1 | EGFR, MITF, NFE2L2, TGFA
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| NRF2 Enables EGFR Signaling in Melanoma Cells.
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| Kreß JKC, Jessen C, Marquardt A, Hufnagel A, Meierjohann S.
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| Int J Mol Sci. Apr 7;22(8):3803. doi: 10.3390/ijms22083803. 2021
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2 | IRF6, TGFA
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| Gene-environment interaction in molar-incisor hypomineralization
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| Bezamat M, Souza JF, Silva FMF, Corrêa EG, Fatturi AL, Brancher JA, Carvalho FM, Cavallari T, Bertolazo L, Machado-Souza C, Koruyucu M, Bayram M, Racic A, Harrison BM, Sweat YY, Letra A, Studen-Pavlovich D, Seymen F, Amendt B, Werneck RI, Costa MC, Modesto A, Vieira AR.
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| PLoS One. Jan 6;16(1):e0241898. doi: 10.1371/journal.pone.0241898. 2021
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3 | NFKB1, TGFA
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| Transforming growth factor alpha promotes tumorigenesis and regulates epithelial-mesenchymal transition modulation in colon cancer
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| Yu CY, Chang WC, Zheng JH, Hung WH, Cho EC.
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| Biochem Biophys Res Commun. Dec 2;506(4):901-906. doi: 10.1016/j.bbrc.2018.10.137. Epub 2018 Nov 2. 2018
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4 | NFKB1, TGFA, YY1
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| Transcriptional Regulation of Human Transforming Growth Factor-α in Astrocytes
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| Karki P, Johnson J Jr, Son DS, Aschner M, Lee E.
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| Mol Neurobiol. Mar;54(2):964-976. doi: 10.1007/s12035-016-9705-9. Epub 2016 Jan 21. 2017
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5 | TGFA
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| TGFα expression in myeloid malignancies
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| Kavanagh S, Mirzai B, Fuller K, Erber WN.
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| J Clin Pathol. Jun;69(6):543-6. doi: 10.1136/jclinpath-2015-203526. Epub 2016 Mar 16. 2016
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6 | ICAM1, TGFA
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| Transforming growth factor alpha promotes osteosarcoma metastasis by ICAM-1 and PI3K/Akt signaling pathway.
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| Hou CH, Lin FL, Tong KB, Hou SM, Liu JF.
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| Biochem Pharmacol 89(4):453-63. doi: 10.1016/j.bcp.2014.03.010. Epub 2014 Mar 28.
2014
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7 | P4HTM, TGFA
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| PHD4 stimulates tumor angiogenesis in osteosarcoma cells via TGF-α.
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| Klotzsche-von Ameln A, Prade I, Grosser M, Kettelhake A, Rezaei M, Chavakis T, Flamme I, Wielockx B, Breier G.
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| Mol Cancer Res 11(11):1337-48. doi: 10.1158/1541-7786.MCR-13-0201. Epub 2013 Sep 18.
2013
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8 | MMP1, TGFA
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| Transforming growth factor-α activates pancreatic stellate cells and may be involved in matrix metalloproteinase-1 upregulation.
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| Tahara H, Sato K, Yamazaki Y, Ohyama T, Horiguchi N, Hashizume H, Kakizaki S, Takagi H, Ozaki I, Arai H, Hirato J, Jesenofsky R, Masamune A, Mori M.
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| Lab Invest 93(6):720-32. doi: 10.1038/labinvest.2013.59. Epub 2013 Apr 22.
2013
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9 | ADAM17, TGFA
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| ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes
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| Hall KC, Hill D, Otero M, Plumb DA, Froemel D, Dragomir CL, Maretzky T, Boskey A, Crawford HC, Selleri L, Goldring MB, Blobel CP.
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| Mol Cell Biol. Aug;33(16):3077-90. doi: 10.1128/MCB.00291-13. Epub 2013 Jun 3. 2013
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10 | IRF6, TGFA
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| Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate.
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| Letra A, Fakhouri W, Fonseca RF, Menezes R, Kempa I, Prasad JL, McHenry TG, Lidral AC, Moreno L, Murray JC, Daack-Hirsch S, Marazita ML, Castilla EE, Lace B, Orioli IM, Granjeiro JM, Schutte BC, Vieira AR.
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| PLoS One 7(9):e45441. doi: 10.1371/journal.pone.0045441. Epub 2012 Sep 20.
2012
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11 | TGFA
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| Transforming growth factor alpha (TGFα) regulates granulosa cell tumor (GCT) cell proliferation and migration through activation of multiple pathways.
