| 1 | NCOA4, THRB
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| Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
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| Gao X, Lee HY, Li W, Platt RJ, Barrasa MI, Ma Q, Elmes RR, Rosenfeld MG, Lodish HF.
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| Proc Natl Acad Sci U S A 114(38):10107-10112. doi: 10.1073/pnas.1711058114. Epub 2017 Sep 1.
2017
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| 2 | THRA, THRB
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| Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration.
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| Ma H, Yang F, Butler MR, Belcher J, Redmond TM, Placzek AT, Scanlan TS, Ding XQ.
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| FASEB J. Aug;31(8):3425-3438. doi: 10.1096/fj.201601166RR. Epub 2017 Apr 20 2017
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| 3 | CHNG6, GHTR, THRA, THRB
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| Thyroid hormone receptors and resistance to thyroid hormone disorders.
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| Ortiga-Carvalho TM, Sidhaye AR, Wondisford FE.
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| Nat Rev Endocrinol. Oct;10(10):582-91. doi: 10.1038/nrendo.2014.143. Epub 2014 Aug 19 2014
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| 4 | G6PC, PCK1, THRA, THRB
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| FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes.
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| Singh BK, Sinha RA, Zhou J, Xie SY, You SH, Gauthier K, Yen PM.
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| J Biol Chem 18;288(42):30365-72. doi: 10.1074/jbc.M113.504845. Epub 2013 Aug 30 2013
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| 5 | GHTR, THRB
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| Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).
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| Fozzatti L, Lu C, Kim DW, Park JW, Astapova I, Gavrilova O, Willingham MC, Hollenberg AN, Cheng SY.
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| Proc Natl Acad Sci U S A 108(42):17462-7. Epub 2011 Oct 10.
2011
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| 6 | CYP3A4, NR1I2, NR2F1, NR2F2, THRA, THRB
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| Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding.
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| Istrate MA, Nussler AK, Eichelbaum M, Burk O.
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| Biochem Biophys Res Commun 393(4):688-93. Epub 2010 Feb 18.PMID: 20171174 2010
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| 7 | THRB
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| Identification of a novel human thyroid hormone receptor beta isoform as a transcriptional modulator.
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| Tagami T, Yamamoto H, Moriyama K, Sawai K, Usui T, Shimatsu A, Naruse M.
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| Biochem Biophys Res Commun 396(4):983-8. Epub 2010 May 12.
2010
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| 8 | THRB
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| Thyroid hormone receptor beta mutation causes severe impairment of cerebellar development.
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| Portella AC, Carvalho F, Faustino L, Wondisford FE, Ortiga-Carvalho TM, Gomes FC.
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| Mol Cell Neurosci 44(1):68-77. Epub 2010 Mar 1.PMID: 20193766 2010
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| 9 | THRB
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| Aberrant methylation of the THRB gene in tissue and plasma of breast cancer patients.
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| Ling Y, Xu X, Hao J, Ling X, Du X, Liu X, Zhao X.
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| Cancer Genet Cytogenet 196(2):140-5.PMID: 20082849 2010
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| 10 | GATA2, THRB, TSHB
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| Dissecting the Relation between a nuclear receptor and GATA: binding affinity studies of thyroid hormone receptor and GATA2 on TSHβ promoter.
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| Figueira AC, Polikarpov I, Veprintsev D, Santos GM.
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| PLoS One 5(9):e12628. doi: 10.1371/journal.pone.0012628.
2010
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| 11 | THRA, THRB
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| Isoform-specific transcriptional activity of overlapping target genes that respond to thyroid hormone receptors alpha1 and beta1.
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| Chan IH, Privalsky ML.
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| Mol Endocrinol 23(11):1758-75. Epub 2009 Jul 23.PMID: 19628582 2009
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| 12 | THRB
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| Developmental expression of thyroid hormone receptor beta2 protein in cone photoreceptors in the mouse.
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| Ng L, Ma M, Curran T, Forrest D.
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| Neuroreport 20(6):627-31.PMID: 19282790 2009
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| 13 | GHTR, THRB
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| Biochemical characterization of four novel mutations in the thyroid hormone receptor beta gene in patients with resistance to thyroid hormone.
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| Asadi AB, Torjesen PA, Haug E, Berg JP.
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| Scand J Clin Lab Invest 68(7):563-7.PMID: 19378427 2008
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| 14 | THRB
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| Lack of Mutations in the Thyroid Hormone Receptor (TR) {alpha} and Genes but Frequent Hypermethylation of the TR Gene in Differentiated Thyroid Tumors.
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| Joseph B, Ji M, Liu D, Hou P, Xing M.
