Citations for
1FN1, TGM2
Dissecting the interaction between transglutaminase 2 and fibronectin.
Cardoso I, Řsterlund EC, Stamnaes J, Iversen R, Andersen JT, Jřrgensen TJ, Sollid LM.
Amino Acids 49(3):489-500. doi: 10.1007/s00726-016-2296-y. Epub 2016 Jul 9. 2017
Transglutaminase 2 is upregulated in primary hepatocellular carcinoma with early recurrence as determined by proteomic profiles.
Yamaguchi H, Kuroda K, Sugitani M, Takayama T, Hasegawa K, Esumi M.
Int J Oncol 50(5):1749-1759. doi: 10.3892/ijo.2017.3917. Epub 2017 Mar 20. 2017
Inhibition or ablation of transglutaminase 2 impairs astrocyte migration.
Monteagudo A, Ji C, Akbar A, Keillor JW, Johnson GV.
Biochem Biophys Res Commun 482(4):942-947. doi: 10.1016/j.bbrc.2016.11.137. Epub 2016 Nov 27. 2017
Is monocyte- and macrophage-derived tissue transglutaminase involved in inflammatory processes?
Chrobok NL, Sestito C, Wilhelmus MM, Drukarch B, van Dam AM.
Amino Acids 49(3):441-452. doi: 10.1007/s00726-016-2334-9. Epub 2016 Sep 22. Review. 2017
Transglutaminase-2: evolution from pedestrian protein to a promising therapeutic target.
Agnihotri N, Mehta K.
Amino Acids 49(3):425-439. doi: 10.1007/s00726-016-2320-2. Epub 2016 Aug 25. Review. 2017
Inter-molecular crosslinking activity is engendered by the dimeric form of transglutaminase 2.
Kim N, Lee WK, Lee SH, Jin KS, Kim KH, Lee Y, Song M, Kim SY.
Amino Acids 49(3):461-471. doi: 10.1007/s00726-016-2293-1. Epub 2016 Jul 9. 2017
Genomic variants reveal differential evolutionary constraints on human transglutaminases and point towards unrecognized significance of transglutaminase 2.
Thangaraju K, Király R, Demény MA, András Mótyán J, Fuxreiter M, Fésüs L.
PLoS One 12(3):e0172189. doi: 10.1371/journal.pone.0172189. eCollection 2017. 2017
8FN1, TGM2
Transglutaminase 2 strongly binds to an extracellular matrix component other than fibronectin via its second C-terminal beta-barrel domain.
Stamnaes J, Cardoso I, Iversen R, Sollid LM.
FEBS J 283(21):3994-4010. doi: 10.1111/febs.13907. Epub 2016 Oct 11. 2016
Transglutaminase type 2-dependent selective recruitment of proteins into exosomes under stressful cellular conditions.
Diaz-Hidalgo L, Altuntas S, Rossin F, D'Eletto M, Marsella C, Farrace MG, Falasca L, Antonioli M, Fimia GM, Piacentini M.
Biochim Biophys Acta 1863(8):2084-92. doi: 10.1016/j.bbamcr.2016.05.005. Epub 2016 May 8. 2016
10CDKN1A, TGM2, TP53
Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.
Yeo SY, Itahana Y, Guo AK, Han R, Iwamoto K, Nguyen HT, Bao Y, Kleiber K, Wu YJ, Bay BH, Voorhoeve M, Itahana K.
Elife 5:e07101. doi: 10.7554/eLife.07101. 2016
11COL18A1, TGM2
Endostatin and transglutaminase 2 are involved in fibrosis of the aging kidney.
Lin CH, Chen J, Zhang Z, Johnson GV, Cooper AJ, Feola J, Bank A, Shein J, Ruotsalainen HJ, Pihlajaniemi TA, Goligorsky MS.
Kidney Int 89(6):1281-92. doi: 10.1016/j.kint.2016.01.030. Epub 2016 Apr 14. 2016
12SDC4, TGM2
Transglutaminase 2 interacts with syndecan-4 and CD44 at the surface of human macrophages to promote removal of apoptotic cells.
Nadella V, Wang Z, Johnson TS, Griffin M, Devitt A.
Biochim Biophys Acta 1853(1):201-12. doi: 10.1016/j.bbamcr.2014.09.020. Epub 2014 Oct 29. 2015
The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation.
Altuntas S, Rossin F, Marsella C, D'Eletto M, Diaz-Hidalgo L, Farrace MG, Campanella M, Antonioli M, Fimia GM, Piacentini M.
Oncotarget 6(42):44941-54. doi: 10.18632/oncotarget.6759. 2015
Transglutaminase 2 expressed in mast cells recruited into skin or bone marrow induces the development of pediatric mastocytosis.
Ahn YM, Hong GU, Kim SH, Lee HJ, Baek HS, Kim MN, Park KY, Ro JY.
Pediatr Allergy Immunol 26(5):438-45. doi: 10.1111/pai.12403. 2015
Transglutaminase 2 promotes PDGF-mediated activation of PDGFR/Akt1 and β-catenin signaling in vascular smooth muscle cells and supports neointima formation.
