1 | TGIF1
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| TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone.
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| Saito H, Gasser A, Bolamperti S, Maeda M, Matthies L, Jähn K, Long CL, Schlüter H, Kwiatkowski M, Saini V, Pajevic PD, Bellido T, van Wijnen AJ, Mohammad KS, Guise TA, Taipaleenmäki H, Hesse E.
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| Nat Commun 10(1):1354. doi: 10.1038/s41467-019-08778-x.
2019
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2 | TGIF1, TGIF2
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| TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth.
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| Shah A, Melhuish TA, Fox TE, Frierson HF Jr, Wotton D.
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| Genes Dev enes Dev. 2019 Feb 26. doi: 10.1101/gad.320127.118. [Epub ahead of print]
2019
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3 | SMAD2, SMAD4, TGFB1, TGIF1
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| TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling.
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| Guca E, Suñol D, Ruiz L, Konkol A, Cordero J, Torner C, Aragon E, Martin-Malpartida P, Riera A, Macias MJ.
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| Nucleic Acids Res 46(17):9220-9235. doi: 10.1093/nar/gky680.
2018
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4 | TGIF1
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| Characterization of the interaction interface and conformational dynamics of human TGIF1 homeodomain upon the binding of consensus DNA.
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| Li S, Hu R, Yao H, Long D, Luo F, Zhou X, Zhang X, Liu M, Zhu J, Yang Y.
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| Biochim Biophys Acta Proteins Proteom 1866(10):1021-1028. doi: 10.1016/j.bbapap.2018.07.005. [Epub ahead of print]
2018
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5 | NODAL, SHH, TGFB1, TGIF1, TGIF2
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| Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly.
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| Wotton D, Taniguchi K.
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| Am J Med Genet C Semin Med Genet 178(2):128-139. doi: 10.1002/ajmg.c.31612. Epub 2018 May 11.
2018
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6 | TGIF1, ZIC2
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| Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression.
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| Ishiguro A, Hatayama M, Otsuka MI, Aruga J.
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| Sci Rep 8(1):2140. doi: 10.1038/s41598-018-20242-2.
2018
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7 | TGIF1
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| Structural insights into the impact of two holoprosencephaly-related mutations on human TGIF1 homeodomain.
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| Zhu J, Li S, Ramelot TA, Kennedy MA, Liu M, Yang Y.
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| Biochem Biophys Res Commun 496(2):575-581. doi: 10.1016/j.bbrc.2018.01.099.
2018
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8 | EVI5L, TGIF1, TGIF2
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| Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.
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| Anderson AE, Taniguchi K, Hao Y, Melhuish TA, Shah A, Turner SD, Sutherland AE, Wotton D.
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| Mol Cell Biol 37(5). pii: e00527-16. doi: 10.1128/MCB.00527-16. Print 2017 Mar 1.
2017
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9 | TGIF1
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| Homeobox gene TGIF-1 is increased in placental endothelial cells of human fetal growth restriction.
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| Gunatillake T, Yong HE, Dunk CE, Keogh RJ, Borg AJ, Cartwright JE, Whitley GS, Murthi P.
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| Reproduction 152(5):457-65. doi: 10.1530/REP-16-0068. Epub 2016 Aug 18.
2016
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10 | TGIF1, TGIF2
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| Tgif1 and Tgif2 Regulate Axial Patterning in Mouse.
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| Melhuish TA, Taniguchi K, Wotton D.
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| PLoS One 11(5):e0155837. doi: 10.1371/journal.pone.0155837. eCollection 2016.
2016
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11 | TGIF1
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| TGIF1 promoted the growth and migration of cancer cells in nonsmall cell lung cancer.
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| Xiang G, Yi Y, Weiwei H, Weiming W.
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| Tumour Biol 36(12):9303-10. doi: 10.1007/s13277-015-3676-8. Epub 2015 Jun 24.
2015
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12 | SOAT2, TGIF1
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| TG-interacting factor 1 acts as a transcriptional repressor of sterol O-acyltransferase 2.
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| Pramfalk C, Melhuish TA, Wotton D, Jiang ZY, Eriksson M, Parini P.
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| J Lipid Res 55(4):709-17. doi: 10.1194/jlr.M045922. Epub 2014 Jan 29.
2014
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13 | TGIF1
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| TGIF1 splicing variant 8 is overexpressed in oral squamous cell carcinoma and is related to pathologic and clinical behavior.
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| Libório TN, Ferreira EN, Aquino Xavier FC, Carraro DM, Kowalski LP, Soares FA, Nunes FD.
