Citations for
1TH
Regulation of tyrosine hydroxylase in periodontal fibroblasts and tissues by obesity-associated stimuli.
Memmert S, Damanaki A, Nogueira AVB, Nokhbehsaim M, Götz W, Cirelli JA, Rath-Deschner B, Jäger A, Deschner J.
Cell Tissue Res 375(3):619-628. doi: 10.1007/s00441-018-2941-8. Epub 2018 Oct 25. 2019
2NR4A2, SLC18A1, SLC6A3, TH
Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells.
Paliga D, Raudzus F, Leppla SH, Heumann R, Neumann S.
Mol Neurobiol 56(5):3393-3403. doi: 10.1007/s12035-018-1311-6. Epub 2018 Aug 18. 2019
3DPDV, DYT5, GCH1, TH
Dopa-Responsive Dystonia in Han Chinese Patients: One Novel Heterozygous Mutation in GTP Cyclohydrolase 1 (GCH1) and Three Known Mutations in TH.
Yang K, Yin R, Lan X, Zhang Y, Cheng H, Wang S, Wang C, Lu Y, Xi J, Lu Q, Huang J, Chen Y.
Med Sci Monit 24:751-757. 2018
4CTCF, TH
Conserved Upstream Regulatory Regions in Mammalian Tyrosine Hydroxylase.
Wang M, Fones L, Cave JW.
Mol Neurobiol 55(9):7340-7351. doi: 10.1007/s12035-018-0936-9. Epub 2018 Feb 5. 2018
5ESRRA, TH
Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.
Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang CY, Wu Y, Gigučre V, Bay BH, Vanacker JM, Ghosh S, Gauthier K, Hollenberg AN, McDonnell DP, Yen PM.
Sci Signal. Jun 26;11(536):eaam5855. doi: 10.1126/scisignal.aam5855 2018
6TH
Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules.
Jorge-Finnigan A, Kleppe R, Jung-Kc K, Ying M, Marie M, Rios-Mondragon I, Salvatore MF, Saraste J, Martinez A.
J Biol Chem 292(34):14092-14107. doi: 10.1074/jbc.M116.762344. Epub 2017 Jun 21. 2017
7DPDV, TH
A novel tyrosine hydroxylase variant in a group of Chinese patients with dopa-responsive dystonia.
Yan YP, Zhang B, Mao YF, Guo ZY, Tian J, Zhao GH, Pu JL, Luo W, Ouyang ZY, Zhang BR.
Int J Neurosci 127(8):694-700. doi: 10.1080/00207454.2016.1236381. Epub 2016 Oct 5. 2017
8SLC6A3, TH
Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice.
Salvatore MF, Calipari ES, Jones SR.
ACS Chem Neurosci 7(7):941-51. doi: 10.1021/acschemneuro.6b00064. Epub 2016 May 10. 2016
9TH
Tyrosine hydroxylase-producing neurons in the human cerebral cortex do not colocalize with calcium-binding proteins or the serotonin 3A receptor.
Asmus SE, Raghanti MA, Beyerle ER, Fleming-Beattie JC, Hawkins SM, McKernan CM, Rauh NA.
J Chem Neuroanat 78:1-9. doi: 10.1016/j.jchemneu.2016.07.007. Epub 2016 Jul 20. 2016
10RXRG, TH
Whole-exome identifies RXRG and TH germline variants in familial isolated prolactinoma.
Melo FM, Couto PP, Bale AE, Bastos-Rodrigues L, Passos FM, Lisboa RG, Ng JM, Curran T, Dias EP, Friedman E, De Marco L.
Cancer Genet 209(6):251-7. doi: 10.1016/j.cancergen.2016.05.065. Epub 2016 May 4. 2016
11TH
Clinical Significance of Tyrosine Hydroxylase mRNA Transcripts in Peripheral Blood at Diagnosis in Patients with Neuroblastoma.
Lee NH, Son MH, Choi YB, Yi E, Lee JW, Yoo KH, Sung KW, Koo HH.
Cancer Res Treat 48(4):1399-1407. Epub 2016 Mar 24. 2016
12DCX, TH
TH and DCX mRNAs in peripheral blood and bone marrow predict outcome in metastatic neuroblastoma patients.
Yáńez Y, Hervás D, Grau E, Oltra S, Pérez G, Palanca S, Bermúdez M, Márquez C, Cańete A, Castel V.