Nurminskaya M, Beazley KE, Smith EP, Belkin AM.
J Vasc Res 51(6):418-28. doi: 10.1159/000369461. Epub 2015 Jan 22. 2014
16SPP1, TGM2
Identification of transglutaminase reactive residues in human osteopontin and their role in polymerization.
Christensen B, Zachariae ED, Scavenius C, Thybo M, Callesen MM, Klřverpris S, Oxvig C, Enghild JJ, Sřrensen ES.
PLoS One 9(11):e113650. doi: 10.1371/journal.pone.0113650. eCollection 2014. 2014
Crystal structure of transglutaminase 2 with GTP complex and amino acid sequence evidence of evolution of GTP binding site.
Jang TH, Lee DS, Choi K, Jeong EM, Kim IG, Kim YW, Chun JN, Jeon JH, Park HH.
PLoS One 9(9):e107005. doi: 10.1371/journal.pone.0107005. eCollection 2014. 2014
Enhanced transglutaminase 2 expression in response to stress-related catecholamines in macrophages.
Yanagawa Y, Hiraide S, Matsumoto M, Shimamura K, Togashi H.
Immunobiology 219(9):680-6. doi: 10.1016/j.imbio.2014.04.002. Epub 2014 May 6. 2014
Endoplasmic reticulum stress activates transglutaminase 2 leading to protein aggregation.
Lee JH, Jeong J, Jeong EM, Cho SY, Kang JW, Lim J, Heo J, Kang H, Kim IG, Shin DM.
Int J Mol Med 33(4):849-55. doi: 10.3892/ijmm.2014.1640. Epub 2014 Jan 30. 2014
GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2.
Yang L, Friedland S, Corson N, Xu L.
Cancer Res 74(4):1022-31. doi: 10.1158/0008-5472.CAN-13-1268. Epub 2013 Dec 19. 2014
Transglutaminase-2 in cell adhesion: all roads lead to paxillin?
Png E, Tong L.
Cell Adh Migr 7(5):412-7. doi: 10.4161/cam.26344. Epub 2013 Sep 12. 2013
22LRP6, TGM2
Transglutaminase 2 as a novel activator of LRP6/β-catenin signaling.
Deasey S, Nurminsky D, Shanmugasundaram S, Lima F, Nurminskaya M.
Cell Signal 25(12):2646-51. doi: 10.1016/j.cellsig.2013.08.016. Epub 2013 Aug 29. 2013
Glucose homeostasis in mice is transglutaminase 2 independent.
Iismaa SE, Aplin M, Holman S, Yiu TW, Jackson K, Burchfield JG, Mitchell CJ, O'Reilly L, Davenport A, Cantley J, Schmitz-Peiffer C, Biden TJ, Cooney GJ, Graham RM.
PLoS One 8(5):e63346. doi: 10.1371/journal.pone.0063346. Print 2013. 2013
Molecular mechanism of transglutaminase-2 in corneal epithelial migration and adhesion.
Tong L, Png E, Aihua H, Yong SS, Yeo HL, Riau A, Mendoz E, Chaurasia SS, Lim CT, Yiu TW, Iismaa SE.
Biochim Biophys Acta 1833(6):1304-15. doi: 10.1016/j.bbamcr.2013.02.030. Epub 2013 Mar 4. 2013
Transglutaminase 2 facilitates or ameliorates HIF signaling and ischemic cell death depending on its conformation and localization.
Gundemir S, Colak G, Feola J, Blouin R, Johnson GV.
Biochim Biophys Acta 1833(1):1-10. doi: 10.1016/j.bbamcr.2012.10.011. Epub 2012 Oct 17. 2013
Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells.
Zemskov EA, Mikhailenko I, Smith EP, Belkin AM.
J Cell Physiol 227(5):2089-96. doi: 10.1002/jcp.22938. 2012
TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M.
Proc Natl Acad Sci U S A 109(4):E177-86. doi: 10.1073/pnas.1119296109. Epub 2011 Dec 27. Erratum in: Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4332–5 2012
Tissue transglutaminase constitutively activates HIF-1α promoter and nuclear factor-κB via a non-canonical pathway.
Kumar S, Mehta K.
PLoS One 7(11):e49321. doi: 10.1371/journal.pone.0049321. Epub 2012 Nov 19. 2012
29SDC4, TGM2
Importance of syndecan-4 and syndecan -2 in osteoblast cell adhesion and survival mediated by a tissue transglutaminase-fibronectin complex.
Wang Z, Telci D, Griffin M.
Exp Cell Res 317(3):367-81. Epub 2010 Oct 28. 2011
Activation of extracellular transglutaminase 2 by thioredoxin.
Jin X, Stamnaes J, Klöck C, DiRaimondo TR, Sollid LM, Khosla C.
J Biol Chem 286(43):37866-73. Epub 2011 Sep 9. 2011
Tissue transglutaminase 2 as a biomarker of cervical intraepithelial neoplasia (CIN) and its relationship to p16INK4A and nuclear factor kappaB expression.
Gupta R, Srinivasan R, Nijhawan R, Suri V.
Virchows Arch 456(1):45-51. Epub 2009 Nov 25. 2010
Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-kappaB activity in hypoxic tumor cells.
