Citations for
The Thoc1 ribonucleoprotein and prostate cancer progression.
Chinnam M, Wang Y, Zhang X, Gold DL, Khoury T, Nikitin AY, Foster BA, Li Y, Bshara W, Morrison CD, Payne Ondracek RD, Mohler JL, Goodrich DW.
J Natl Cancer Inst 106(11). pii: dju306. doi: 10.1093/jnci/dju306. Print 2014 Nov. 2014
Thoc1 inhibits cell growth via induction of cell cycle arrest and apoptosis in lung cancer cells.
Wan J, Zou S, Hu M, Zhu R, Xu J, Jiao Y, Fan S.
Mol Med Rep 9(6):2321-7. doi: 10.3892/mmr.2014.2088. Epub 2014 Mar 28. 2014
Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA.
Chi B, Wang Q, Wu G, Tan M, Wang L, Shi M, Chang X, Cheng H.
Nucleic Acids Res 41(2):1294-306. doi: 10.1093/nar/gks1188. Epub 2012 Dec 7. 2013
The THO ribonucleoprotein complex is required for stem cell homeostasis in the adult mouse small intestine.
Pitzonka L, Wang X, Ullas S, Wolff DW, Wang Y, Goodrich DW.
Mol Cell Biol 33(17):3505-14. doi: 10.1128/MCB.00751-13. Epub 2013 Jul 1. 2013
The Thoc1 encoded ribonucleoprotein is a substrate for the NEDD4-1 E3 ubiquitin protein ligase.
Song F, Fan C, Wang X, Goodrich DW.
PLoS One 8(2):e57995. doi: 10.1371/journal.pone.0057995. Epub 2013 Feb 27. 2013
The suppression of thoc1 in cancer cell apoptosis mediated by activated macrophages is nitric oxide-dependent.
Lin YS, Lin CH, Huang LD, Chao T, Kuo CD, Hung LC, Wong FH, Lin CC, Fu SL.
Biochem Pharmacol 86(2):242-52. doi: 10.1016/j.bcp.2013.05.009. Epub 2013 May 17. 2013
Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers.
Domínguez-Sánchez MS, Sáez C, Japón MA, Aguilera A, Luna R.
BMC Cancer 11:77. doi: 10.1186/1471-2407-11-77. 2011
Genome instability and transcription elongation impairment in human cells depleted of THO/TREX.
Domínguez-Sánchez MS, Barroso S, Gómez-González B, Luna R, Aguilera A.
PLoS Genet 7(12):e1002386. doi: 10.1371/journal.pgen.1002386. Epub 2011 Dec 1. 2011
Thoc1 deficiency compromises gene expression necessary for normal testis development in the mouse.
Wang X, Chinnam M, Wang J, Wang Y, Zhang X, Marcon E, Moens P, Goodrich DW.
Mol Cell Biol 29(10):2794-803. doi: 10.1128/MCB.01633-08. Epub 2009 Mar 23. 2009
Relationships of hHpr1/p84/Thoc1 expression to clinicopathologic characteristics and prognosis in non-small cell lung cancer.
Yang J, Li Y, Khoury T, Alrawi S, Goodrich DW, Tan D.
Ann Clin Lab Sci 38(2):105-12. 2008
Cancer cells and normal cells differ in their requirements for Thoc1.
Li Y, Lin AW, Zhang X, Wang Y, Wang X, Goodrich DW.
Cancer Res 67(14):6657-64. 2007
Coordination of Hpr1 and ubiquitin binding by the UBA domain of the mRNA export factor Mex67.
Hobeika M, Brockmann C, Iglesias N, Gwizdek C, Neuhaus D, Stutz F, Stewart M, Divita G, Dargemont C.
Mol Biol Cell 18(7):2561-8. Epub 2007 May 2. 2007
Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors.
Li Y, Wang X, Zhang X, Goodrich DW.
Mol Cell Biol 25(10):4023-33. 2005
Recruitment of the human TREX complex to mRNA during splicing.
Masuda S, Das R, Cheng H, Hurt E, Dorman N, Reed R.
Genes Dev 19(13):1512-7. 2005
Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation.
Rondon AG, Jimeno S, Garcia-Rubio M, Aguilera A.
J Biol Chem 278(40):39037-43. Epub 2003 Jul 18. 2003
TREX is a conserved complex coupling transcription with messenger RNA export.
Strasser K, Masuda S, Mason P, Pfannstiel J, Oppizzi M, Rodriguez-Navarro S, Rondon AG, Aguilera A, Struhl K, Reed R, Hurt E.
Nature 417(6886):304-8. 2002