Citations for
1SDE2, TIMELESS
SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks.
Rageul J, Park JJ, Zeng PP, Lee EA, Yang J, Hwang S, Lo N, Weinheimer AS, Schärer OD, Yeo JE, Kim H.
Nat Commun. Oct 30;11(1):5495. doi: 10.1038/s41467-020-19162-5 2020
2TIMELESS
Morphological characterization of mammalian timeless in the mouse brain development.
Inaguma Y, Ito H, Hara A, Iwamoto I, Matsumoto A, Yamagata T, Tabata H, Nagata K.
Neurosci Res 92:21-8. doi: 10.1016/j.neures.2014.10.017. Epub 2014 Nov 6. 2015
3CLSPN, TIMELESS, TIPIN, WDHD1
DNA replication and homologous recombination factors: acting together to maintain genome stability.
Aze A, Zhou JC, Costa A, Costanzo V.
Chromosoma 122(5):401-13. doi: 10.1007/s00412-013-0411-3. Epub 2013 Apr 16. Review. 2013
4TIMELESS, TIPIN
Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases.
Cho WH, Kang YH, An YY, Tappin I, Hurwitz J, Lee JK.
Proc Natl Acad Sci U S A 110(7):2523-7. doi: 10.1073/pnas.1222494110. Epub 2013 Jan 28. 2013
5TIMELESS
Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses.
Mao Y, Fu A, Leaderer D, Zheng T, Chen K, Zhu Y.
BMC Cancer 13:498. doi: 10.1186/1471-2407-13-498. 2013
6TIMELESS
Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock.
Engelen E, Janssens RC, Yagita K, Smits VA, van der Horst GT, Tamanini F.
PLoS One 8(2):e56623. doi: 10.1371/journal.pone.0056623. Epub 2013 Feb 13. 2013
7TIMELESS
Individual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.
O'Reilly LP, Zhang X, Smithgall TE.
Cell Signal 25(4):860-6. doi: 10.1016/j.cellsig.2012.12.009. Epub 2012 Dec 22. 2013
8CLSPN, TIMELESS, TIPIN
Mechanisms of replication fork protection: a safeguard for genome stability.
Errico A, Costanzo V.
Crit Rev Biochem Mol Biol 47(3):222-35. doi: 10.3109/10409238.2012.655374. Epub 2012 Feb 11. Review. 2012
9TIMELESS
Timeless preserves telomere length by promoting efficient DNA replication through human telomeres.
Leman AR, Dheekollu J, Deng Z, Lee SW, Das MM, Lieberman PM, Noguchi E.
Cell Cycle 11(12):2337-47. doi: 10.4161/cc.20810. Epub 2012 Jun 15. 2012
10CLSPN, TIMELESS, TIPIN
Timeless links replication termination to mitotic kinase activation.
Dheekollu J, Wiedmer A, Hayden J, Speicher D, Gotter AL, Yen T, Lieberman PM.
PLoS One 6(5):e19596. doi: 10.1371/journal.pone.0019596. 2011
11CLSPN, TIMELESS, TIPIN
Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblasts.
Smith-Roe SL, Patel SS, Simpson DA, Zhou YC, Rao S, Ibrahim JG, Kaiser-Rogers KA, Cordeiro-Stone M, Kaufmann WK.
Cell Cycle 10(10):1618-24. Epub 2011 May 15. 2011
12TIMELESS
Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control.
Yang X, Wood PA, Hrushesky WJ.
J Biol Chem 285(5):3030-4. Epub 2009 Dec 7.PMID: 19996108 2010
13MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, TIMELESS, TIPIN
Interaction of human MCM2-7 proteins with TIM, TIPIN and Rb.
Numata Y, Ishihara S, Hasegawa N, Nozaki N, Ishimi Y.
J Biochem 147(6):917-27. Epub 2010 Mar 17.PMID: 20299328 2010
14CLSPN, TIMELESS, TIPIN
Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.
Kemp MG, Akan Z, Yilmaz S, Grillo M, Smith-Roe SL, Kang TH, Cordeiro-Stone M, Kaufmann WK, Abraham RT, Sancar A, Unsal-Kaçmaz K.
J Biol Chem 285(22):16562-71. doi: 10.1074/jbc.M110.110304. Epub 2010 Mar 15. 2010
15TIMELESS, TIPIN
Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion.
Leman AR, Noguchi C, Lee CY, Noguchi E.
J Cell Sci 123(Pt 5):660-70. doi: 10.1242/jcs.057984. Epub 2010 Feb 2. 2010
16ATR, TIMELESS, TIPIN
Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis.
Smith KD, Fu MA, Brown EJ.
J Cell Biol 187(1):15-23. doi: 10.1083/jcb.200905006. 2009
17TIMELESS
TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo.
Meissner RA, Kilman VL, Lin JM, Allada R.
J Neurosci 28(39):9732-40. 2008
18TIMELESS, TIPIN
Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint.
Yoshizawa-Sugata N, Masai H.
J Biol Chem 282(4):2729-40. Epub 2006 Nov 13. 2007
19TIMELESS, TIPIN
Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function.
Chou DM, Elledge SJ.
Proc Natl Acad Sci U S A 103(48):18143-7. Epub 2006 Nov 20. 2006
20TIMELESS
Chromosome cohesion is regulated by a clock gene paralogue TIM-1.
Chan RC, Chan A, Jeon M, Wu TF, Pasqualone D, Rougvie AE, Meyer BJ.
Nature 424(6943):1002-9. 2003
21TIPIN, TIMELESS
Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association.
Gotter AL.
J Mol Biol 331(1):167-76. 2003
22TIMELESS
Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1.
Koike N, Hida A, Numano R, Hirose M, Sakaki Y, Tei H.
FEBS Lett 441(3):427-31. 1998
23TIMELESS
Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription.
Sangoram AM, Saez L, Antoch MP, Gekakis N, Staknis D, Whiteley A, Fruechte EM, Vitaterna MH, Shimomura K, King DP, Young MW, Weitz CJ, Takahashi JS.
Neuron 21(5):1101-13. 1998