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| Wang C, Lv X, Jiang C, Cordes CM, Fu L, Lele SM, Davis JS.
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| PLoS One 7(11):e48299. doi: 10.1371/journal.pone.0048299. Epub 2012 Nov 14.
2012
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12 | TGFA
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| Transforming growth factor alpha controls the transition from hypertrophic cartilage to bone during endochondral bone growth.
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| Usmani SE, Pest MA, Kim G, Ohora SN, Qin L, Beier F.
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| Bone 51(1):131-41. doi: 10.1016/j.bone.2012.04.012. Epub 2012 May 1.
2012
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13 | MMP9, PPARD, TGFA
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| AP1-dependent repression of TGFα-mediated MMP9 upregulation by PPARδ agonists in keratinocytes.
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| Meissner M, Berlinski B, Doll M, Hrgovic I, Laubach V, Reichenbach G, Kippenberger S, Gille J, Kaufmann R.
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| Exp Dermatol 20(5):425-9. doi: 10.1111/j.1600-0625.2011.01253.x.
2011
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14 | TGFA
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| Transforming growth factor-α attenuates hepatic fibrosis: possible involvement of matrix metalloproteinase-1.
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| Ohyama T, Yamazaki Y, Sato K, Horiguchi N, Ichikawa T, Kakizaki S, Takagi H, Mori M.
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| Liver Int 31(4):572-84. doi: 10.1111/j.1478-3231.2011.02475.x. Epub 2011 Feb 15.
2011
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15 | EGF, TGFA
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| Potential for functional redundancy in EGF and TGFalpha signaling in desmoid cells: a cDNA microarray analysis.
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| Trang SH, Joyner DE, Damron TA, Aboulafia AJ, Randall RL.
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| Growth Factors 28(1):10-23.
2010
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16 | TGFA
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| Evidence that TGFA influences risk to cleft lip with/without cleft palate through unconventional genetic mechanisms.
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| Sull JW, Liang KY, Hetmanski JB, Wu T, Fallin MD, Ingersoll RG, Park JW, Wu-Chou YH, Chen PK, Chong SS, Cheah F, Yeow V, Park BY, Jee SH, Jabs EW, Redett R, Scott AF, Beaty TH.
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| Hum Genet 126(3):385-94. Epub 2009 May 15.PMID: 19444471 2009
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17 | TGFA
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| Transforming growth factor-alfa gene (TGFA), human tooth agenesis, and evidence of segmental uniparental isodisomy.
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| Callahan N, Modesto A, Deeley K, Meira R, Vieira AR.
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| Eur J Oral Sci 117(1):20-6.PMID: 19196314 2009
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18 | AREG, EREG, TGFA
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| Differential effects of EGFR ligands on endocytic sorting of the receptor.
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| Roepstorff K, Grandal MV, Henriksen L, Knudsen SL, Lerdrup M, Grøvdal L, Willumsen BM, van Deurs B.
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| Traffic 10(8):1115-27. doi: 10.1111/j.1600-0854.2009.00943.x. Epub 2009 May 19.
2009
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19 | CD9, TGFA
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| Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization.
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| Imhof I, Gasper WJ, Derynck R.
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| J Cell Sci 121(Pt 13):2265-74. Epub 2008 Jun 10.PMID: 18544636 2008
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20 | NKD1, NKD2, TGFA
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| EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.
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| Ding W, Li C, Hu T, Graves-Deal R, Fotia AB, Weissman AM, Coffey RJ.
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| Proc Natl Acad Sci U S A 105(36):13433-8. Epub 2008 Aug 29.PMID: 18757723 2008
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21 | TGFA
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| Expression of intermediate filaments, EGF and TGF-alpha in early human kidney development.
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| Carev D, Saraga M, Saraga-Babic M.
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| J Mol Histol 39(2):227-35. Epub 2007 Dec 15.PMID: 18080773 2008
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22 | NKD2, TGFA
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| Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells.
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| Li C, Hao M, Cao Z, Ding W, Graves-Deal R, Hu J, Piston DW, Coffey RJ.
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| Mol Biol Cell 18(8):3081-93. Epub 2007 Jun 6.PMID: 17553928 2007
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23 | TGFA, OFC2
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| Association between the transforming growth factor alpha gene and nonsyndromic oral clefts: a HuGE review.
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| Vieira AR.
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| Am J Epidemiol 163(9):790-810. Epub 2006 Feb 22. Review. 2006
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24 | TGFA, SATB2, OFC2, OFC7
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| Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations.
