| 1 | DDIDSDS, TIAM1
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| Loss-of-function variants in TIAM1 are associated with developmental delay, intellectual disability, and seizures
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| Lu S, Hernan R, Marcogliese PC, Huang Y, Gertler TS, Akcaboy M, Liu S, Chung HL, Pan X, Sun X, Oguz MM, Oztoprak U, de Baaij JHF, Ivanisevic J, McGinnis E, Guillen Sacoto MJ, Chung WK, Bellen HJ.
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| Am J Hum Genet. Apr 7;109(4):571-586. doi: 10.1016/j.ajhg.2022.01.020. Epub 2022 Mar 2. 2022
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| 2 | RAC1, TIAM1
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| Tiam1 mediates Rac1 activation and contraction-induced glucose uptake in skeletal muscle cells
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| Yue Y, Zhang C, Zhao X, Liu S, Lv X, Zhang S, Yang J, Chen L, Duan H, Zhang Y, Yao Z, Niu W.
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| FASEB J. Feb;35(2):e21210. doi: 10.1096/fj.202001312R. Epub 2020 Nov 22. 2021
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| 3 | BTRC, PLK4, TIAM1
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| The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels
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| Porter AP, Reed H, White GRM, Ogg EL, Whalley HJ, Malliri A.
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| J Cell Sci. Apr 1;134(7):jcs252502. doi: 10.1242/jcs.252502. Epub 2021 Apr 13. 2021
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| 4 | TIAM1
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| The Rac-GEF Tiam1 Promotes Dendrite and Synapse Stabilization of Dentate Granule Cells and Restricts Hippocampal-Dependent Memory Functions
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| Cheng J, Scala F, Blanco FA, Niu S, Firozi K, Keehan L, Mulherkar S, Froudarakis E, Li L, Duman JG, Jiang X, Tolias KF.
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| J Neurosci. Feb 10;41(6):1191-1206. doi: 10.1523/JNEUROSCI.3271-17.2020. Epub 2020 Dec 16. 2021
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| 5 | TIAM1
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| Tiam1 is Critical for Glutamatergic Synapse Structure and Function in the Hippocampus
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| Rao S, Kay Y, Herring BE.
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| J Neurosci. Nov 20;39(47):9306-9315. doi: 10.1523/JNEUROSCI.1566-19.2019. Epub 2019 Oct 9. 2019
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| 6 | TIAM1
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| Tiam1 promotes thyroid carcinoma metastasis by modulating EMT via Wnt/β-catenin signaling
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| Liu L, Wu B, Cai H, Li D, Ma Y, Zhu X, Lv Z, Fan Y, Zhang X.
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| Exp Cell Res. Jan 15;362(2):532-540. doi: 10.1016/j.yexcr.2017.12.019. Epub 2017 Dec 22. 2018
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| 7 | SH3GL3, TIAM1
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| Competition between TIAM1 and Membranes Balances Endophilin A3 Activity in Cancer Metastasis
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| Poudel KR, Roh-Johnson M, Su A, Ho T, Mathsyaraja H, Anderson S, Grady WM, Moens CB, Conacci-Sorrell M, Eisenman RN, Bai J.
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| Dev Cell. Jun 18;45(6):738-752.e6. doi: 10.1016/j.devcel.2018.05.021. 2018
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| 8 | SETDB1, TIAM1
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| Histone methyltransferase SETDB1 promotes cells proliferation and migration by interacting withTiam1 in hepatocellular carcinoma.
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| Zhang Y, Huang J, Li Q, Chen K, Liang Y, Zhan Z, Ye F, Ni W, Chen L, Ding Y.
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| BMC Cancer. May 8;18(1):539. doi: 10.1186/s12885-018-4464-9. 2018
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| 9 | TIAM1
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| The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain.
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| Xu Z, Gakhar L, Bain FE, Spies M, Fuentes EJ.
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| J Biol Chem. Oct 27;292(43):17777-17793. doi: 10.1074/jbc.M117.799114. Epub 2017 Sep 7. 2017
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| 10 | ITGB1, RAB23, RAC1, TIAM1
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| Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin β1/Rac1 pathway.
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| Jian Q, Miao Y, Tang L, Huang M, Yang Y, Ba W, Liu Y, Chi S, Li C.
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| Oncotarget 7(5):5342-52. doi: 10.18632/oncotarget.6701.
2016
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| 11 | TIAM1
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| Tiam1/Rac1 complex controls Il17a transcription and autoimmunity.
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| Kurdi AT, Bassil R, Olah M, Wu C, Xiao S, Taga M, Frangieh M, Buttrick T, Orent W, Bradshaw EM, Khoury SJ, Elyaman W.
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| Nat Commun. Oct 11;7:13048. doi: 10.1038/ncomms13048. 2016
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| 12 | TIAM1
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| GABARAP proteins as scaffolds in localized TIAM1-RAC1 signaling.
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| Genau HM, Behrends C.
