| 1 | MDDS2, TK2
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| Adult cases of mitochondrial DNA depletion due to TK2 defect: an expanding spectrum.
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| Béhin A, Jardel C, Claeys KG, Fagart J, Louha M, Romero NB, Laforêt P, Eymard B, Lombès A.
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| Neurology 78(9):644-8. Epub 2012 Feb 15.
2012
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| 2 | MDDS2, TK2
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| Recent Advances in Thymidine Kinase 2 (TK2) Inhibitors and New Perspectives for Potential Applications.
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| Priego EM, Karlsson A, Gago F, Camarasa MJ, Balzarini J, Perez-Perez MJ.
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| Curr Pharm Des 18(20):2981-94.
2012
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| 3 | MDDS2, TK2
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| Thymidine kinase 2 mutations in autosomal recessive progressive external ophthalmoplegia with multiple mitochondrial DNA deletions.
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| Tyynismaa H, Sun R, Ahola-Erkkilä S, Almusa H, Pöyhönen R, Korpela M, Honkaniemi J, Isohanni P, Paetau A, Wang L, Suomalainen A.
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| Hum Mol Genet 21(1):66-75. Epub 2011 Sep 21.
2012
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| 4 | TK2
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| Oxidative stress induced S-glutathionylation and proteolytic degradation of mitochondrial thymidine kinase 2.
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| Sun R, Eriksson S, Wang L.
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| J Biol Chem 287(29):24304-12. doi: 10.1074/jbc.M112.381996. Epub 2012 Jun 1.
2012
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| 5 | MDDS2, TK2
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| Onset and organ specificity of Tk2 deficiency depends on Tk1 down-regulation and transcriptional compensation.
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| Dorado B, Area E, Akman HO, Hirano M.
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| Hum Mol Genet 20(1):155-64. Epub 2010 Oct 11.
2011
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| 6 | TK2
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| Targeted impairment of thymidine kinase 2 expression in cells induces mitochondrial DNA depletion and reveals molecular mechanisms of compensation of mitochondrial respiratory activity.
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| Villarroya J, Lara MC, Dorado B, Garrido M, García-Arumí E, Meseguer A, Hirano M, Vilà MR.
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| Biochem Biophys Res Commun 407(2):333-8. Epub 2011 Mar 5.
2011
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| 7 | TK2
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| Thymidine kinase 2 deficiency-induced mitochondrial DNA depletion causes abnormal development of adipose tissues and adipokine levels in mice.
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| Villarroya J, Dorado B, Vilà MR, Garcia-Arumí E, Domingo P, Giralt M, Hirano M, Villarroya F.
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| PLoS One 6(12):e29691. Epub 2011 Dec 27.
2011
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| 8 | MDDS2, TK2
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| Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration.
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| Bartesaghi S, Betts-Henderson J, Cain K, Dinsdale D, Zhou X, Karlsson A, Salomoni P, Nicotera P.
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| Hum Mol Genet 19(9):1669-77. Epub 2010 Feb 1.PMID: 20123860 2010
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| 9 | TK1, TK2
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| Hematopoiesis in the thymidine kinase 2 deficient mouse model of mitochondrial DNA depletion syndrome.
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| Zhou X, Johansson M, Solaroli N, Rozell B, Grandien A, Karlsson A.
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| J Inherit Metab Dis 33(3):231-6. Epub 2010 May 4.
2010
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| 10 | TK1, TK2
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| Enzymatic regulation of cytosolic thymidine kinase 1 and mitochondrial thymidine kinase 2: a mini review.
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| Munch-Petersen B.
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| Nucleosides Nucleotides Nucleic Acids 29(4-6):363-9. Review.
2010
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| 11 | MDDS2, TK2
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| Progressive myofiber loss with extensive fibro-fatty replacement in a child with mitochondrial DNA depletion syndrome and novel thymidine kinase 2 gene mutations.
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| Collins J, Bove KE, Dimmock D, Morehart P, Wong LJ, Wong B.
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| Neuromuscul Disord 19(11):784-7. Epub 2009 Sep 6.
2009
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| 12 | MDDS2, TK2
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| Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts.
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| Frangini M, Rampazzo C, Franzolin E, Lara MC, Vilà MR, Martí R, Bianchi V.
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| FEBS J 276(4):1104-13. Epub 2009 Jan 16.
2009
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| 13 | MDDS2, TK2
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| Novel mutations in the TK2 gene associated with fatal mitochondrial DNA depletion myopathy.
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| Blakely E, He L, Gardner JL, Hudson G, Walter J, Hughes I, Turnbull DM, Taylor RW.