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| J Clin Endocrinol Metab 92(12):4766-70. Epub 2007 Oct 2. 2007
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| 15 | THRA, THRB
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| Lack of mutations in the thyroid hormone receptor (TR) alpha and beta genes but frequent hypermethylation of the TRbeta gene in differentiated thyroid tumors.
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| Joseph B, Ji M, Liu D, Hou P, Xing M.
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| J Clin Endocrinol Metab 92(12):4766-70. Epub 2007 Oct 2.
2007
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| 16 | OPN1SW, THRB
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| Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis.
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| Applebury ML, Farhangfar F, Glösmann M, Hashimoto K, Kage K, Robbins JT, Shibusawa N, Wondisford FE, Zhang H.
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| Dev Dyn 236(5):1203-12.
2007
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| 17 | THRB
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| A novel splice variant involving the 5' untranslated region of thyroid hormone receptor beta1 (TRbeta1).
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| Mannavola D, Moeller LC, Beck-Peccoz P, Persani L, Weiss RE, Refetoff S.
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| J Endocrinol Invest 27(4):318-22. 2004
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| 18 | THRA, THRB
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| Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer.
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| Silva JM, Dominguez G, Gonzalez-Sancho JM, Garcia JM, Silva J, Garcia-Andrade C, Navarro A, Munoz A, Bonilla F.
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| Oncogene 21(27):4307-16. 2002
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| 19 | THRB
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| A thyroid hormone receptor that is required for the development of green cone photoreceptors.
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| Ng L, Hurley JB, Dierks B, Srinivas M, Salto C, Vennstrom B, Reh TA, Forrest D.
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| Nat Genet 27(1):94-8. 2001
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| 20 | GHTR, THRB
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| A Novel Mutation (M310L) in the Thyroid Hormone Receptor beta Causing Resistance to Thyroid Hormone in a Brazilian Kindred and a Neonate.
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| Furlanetto TW, Kopp P, Peccin S, Gu WX, Jameson JL.
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| Mol Genet Metab 71(3):520-526. 2000
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| 21 | THRB
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| Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone.
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| Kaneshige M, Kaneshige K, Zhu X, Dace A, Garrett L, Carter TA, Kazlauskaite R, Pankratz DG, Wynshaw-Boris A, Refetoff S, Weintraub B, Willingham MC, Barlow C, Cheng S.
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| Proc Natl Acad Sci U S A 97(24):13209-14. 2000
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| 22 | NR1D2, RARB, THRB
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| Linkage of the nuclear hormone receptor genes NR1D2, THRB, and RARB: evidence for an ancient, large-scale duplication.
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| Koh YS, et al.
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| Genomics 57(2):289-92. 1999
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| 23 | GHTR, THRB
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| A novel TRbeta mutation (R383H) in resistance to thyroid hormone syndrome predominantly impairs corepressor release and negative transcriptional regulation.
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| Clifton-Bligh RJ, et al.
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| Mol Endocrinol 12 : 609-621. 1998
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| 24 | GHTR, THRB
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| Detection of a new de novo mutation at codon 251 of exon 8 of thyroid hormone receptor beta gene in an Italian kindred with resistance to thyroid hormone.
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| Macchia E, et al.
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| J Endocrinol Invest 21 : 226-233. 1998
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| 25 | GHTR, THRB
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| A natural transactivation mutation in the thyroid hormone beta receptor : impaired interaction with putative transcriptional mediators.
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| Collingwood TN, et al.
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| Proc Natl Acad Sci U S A 94 : 248-253. 1997
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| 26 | GHTR, THRB
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| A mutant thyroid hormone receptor beta 1 identified in a patient with resistance to thyroid hormone inhibits the activities of not only the wild-type TRs, but also other nuclear receptors.
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| Miyoshi Y, Nakao K.
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| Biochem Biophys Res Commun 238(1):39-43. 1997
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| 27 | GHTR, THRB
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| A novel missense mutation in the thyroid hormone receptor beta gene in akindred with resistance to thyroid hormone.
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| Kijima H, et al.
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| Hum Genet 97 : 407-408. 1996
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| 28 | THRB, GHTR
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| Thyroid hormone receptor beta is essential for development of auditory function.
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| Forrest D, et al.
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| Nat Genet 13 : 354-357. 1996
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| 29 | GHTR, THRB
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| New point mutation (R243W) in the hormone binding domain of the c-erbA beta1 gene in a family with generalized resistance to thyroid hormone.
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| Pohlenz J, et al.
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| Hum Mutat 7 : 79-81. 1996
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| 30 | GHTR, THRB
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| Three novel mutations of thyroid hormone receptor beta gene in unrelated patients with resistance to thyroid hormone : two mutations of the same codon (H435L and H435Q) produce separate subtypes of resistance.
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| Tsukaguchi H, et al.