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| Mol Cell Oncol. Apr 14;3(1):e1027440. doi: 10.1080/23723556.2015.1027440. 2015
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| 13 | SIRT1, SIRT2, TIAM1
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| The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration
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| Saxena M, Dykes SS, Malyarchuk S, Wang AE, Cardelli JA, Pruitt K.
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| Oncogene. Jan 8;34(2):188-98. doi: 10.1038/onc.2013.549. Epub 2013 Dec 23. 2015
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| 14 | RAC1, TIAM1
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| Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.
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| Blanco-Suárez E, Fiuza M, Liu X, Chakkarapani E, Hanley JG.
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| J Cereb Blood Flow Metab. Dec;34(12):1898-906. doi: 10.1038/jcbfm.2014.158. Epub 2014 Sep 24. 2014
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| 15 | ADGRB1, PARD3, TIAM1
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| The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites.
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| Duman JG, Tzeng CP, Tu YK, Munjal T, Schwechter B, Ho TS, Tolias KF.
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| J Neurosci 33(16):6964-78. doi: 10.1523/JNEUROSCI.3978-12.2013. 2013
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| 16 | TIAM1
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| Tiam1 is associated with hepatocellular carcinoma metastasis
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| Huang J, Ye X, Guan J, Chen B, Li Q, Zheng X, Liu L, Wang S, Ding Y, Ding Y, Chen L.
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| Int J Cancer. Jan 1;132(1):90-100. doi: 10.1002/ijc.27627. Epub 2012 May 29. Erratum in: Int J Cancer. 2015 Oct 15;137(8):E14. Erratum in: Int 2013
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| 17 | MAP1B, TIAM1
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| The light chain 1 subunit of the microtubule-associated protein 1B (MAP1B) is responsible for Tiam1 binding and Rac1 activation in neuronal cells.
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| Henríquez DR, Bodaleo FJ, Montenegro-Venegas C, González-Billault C.
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| PLoS One 7(12):e53123. doi: 10.1371/journal.pone.0053123. Epub 2012 Dec 27.
2012
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| 18 | ETV1, GRIN2C, TIAM1
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| Gene regulation via excitation and BDNF is mediated by induction and phosphorylation of the Etv1 transcription factor in cerebellar granule cells.
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| Abe H, Okazawa M, Nakanishi S.
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| Proc Natl Acad Sci U S A 109(22):8734-9. doi: 10.1073/pnas.1206418109. Epub 2012 May 14.
2012
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| 19 | TIAM1, pARD3
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| Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration.
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| Wang S, Watanabe T, Matsuzawa K, Katsumi A, Kakeno M, Matsui T, Ye F, Sato K, Murase K, Sugiyama I, Kimura K, Mizoguchi A, Ginsberg MH, Collard JG, Kaibuchi K.
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| J Cell Biol 199(2):331-45. doi: 10.1083/jcb.201202041.
2012
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| 20 | PARD3, PARD6A, PRKCI, TIAM1
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| Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration.
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| Wang S, Watanabe T, Matsuzawa K, Katsumi A, Kakeno M, Matsui T, Ye F, Sato K, Murase K, Sugiyama I, Kimura K, Mizoguchi A, Ginsberg MH, Collard JG, Kaibuchi K.
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| J Cell Biol 199(2):331-45. doi: 10.1083/jcb.201202041.
2012
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| 21 | TIAM1
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| Methylation status of T-lymphoma invasion and metastasis 1 promoter and its overexpression in colorectal cancer.
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| Jin H, Li T, Ding Y, Deng Y, Zhang W, Yang H, Zhou J, Liu C, Lin J, Ding Y.
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| Hum Pathol 42(4):541-51. Epub 2011 Jan 15.
2011
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| 22 | TIAM1
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| Overexpression of Tiam1 predicts poor prognosis in patients with esophageal squamous cell carcinoma.
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| Liu H, Shi G, Liu X, Wu H, Fan Q, Wang X.
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| Oncol Rep 25(3):841-8. doi: 10.3892/or.2010.1122. Epub 2010 Dec 24.
2011
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| 23 | ITGB2, TIAM1
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| TCR-induced activation of LFA-1 involves signaling through Tiam1.
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| Grönholm M, Jahan F, Marchesan S, Karvonen U, Aatonen M, Narumanchi S, Gahmberg CG.
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| J Immunol 187(7):3613-9. Epub 2011 Aug 29.
2011
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| 24 | TIAM1
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| The role of fibroblast Tiam1 in tumor cell invasion and metastasis.
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| Xu K, Rajagopal S, Klebba I, Dong S, Ji Y, Liu J, Kuperwasser C, Garlick JA, Naber SP, Buchsbaum RJ.
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| Oncogene 29(50):6533-42. Epub 2010 Aug 30.
2010
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| 25 | CNTNAP4, SDC1, TIAM1
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| The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.
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| Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ.
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| J Mol Biol 398(5):730-46. Epub 2010 Mar 31.
