Citations for
1TIMP3
Loss of TIMP3 expression induces inflammation, matrix degradation, and vascular ingrowth in nucleus pulposus: A new mechanism of intervertebral disc degeneration.
Li Y, Zhang T, Tian W, Hu H, Xin Z, Ma X, Ye C, Hang K, Han X, Zhao J, Li W.
FASEB J ASEB J. 2020 Feb 27. doi: 10.1096/fj.201902364RR. [Epub ahead of print] 2020
2CDKN2A, TIMP3
P14ARF inhibits regional inflammation and vascularization in intervertebral disc degeneration by upregulating TIMP3.
He M, Pang J, Sun H, Zheng G, Lin Y, Ge W.
Am J Physiol Cell Physiol 318(4):C751-C761. doi: 10.1152/ajpcell.00271.2019. Epub 2020 Feb 5. 2020
3TIMP3
Overexpression of TIMP3 inhibits discogenic pain by suppressing angiogenesis and the expression of substance P in nucleus pulposus.
He M, Pang J, Sun H, Zheng G, Lin Y, Ge W.
Mol Med Rep 21(3):1163-1171. doi: 10.3892/mmr.2020.10922. Epub 2020 Jan 9. 2020
4SFD, TIMP3
The N-terminal p.(Ser38Cys) TIMP3 mutation underlying Sorsby fundus dystrophy is a founder mutation disrupting an intramolecular disulfide bond.
Naessens S, De Zaeytijd J, Syx D, Vandenbroucke RE, Smeets F, Van Cauwenbergh C, Leroy BP, Peelman F, Coppieters F.
Hum Mutat 40(5):539-551. doi: 10.1002/humu.23713. Epub 2019 Feb 6. 2019
5TIMP3
TIMP-3 suppression induces choroidal neovascularization by moderating the polarization of macrophages in age-related macular degeneration.
Cheng Y, Cheng T, Qu Y.
Mol Immunol 106:119-126. doi: 10.1016/j.molimm.2018.12.026. Epub 2018 Dec 27. 2019
6IL32, TIMP3
IL-32 gamma reduces lung tumor development through upregulation of TIMP-3 overexpression and hypomethylation.
Yun J, Park MH, Son DJ, Nam KT, Moon DB, Ju JH, Hwang OK, Choi JS, Kim TH, Jung YS, Hwang DY, Han SB, Yoon DY, Hong JT.
Cell Death Dis 9(3):306. doi: 10.1038/s41419-018-0375-6. 2018
7TIMP3
TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease.
Zhabyeyev P, Das SK, Basu R, Shen M, Patel VB, Kassiri Z, Oudit GY.
Am J Physiol Heart Circ Physiol 314(5):H978-H990. doi: 10.1152/ajpheart.00597.2017. Epub 2018 Jan 26. 2018
8TIMP3
TIMP3 is a CLOCK-dependent diurnal gene that inhibits the expression of UVB-induced inflammatory cytokines in human keratinocytes.
Park S, Kim K, Bae IH, Lee SH, Jung J, Lee TR, Cho EG.
FASEB J 32(3):1510-1523. doi: 10.1096/fj.201700693R. Epub 2018 Jan 3. 2018
9ADAM17, TIMP3
Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma.
Casagrande V, Mauriello A, Bischetti S, Mavilio M, Federici M, Menghini R.
Sci Rep 7(1):6747. doi: 10.1038/s41598-017-06439-x. 2017
10TIMP3
Plasma levels of the tissue inhibitor matrix metalloproteinase-3 as a potential biomarker in oral cancer progression.
Su CW, Su BF, Chiang WL, Yang SF, Chen MK, Lin CW.
Int J Med Sci 14(1):37-44. doi: 10.7150/ijms.17024. eCollection 2017. 2017
11LIPC, SLC16A8, TIMP3
Serum Levels of TIMP-3, LIPC, IER3, and SLC16A8 in CFH-Negative AMD Cases.
Sharma K, Tyagi R, Singh R, Sharma SK, Anand A.
J Cell Biochem 118(8):2087-2095. doi: 10.1002/jcb.25837. Epub 2017 Apr 18. 2017
12SFD, TIMP3
A new autosomal dominant eye and lung syndrome linked to mutations in TIMP3 gene.
