Citations for
TIGAR Attenuates High Glucose-Induced Neuronal Apoptosis via an Autophagy Pathway.
Zhou W, Yao Y, Li J, Wu D, Zhao M, Yan Z, Pang A, Kong L.
Front Mol Neurosci 12:193. doi: 10.3389/fnmol.2019.00193. eCollection 2019. 2019
TIGAR promotes growth, survival and metastasis through oxidation resistance and AKT activation in glioblastoma.
Tang Z, He Z.
Oncol Lett 18(3):2509-2517. doi: 10.3892/ol.2019.10574. Epub 2019 Jul 5. 2019
TIGAR suppresses seizures induced by kainic acid through inhibiting oxidative stress and neuronal apoptosis.
Chen C, Mei Q, Wang L, Feng X, Tao X, Qiu C, Zhu J.
Biochem Biophys Res Commun 515(3):436-441. doi: 10.1016/j.bbrc.2019.05.156. Epub 2019 May 31. 2019
Down-regulation of TFAM increases the sensitivity of tumour cells to radiation via p53/TIGAR signalling pathway.
Jiang X, Wang J.
J Cell Mol Med 23(7):4545-4558. doi: 10.1111/jcmm.14350. Epub 2019 May 6. 2019
TIGAR promotes neural stem cell differentiation through acetyl-CoA-mediated histone acetylation.
Zhou W, Zhao T, Du J, Ji G, Li X, Ji S, Tian W, Wang X, Hao A.
Cell Death Dis 10(3):198. doi: 10.1038/s41419-019-1434-3. 2019
TIGAR regulates mitochondrial functions through SIRT1-PGC1α pathway and translocation of TIGAR into mitochondria in skeletal muscle.
Geng J, Wei M, Yuan X, Liu Z, Wang X, Zhang D, Luo L, Wu J, Guo W, Qin ZH.
FASEB J 33(5):6082-6098. doi: 10.1096/fj.201802209R. Epub 2019 Feb 6. 2019
The diverse role of TIGAR in cellular homeostasis and cancer.
Geng J, Yuan X, Wei M, Wu J, Qin ZH.
Free Radic Res 52(11-12):1240-1249. doi: 10.1080/10715762.2018.1489133. Epub 2018 Oct 4. Review. 2018
Loss of TIGAR Induces Oxidative Stress and Meiotic Defects in Oocytes from Obese Mice.
Wang H, Cheng Q, Li X, Hu F, Han L, Zhang H, Li L, Ge J, Ying X, Guo X, Wang Q.
Mol Cell Proteomics 17(7):1354-1364. doi: 10.1074/mcp.RA118.000620. Epub 2018 May 18. 2018
The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC.
Tang Y, Kwon H, Neel BA, Kasher-Meron M, Pessin JB, Yamada E, Pessin JE.
J Biol Chem 293(20):7578-7591. doi: 10.1074/jbc.RA118.002727. Epub 2018 Apr 12. 2018
TIGAR inhibits ischemia/reperfusion-induced inflammatory response of astrocytes.
Chen J, Zhang DM, Feng X, Wang J, Qin YY, Zhang T, Huang Q, Sheng R, Chen Z, Li M, Qin ZH.
Neuropharmacology 131:377-388. doi: 10.1016/j.neuropharm.2018.01.012. Epub 2018 Jan 10. 2018
TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia.
Qian S, Li J, Hong M, Zhu Y, Zhao H, Xie Y, Huang J, Lian Y, Li Y, Wang S, Mao J, Chen Y.
J Hematol Oncol 9(1):128. 2016
Akt mediates TIGAR induction in HeLa cells following PFKFB3 inhibition.
Simon-Molas H, Calvo-Vidal MN, Castaño E, Rodríguez-García A, Navarro-Sabaté À, Bartrons R, Manzano A.
FEBS Lett 590(17):2915-26. doi: 10.1002/1873-3468.12338. Epub 2016 Aug 24. 2016
Endogenous level of TIGAR in brain is associated with vulnerability of neurons to ischemic injury.
Cao L, Chen J, Li M, Qin YY, Sun M, Sheng R, Han F, Wang G, Qin ZH.
Neurosci Bull 31(5):527-40. doi: 10.1007/s12264-015-1538-4. Epub 2015 Jul 28. 2015
TIGAR regulates glycolysis in ischemic kidney proximal tubules.
Kim J, Devalaraja-Narashimha K, Padanilam BJ.
Am J Physiol Renal Physiol 308(4):F298-308. doi: 10.1152/ajprenal.00459.2014. Epub 2014 Dec 10. 2015
TIGAR has a dual role in cancer cell survival through regulating apoptosis and autophagy.
Xie JM, Li B, Yu HP, Gao QG, Li W, Wu HR, Qin ZH.
