Citations for
1NCOA4, THRB
Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
Gao X, Lee HY, Li W, Platt RJ, Barrasa MI, Ma Q, Elmes RR, Rosenfeld MG, Lodish HF.
Proc Natl Acad Sci U S A 114(38):10107-10112. doi: 10.1073/pnas.1711058114. Epub 2017 Sep 1. 2017
2THRA, THRB
Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration.
Ma H, Yang F, Butler MR, Belcher J, Redmond TM, Placzek AT, Scanlan TS, Ding XQ.
FASEB J. Aug;31(8):3425-3438. doi: 10.1096/fj.201601166RR. Epub 2017 Apr 20 2017
3CHNG6, GHTR, THRA, THRB
Thyroid hormone receptors and resistance to thyroid hormone disorders.
Ortiga-Carvalho TM, Sidhaye AR, Wondisford FE.
Nat Rev Endocrinol. Oct;10(10):582-91. doi: 10.1038/nrendo.2014.143. Epub 2014 Aug 19 2014
4G6PC, PCK1, THRA, THRB
FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes.
Singh BK, Sinha RA, Zhou J, Xie SY, You SH, Gauthier K, Yen PM.
J Biol Chem 18;288(42):30365-72. doi: 10.1074/jbc.M113.504845. Epub 2013 Aug 30 2013
5GHTR, THRB
Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).
Fozzatti L, Lu C, Kim DW, Park JW, Astapova I, Gavrilova O, Willingham MC, Hollenberg AN, Cheng SY.
Proc Natl Acad Sci U S A 108(42):17462-7. Epub 2011 Oct 10. 2011
6CYP3A4, NR1I2, NR2F1, NR2F2, THRA, THRB
Regulation of CYP3A4 by pregnane X receptor: The role of nuclear receptors competing for response element binding.
Istrate MA, Nussler AK, Eichelbaum M, Burk O.
Biochem Biophys Res Commun 393(4):688-93. Epub 2010 Feb 18.PMID: 20171174 2010
7THRB
Identification of a novel human thyroid hormone receptor beta isoform as a transcriptional modulator.
Tagami T, Yamamoto H, Moriyama K, Sawai K, Usui T, Shimatsu A, Naruse M.
Biochem Biophys Res Commun 396(4):983-8. Epub 2010 May 12. 2010
8THRB
Thyroid hormone receptor beta mutation causes severe impairment of cerebellar development.
Portella AC, Carvalho F, Faustino L, Wondisford FE, Ortiga-Carvalho TM, Gomes FC.
Mol Cell Neurosci 44(1):68-77. Epub 2010 Mar 1.PMID: 20193766 2010
9THRB
Aberrant methylation of the THRB gene in tissue and plasma of breast cancer patients.
Ling Y, Xu X, Hao J, Ling X, Du X, Liu X, Zhao X.
Cancer Genet Cytogenet 196(2):140-5.PMID: 20082849 2010
10GATA2, THRB, TSHB
Dissecting the Relation between a nuclear receptor and GATA: binding affinity studies of thyroid hormone receptor and GATA2 on TSHβ promoter.
Figueira AC, Polikarpov I, Veprintsev D, Santos GM.
PLoS One 5(9):e12628. doi: 10.1371/journal.pone.0012628. 2010
11THRA, THRB
Isoform-specific transcriptional activity of overlapping target genes that respond to thyroid hormone receptors alpha1 and beta1.
Chan IH, Privalsky ML.
Mol Endocrinol 23(11):1758-75. Epub 2009 Jul 23.PMID: 19628582 2009
12THRB
Developmental expression of thyroid hormone receptor beta2 protein in cone photoreceptors in the mouse.
Ng L, Ma M, Curran T, Forrest D.
Neuroreport 20(6):627-31.PMID: 19282790 2009
13GHTR, THRB
Biochemical characterization of four novel mutations in the thyroid hormone receptor beta gene in patients with resistance to thyroid hormone.
Asadi AB, Torjesen PA, Haug E, Berg JP.
Scand J Clin Lab Invest 68(7):563-7.PMID: 19378427 2008
14THRB
Lack of Mutations in the Thyroid Hormone Receptor (TR) {alpha} and Genes but Frequent Hypermethylation of the TR Gene in Differentiated Thyroid Tumors.