J Cancer Res Clin Oncol 142(3):573-80. doi: 10.1007/s00432-015-2054-7. Epub 2015 Oct 24. 2016
13TH
Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency.
Korner G, Noain D, Ying M, Hole M, Flydal MI, Scherer T, Allegri G, Rassi A, Fingerhut R, Becu-Villalobos D, Pillai S, Wueest S, Konrad D, Lauber-Biason A, Baumann CR, Bindoff LA, Martinez A, Thöny B.
Brain 138(Pt 10):2948-63. doi: 10.1093/brain/awv224. Epub 2015 Aug 14. 2015
14TH
Catalytic domain surface residues mediating catecholamine inhibition in tyrosine hydroxylase.
Briggs GD, Bulley J, Dickson PW.
J Biochem 155(3):183-93. doi: 10.1093/jb/mvt110. Epub 2013 Dec 11. 2014
15TH
The N-terminal sequence of tyrosine hydroxylase is a conformationally versatile motif that binds 14-3-3 proteins and membranes.
Skjevik AA, Mileni M, Baumann A, Halskau O, Teigen K, Stevens RC, Martinez A.
J Mol Biol 426(1):150-68. doi: 10.1016/j.jmb.2013.09.012. Epub 2013 Sep 17. 2014
16NR4A2, TH
Nurr1 represses tyrosine hydroxylase expression via SIRT1 in human neural stem cells.
Kim TE, Seo JS, Yang JW, Kim MW, Kausar R, Joe E, Kim BY, Lee MA.
PLoS One 8(8):e71469. doi: 10.1371/journal.pone.0071469. eCollection 2013. Erratum in: PLoS One. 2014;9(11):e113335. Seo, Ji Sun [correct 2013
17TH
Evolutionary conservation of an atypical glucocorticoid-responsive element in the human tyrosine hydroxylase gene.
Sheela Rani CS, Soto-Pina A, Iacovitti L, Strong R.
J Neurochem 126(1):19-28. doi: 10.1111/jnc.12294. Epub 2013 May 28. 2013
18DPDV, TH
Myoclonus-dystonia syndrome due to tyrosine hydroxylase deficiency.
Stamelou M, Mencacci NE, Cordivari C, Batla A, Wood NW, Houlden H, Hardy J, Bhatia KP.
Neurology 79(5):435-41. doi: 10.1212/WNL.0b013e318261714a. Epub 2012 Jul 18. 2012
19TH
Expression of tyrosine hydroxylase is epigenetically regulated in neural stem cells.
Yang JW, Choi EY, Park MJ, Lee MA.
Biochem Biophys Res Commun 414(4):712-8. doi: 10.1016/j.bbrc.2011.09.141. Epub 2011 Oct 6. 2011
20TH
Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme.
Nakashima A, Mori K, Kaneko YS, Hayashi N, Nagatsu T, Ota A.
Biochem Biophys Res Commun 407(2):343-7. doi: 10.1016/j.bbrc.2011.03.020. Epub 2011 Mar 8. 2011
21MTA1, TH
Multiple coregulatory control of tyrosine hydroxylase gene transcription.
Reddy SD, Rayala SK, Ohshiro K, Pakala SB, Kobori N, Dash P, Yun S, Qin J, O'Malley BW, Kumar R.
Proc Natl Acad Sci U S A 108(10):4200-5. doi: 10.1073/pnas.1101193108. Epub 2011 Feb 22. 2011
22PARK7, TH
Human DJ-1-specific transcriptional activation of tyrosine hydroxylase gene.
Ishikawa S, Taira T, Takahashi-Niki K, Niki T, Ariga H, Iguchi-Ariga SM.
J Biol Chem 285(51):39718-31. doi: 10.1074/jbc.M110.137034. Epub 2010 Oct 11. 2010
23TH
Human tyrosine hydroxylase natural genetic variation: delineation of functional transcriptional control motifs disrupted in the proximal promoter.
Zhang K, Zhang L, Rao F, Brar B, Rodriguez-Flores JL, Taupenot L, O'Connor DT.
Circ Cardiovasc Genet 3(2):187-98. doi: 10.1161/CIRCGENETICS.109.904813. Epub 2010 Feb 2. 2010
24DPDV, DYT5, GCH1, TH
Genotype-phenotype correlates in Taiwanese patients with early-onset recessive parkinsonism.