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| J Clin Endocrinol Metab 80 : 3613-3616. 1995
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| 31 | GHTR, THRB
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| Phenotypic variability in patients with generalised resistance to thyroid hormone.
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| Pohlenz J, et al.
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| J Med Genet 32 : 393-395. 1995
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| 32 | THRB, GHTR
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| Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone.
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| Adams M, et al.
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| J Clin Invest 94 : 506-515. 1994
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| 33 | GHTR, THRB
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| Three new mutations of thyroid hormone receptor-beta associated with resistance to thyroid hormone.
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| Bartolone L, et al.
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| J Clin Endocrinol Metab 79 : 323-326. 1994
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| 34 | GHTR, THRB
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| A new point mutation (C446R) in the thyroid hormone receptor-beta gene of a family with resistance to thyroid hormone.
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| Weiss RE, et al.
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| J Clin Endocrinol Metab 78 : 1253-1256. 1994
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| 35 | THRB
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| Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine-guanine-rich areas of the thyroid hormone receptor beta gene. Analysis of 15 families.
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| Weiss RE, et al.
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| J Clin Invest 91 : 2408-2415. 1993
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| 36 | THRB
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| A microsatellite polymorphism at the THRB locus.
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| Brett PM, et al.
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| Hum Mol Genet 2 : 1083. 1993
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| 37 | NR1D2, P4HB, THRB
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| Close proximity of c-erbA2 and c-erbA-beta genes on the short arm of chromosome 3.
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| Ali IU, et al.
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| Oncogene 8 : 2299-2301. 1993
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| 38 | THRB
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| An arginine to histidine mutation in codon 311 of the C-erbA-beta gene results in a mutant thyroid hormone receptor that does not mediate a dominant negative phenotype.
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| Geffner ME, et al.
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| J Clin Invest 91 : 538-546. 1993
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| 39 | THRB
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| A point mutation of the T3 receptor beta1 gene in a kindred of generalized resistance to thyroid hormone.
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| Sasaki S, et al.
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| Mol Cell Endocrinol 84 : 159-166. 1992
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| 40 | APEH, THRB, D3S3
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| Localization of three novel hybrid breakpoints and refinement of 18 marker assignments in the human 3cen-p21.1 region.
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| Wang N, et al.
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| Genomics 14 : 891-896. 1992
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| 41 | THRB
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| Recessive inheritance of thyroid hormone resitance caused by complete deletion of the protein-coding region of the thyroid hormone receptor-beta gene.
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| Takeda K, et al.
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| J Clin Endocrinol Metab 74 : 49-55. 1992
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| 42 | THRB
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| Thyroid hormone resistance syndrome. Inhibition of normal receptor function by mutant hormone receptors.
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| Chatterjee VKK, et al.
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| J Clin Invest 87 : 1977-1984. 1991
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| 43 | THRB
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| Polymerase chain reaction (PCR) for detection of BamHI polymorphism at the THRB gene.
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| Ganly PS, et al.
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| Nucleic Acids Res 19 : 3757. 1991
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| 44 | THRB
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| Polymerase chain reaction (PCR) for detection of MspI and DraI polymorphism at the THRB gene.
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| Ganly PS, et al.
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| Nucleic Acids Res 19 : 3760. 1991
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| 45 | THRB
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| PCR detection of the HindIII polymorphism at the thyroid hormone receptor, beta, gene (THRB).
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| Ganly PS, et al.
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| Nucleic Acids Res 19 : 3761. 1991
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| 46 | THRB
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| A homozygous deletion in the c-erbA-beta thyroid hormone receptor gene in a patient with generalized thyroid hormone resistance : isolation and characterization of the mutant receptor.
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| Usala SJ, et al.
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| Mol Endocrinol 5 : 327-335. 1991
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| 47 | THRB
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| BglI RFLP for the human erb-A-beta locus on chromosome 3p22-3p24.1 (THRB).
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| Kanaka C, et al.
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| Nucleic Acids Res 19 : 4574. 1991
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| 48 | THRB
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| Homozygosity for a dominant negative thyroid hormone receptor gene responsible for generalized resistance to thyroid hormone.
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| Ono S, et al.
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| J Clin Endocrinol Metab 73 : 990-994. 1991
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| 49 | THRB
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| Single base mutation in the hormone binding domain of the thyroid hormone receptor beta gene in generalised thyroid hormone resistance demonstrated by single stranded conformation polymorphism analysis.
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| Boothroyd CV, et al.
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| Biochem Biophys Res Commun 178 : 606-612. 1991
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| 50 | THRB
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| Dinucleotide repeat polymorphism in the human thyroid hormone receptor beta gene (THRB) on chromosome 3.
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| Sakurai A, et al.