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| Oral Surg Oral Med Oral Pathol Oral Radiol 116(5):614-25. doi: 10.1016/j.oooo.2013.07.014.
2013
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14 | TGIF1
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| Tgif1 regulates quiescence and self-renewal of hematopoietic stem cells.
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| Yan L, Womack B, Wotton D, Guo Y, Shyr Y, Davé U, Li C, Hiebert S, Brandt S, Hamid R.
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| Mol Cell Biol 33(24):4824-33. doi: 10.1128/MCB.01076-13. Epub 2013 Oct 7.
2013
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15 | RXRA, TGIF1
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| The TG-interacting factor TGIF1 regulates stress-induced proinflammatory phenotype of endothelial cells.
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| Hneino M, Blirando K, Buard V, Tarlet G, Benderitter M, Hoodless P, François A, Milliat F.
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| J Biol Chem 287(46):38913-21. doi: 10.1074/jbc.M112.388389. Epub 2012 Sep 20.
2012
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16 | TGIF1
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| Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway.
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| Taniguchi K, Anderson AE, Sutherland AE, Wotton D.
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| PLoS Genet 8(2):e1002524. doi: 10.1371/journal.pgen.1002524. Epub 2012 Feb 23.
2012
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17 | HPE2, HPE3, HPE4, HPE5, SHH, SIX3, TGIF1, ZIC2
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| Analysis of genotype-phenotype correlations in human holoprosencephaly.
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| Solomon BD, Mercier S, Vélez JI, Pineda-Alvarez DE, Wyllie A, Zhou N, Dubourg C, David V, Odent S, Roessler E, Muenke M.
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| Am J Med Genet C Semin Med Genet 154C(1):133-41. Review.PMID: 20104608 2010
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18 | FBXW7, TGIF1
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| Tumor suppressor Fbxw7 regulates TGFâ signaling by targeting TGIF1 for degradation.
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| Bengoechea-Alonso MT, Ericsson J.
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| Oncogene 29(38):5322-8. Epub 2010 Jul 12.
2010
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19 | TGIF1
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| Tgif1 represses apolipoprotein gene expression in liver.
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| Melhuish TA, Chung DD, Bjerke GA, Wotton D.
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| J Cell Biochem 111(2):380-90.PMID: 20506222 2010
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20 | NODAL, TGIF1, TGIF2
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| Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.
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| Powers SE, Taniguchi K, Yen W, Melhuish TA, Shen J, Walsh CA, Sutherland AE, Wotton D.
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| Development 137(2):249-59.PMID: 20040491 2010
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21 | TGIF1
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| Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cells.
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| Hamid R, Brandt SJ.
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| Mol Oncol 3(5-6):451-63. Epub 2009 Jul 29.PMID: 19699159 2009
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22 | TGIF1
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| Assessment of TGIF as a candidate gene for myopia.
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| Pertile KK, SchŠche M, Islam FM, Chen CY, Dirani M, Mitchell P, Baird PN.
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| Invest Ophthalmol Vis Sci 49(1):49-54. 2008
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23 | TGIF1, HPE4
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| Zebrafish model of holoprosencephaly demonstrates a key role for TGIF in regulating retinoic acid metabolism.
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| Gongal PA, Waskiewicz AJ.
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| Hum Mol Genet 17(4):525-38. Epub 2007 Nov 12. 2008
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24 | TGIF1
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| Genomic structure, alternative splicing and expression of TG-interacting factor, in human myeloid leukemia blasts and cell lines.
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| Hamid R, Patterson J, Brandt SJ.
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| Biochim Biophys Acta 1779(5):347-55. Epub 2008 Apr 13.PMID: 18455519 2008
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25 | DEL18P, TGIF1
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| Towards mapping phenotypical traits in 18p- syndrome by array-based comparative genomic hybridisation and fluorescent in situ hybridisation.
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| Brenk CH, Prott EC, Trost D, Hoischen A, Walldorf C, Radlwimmer B, Wieczorek D, Propping P, Gillessen-Kaesbach G, Weber RG, Engels H.
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| Eur J Hum Genet 15(1):35-44. Epub 2006 Oct 4. 2007
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26 | DEL18P, TGIF1
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| Midline defects in deletion 18p syndrome: clinical and molecular characterization of three patients.
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| Portnoi MF, Gruchy N, Marlin S, Finkel L, Denoyelle F, Dubourg C, Odent S, Siffroi JP, Le Bouc Y, Houang M.
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| Clin Dysmorphol 16(4):247-252. 2007
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27 | HPE 3, HPE4, SHH, TGIF1, HPE10, HPE1, HPE9
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| MLPA screening reveals novel subtelomeric rearrangements in holoprosencephaly.
