLR4
Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria.
Elson G, Dunn-Siegrist I, Daubeuf B, Pugin J.
Blood 109(4):1574-83. Epub 2006 Oct 12. 2007
76TLR4
Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann-Pick disease type C (NPC) fibroblasts: a potential basis for glial cell activation in the NPC brain.
Suzuki M, Sugimoto Y, Ohsaki Y, Ueno M, Kato S, Kitamura Y, Hosokawa H, Davies JP, Ioannou YA, Vanier MT, Ohno K, Ninomiya H.
J Neurosci 27(8):1879-91. 2007
77TLR4, HSPA1B
Heat shock protein 72 (HSPA1B) gene polymorphism and Toll-like receptor (TLR) 4 mutation are associated with increased risk of urinary tract infection in children.
Karoly E, Fekete A, Banki NF, Szebeni B, Vannay A, Szabo AJ, Tulassay T, Reusz GS.
Pediatr Res 61(3):371-4. 2007
78TLR4
Characterization of heme as activator of Toll-like receptor 4.
Figueiredo RT, Fernandez PL, Mourao-Sa DS, Porto BN, Dutra FF, Alves LS, Oliveira MF, Oliveira PL, Graa-Souza AV, Bozza MT.
J Biol Chem 282(28):20221-9. Epub 2007 May 14. 2007
79TLR4
MAPPIT analysis of TLR adaptor complexes.
Ulrichts P, Peelman F, Beyaert R, Tavernier J.
FEBS Lett. 581(4):629-36. 2007
80TLR4, TREM1
Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages.
Ornatowska M, Azim AC, Wang X, Christman JW, Xiao L, Joo M, Sadikot RT.
Am J Physiol Lung Cell Mol Physiol 293(6):L1377-84. Epub 2007 Sep 28. 2007
81LY96, TLR4
Human MD-2 discrimination of meningococcal lipid A structures and activation of TLR4.
Zimmer SM, Zughaier SM, Tzeng YL, Stephens DS.
Glycobiology 17(8):847-56. Epub 2007 Jun 2. 2007
82ATF3, TLR4, IL6, IL12B
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.
Gilchrist M, Thorsson V, Li B, Rust AG, Korb M, Kennedy K, Hai T, Bolouri H, Aderem A.
Nature 441(7090):173-8. 2006
83TLR4
TLR4 is required for host resistance in Pseudomonas aeruginosa keratitis.
Huang X, Du W, McClellan SA, Barrett RP, Hazlett LD.
Invest Ophthalmol Vis Sci 47(11):4910-6. 2006
84TLR4, CNPY4
A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression.
Konno K, Wakabayashi Y, Akashi-Takamura S, Ishii T, Kobayashi M, Takahashi K, Kusumoto Y, Saitoh S, Yoshizawa Y, Miyake K.
Biochem Biophys Res Commun 339(4):1076-82. Epub 2005 Dec 5. 2006
85BTK, TIRAP, TLR2, TLR4
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction.
Gray P, Dunne A, Brikos C, Jefferies CA, Doyle SL, O'Neill LA.
J Biol Chem 281(15):10489-95. Epub 2006 Jan 26. 2006
86HMGB1, TLR4
High mobility group box 1 protein interacts with multiple Toll-like receptors.
Park JS, Gamboni-Robertson F, He Q, Svetkauskaite D, Kim JY, Strassheim D, Sohn JW, Yamada S, Maruyama I, Banerjee A, Ishizaka A, Abraham E.
Am J Physiol Cell Physiol. 290(3):C917-24 2006
87TICAM2, TLR4
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'Neill LA, Fitzgerald KA, Golenbock DT.
Proc Natl Acad Sci U S A 103(16):6299-304. Epub 2006 Apr 7. 2006
88LY96, TLR4
Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering.
Kobayashi M, Saitoh S, Tanimura N, Takahashi K, Kawasaki K, Nishijima M, Fujimoto Y, Fukase K, Akashi-Takamura S, Miyake K.
J Immunol 176(10):6211-8. 2006
89TLR4
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease.
Hawn TR, Verbon A, Janer M, Zhao LP, Beutler B, Aderem A.
Proc Natl Acad Sci U S A 102(7):2487-9. Epub 2005 Feb 7. 2005
90TLR4
The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy.
Tanga FY, Nutile-McMenemy N, Deleo JA.
Proc Natl Acad Sci U S A 102(16):5856-61. Epub 2005 Apr 4. 2005
91TLR4
Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration.