Joseph B, Ji M, Liu D, Hou P, Xing M.
J Clin Endocrinol Metab 92(12):4766-70. Epub 2007 Oct 2. 2007
15THRA, THRB
Lack of mutations in the thyroid hormone receptor (TR) alpha and beta genes but frequent hypermethylation of the TRbeta gene in differentiated thyroid tumors.
Joseph B, Ji M, Liu D, Hou P, Xing M.
J Clin Endocrinol Metab 92(12):4766-70. Epub 2007 Oct 2. 2007
16OPN1SW, THRB
Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis.
Applebury ML, Farhangfar F, Glösmann M, Hashimoto K, Kage K, Robbins JT, Shibusawa N, Wondisford FE, Zhang H.
Dev Dyn 236(5):1203-12. 2007
17THRB
A novel splice variant involving the 5' untranslated region of thyroid hormone receptor beta1 (TRbeta1).
Mannavola D, Moeller LC, Beck-Peccoz P, Persani L, Weiss RE, Refetoff S.
J Endocrinol Invest 27(4):318-22. 2004
18THRA, THRB
Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer.
Silva JM, Dominguez G, Gonzalez-Sancho JM, Garcia JM, Silva J, Garcia-Andrade C, Navarro A, Munoz A, Bonilla F.
Oncogene 21(27):4307-16. 2002
19THRB
A thyroid hormone receptor that is required for the development of green cone photoreceptors.
Ng L, Hurley JB, Dierks B, Srinivas M, Salto C, Vennstrom B, Reh TA, Forrest D.
Nat Genet 27(1):94-8. 2001
20GHTR, THRB
A Novel Mutation (M310L) in the Thyroid Hormone Receptor beta Causing Resistance to Thyroid Hormone in a Brazilian Kindred and a Neonate.
Furlanetto TW, Kopp P, Peccin S, Gu WX, Jameson JL.
Mol Genet Metab 71(3):520-526. 2000
21THRB
Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone.
Kaneshige M, Kaneshige K, Zhu X, Dace A, Garrett L, Carter TA, Kazlauskaite R, Pankratz DG, Wynshaw-Boris A, Refetoff S, Weintraub B, Willingham MC, Barlow C, Cheng S.
Proc Natl Acad Sci U S A 97(24):13209-14. 2000
22NR1D2, RARB, THRB
Linkage of the nuclear hormone receptor genes NR1D2, THRB, and RARB: evidence for an ancient, large-scale duplication.
Koh YS, et al.
Genomics 57(2):289-92. 1999
23GHTR, THRB
A novel TRbeta mutation (R383H) in resistance to thyroid hormone syndrome predominantly impairs corepressor release and negative transcriptional regulation.
Clifton-Bligh RJ, et al.
Mol Endocrinol 12 : 609-621. 1998
24GHTR, THRB
Detection of a new de novo mutation at codon 251 of exon 8 of thyroid hormone receptor beta gene in an Italian kindred with resistance to thyroid hormone.
Macchia E, et al.
J Endocrinol Invest 21 : 226-233. 1998
25GHTR, THRB
A natural transactivation mutation in the thyroid hormone beta receptor : impaired interaction with putative transcriptional mediators.
Collingwood TN, et al.
Proc Natl Acad Sci U S A 94 : 248-253. 1997
26GHTR, THRB
A mutant thyroid hormone receptor beta 1 identified in a patient with resistance to thyroid hormone inhibits the activities of not only the wild-type TRs, but also other nuclear receptors.
Miyoshi Y, Nakao K.
Biochem Biophys Res Commun 238(1):39-43. 1997
27GHTR, THRB
A novel missense mutation in the thyroid hormone receptor beta gene in akindred with resistance to thyroid hormone.
Kijima H, et al.
Hum Genet 97 : 407-408. 1996
28THRB, GHTR
Thyroid hormone receptor beta is essential for development of auditory function.
Forrest D, et al.
Nat Genet 13 : 354-357. 1996
29GHTR, THRB
New point mutation (R243W) in the hormone binding domain of the c-erbA beta1 gene in a family with generalized resistance to thyroid hormone.
Pohlenz J, et al.
Hum Mutat 7 : 79-81. 1996
30GHTR, THRB
Three novel mutations of thyroid hormone receptor beta gene in unrelated patients with resistance to thyroid hormone : two mutations of the same codon (H435L and H435Q) produce separate subtypes of resistance.