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| Nucleic Acids Res 19 : 6661. 1991
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| 51 | THRB
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| Screening of nineteen unrelated families with generalized resistance to thyroid hormone for known point mutations in the thyroid hormone receptor beta gene and the detection of a new mutation.
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| Takeda K, et al.
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| J Clin Invest 87 : 496-502. 1991
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| 52 | THRB
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| A pulsed-field gel electrophoresis map locates the polymorphic probes for ERBA2 and ErbA-beta within 120kb of each other, confirming that THRB (formerly ERBA2) maps to chromosome 3.
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| Douglas JB, et al.
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| Genomics 9 : 398-400. 1991
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| 53 | THRB
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| Mspl and Dral polymorphisms at the ERBA beta locus on chromosome 3p.
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| Brauch H, et al.
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| Nucleic Acids Res 18 : 2833. 1990
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| 54 | THRB
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| A base mutation of the c-erbA-beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance: molecular heterogeneity in two other kindreds.
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| Usala SJ, et al.
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| J Clin Invest 85 : 93-100. 1990
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| 55 | THRB, RARB, RAF1
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| Co-localization of the chromosome 3 genes; thyroid hormone receptor (THRB) retinoic acid receptor (RARB) and the rat oncogene (RAFI) to 3p24.2-3p25.
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| Wood ME, et al.
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| Am J Hum Genet 47 : A266. 1990
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| 56 | THRB
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| Dominant negative transcriptional regulation by a mutant thyroid hormone receptor-beta in a family with generalized resistance to thyroid hormone.
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| Sakurai A, et al.
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| Mol Endocrinol 4 : 1988-1994. 1990
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| 57 | THRB, TSG3B
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| Localization of the human ERBA2 to the 3p22-3p24.1 region of chromosome 3 and variable deletion in small cell lung cancer.
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| Drabkin H, Kao FT, Hartz J, Hart I, Gazdar A, Weinberger C, Evans R, Gerber M.
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| Proc Natl Acad Sci U S A 85 : 9258-9262. 1988
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| 58 | P4HB, THRB, TSG3B
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| erb-A-related sequence coding for DNA-binding hormone receptor localizedto chromosome 3p21-3p25 and deleted in small lung carcinoma.
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| Dobrovic A, et al.
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| Cancer Res 48 : 682-685. 1988
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| 59 | THRB
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| Tight linkage between the syndrome of generalized thyroid hormone resistance and the human c-erbA-beta gene.
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| Usala SJ, et al.
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| Mol Endocrinol 2 : 1217-1220. 1988
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| 60 | RARB, THRB
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| A frequent HindIII RFLP on chromosome 3p21-25 detected by a genomic erbAbeta sequence.
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| Gareau JLP, et al.
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| Nucleic Acids Res 16 : 1223. 1988
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| 61 | THRB
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| A cDNA probe (PheA12) from the hc-(ERBA) gene on chromosome 3 detects a high frequency RFLP.
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| Bale AE, et al.
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| Nucleic Acids Res 16 : 7756. 1988
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| 62 | THRB
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| RFLP for the human erb-A§ locus.
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| Wyllie FS, et al.
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| Nucleic Acids Res 16 : 5224. 1988
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| 63 | THRB
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| The thyroid hormone receptor (THR) maps to the chromosome region 3p21-p25 and is deleted in small cell lung carcinoma.
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| Dobrovic A, et al.
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| (HGM9) Cytogenet Cell Genet 46 : 607. 1987
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| 64 | THRB
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| Localization of the oncogene c-erbA2 to human chromosome 3.
|
| Rider SH, et al.
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| Ann Hum Genet 51 : 153-160. 1987
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| 65 | THRB
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| Human c-erb-A is located at chromosome 3p21.33-p22.
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| Drabkin HA, et al.
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| Am J Hum Genet 41 : A25. 1987
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| 66 | THRB
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| Chromosomal localization of the human oncogene ERBA2.
|
| Gosden JR, et al.
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| Cytogenet Cell Genet 43 : 150-153. 1986
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| 67 | THRA, THRB
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| The c-erb-A gene encodes a thyroid hormone receptor.
|
| Weinberger C, et al.
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| Nature 324 : 641-646. 1986
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| 68 | THRA, THRB
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| The c-erb-A protein is a high-affinity receptor for thyroid hormone.
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| Sap J, et al.
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| Nature 324 : 635-640. 1986
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| 69 | THRB
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| Familial partial target organ resistance to thyroid hormones.
|
| Elewaut A, et al.
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| J Clin Endocrinol Metab 43 : 575-580. 1976
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| 70 | THRB
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| Familial syndrome combining deaf-mutism, stippled epiphyses, goiter and abnormally high PBI : possible target organ refractoriness to thyroid hormone.
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| Refetoff S, et al.
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| J Clin Endocrinol Metab 27 : 279-294. 1967
|