| 1 | CD36, THBS1
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| Supporting roles of platelet thrombospondin-1 and CD36 in thrombus formation on collagen.
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| Kuijpers MJ, de Witt S, Nergiz-Unal R, van Kruchten R, Korporaal SJ, Verhamme P, Febbraio M, Tjwa M, Voshol PJ, Hoylaerts MF, Cosemans JM, Heemskerk JW.
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| Arterioscler Thromb Vasc Biol 34(6):1187-92. doi: 10.1161/ATVBAHA.113.302917. Epub 2014 Mar 27.
2014
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| 2 | PRMT6, THBS1
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| PRMT6 overexpression upregulates TSP-1 and downregulates MMPs: its implication in motility and invasion.
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| Kim NH, Kim SN, Seo DW, Han JW, Kim YK.
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| Biochem Biophys Res Commun 432(1):60-5. doi: 10.1016/j.bbrc.2013.01.085. Epub 2013 Feb 1.
2013
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| 3 | NOL7, THBS1
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| The novel tumor suppressor NOL7 post-transcriptionally regulates thrombospondin-1 expression.
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| Doçi CL, Zhou G, Lingen MW.
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| Oncogene 32(37):4377-86. doi: 10.1038/onc.2012.464. Epub 2012 Oct 22.
2013
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| 4 | THBS1, THBS2
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| Thrombospondin-1 (TSP1)-null and TSP2-null mice exhibit lower intraocular pressures.
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| Haddadin RI, Oh DJ, Kang MH, Villarreal G Jr, Kang JH, Jin R, Gong H, Rhee DJ.
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| Invest Ophthalmol Vis Sci 53(10):6708-17.
2012
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| 5 | THBS1
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| A motif within the N-terminal domain of TSP-1 specifically promotes the proangiogenic activity of endothelial colony-forming cells.
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| Dias JV, Benslimane-Ahmim Z, Egot M, Lokajczyk A, Grelac F, Galy-Fauroux I, Juliano L, Le-Bonniec B, Takiya CM, Fischer AM, Blanc-Brude O, Morandi V, Boisson-Vidal C.
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| Biochem Pharmacol 84(8):1014-23. doi: 10.1016/j.bcp.2012.07.006. Epub 2012 Jul 14.
2012
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| 6 | THBS1
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| Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2- and MAPK-dependent pathways.
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| Chavez RJ, Haney RM, Cuadra RH, Ganguly R, Adapala RK, Thodeti CK, Raman P.
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| Am J Physiol Cell Physiol 303(2):C179-91. doi: 10.1152/ajpcell.00008.2012. Epub 2012 May 16.
2012
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| 7 | PTPRJ, THBS1
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| Thrombospondin-1 acts as a ligand for CD148 tyrosine phosphatase.
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| Takahashi K, Mernaugh RL, Friedman DB, Weller R, Tsuboi N, Yamashita H, Quaranta V, Takahashi T.
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| Proc Natl Acad Sci U S A 109(6):1985-90. doi: 10.1073/pnas.1106171109. Epub 2012 Jan 23.
2012
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| 8 | THBS1
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| Loss-of-function thrombospondin-1 mutations in familial pulmonary hypertension.
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| Maloney JP, Stearman RS, Bull TM, Calabrese DW, Tripp-Addison ML, Wick MJ, Broeckel U, Robbins IM, Wheeler LA, Cogan JD, Loyd JE.
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| Am J Physiol Lung Cell Mol Physiol 302(6):L541-54. doi: 10.1152/ajplung.00282.2011. Epub 2011 Dec 23.
2012
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| 9 | THBS1
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| Circulating levels of thrombospondin-1 are decreased in HELLP syndrome.
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| Stenczer B, Molvarec A, Szabó G, Szarka A, Fügedi G, Szijártó J, Rigó J Jr.
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| Thromb Res 129(4):470-3. doi: 10.1016/j.thromres.2011.09.032. Epub 2011 Oct 26.
2012
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| 10 | THBS1
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| Thrombospondin-1: an islet endothelial cell signal of importance for β-cell function.
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| Olerud J, Mokhtari D, Johansson M, Christoffersson G, Lawler J, Welsh N, Carlsson PO.