Lee MJ, Mata IF, Lin CH, Tzen KY, Lincoln SJ, Bounds R, Lockhart PJ, Hulihan MM, Farrer MJ, Wu RM.
Mov Disord 24(1):104-8. 2009
25TH
Characterisation of novel splicing variants of the tyrosine hydroxylase C-terminal domain in human neuroblastic tumours.
Roma J, Saus E, Cuadros M, Reventós J, Sánchez de Toledo J, Gallego S.
Biol Chem 388(4):419-26. 2007
26TH
Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo.
Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, Rana BK, Das M, Rodriguez-Flores JL, Smith DW, Cadman PE, Salem RM, Mahata SK, Schork NJ, Taupenot L, Ziegler MG, O'Connor DT.
Circulation 116(9):993-1006. Epub 2007 Aug 13. 2007
27TH
Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor.
Kim SM, Yang JW, Park MJ, Lee JK, Kim SU, Lee YS, Lee MA.
Biochem Biophys Res Commun 346(2):426-35. Epub 2006 Jun 2. 2006
28TH
The human tyrosine hydroxylase gene promoter.
Kessler MA, Yang M, Gollomp KL, Jin H, Iacovitti L.
Brain Res Mol Brain Res 112(1-2):8-23. 2003
29DPDV, TH
A branch site mutation leading to aberrant splicing of the human tyrosine hydroxylase gene in a child with a severe extrapyramidal movement disorder.
Janssen RJ, Wevers RA, Haussler M, Luyten JA, Steenbergen-Spanjers GC, Hoffmann GF, Nagatsu T, Van den Heuvel LP.
Ann Hum Genet 64(Pt 5):375-82. 2000
30TH, DPDV
A review of biochemical and molecular genetic aspects of tyrosine hydroxylase deficiency including a novel mutation (291delC).
Wevers RA, et al.
J Inherit Metab Dis 22(4):364-73. 1999
31TH
Tyrosine hydroxylase polymorphism and phenotypic heterogeneity in bipolar affective disorder: A multicenter association study.
Souery D, et al.
Am J Med Genet 88(5):527-532 1999
32TH
Biochemical and molecular genetic characteristics of the severe form of tyrosine hydroxylase deficiency.
Brautigam C, Steenbergen-Spanjers GC, Hoffmann GF, Dionisi-Vici C, van den Heuvel LP, Smeitink JA, Wevers RA.
Clin Chem 45(12):2073-8. 1999
33DPDV, DYT5, GCH1, TH
Molecular genetics of dopa-responsive dystonia.
Ichinose H, Suzuki T, Inagaki H, Ohye T, Nagatsu T.
Biol Chem 380(12):1355-64. Review. 1999
34TH
A tetranucleotide polymorphic microsatellite, located in the first intron of the tyrosine hydroxylase gene, acts as a transcription regulatory element in vitro.
Meloni R, Albanese V, Ravassard P, Treilhou F, Mallet J.
Hum Mol Genet 7(3):423-8. 1998
35DPDV, TH
A common point mutation in the tyrosine hydroxylase gene in autosomal recessive L-DOPA-responsive dystonia in the Dutch population.
van den Heuvel LPWJ, et al.
Hum Genet 102 : 644-646. 1998
36TH
Association study of structural mutations of the tyrosine hydroxylase gene with schizophrenia and Parkinson's disease.
Kunugi H, Kawada Y, Hattori M, Ueki A, Otsuka M, Nanko S.
Am J Med Genet 81 : 131-133. 1998
37FGA, TH, TPO
The short tandem repeat loci hTPO, THO1 and FGA.
Poltl R, Luckenbach C, Hixson J, Ritter H.
Hum Hered 48 : 318-324. 1998
38PARP1, TH
Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2).
De Benedictis G, et al.
Eur J Hum Genet 6 : 534-541. 1998
39DPDV, TH
Recessively inherited L-DOPA-responsive parkinsonism in infancy caused by a point mutation (L205P) in the tyrosine hydroxylase gene.
LŸdecke B, et al.
Hum Mol Genet 5 : 1023-1028. 1996
40DRD2, DRD3, SLC6A3, TH
Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission : DRD2,DRD3,DAT1, and TH genes.
Souery D, et al.
Am J Med Genet 67 : 551-555. 1996
41TH
New species of human tyrosine hydroxylase mRNA are produced in variable amounts in adrenal medulla and are overexpressed in progressive supranuclear palsy.