Jang GY, Jeon JH, Cho SY, Shin DM, Kim CW, Jeong EM, Bae HC, Kim TW, Lee SH, Choi Y, Lee DS, Park SC, Kim IG.
Oncogene 29(3):356-67. Epub 2009 Oct 19. 2010
33COL18A1, TGM2
Transglutaminase-2: a new endostatin partner in the extracellular matrix of endothelial cells.
Faye C, Inforzato A, Bignon M, Hartmann DJ, Muller L, Ballut L, Olsen BR, Day AJ, Ricard-Blum S.
Biochem J 427(3):467-75. 2010
The TGM2 gene is associated with schizophrenia in a British population.
Bradford M, Law MH, Stewart AD, Shaw DJ, Megson IL, Wei J.
Am J Med Genet B Neuropsychiatr Genet 150B(3):335-40. 2009
Transglutaminase 2 regulates the GTPase-activating activity of Bcr.
Yi SJ, Groffen J, Heisterkamp N.
J Biol Chem 284(51):35645-51. Epub . 2009
Increased TG2 expression can result in induction of transforming growth factor beta1, causing increased synthesis and deposition of matrix proteins, which can be regulated by nitric oxide.
Telci D, Collighan RJ, Basaga H, Griffin M.
J Biol Chem 284(43):29547-58. Epub 2009 Aug 5. 2009
Transglutaminase 2 and nucleoside diphosphate kinase activity are correlated in epithelial membranes and are abnormal in cystic fibrosis.
Treharne KJ, Giles Best O, Mehta A.
FEBS Lett 583(17):2789-92. Epub 2009 Jul 18. 2009
Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages.
Rébé C, Raveneau M, Chevriaux A, Lakomy D, Sberna AL, Costa A, Bessčde G, Athias A, Steinmetz E, Lobaccaro JM, Alves G, Menicacci A, Vachenc S, Solary E, Gambert P, Masson D.
Circ Res 105(4):393-401. Epub 2009 Jul 23. 2009
Tissue transglutaminase regulates matrix metalloproteinase-2 in ovarian cancer by modulating cAMP-response element-binding protein activity.
Satpathy M, Shao M, Emerson R, Donner DB, Matei D.
J Biol Chem 284(23):15390-9. Epub 2009 Mar 26. 2009
Transglutaminase 2 protects against ischemic insult, interacts with HIF1beta, and attenuates HIF1 signaling.
Filiano AJ, Bailey CD, Tucholski J, Gundemir S, Johnson GV.
FASEB J 22(8):2662-75. Epub 2008 Mar 28. 2008
Involvement of transglutaminase-2 in pathological changes in renal disease.
Ikee R, Kobayashi S, Hemmi N, Saigusa T, Namikoshi T, Yamada M, Imakiire T, Kikuchi Y, Suzuki S, Miura S.
Nephron Clin Pract 105(3):c139-46. Epub 2007 Jan 16. 2007
42TGM2, TGM3, TGM5
Identification of transglutaminase 3 splicing isoforms.
Zocchi L, Terrinoni A, Candi E, Ahvazi B, Bagetta G, Corasaniti MT, Lena AM, Melino G.
J Invest Dermatol 127(7):1791-4. Epub 2007 Mar 22. No abstract available. 2007
Identification of two GTP-independent alternatively spliced forms of tissue transglutaminase in human leukocytes, vascular smooth muscle, and endothelial cells.
Lai TS, Liu Y, Li W, Greenberg CS.
FASEB J 21(14):4131-43. Epub 2007 Jul 3.PMID: 17609251 2007
GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis.
Xu L, Begum S, Hearn JD, Hynes RO.
Proc Natl Acad Sci U S A 103(24):9023-8. Epub 2006 Jun 6. 2006
Transglutaminase Participates in UVB-Induced Cell Death Pathways in Human Corneal Epithelial Cells.
Tong L, Chen Z, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC.
Invest Ophthalmol Vis Sci 47(10):4295-301. 2006
Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity.
Begg GE, Holman SR, Stokes PH, Matthews JM, Graham RM, Iismaa SE.
J Biol Chem 281(18):12603-9. Epub 2006 Mar 7. 2006
Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei.
Karpuj MV, et al.
Proc Natl Acad Sci U S A 96(13):7388-93. 1999
Transglutaminase action imitates Huntington's disease: selective polymerization of Huntingtin containing expanded polyglutamine.
Kahlem P, et al.
Mol Cell 1(4):595-601. 1998
The human tissue transglutaminase gene maps on chromosome 20q12 by in situ fluorescence hybridization.
Gentile V, et al.
Genomics 20 : 295-297. 1994
50TGM2, TGM3
Assignment of the human transglutaminase 2 (TGM2) and transglutaminase 3 (TGM3) genes to chromosome 20q11.2.
Wang M, et al.
Genomics 23 : 721-722. 1994
51TGM3, TGM2
Structure and organization of the human transglutaminase 3 gene : evolutionary relationship to the transglutaminase family.
Kim IG, et al.
J Invest Dermatol 103 : 137-142. 1994