Meunier I, Bocquet B, Labesse G, Zeitz C, Defoort-Dhellemmes S, Lacroux A, Mauget-Faysse M, Drumare I, Gamez AS, Mathieu C, Marquette V, Sagot L, Dhaenens CM, Arndt C, Carroll P, Remy-Jardin M, Cohen SY, Sahel JA, Puech B, Audo I, Mrejen S, Hamel CP.
Sci Rep 6:32544. doi: 10.1038/srep32544. 2016
13TIMP3
Association Between Tissue Inhibitor of Metalloproteinase-3 Gene Methylation and Gastric Cancer Risk: A Meta-Analysis.
Cao J, Li Z, Yang L, Liu C, Luan X.
Genet Test Mol Biomarkers 20(8):427-31. doi: 10.1089/gtmb.2015.0332. Epub 2016 Jun 17. 2016
14TIMP3
TIMP3 regulates osteosarcoma cell migration, invasion, and chemotherapeutic resistances.
Han XG, Li Y, Mo HM, Li K, Lin D, Zhao CQ, Zhao J, Tang TT.
Tumour Biol 37(7):8857-67. doi: 10.1007/s13277-015-4757-4. Epub 2016 Jan 9. 2016
15ADAMTS4, TIMP3
The imbalance between TIMP3 and matrix-degrading enzymes plays an important role in intervertebral disc degeneration.
Li Y, Li K, Han X, Mao C, Zhang K, Zhao T, Zhao J.
Biochem Biophys Res Commun 469(3):507-14. doi: 10.1016/j.bbrc.2015.12.020. Epub 2015 Dec 12. 2016
16TIMP3
TIMP3 Attenuates the Loss of Neural Stem Cells, Mature Neurons and Neurocognitive Dysfunction in Traumatic Brain Injury.
Gibb SL, Zhao Y, Potter D, Hylin MJ, Bruhn R, Baimukanova G, Zhao J, Xue H, Abdel-Mohsen M, Pillai SK, Moore AN, Johnson EM, Cox CS Jr, Dash PK, Pati S.
Stem Cells 33(12):3530-44. doi: 10.1002/stem.2189. Epub 2015 Oct 23. 2015
17TIMP3
Tissue inhibitor of metalloproteinase-3 (TIMP3) promotes endothelial apoptosis via a caspase-independent mechanism.
Qi JH, Anand-Apte B.
Apoptosis 20(4):523-34. doi: 10.1007/s10495-014-1076-y. 2015
18TIMP3
Loss of TIMP3 exacerbates atherosclerosis in ApoE null mice.
Stöhr R, Cavalera M, Menini S, Mavilio M, Casagrande V, Rossi C, Urbani A, Cardellini M, Pugliese G, Menghini R, Federici M.
Atherosclerosis 235(2):438-43. doi: 10.1016/j.atherosclerosis.2014.05.946. Epub 2014 Jun 4. 2014
19TIMP2, TIMP3
Differential role of TIMP2 and TIMP3 in cardiac hypertrophy, fibrosis, and diastolic dysfunction.
Fan D, Takawale A, Basu R, Patel V, Lee J, Kandalam V, Wang X, Oudit GY, Kassiri Z.
Cardiovasc Res 103(2):268-80. doi: 10.1093/cvr/cvu072. Epub 2014 Apr 1. 2014
20TIMP3
Ovarian expression, localization, and function of tissue inhibitor of metalloproteinase 3 (TIMP3) during the periovulatory period of the human menstrual cycle.
Rosewell KL, Li F, Puttabyatappa M, Akin JW, Brännström M, Curry TE Jr.
Biol Reprod 89(5):121. doi: 10.1095/biolreprod.112.106989. Print 2013 Nov. 2013
21TIMP3
Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages.
Gill SE, Gharib SA, Bench EM, Sussman SW, Wang RT, Rims C, Birkland TP, Wang Y, Manicone AM, McGuire JK, Parks WC.
Am J Respir Cell Mol Biol 49(5):768-77. doi: 10.1165/rcmb.2012-0377OC. 2013
22LRP1, TIMP3
Differential regulation of extracellular tissue inhibitor of metalloproteinases-3 levels by cell membrane-bound and shed low density lipoprotein receptor-related protein 1.
Scilabra SD, Troeberg L, Yamamoto K, Emonard H, Thøgersen I, Enghild JJ, Strickland DK, Nagase H.