Zareparsi S, Buraczynska M, Branham KE, Shah S, Eng D, Li M, Pawar H, Yashar BM, Moroi SE, Lichter PR, Petty HR, Richards JE, Abecasis GR, Elner VM, Swaroop A.
Hum Mol Genet 14(11):1449-55. Epub 2005 Apr 13. 2005
92CD180, TLR4
Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105.
Divanovic S, Trompette A, Atabani SF, Madan R, Golenbock DT, Visintin A, Finberg RW, Tarakhovsky A, Vogel SN, Belkaid Y, Kurt-Jones EA, Karp CL.
Nat Immunol 6(6):571-8. Epub 2005 Apr 24. 2005
93TLR4
TLR4 mediates human retinal pigment epithelial endotoxin binding and cytokine expression.
Elner SG, Petty HR, Elner VM, Yoshida A, Bian ZM, Yang D, Kindezelskii AL.
Trans Am Ophthalmol Soc 103:126-35; discussion 135-7. 2005
94TLR4
Participation of Rip2 in lipopolysaccharide signaling is independent of its kinase activity.
Lu C, Wang A, Dorsch M, Tian J, Nagashima K, Coyle AJ, Jaffee B, Ocain TD, Xu Y.
J Biol Chem. 280(16):16278-83. 2005
95LY96, TLR4
The Toll-like receptor 4 region Glu24-Pro34 is critical for interaction with MD-2.
Nishitani C, Mitsuzawa H, Hyakushima N, Sano H, Matsushima N, Kuroki Y.
Biochem Biophys Res Commun 328(2):586-90. 2005
96TNF, TLR4
TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury.
Barber RC, Aragaki CC, Rivera-Chavez FA, Purdue GF, Hunt JL, Horton JW.
J Med Genet 41(11):808-13. 2004
97TLR4
Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B.
Park HS, Jung HY, Park EY, Kim J, Lee WJ, Bae YS.
J Immunol. 173(6):3589-93. 2004
98TLR4
Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways.
Arndt PG, Suzuki N, Avdi NJ, Malcolm KC, Worthen GS.
J Biol Chem. 279(12):10883-91. 2004
99TLR4
Toll-like receptor 2 (TLR2) and TLR4 are present inside human dendritic cells, associated with microtubules and the Golgi apparatus but are not detectable on the cell surface: integrity of microtubules is required for interleukin-12 production in response to internalized bacteria.
Uronen-Hansson H, Allen J, Osman M, Squires G, Klein N, Callard RE.
Immunology. 111(2):173-8. 2004
100ADRBK1, GRK5, TLR4
Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors.
Fan J, Malik AB.
Nat Med 9(3):315-21. 2003
101TLR2, TLR4, TLR5
Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophage.
Oshikawa K, Sugiyama Y.
Biochem Biophys Res Commun 305(3):649-55. 2003
102TICAM1, TICAM2, TLR4
TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.
Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T.
J Biol Chem 278(50):49751-62. Epub 2003 Sep 30. 2003
103TLR4
Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.
Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O'Neill LA.
J Biol Chem. 278(28):26258-64. 2003
104TLR4
JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation.
Matsuguchi T, Masuda A, Sugimoto K, Nagai Y, Yoshikai Y.
EMBO J. 22(17):4455-64. 2003
105TLR4
Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes.
Mizel SB, Honko AN, Moors MA, Smith PS, West AP.
J Immunol. 170(12):6217-23. 2003
106TLR4
Endothelium-derived Toll-like receptor-4 is the key molecule in LPS-induced neutrophil sequestration into lungs.
Andonegui G, Bonder CS, Green F, Mullaly SC, Zbytnuik L, Raharjo E, Kubes P.
J Clin Invest. 111(7):1011-20. 2003
107TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9
Toll-like receptors.
Lien E, Ingalls RR.
Crit Care Med 30(1 Suppl):S1-11. Review. 2002
108MYD88, TIRAP, TLR2, TLR4
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S.
Nature 420(6913):324-9. 2002
109TLR1, TLR4
Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells.
Spitzer JH, Visintin A, Mazzoni A, Kennedy MN, Segal DM.
Eur J Immunol 32(4):1182-7. 2002
110CD14, LBP, TLR4
TLR4-dependent recognition of lipopolysaccharide by epithelial cells requires sCD14.
Backhed F, Meijer L, Normark S, Richter-Dahlfors A.
Cell Microbiol 4(8):493-501. 2002
111CD14, LY96, TLR4
Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.
Latz E, Visintin A, Lien E, Fitzgerald KA, Monks BG, Kurt-Jones EA, Golenbock DT, Espevik T.