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| Diabetes 60(7):1946-54. doi: 10.2337/db10-0277. Epub 2011 May 26.
2011
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| 11 | THBS1
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| Thrombospondin-1 modulates the angiogenic phenotype of human cerebral arteriovenous malformation endothelial cells.
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| Stapleton CJ, Armstrong DL, Zidovetzki R, Liu CY, Giannotta SL, Hofman FM.
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| Neurosurgery 68(5):1342-53; discussion 1353. doi: 10.1227/NEU.0b013e31820c0a68.
2011
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| 12 | NEDD4, NEDD4L, THBS1
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| The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1.
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| Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H, Brose N, Henkelman RM, Huang A, Bruneau BG, Rotin D.
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| J Biol Chem 285(9):6770-80. Epub 2009 Dec 21.PMID: 20026598 2010
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| 13 | ADAMTS13, THBS1, VWF
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| Thrombospondin-1 and ADAMTS13 competitively bind to VWF A2 and A3 domains in vitro.
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| Wang A, Liu F, Dong N, Ma Z, Zhang J, Su J, Zhao Y, Ruan C.
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| Thromb Res 126(4):e260-5. Epub 2010 Aug 11.
2010
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| 14 | ELL, THBS1
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| Elongation factor ELL (Eleven-Nineteen Lysine-rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation.
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| Zhou J, Feng X, Ban B, Liu J, Wang Z, Xiao W.
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| J Biol Chem 284(28):19142-52. Epub 2009 May 15.
2009
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| 15 | SSTR2, THBS1
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| Thrombospondin-1 is a critical effector of oncosuppressive activity of sst2 somatostatin receptor on pancreatic cancer.
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| Laklai H, Laval S, Dumartin L, Rochaix P, Hagedorn M, Bikfalvi A, Le Guellec S, Delisle MB, Schally AV, Susini C, Pyronnet S, Bousquet C.
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| Proc Natl Acad Sci U S A 106(42):17769-74. Epub 2009 Oct 1.PMID: 19805200 2009
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| 16 | PRMT6, THBS1
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| Thrombospondin-1 is a transcriptional repression target of PRMT6.
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| Michaud-Levesque J, Richard S.
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| J Biol Chem 284(32):21338-46. Epub 2009 Jun 9.PMID: 19509293 2009
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| 17 | THBS1
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| Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells.
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| Martin-Manso G, Galli S, Ridnour LA, Tsokos M, Wink DA, Roberts DD.
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| Cancer Res 68(17):7090-9. 2008
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| 18 | CD47, THBS1
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| Human thrombospondin's (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: a molecular modeling study.
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| Floquet N, Dedieu S, Martiny L, Dauchez M, Perahia D.
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| Arch Biochem Biophys 478(1):103-9. Epub 2008 Jul 23.
2008
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| 19 | SDC4, THBS1
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| Syndecan-4 contributes to endothelial tubulogenesis through interactions with two motifs inside the pro-angiogenic N-terminal domain of thrombospondin-1.
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| Nunes SS, Outeiro-Bernstein MA, Juliano L, Vardiero F, Nader HB, Woods A, Legrand C, Morandi V.
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| J Cell Physiol 214(3):828-37.
2008
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| 20 | GPX1, THBS1
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| Assessment of genetic risk factors for thoracic aortic aneurysm in hypertensive patients.
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| Kato K, Oguri M, Kato N, Hibino T, Yajima K, Yoshida T, Metoki N, Yoshida H, Satoh K, Watanabe S, Yokoi K, Murohara T, Yamada Y.
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| Am J Hypertens 21(9):1023-7. Epub 2008 Jul 3.
2008
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| 21 | THBS1
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| Novel antiangiogenic pathway of thrombospondin-1 mediated by suppression of the cell cycle.
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| Yamauchi M, Imajoh-Ohmi S, Shibuya M.
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| Cancer Sci 98(9):1491-7. Epub 2007 Jul 26.
2007
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| 22 | THBS1, THBS2
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| EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins.
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| Potikyan G, Savene RO, Gaulden JM, France KA, Zhou Z, Kleinerman ES, Lessnick SL, Denny CT.
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| Cancer Res 67(14):6675-84.