J Biol Chem 288(1):332-42. doi: 10.1074/jbc.M112.393322. Epub 2012 Nov 19. 2013
23SFD, TIMP3
A novel mutation at the N-terminal domain of the TIMP3 gene in Sorsby fundus dystrophy.
Schoenberger SD, Agarwal A.
Retina 33(2):429-35. doi: 10.1097/IAE.0b013e318263d3b4. 2013
24ITGA7, TIMP3
Integrin α7 binds tissue inhibitor of metalloproteinase 3 to suppress growth of prostate cancer cells.
Tan LZ, Song Y, Nelson J, Yu YP, Luo JH.
Am J Pathol 183(3):831-40. doi: 10.1016/j.ajpath.2013.05.010. Epub 2013 Jul 2. 2013
25MIR21, PDCD4, TIMP3
Association of microRNA-21 expression with its targets, PDCD4 and TIMP3, in pancreatic ductal adenocarcinoma.
Nagao Y, Hisaoka M, Matsuyama A, Kanemitsu S, Hamada T, Fukuyama T, Nakano R, Uchiyama A, Kawamoto M, Yamaguchi K, Hashimoto H.
Mod Pathol 25(1):112-21. doi: 10.1038/modpathol.2011.142. Epub 2011 Oct 7. 2012
26TIMP3
Loss of Timp3 gene leads to abdominal aortic aneurysm formation in response to angiotensin II.
Basu R, Fan D, Kandalam V, Lee J, Das SK, Wang X, Baldwin TA, Oudit GY, Kassiri Z.
J Biol Chem 287(53):44083-96. doi: 10.1074/jbc.M112.425652. Epub 2012 Nov 9. 2012
27TIMP3
TIMP3 regulates migration, invasion and in vivo tumorigenicity of thyroid tumor cells.
Anania MC, Sensi M, Radaelli E, Miranda C, Vizioli MG, Pagliardini S, Favini E, Cleris L, Supino R, Formelli F, Borrello MG, Pierotti MA, Greco A.
Oncogene 30(27):3011-23. doi: 10.1038/onc.2011.18. Epub 2011 Feb 21. 2011
28TIMP3
TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence.
Hojilla CV, Jackson HW, Khokha R.
PLoS One 6(10):e26718. doi: 10.1371/journal.pone.0026718. Epub 2011 Oct 28. 2011
29TIMP3
Down-regulation of tissue inhibitor of metalloproteinase-3 (TIMP-3) expression is necessary for adipocyte differentiation.
Bernot D, Barruet E, Poggi M, Bonardo B, Alessi MC, Peiretti F.
J Biol Chem 285(9):6508-14. Epub 2010 Jan 7.PMID: 20056610 2010
30ARMS2, CETP, CFH, LIPC, TIMP3
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL; Complications of Age-Related Macular Degeneration Prevention Trial Research Group, Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Cortón M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A.
Proc Natl Acad Sci U S A 107(16):7401-6. Epub 2010 Apr 12. 2010
31TIMP3
TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool.
Nakajima H, Ito M, Smookler DS, Shibata F, Fukuchi Y, Morikawa Y, Ikeda Y, Arai F, Suda T, Khokha R, Kitamura T.
Blood 116(22):4474-82. Epub 2010 Aug 26. 2010
32TIMP3
TIMP-3: a novel target for glucocorticoid signaling at the blood-brain barrier.
Hartmann C, El-Gindi J, Lohmann C, Lischper M, Zeni P, Galla HJ.
Biochem Biophys Res Commun 390(2):182-6. Epub 2009 Sep 2.PMID: 19732745 2009
33SIRT1, TIMP3
TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.
Cardellini M, Menghini R, Martelli E, Casagrande V, Marino A, Rizza S, Porzio O, Mauriello A, Solini A, Ippoliti A, Lauro R, Folli F, Federici M.
Diabetes 58(10):2396-401. Epub 2009 Jul 6.PMID: 19581416 2009
34TIMP2, TIMP3
Polymorphisms in tissue inhibitors of metalloproteinases-2 and -3 and breast cancer susceptibility and survival.
Peterson NB, Beeghly-Fadiel A, Gao YT, Long J, Cai Q, Shu XO, Zheng W.
Int J Cancer 125(4):844-50.PMID: 19431211 2009
35TIMP3
S156C mutation in tissue inhibitor of metalloproteinases-3 induces increased angiogenesis.