J Biol Chem 277(49):47834-43. 2002
112LY96, TLR4
Essential role of MD-2 in LPS responsiveness and TLR4 distribution.
Nagai Y, Akashi S, Nagafuku M, Ogata M, Iwakura Y, Akira S, Kitamura T, Kosugi A, Kimoto M, Miyake K.
Nat Immunol 3(7):667-72. 2002
113LY96, TLR4
TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells.
Abreu MT, Arnold ET, Thomas LS, Gonsky R, Zhou Y, Hu B, Arditi M.
J Biol Chem 277(23):20431-7. 2002
114TLR2, TLR4, TOLLIP
Negative regulation of toll-like receptor-mediated signaling by Tollip.
Zhang G, Ghosh S.
J Biol Chem 277(9):7059-65. 2002
115IRF3, TLR3, TLR4
IRF3 mediates a TLR3/TLR4-specific antiviral gene program.
Doyle S, Vaidya S, O'Connell R, Dadgostar H, Dempsey P, Wu T, Rao G, Sun R, Haberland M, Modlin R, Cheng G.
Immunity 17(3):251-63. 2002
116TLR4
Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity.
Supajatura V, Ushio H, Nakao A, Akira S, Okumura K, Ra C, Ogawa H.
J Clin Invest. 109(10):1351-9. 2002
117TLR4
Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2.
Biragyn A, Ruffini PA, Leifer CA, Klyushnenkova E, Shakhov A, Chertov O, Shirakawa AK, Farber JM, Segal DM, Oppenheim JJ, Kwak LW.
Science. 298(5595):1025-9. 2002
118TLR4
The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway.
Vabulas RM, Braedel S, Hilf N, Singh-Jasuja H, Herter S, Ahmad-Nejad P, Kirschning CJ, Da Costa C, Rammensee HG, Wagner H, Schild H.
J Biol Chem. 277(23):20847-53. 2002
119TLR4
Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness.
Re F, Strominger JL.
J Biol Chem. 277(26):23427-32. 2002
120MIF, TLR4
MIF regulates innate immune responses through modulation of Toll-like receptor 4.
Roger T, David J, Glauser MP, Calandra T.
Nature 414(6866):920-4. 2001
121TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9
Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
Kadowaki N, Ho S, Antonenko S, Malefyt RW, Kastelein RA, Bazan F, Liu YJ.
J Exp Med 194(6):863-9. 2001
122TIRAP, TLR4
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction.
Fitzgerald KA, Palsson-McDermott EM, Bowie AG, Jefferies CA, Mansell AS, Brady G, Brint E, Dunne A, Gray P, Harte MT, McMurray D, Smith DE, Sims JE, Bird TA, O'Neill LA.
Nature 413(6851):78-83. 2001
123TIRAP, TLR4
TIRAP: an adapter molecule in the Toll signaling pathway.
Horng T, Barton GM, Medzhitov R.
Nat Immunol 2(9):835-41. 2001
124TLR2, TLR4, TOLLIP
Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling.
Bulut Y, Faure E, Thomas L, Equils O, Arditi M.
J Immunol 167(2):987-94. 2001
125TLR4
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.
Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA.
Nat Genet 25(2):187-91. 2000
126TLR1, TLR2, TLR3, TLR4, TLR5, TLR6
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.
Ozinsky A, Underhill DM, Fontenot JD, Hajjar AM, Smith KD, Wilson CB, Schroeder L, Aderem A.
Proc Natl Acad Sci U S A 97(25):13766-71. 2000
127TLR4
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus.
Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, Finberg RW.
Nat Immunol. 1(5):398-401. 2000
128LY96, TLR4
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4.
Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, Kimoto M.
J Exp Med 189(11):1777-82. 1999
129TLR4
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
Qureshi ST, Larivière L, Leveque G, Clermont S, Moore KJ, Gros P, Malo D.
J Exp Med. 189(4):615-25. 1999
130TLR1, TLR2, TLR3, TLR4, TLR5
A family of human receptors structurally related to Drosophila toll.
Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF.
Proc Natl Acad Sci U S A 95(2):588-93. 1998
131TLR4
Sequencing analysis of forty-eight human image cDNA clones similar to Drosophila mutant protein.
Volorio S, Simon G, Repetto M, Cucciardi M, Banfi S, Borsani G, Ballabio A, Zollo M.
DNA Seq 9(5-6):307-15.PMID: 10524757 1998
132TLR4
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity.
Medzhitov R, Preston-Hurlburt P, Janeway CA Jr.
Nature 388(6640):394-7 1997