2010
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| 26 | TIAM1
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| Tiam1 as a signaling mediator of nerve growth factor-dependent neurite outgrowth.
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| Shirazi Fard S, Kele J, Vilar M, Paratcha G, Ledda F.
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| PLoS One 5(3):e9647.
2010
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| 27 | CADM1, TIAM1
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| CADM1 interacts with Tiam1 and promotes invasive phenotype of human T-cell leukemia virus type I-transformed cells and adult T-cell leukemia cells.
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| Masuda M, Maruyama T, Ohta T, Ito A, Hayashi T, Tsukasaki K, Kamihira S, Yamaoka S, Hoshino H, Yoshida T, Watanabe T, Stanbridge EJ, Murakami Y.
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| J Biol Chem 285(20):15511-22. Epub 2010 Mar 9.
2010
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| 28 | BAIAP2, PPP1R9B, TIAM1
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| Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1).
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| Rajagopal S, Ji Y, Xu K, Li Y, Wicks K, Liu J, Wong KW, Herman IM, Isberg RR, Buchsbaum RJ.
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| J Biol Chem 285(23):18060-71. Epub 2010 Apr 1.
2010
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| 29 | EPHA5, EPHA8, TIAM1
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| EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor.
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| Yoo S, Shin J, Park S.
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| Mol Cells 29(6):603-9. doi: 10.1007/s10059-010-0075-2. Epub 2010 May 22.
2010
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| 30 | TIAM1
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| SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1.
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| Woodcock SA, Rooney C, Liontos M, Connolly Y, Zoumpourlis V, Whetton AD, Gorgoulis VG, Malliri A.
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| Mol Cell 33(5):639-53.
2009
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| 31 | TIAM1
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| The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration.
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| Gérard A, van der Kammen RA, Janssen H, Ellenbroek SI, Collard JG.
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| Blood 113(24):6138-47. Epub 2009 Jan 12.
2009
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| 32 | TIAM1
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| Tiam1 and Rac1 are required for platelet-activating factor-induced endothelial junctional disassembly and increase in vascular permeability.
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| Knezevic II, Predescu SA, Neamu RF, Gorovoy MS, Knezevic NM, Easington C, Malik AB, Predescu DN.
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| J Biol Chem 284(8):5381-94. Epub 2008 Dec 17.
2009
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| 33 | RAC1, TIAM1
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| The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development.
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| Tolias KF, Bikoff JB, Kane CG, Tolias CS, Hu L, Greenberg ME.
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| Proc Natl Acad Sci U S A 104(17):7265-70. Epub 2007 Apr 17.
2007
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| 34 | TIAM1
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| Tiam1 regulates cell adhesion, migration and apoptosis in colon tumor cells.
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| Minard ME, Ellis LM, Gallick GE.
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| Clin Exp Metastasis 23(5-6):301-13. Epub 2006 Nov 3.
2006
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| 35 | TIAM1
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| Tiam1 gene expression and its significance in colorectal carcinoma.
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| Liu L, Wu DH, Ding YQ.
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| World J Gastroenterol 11(5):705-7. 2005
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| 36 | PARD3, TIAM1
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| Par-3 controls tight junction assembly through the Rac exchange factor Tiam1.
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| Chen X, Macara IG.
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| Nat Cell Biol 7(3):262-9. Epub 2005 Feb 20. 2005
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| 37 | EPHA2, EPHB1, TIAM1
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| Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2.
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| Tanaka M, Ohashi R, Nakamura R, Shinmura K, Kamo T, Sakai R, Sugimura H.
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| EMBO J 23(5):1075-88. Epub 2004 Feb 26.
2004
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| 38 | TIAM1, TIAM2
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| Roles of STEF/Tiam1, guanine nucleotide exchange factors for Rac1, in regulation of growth cone morphology.
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| Matsuo N, Terao M, Nabeshima Y, Hoshino M.
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| Mol Cell Neurosci 24(1):69-81. 2003
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| 39 | TIAM1
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| Increased levels of a chromosome 21-encoded tumour invasion and metastasis factor (TIAMI) mRNA in bone marrow of Down syndrome children during the acute phase of AML(M7).
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| Ives JH, et al.
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| Genes Chromosomes Cancer 23 : 61-66. 1998
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| 40 | RHOA, TIAM1
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| Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling.
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| Stam JC, Michiels F, van der Kammen RA, Moolenaar WH, Collard JG.
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| EMBO J 17(14):4066-74. 1998
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| 41 | TIAM1
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| Localization of a human homolog of the mouse Tiam-1 gene to chromosome 21q22.1.
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| Chen H, et al.
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| Genomics 30 : 123-127. 1995
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| 42 | TIAM1
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| The invasion-inducing TIAM1 gene maps to human chromosome band 21q22 and mouse chromosome 16.
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| Habets GGM, et al.
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| Cytogenet Cell Genet 70 : 48-51. 1995
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| 43 | TIAM1
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| Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.
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| Habets GGM, et al.
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| Cell 77 : 537-549. 1994
|