Qi JH, Dai G, Luthert P, Chaurasia S, Hollyfield J, Weber BH, Stöhr H, Anand-Apte B.
J Biol Chem 284(30):19927-36. Epub 2009 May 28.PMID: 19478078 2009
36TIMP3
Loss of TIMP3 enhances interstitial nephritis and fibrosis.
Kassiri Z, Oudit GY, Kandalam V, Awad A, Wang X, Ziou X, Maeda N, Herzenberg AM, Scholey JW.
J Am Soc Nephrol 20(6):1223-35. Epub 2009 Apr 30.PMID: 19406980 2009
37TIMP3
MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3.
Selaru FM, Olaru AV, Kan T, David S, Cheng Y, Mori Y, Yang J, Paun B, Jin Z, Agarwal R, Hamilton JP, Abraham J, Georgiades C, Alvarez H, Vivekanandan P, Yu W, Maitra A, Torbenson M, Thuluvath PJ, Gores GJ, LaRusso NF, Hruban R, Meltzer SJ.
Hepatology 49(5):1595-601.PMID: 19296468 2009
38TIMP3
Tissue inhibitor of matrix metalloproteinase-3 levels in the extracellular matrix of lung, kidney, and eye increase with age.
Macgregor AM, Eberhart CG, Fraig M, Lu J, Halushka MK.
J Histochem Cytochem 57(3):207-13. Epub 2008 Oct 27.PMID: 18955737 2009
39TIMP3
Promoter methylation of TIMP3 and CDH1 predicts better outcome in head and neck squamous cell carcinoma treated by radiotherapy only.
De Schutter H, Geeraerts H, Verbeken E, Nuyts S.
Oncol Rep 21(2):507-13.PMID: 19148529 2009
40TIMP3, TIMP1, TIMP2, TIMP4
Identification of the extracellular matrix (ECM) binding motifs of tissue inhibitor of metalloproteinases (TIMP)-3 and effective transfer to TIMP-1.
Lee MH, Atkinson S, Murphy G.
J Biol Chem 282(9):6887-98. Epub 2007 Jan 3. 2007
41TIMP3
TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4.
Wayne GJ, Deng SJ, Amour A, Borman S, Matico R, Carter HL, Murphy G.
J Biol Chem 282(29):20991-8. Epub 2007 Apr 30. 2007
42ARR3, CRX, GCAP1, GNB3, GNGT1, GNGT2, IMPDH1, OPN1LW, OPN1MW, PDE6C, RP1L1, TIMP3
Identification of novel retinal target genes of thyroid hormone in the human WERI cells by expression microarray analysis.
Liu Y, Fu L, Chen DG, Deeb SS.
Vision Res 47(17):2314-26. Epub 2007 Jul 25. 2007
43TIMP3, SFD
A novel His158Arg mutation in TIMP3 causes a late-onset form of Sorsby fundus dystrophy.
Lin RJ, Blumenkranz MS, Binkley J, Wu K, Vollrath D.
Am J Ophthalmol 142(5):839-48. Epub 2006 Sep 20. 2006
44ADAMTS2, TIMP3
TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2.
Wang WM, Ge G, Lim NH, Nagase H, Greenspan DS.
Biochem J 398(3):515-9. 2006
45SFD, TIMP3, MMP2
Sorsby's fundus dystrophy mutations impair turnover of TIMP-3 by retinal pigment epithelial cells.
Langton KP, McKie N, Smith BM, Brown NJ, Barker MD.
Hum Mol Genet 14(23):3579-86. Epub 2005 Oct 13. 2005
46TIMP3, EFEMP1
Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a binding partner of epithelial growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1). Implications for macular degenerations.
Klenotic PA, Munier FL, Marmorstein LY, Anand-Apte B.
J Biol Chem 279(29):30469-73. Epub 2004 Apr 28. 2004
47TIMP3, VEGFA, KDR
A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2.
Qi JH, Ebrahem Q, Moore N, Murphy G, Claesson-Welsh L, Bond M, Baker A, Anand-Apte B.
Nat Med 9(4):407-15. 2003
48ADAMTS1, ADAMTS2, ADAMTS3, ADAMTS4, ADAMTS5, ADAMTS6, ADAMTS7, ADAMTS8, ADAMTS9, TIMP3
Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19: transcriptional regulation by TNFalpha.