Tsukaguchi H, et al.
J Clin Endocrinol Metab 80 : 3613-3616. 1995
31GHTR, THRB
Phenotypic variability in patients with generalised resistance to thyroid hormone.
Pohlenz J, et al.
J Med Genet 32 : 393-395. 1995
32THRB, GHTR
Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone.
Adams M, et al.
J Clin Invest 94 : 506-515. 1994
33GHTR, THRB
Three new mutations of thyroid hormone receptor-beta associated with resistance to thyroid hormone.
Bartolone L, et al.
J Clin Endocrinol Metab 79 : 323-326. 1994
34GHTR, THRB
A new point mutation (C446R) in the thyroid hormone receptor-beta gene of a family with resistance to thyroid hormone.
Weiss RE, et al.
J Clin Endocrinol Metab 78 : 1253-1256. 1994
35THRB
Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine-guanine-rich areas of the thyroid hormone receptor beta gene. Analysis of 15 families.
Weiss RE, et al.
J Clin Invest 91 : 2408-2415. 1993
36THRB
A microsatellite polymorphism at the THRB locus.
Brett PM, et al.
Hum Mol Genet 2 : 1083. 1993
37NR1D2, P4HB, THRB
Close proximity of c-erbA2 and c-erbA-beta genes on the short arm of chromosome 3.
Ali IU, et al.
Oncogene 8 : 2299-2301. 1993
38THRB
An arginine to histidine mutation in codon 311 of the C-erbA-beta gene results in a mutant thyroid hormone receptor that does not mediate a dominant negative phenotype.
Geffner ME, et al.
J Clin Invest 91 : 538-546. 1993
39THRB
A point mutation of the T3 receptor beta1 gene in a kindred of generalized resistance to thyroid hormone.
Sasaki S, et al.
Mol Cell Endocrinol 84 : 159-166. 1992
40APEH, THRB, D3S3
Localization of three novel hybrid breakpoints and refinement of 18 marker assignments in the human 3cen-p21.1 region.
Wang N, et al.
Genomics 14 : 891-896. 1992
41THRB
Recessive inheritance of thyroid hormone resitance caused by complete deletion of the protein-coding region of the thyroid hormone receptor-beta gene.
Takeda K, et al.
J Clin Endocrinol Metab 74 : 49-55. 1992
42THRB
Thyroid hormone resistance syndrome. Inhibition of normal receptor function by mutant hormone receptors.
Chatterjee VKK, et al.
J Clin Invest 87 : 1977-1984. 1991
43THRB
Polymerase chain reaction (PCR) for detection of BamHI polymorphism at the THRB gene.
Ganly PS, et al.
Nucleic Acids Res 19 : 3757. 1991
44THRB
Polymerase chain reaction (PCR) for detection of MspI and DraI polymorphism at the THRB gene.
Ganly PS, et al.
Nucleic Acids Res 19 : 3760. 1991
45THRB
PCR detection of the HindIII polymorphism at the thyroid hormone receptor, beta, gene (THRB).
Ganly PS, et al.
Nucleic Acids Res 19 : 3761. 1991
46THRB
A homozygous deletion in the c-erbA-beta thyroid hormone receptor gene in a patient with generalized thyroid hormone resistance : isolation and characterization of the mutant receptor.
Usala SJ, et al.
Mol Endocrinol 5 : 327-335. 1991
47THRB
BglI RFLP for the human erb-A-beta locus on chromosome 3p22-3p24.1 (THRB).
Kanaka C, et al.
Nucleic Acids Res 19 : 4574. 1991
48THRB
Homozygosity for a dominant negative thyroid hormone receptor gene responsible for generalized resistance to thyroid hormone.
Ono S, et al.
J Clin Endocrinol Metab 73 : 990-994. 1991
49THRB
Single base mutation in the hormone binding domain of the thyroid hormone receptor beta gene in generalised thyroid hormone resistance demonstrated by single stranded conformation polymorphism analysis.
Boothroyd CV, et al.
Biochem Biophys Res Commun 178 : 606-612. 1991
50THRB
Dinucleotide repeat polymorphism in the human thyroid hormone receptor beta gene (THRB) on chromosome 3.
Sakurai A, et al.