Cancer Res 74(18):5127-38. doi: 10.1158/0008-5472.CAN-13-3517. Epub 2014 Aug 1. 2014
A TIGAR-regulated metabolic pathway is critical for protection of brain ischemia.
Li M, Sun M, Cao L, Gu JH, Ge J, Chen J, Han R, Qin YY, Zhou ZP, Ding Y, Qin ZH.
J Neurosci 34(22):7458-71. doi: 10.1523/JNEUROSCI.4655-13.2014. 2014
CREB, another culprit for TIGAR promoter activity and expression.
Zou S, Wang X, Deng L, Wang Y, Huang B, Zhang N, Fan Q, Luo J.
Biochem Biophys Res Commun 439(4):481-6. doi: 10.1016/j.bbrc.2013.08.098. Epub 2013 Sep 11. 2013
TIGAR is required for efficient intestinal regeneration and tumorigenesis.
Cheung EC, Athineos D, Lee P, Ridgway RA, Lambie W, Nixon C, Strathdee D, Blyth K, Sansom OJ, Vousden KH.
Dev Cell 25(5):463-77. doi: 10.1016/j.devcel.2013.05.001. Epub 2013 May 30. 2013
Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer.
Won KY, Lim SJ, Kim GY, Kim YW, Han SA, Song JY, Lee DK.
Hum Pathol 43(2):221-8. doi: 10.1016/j.humpath.2011.04.021. Epub 2011 Aug 4. 2012
Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death.
Cheung EC, Ludwig RL, Vousden KH.
Proc Natl Acad Sci U S A 109(50):20491-6. doi: 10.1073/pnas.1206530109. Epub 2012 Nov 26. 2012
Tp53-induced glycolysis and apoptosis regulator (TIGAR) protects glioma cells from starvation-induced cell death by up-regulating respiration and improving cellular redox homeostasis.
Wanka C, Steinbach JP, Rieger J.
J Biol Chem 287(40):33436-46. Epub 2012 Aug 10. 2012
TIGAR induces p53-mediated cell-cycle arrest by regulation of RB-E2F1 complex.
Madan E, Gogna R, Kuppusamy P, Bhatt M, Pati U, Mahdi AA.
Br J Cancer 107(3):516-26. doi: 10.1038/bjc.2012.260. Epub 2012 Jul 10. 2012
SP1 plays a pivotal role for basal activity of TIGAR promoter in liver cancer cell lines.
Zou S, Gu Z, Ni P, Liu X, Wang J, Fan Q.
Mol Cell Biochem 359(1-2):17-23. doi: 10.1007/s11010-011-0993-0. Epub 2011 Jul 15. 2012
Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death.
Lui VW, Wong EY, Ho K, Ng PK, Lau CP, Tsui SK, Tsang CM, Tsao SW, Cheng SH, Ng MH, Ng YK, Lam EK, Hong B, Lo KW, Mok TS, Chan AT, Mills GB.
Oncogene 30(9):1127-34. Epub 2010 Nov 8. 2011
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect.
Zhang C, Lin M, Wu R, Wang X, Yang B, Levine AJ, Hu W, Feng Z.
Proc Natl Acad Sci U S A 108(39):16259-64. Epub 2011 Sep 19. 2011
Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator).
Li H, Jogl G.
J Biol Chem 284(3):1748-54. Epub 2008 Nov 17. 2009
Modulation of intracellular ROS levels by TIGAR controls autophagy.
Bensaad K, Cheung EC, Vousden KH.
EMBO J 28(19):3015-26. doi: 10.1038/emboj.2009.242. Epub 2009 Aug 27. 2009
Identification of TIGAR in the equilibrative nucleoside transporter 2-mediated response to fludarabine in chronic lymphocytic leukemia cells.
López-Guerra M, Trigueros-Motos L, Molina-Arcas M, Villamor N, Casado FJ, Montserrat E, Campo E, Colomer D, Pastor-Anglada M.
Haematologica 93(12):1843-51. Epub 2008 Oct 22. 2008
The histidine phosphatase superfamily: structure and function.
Rigden DJ.
Biochem J 409(2):333-48. Review. 2008
TIGAR, a p53-inducible regulator of glycolysis and apoptosis.
Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, Gottlieb E, Vousden KH.
Cell 126(1):107-20. 2006
31ADHR, C12orf4, FGF23, GPR92, TIGAR
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. The ADHR Consortium.
Kenneth E. White, Wayne E. Evans, Jeffery L.H. O'Riordan, Marcy C. Speer, Michael J. Econs, Bettina Lorenz-Depiereux, Monika Grabowski, Thomas Meitinger, Tim M. Strom.
Nat Genet 26(3):345-8. 2000