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| Bendavid C, Dubourg C, Pasquier L, Gicquel I, Le Gallou S, Mottier S, Durou MR, Henry C, Odent S, David V.
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| Hum Mutat 28(12):1189-1197. 2007
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28 | HPE3, HPE2, HPE4, HPE5, SHH, SIX3, TGIF1, ZIC2
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| Molecular evaluation of foetuses with holoprosencephaly shows high incidence of microdeletions in the HPE genes.
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| Bendavid C, Dubourg C, Gicquel I, Pasquier L, Saugier-Veber P, Durou MR, Jaillard S, Frebourg T, Haddad BR, Henry C, Odent S, David V.
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| Hum Genet 119(1-2):1-8. Epub 2005 Dec 2. 2006
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29 | DEL18P, TGIF1
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| Clinical and molecular characterization of individuals with 18p deletion: A genotype-phenotype correlation.
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| Wester U, Bondeson ML, Edeby C, Anneren G.
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| Am J Med Genet A 140(11):1164-71. 2006
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30 | TGIF1
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| Intragenic deletion of Tgif causes defectsin brain development.
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| Kuang C, Xiao Y, Yang L, Chen Q, Wang Z, Conway SJ, Chen Y.
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| Hum Mol Genet 15(24):3508-19. Epub 2006 Nov 2. 2006
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31 | DEL18P, HPE4, TGIF1
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| Contiguous gene syndrome of holoprosencephaly and hypotrichosis simplex: association with an 18p11.3 deletion.
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| Kantaputra PN, Limwongse C, Tochareontanaphol C, Mutirangura A, Mevatee U, Praphanphoj V.
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| Am J Med Genet A 140(23):2598-602. 2006
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32 | SHH, ZIC2, SIX3, TGIF1, HPE3, HPE5, HPE2, HPE4
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| Molecular screening of SHH, ZIC2, SIX3, and TGIF genes in patients with features of holoprosencephaly spectrum: Mutation review and genotype-phenotype correlations.
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| Dubourg C, Lazaro L, Pasquier L, Bendavid C, Blayau M, Le Duff F, Durou MR, Odent S, David V.
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| Hum Mutat 24(1):43-51. 2004
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33 | TGIF1
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| Molecular screening of the TGIF gene in holoprosencephaly: identification of two novel mutations
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| Aguilella C, Dubourg C, Attia-Sobol J, Vigneron J, Blayau M, Pasquier L, Lazaro L, Odent S, David V.
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| Hum Genet 112(2):131-4. 2003
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34 | TGIF1
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| Molecular diagnosis of a novel heterozygous 268C-->T (R90C) mutation in TGIF gene in a fetus with holoprosencephaly and premaxillary agenesis.
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| Chen CP, Chern SR, Du SH, Wang W.
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| Prenat Diagn 22(1):5-7. 2002
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35 | NDC80, TGIF1, TYMS, YES1
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| Novel targets for the 18p11.3 amplification frequently observed in esophageal squamous cell carcinomas.
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| Nakakuki K, Imoto I, Pimkhaokham A, Fukuda Y, Shimada Y, Imamura M, Amagasa T, Inazawa J.
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| Carcinogenesis 23(1):19-24. 2002
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36 | HDAC1, TGIF1, TGIF2
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| TGIF2 interacts with histone deacetylase 1 and represses transcription.
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| Melhuish TA, Gallo CM, Wotton D.
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| J Biol Chem 276(34):32109-14. 2001
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37 | HPE2, HPE3, HPE4, HPE8, SHH, SIX3, TGIF1, ZIC2
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| Mutations in holoprosencephaly.
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| Wallis D, Muenke M.
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| Hum Mutat 16(2):99-108. 2000
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38 | TGIF1, HPE4, DEL18P
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| Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.
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| Gripp KW, Wotton D, Edwards MC, Roessler E, Ades L, Meinecke P, Richieri-Costa A, Zackai EH, Massague J, Muenke M, Elledge SJ.
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| Nat Genet 25(2):205-8. 2000
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39 | TGIF1
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| A Smad transcriptional corepressor.
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| Wotton D, et al.
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| Cell 97(1):29-39 1999
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40 | HPE4, TGIF1
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| Mutations in the HPE4 gene, TGIF, on chromosome 18p cause holoprosencephaly : towards understanding the molecular basis of agnathia and holoprosencephaly
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| Gripp KW. et al
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| 19th Annual D.W. Smith Workshop on Malformations & Morphogenesis 11-108 1998
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41 | TGIF1
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| A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif.
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| Bertolino E, et al.
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| J Biol Chem 270(52):31178-88 1995
|