2007
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| 23 | ADAMTS13, THBS1
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| The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow.
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| Zhang P, Pan W, Rux AH, Sachais BS, Zheng XL.
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| Blood 110(6):1887-94. Epub 2007 May 31.
2007
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| 24 | ITGA9, ITGB1, THBS1
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| Interaction of alpha9beta1 integrin with thrombospondin-1 promotes angiogenesis.
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| Staniszewska I, Zaveri S, Del Valle L, Oliva I, Rothman VL, Croul SE, Roberts DD, Mosher DF, Tuszynski GP, Marcinkiewicz C.
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| Circ Res 100(9):1308-16. Epub 2007 Apr 5.
2007
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| 25 | PRR13, THBS1
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| Txr1: a transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes.
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| Lih CJ, Wei W, Cohen SN.
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| Genes Dev 20(15):2082-95. Epub 2006 Jul 17. 2006
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| 26 | RSPO3, THBS1
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| A polymorphism in thrombospondin-1 associated with familial premature coronary heart disease causes a local change in conformation of the Ca2+-binding repeats.
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| Hannah BL, Misenheimer TM, Annis DS, Mosher DF.
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| J Biol Chem 278(11):8929-34. 2003
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| 27 | THBS1
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| Reduced expression of the TSP1 gene and its association with promoter hypermethylation in gastric carcinoma.
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| Oue N, Matsumura S, Nakayama H, Kitadai Y, Taniyama K, Matsusaki K, Yasui W.
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| Oncology 64(4):423-9. 2003
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| 28 | THBS1, FN1, SPARC,THY1
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| THY1 expression is associated with tumor suppression of human ovarian cancer.
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| Abeysinghe HR, Cao Q, Xu J, Pollock S, Veyberman Y, Guckert NL, Keng P, Wang N.
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| Cancer Genet Cytogenet 143(2):125-32. 2003
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| 29 | THBS1, EGF, TGFB1
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| Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth factor beta in human cancer cells--transcriptional activation and messenger RNA stabilization.
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| Okamoto M, Ono M, Uchiumi T, Ueno H, Kohno K, Sugimachi K, Kuwano M.
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| Biochim Biophys Acta 1574(1):24-34. 2002
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| 30 | THBS1
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| Structural characterization of the second TSP1-module of human thrombospondin.
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| Roszmusz E, Patthy A, Trexler M, Patthy L.
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| Biochem Biophys Res Commun 296(1):156-60. 2002
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| 31 | THBS1, THBS2, THBS3
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| Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype.
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| Armstrong DJ, Hiscott P, Batterbury M, Kaye S.
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| Int J Biochem Cell Biol 34(6):588-93.
2002
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| 32 | THBS1
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| Expression and characterization of novel thrombospondin 1 type I repeat fusion proteins.
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| Qabar AN, Bullock J, Matej L, Polverini P.
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| Biochem J 346 Pt 1:147-53. 2000
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| 33 | THBS1, THBS2, THBS3, THBS4
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| Cultured human retinal pigment epithelial cells differentially express thrombospondin-1, -2, -3, and -4.
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| Carron JA, Hiscott P, Hagan S, Sheridan CM, Magee R, Gallagher JA.
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| Int J Biochem Cell Biol 32(11-12):1137-42. 2000
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| 34 | TGFB1, THBS1
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| Thrombospondin-1 is a major activator of TGF-beta1 in vivo.
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| Crawford SE, Stellmach V, Murphy-Ullrich JE, Ribeiro SM, Lawler J, Hynes RO, Boivin GP, Bouck N.
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| Cell. 93(7):1159-70. 1998
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| 35 | THBS1
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| Structure and chromosomal localization of the human thrombospondin gene.
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| Wolf FW, et al.
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| Genomics 6 : 685-691. 1990
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| 36 | THBS1
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| Mapping of the thrombospondin gene to human chromosome 15 and mouse chromosome 2 by in situ hybridization.
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| Jaffe E, et al.
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| Genomics 7 : 123-126. 1990
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| 37 | THBS1
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| Dinucleotide repeat polymorphism at the human thrombospondin gene (THBS1).
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| Polymeropoulos MH, et al.
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| Nucleic Acids Res 18 : 7467. 1990
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