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| Neuromuscul Disord 18(7):557-60. Epub 2008 May 27.
2008
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| 14 | TK2
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| Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice.
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| Zhou X, Solaroli N, Bjerke M, Stewart JB, Rozell B, Johansson M, Karlsson A.
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| Hum Mol Genet 17(15):2329-35. Epub 2008 Apr 22.
2008
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| 15 | HIES3, TK2
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| Hyperimmunoglobulin E syndrome and tyrosine kinase 2 deficiency.
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| Minegishi Y, Karasuyama H.
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| Curr Opin Allergy Clin Immunol 7(6):506-9. Review.
2007
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| 16 | TK2
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| A human-derived reporter gene for noninvasive imaging in humans: mitochondrial thymidine kinase type 2.
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| Ponomarev V, Doubrovin M, Shavrin A, Serganova I, Beresten T, Ageyeva L, Cai C, Balatoni J, Alauddin M, Gelovani J.
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| J Nucl Med 48(5):819-26. Epub 2007 Apr 27.
2007
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| 17 | MDDS2, TK2
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| New mutations in TK2 gene associated with mitochondrial DNA depletion.
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| Galbiati S, Bordoni A, Papadimitriou D, Toscano A, Rodolico C, Katsarou E, Sciacco M, Garufi A, Prelle A, Aguennouz M, Bonsignore M, Crimi M, Martinuzzi A, Bresolin N, Papadimitriou A, Comi GP.
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| Pediatr Neurol 34(3):177-85. 2006
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| 18 | HIES3, TK2, TYK2D
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| Human tyrosine kinase 2 deficiency reveals its requisite roles in multiple cytokine signals involved in innate and acquired immunity.
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| Minegishi Y, Saito M, Morio T, Watanabe K, Agematsu K, Tsuchiya S, Takada H, Hara T, Kawamura N, Ariga T, Kaneko H, Kondo N, Tsuge I, Yachie A, Sakiyama Y, Iwata T, Bessho F, Ohishi T, Joh K, Imai K, Kogawa K, Shinohara M, Fujieda M, Wakiguchi H, Pasic S, Abinun M, Ochs HD, Renner ED, Jansson A, Belohradsky BH, Metin A, Shimizu N, Mizutani S, Miyawaki T, Nonoyama S, Karasuyama H.
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| Immunity 25(5):745-55. 2006
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| 19 | DGUOK, TK2, MDDS1, MDDS2
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| Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes.
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| Wang L, Limongelli A, Vila MR, Carrara F, Zeviani M, Eriksson S.
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| Mol Genet Metab 84(1):75-82. 2005
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| 20 | MDDS2, TK2
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| mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK2) deficiency.
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| Saada A, Shaag A, Elpeleg O.
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| Mol Genet Metab 79(1):1-5. 2003
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| 21 | TK2, DGUOK, MDDS1, MDDS2
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| Mitochondrial myopathy of childhood associated with mitochondrial DNA depletion and a homozygous mutation (T77M) in the TK2 gene.
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| Mancuso M, Filosto M, Bonilla E, Hirano M, Shanske S, Vu TH, DiMauro S.
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| Arch Neurol 60(7):1007-9. 2003
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| 22 | MDDS2, TK2
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| The deoxyguanosine kinase gene is mutated in individuals with depleted hepatocerebral mitochondrial DNA.
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| Mandel H, Szargel R, Labay V, Elpeleg O, Saada A, Shalata A, Anbinder Y, Berkowitz D, Hartman C, Barak M, Eriksson S, Cohen N.
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| Nat Genet 29(3):337-41. 2001
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| 23 | ALB, CAD, CCNA2, CDC25A, CDK1, CEBPA, COL1A1, COL1A2, COL3A1, COL6A3, DHFR, DMTF1, GADD45A, JUN, LDHA, MXI1, MYC, ODC1, RCC1, SERPINE1, TERT, TK1, TK2, TP53
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| c-Myc target genes involved in cell growth, apoptosis, and metabolism.
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| Dang CV.
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| Mol Cell Biol 19(1):1-11. Review. No abstract available 1999
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| 24 | TK2
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| Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates.
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| Wang L, et al.
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| FEBS Lett 443(2):170-4. 1999
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| 25 | TK2
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| Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2.
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| Johansson M, et al.
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| J Biol Chem 272 : 8454-8458. 1997
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| 26 | TK2
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| Human mitochondrial thymidine kinase is coded for by a gene on chromosome 16 of the nucleus.
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| Willecke K, et al.
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| Somatic Cell Genet 3 : 237-245. 1977
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