Nucleic Acids Res 19 : 6661. 1991
51THRB
Screening of nineteen unrelated families with generalized resistance to thyroid hormone for known point mutations in the thyroid hormone receptor beta gene and the detection of a new mutation.
Takeda K, et al.
J Clin Invest 87 : 496-502. 1991
52THRB
A pulsed-field gel electrophoresis map locates the polymorphic probes for ERBA2 and ErbA-beta within 120kb of each other, confirming that THRB (formerly ERBA2) maps to chromosome 3.
Douglas JB, et al.
Genomics 9 : 398-400. 1991
53THRB
Mspl and Dral polymorphisms at the ERBA beta locus on chromosome 3p.
Brauch H, et al.
Nucleic Acids Res 18 : 2833. 1990
54THRB
A base mutation of the c-erbA-beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance: molecular heterogeneity in two other kindreds.
Usala SJ, et al.
J Clin Invest 85 : 93-100. 1990
55THRB, RARB, RAF1
Co-localization of the chromosome 3 genes; thyroid hormone receptor (THRB) retinoic acid receptor (RARB) and the rat oncogene (RAFI) to 3p24.2-3p25.
Wood ME, et al.
Am J Hum Genet 47 : A266. 1990
56THRB
Dominant negative transcriptional regulation by a mutant thyroid hormone receptor-beta in a family with generalized resistance to thyroid hormone.
Sakurai A, et al.
Mol Endocrinol 4 : 1988-1994. 1990
57THRB, TSG3B
Localization of the human ERBA2 to the 3p22-3p24.1 region of chromosome 3 and variable deletion in small cell lung cancer.
Drabkin H, Kao FT, Hartz J, Hart I, Gazdar A, Weinberger C, Evans R, Gerber M.
Proc Natl Acad Sci U S A 85 : 9258-9262. 1988
58P4HB, THRB, TSG3B
erb-A-related sequence coding for DNA-binding hormone receptor localizedto chromosome 3p21-3p25 and deleted in small lung carcinoma.
Dobrovic A, et al.
Cancer Res 48 : 682-685. 1988
59THRB
Tight linkage between the syndrome of generalized thyroid hormone resistance and the human c-erbA-beta gene.
Usala SJ, et al.
Mol Endocrinol 2 : 1217-1220. 1988
60RARB, THRB
A frequent HindIII RFLP on chromosome 3p21-25 detected by a genomic erbAbeta sequence.
Gareau JLP, et al.
Nucleic Acids Res 16 : 1223. 1988
61THRB
A cDNA probe (PheA12) from the hc-(ERBA) gene on chromosome 3 detects a high frequency RFLP.
Bale AE, et al.
Nucleic Acids Res 16 : 7756. 1988
62THRB
RFLP for the human erb-A§ locus.
Wyllie FS, et al.
Nucleic Acids Res 16 : 5224. 1988
63THRB
The thyroid hormone receptor (THR) maps to the chromosome region 3p21-p25 and is deleted in small cell lung carcinoma.
Dobrovic A, et al.
(HGM9) Cytogenet Cell Genet 46 : 607. 1987
64THRB
Localization of the oncogene c-erbA2 to human chromosome 3.
Rider SH, et al.
Ann Hum Genet 51 : 153-160. 1987
65THRB
Human c-erb-A is located at chromosome 3p21.33-p22.
Drabkin HA, et al.
Am J Hum Genet 41 : A25. 1987
66THRB
Chromosomal localization of the human oncogene ERBA2.
Gosden JR, et al.
Cytogenet Cell Genet 43 : 150-153. 1986
67THRA, THRB
The c-erb-A gene encodes a thyroid hormone receptor.
Weinberger C, et al.
Nature 324 : 641-646. 1986
68THRA, THRB
The c-erb-A protein is a high-affinity receptor for thyroid hormone.
Sap J, et al.
Nature 324 : 635-640. 1986
69THRB
Familial partial target organ resistance to thyroid hormones.
Elewaut A, et al.
J Clin Endocrinol Metab 43 : 575-580. 1976
70THRB
Familial syndrome combining deaf-mutism, stippled epiphyses, goiter and abnormally high PBI : possible target organ refractoriness to thyroid hormone.
Refetoff S, et al.
J Clin Endocrinol Metab 27 : 279-294. 1967