Bevitt DJ, Mohamed J, Catterall JB, Li Z, Arris CE, Hiscott P, Sheridan C, Langton KP, Barker MD, Clarke MP, McKie N.
Biochim Biophys Acta 1626(1-3):83-91. 2003
49TIMP3
Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development.
van der Velden PA, Zuidervaart W, Hurks MH, Pavey S, Ksander BR, Krijgsman E, Frants RR, Tensen CP, Willemze R, Jager MJ, Gruis NA.
Int J Cancer 106(4):472-9. Erratum in: Int J Cancer. 2004 Oct 10;111(6):982. 2003
50SFD, TIMP3
A novel tissue inhibitor of metalloproteinases-3 mutation reveals a common molecular phenotype in Sorsby's fundus dystrophy.
Langton KP, McKie N, Curtis A, Goodship JA, Bond PM, Barker MD, Clarke M.
J Biol Chem 275(35):27027-31. 2000
51SYN1, SYN2, SYN3, SYN4, TIMP1, TIMP2, TIMP3, TIMP4
Invertebrate tissue inhibitor of metalloproteinase: structure and nested gene organization within the synapsin locus is conserved from Drosophila to human.
Pohar N, et al.
Genomics 57(2):293-6. 1999
52TIMP3
Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggest a suppressor role in kidney, brain, and other human cancers.
Bachman KE, et al.
Cancer Res 59(4):798-802. 1999
53TIMP3, SFD
Localization of the functional domains of human tissue inhibitor of metalloproteinases-3 and the effects of a Sorsby's fundus dystrophy mutation.
Langton KP, et al.
J Biol Chem 273 : 16778-16781. 1998
54SFD, TIMP3
A novel splice site mutation in the tissue inhibitor of the metalloproteinases-3 gene in Sorsby's fundus dystrophy with unusual clinical features.
Tabata Y, et al.
Hum Genet 103 : 179-182. 1998
55SFD, TIMP3
Autosomal recessive Sorsby fundus dystrophy revisited : molecular evidence for dominant inheritance.
Felbor U, et al.
Am J Hum Genet 60 : 57-62. 1997
56TIMP1, TIMP2, TIMP3, TIMP4
Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.
Gomez DE, et al.
Eur J Cell Biol 74(2):111-22. Review. 1997
57SFD, TIMP3
A second independent Tyrp168Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy.
Felbor U, et al.
J Med Genet 33 : 133-236. 1996
58SFD, TIMP3
Sorsby's fundus dystrophy in the British isles : demonstration of a striking founder effect by microsatellite-generated haplotypes.
Wijesuriya SD, et al.
Genome Res 6 : 92-101. 1996
59TIMP3, SFD
Night blindness in Sorsby's fundus dystrophy reversed by vitamin A.
Jacobson SG, et al.
Nat Genet 11 : 27-32. 1995
60SFD, TIMP3
A novel Ser156Cys mutation in the tissue inhibitor of metalloproteinases-3 (TIMP3) in Sorsby's fundus dystrophy with unusual clinical features.
Felbor U, et al.
Hum Mol Genet 4 : 2415-2416. 1995
61TIMP3
Structure of the human TIMP-3 gene and its cell cycle-regulated promoter.
Wick M, et al.
Biochem J 311 : 549-554. 1995
62TIMP3
Genomic organization of the human tissue inhibitor of metalloproteinases-3 (TIMP3).
Stšhr H, et al.
Genome Res 5 : 483-487. 1995
63TIMP3
The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family.
Apte SS, et al.
J Biol Chem 270 : 14313-14318. 1995
64TIMP3
Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22.
Apte SS, et al.
Genomics 19 : 86-90. 1994
65TIMP3
Structure and expression in breast tumors of human TIMP-3, a new member of the metalloproteinase inhibitor family.
Uria JA, et al.
Cancer Res 54 : 2091-2094. 1994
66TIMP3
Cloning and characterization of human tissue inhibitor of metalloproteinases-3.
Wilde CG, et al.
DNA Cell Biol 13 : 711-718. 1994
67TIMP3
Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family.
Silbiger SM, et al.
Gene 141 : 293-297. 1994
68TIMP3, SFD
Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy.
Weber BHF, et al.
Nat Genet 8 : 352-356. 1994