Dumas S, Le Hir H, Bodeau-Pean S, Hirsch E, Thermes C, Mallet J.
J Neurochem 67(1):19-25. 1996
42DPDV, TH
Frequent sequence variant in the human tyrosine hydroxylase gene.
LŸdecke B, et al.
Hum Genet 95 : 716. 1995
43DPDV, TH
Recessively inherited L-DOPA-responsive dystonia caused by a point mutation (Q381K) in the tyrosine hydroxylase gene.
Knappskog PM, et al.
Hum Mol Genet 4 : 1209-1212. 1995
44DPDV, TH
A point mutation in the tyrosine hydroxylase gene associated with Segawa's syndrome.
LŸdecke B, et al.
Hum Genet 95 : 123-125. 1995
45ST5, TH
A new highly polymorphic DNA restriction site marker in the 5' region of the human tyrosine hydroxylase gene (TH) detecting loss of heterozygosity in human embryonal rhadbomyosarcoma.
Besnard-GuŽrin C, et al.
Hum Genet 93 : 349-350. 1994
46TH
Tyrosine hydroxylase gene not linked to manic-depression in seven of eight pedigrees.
Byerley W, et al.
Hum Hered 42 : 259-263. 1992
47FABP2, AR, TH, REN, HPRT1
Genetic variation at five trimeric and tetrameric tandem repeat loci in four human population groups.
Edwards A, et al.
Genomics 12 : 241-253. 1992
48TH
Tetranucleotide repeat polymorphism at the human tyrosine hydroxylase gene (TH).
Polymeropoulos MH, et al.
Nucleic Acids Res 19 : 3753. 1991
49TH
Tyrosine hydroxylase polymorphisms associated with manic-depressive illness.
Leboyer M, et al.
Lancet 335 : 1219. 1990
50TH
RFLP alleles at the tyrosine hydroxylase locus: no association found to affective disorders.
Kšrner J, et al.
Psychiatry Res 32 : 275-280. 1990
51INS, TH
DraI and PstI RFLPs in the tyrosine hydroxylase (TH) and insulin gene (INS) region of chromosome 11.
Sten-Linder M, et al.
Nucleic Acids Res 17 : 5873. 1989
52TH
DraI and ScaI RFLPs at human tyrosine hydroxylase (TH) gene locus.
Tinklenberg KJ, Masharani U, Coleman RT, Taylor J, Cawthorn R, Frossard P.
Nucleic Acids Res 16 : 10948. 1988
53TH
Tyrosine hydroxylase maps to the short arm of chromosome 11 proximal to the insulin and HRAS 1 loci.
Xue F, et al.
Genomics 2 : 288-293. 1988
54TH
Further RFLPs at the human tyrosine hydroxylase locus.
Kšrner J, et al.
Nucleic Acids Res 16 : 9078. 1988
55TH, INS
Human tyrosine hydroxylase and insulin genes are contiguous on chromosome 11.
O'Malley KL, et al.
Nucleic Acids Res 16 : 4437-4446. 1988
56TH
Human tyrosine hydroxylase (TH) genomic fragment (pHGTH4) identifies a PstI polymorphism.
Kelsoe JR, et al.
Nucleic Acids Res 16 : 7760. 1988
57TH
Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types.
Kobayashi K, Kaneda N, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T.
J Biochem (Tokyo) 103(6):907-12. 1988
58TH
Tyrosine hydroxylase maps to 11p near INS and HRAS1.
Xue F, et al.
(HGM9) Cytogenet Cell Genet 46 : 721. 1987
59TH
A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics.
Grima B, Lamouroux A, Boni C, Julien JF, Javoy-Agid F, Mallet J.
Nature 326(6114):707-11. 1987
60TH
Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene.
Kaneda N, Kobayashi K, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T.
Biochem Biophys Res Commun 146(3):971-5. 1987
61TH
Linkage of tyrosine hydroxylase to four other markers on the short arm of chromosome 11.
Moss PAH, et al.
Nucleic Acids Res 14 : 9927-9932. 1986
62TH
Localization of the human tyrosine hydroxylase gene to 11p15 : gene duplication and evolution of metabolic pathways.
Craig SP, et al.
Cytogenet Cell Genet 42 : 29-32. 1986
63TH
Localization of the human tyrosine hydroxylase gene to chromosome11p15.
Craig SP, et al.
(HGM8) Cytogenet Cell Genet 40 : 610. 1985