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| Beaty TH, Hetmanski JB, Fallin MD, Park JW, Sull JW, McIntosh I, Liang KY, Vanderkolk CA, Redett RJ, Boyadjiev SA, Jabs EW, Chong SS, Cheah FS, Wu-Chou YH, Chen PK, Chiu YF, Yeow V, Ng IS, Cheng J, Huang S, Ye X, Wang H, Ingersoll R, Scott AF.
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| Hum Genet 120(4):501-18. Epub 2006 Sep 5. 2006
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25 | NKD2, TGFA
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| Structural studies of human Naked2: a biologically active intrinsically unstructured protein.
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| Hu T, Krezel AM, Li C, Coffey RJ.
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| Biochem Biophys Res Commun 350(4):911-5. Epub 2006 Oct 2.PMID: 17045239 2006
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26 | MAGI3, TGFA
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| Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein.
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| Franklin JL, Yoshiura K, Dempsey PJ, Bogatcheva G, Jeyakumar L, Meise KS, Pearsall RS, Threadgill D, Coffey RJ.
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| Exp Cell Res 303(2):457-70.
2005
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27 | NKD1, NKD2, TGFA
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| Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells.
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| Li C, Franklin JL, Graves-Deal R, Jerome WG, Cao Z, Coffey RJ.
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| Proc Natl Acad Sci U S A 101(15):5571-6. Epub 2004 Apr 2.PMID: 15064403 2004
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28 | GORASP2, TGFA
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| Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55.
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| Kuo A, Zhong C, Lane WS, Derynck R.
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| EMBO J 19(23):6427-39. 2000
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29 | ALMS1, TGFA
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| TGFA : exon-intron structure and evaluation as a candidate gene for Alstrm syndrome.
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| Collin GB, et al.
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| Clin Genet 55 : 61-62. 1999
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30 | OFC2, TGFA
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| Transforming growth factor-alpha (TGFA): genomic structure, boundary sequences, and mutation analysis in nonsyndromic cleft Lip/Palate and cleft palate only.
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| Machida J, Yoshiura Ki, Funkhauser CD, Natsume N, Kawai T, Murray JC.
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| Genomics 61(3):237-42 1999
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31 | OFC2, TGFA
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| Lack of linkage disequilibrium between transforming growth factor alpha Taq I polymorphism and cleft lip with or without cleft palate in families from northeastern Italy.
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| Scapoli L, Pezzetti F, Carinci F, Martinelli M, Carinci P, Tognon M.
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| Am J Med Genet 75(2):203-6. 1998
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32 | OFC2, TGFA
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| Application of transmission disequilibrium tests to nonsyndromic oral clefts : including candidate genes and environmental exposures in the models.
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| Maestri NE, Beaty TH, Hetmanski J, Smith EA, McIntosh I, Wyszynski DF, Liang KY, Duffy DL, VanderKolk C.
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| Am J Med Genet 73(3):337-44. 1997
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33 | TGFA
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| A PCR method for detecting polymorphism in the TGFA gene.
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| Basart AM, et al.
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| Hum Mol Genet 3 : 678. 1994
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34 | TGFA, OFC2
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| Evidence, from family studies, for linkage disequilibrium between TGFA and a gene for nonsyndromic cleft lip with or without cleft palate.
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| Feng H, et al.
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| Am J Hum Genet 55 : 932-936. 1994
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35 | TGFA
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| Transforming growth factor-alpha : characterization of the BamHI, Rsal, and Taql polymorphic regions.
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| Qian JF, et al.
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| Am J Hum Genet 53 : 168-175. 1993
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36 | OFC2, TGFA
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| Association of transforming growth-factor alpha gene polymorphisms with nonsyndromic cleft palate only (CPO).
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| Shiang R, et al.
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| Am J Hum Genet 53 : 836-843. 1993
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37 | TGFA
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| Expression of epidermal growth factor (EGF) receptor and its ligands, EGF and transforming growth factor-alpha, in human fallopian tubes.
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| Lei ZM, Rao CV.
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| Endocrinology 131(2):947-57.PMID: 1639032 1992
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38 | TGFA, OFC2
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| Non-syndromic cleft lip and palate : association and linkage studies with transforming growth factor alpha gene.
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| Holder SE, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 1869-1870. 1991
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39 | TGFA, OFC2
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| No association of genetic variation of the transforming growth factor-alpha with cleft-lip and palate.
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| Qian JF, et al.
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| Am J Hum Genet 49S : 397. 1991
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40 | TGFA
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| A novel BamHI polymorphism for the human transforming growth factor alpha gene (TGF-alpha).
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| Qian JF, et al.
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| Nucleic Acids Res 19 : 6665. 1991
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41 | OFC2, TGFA
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| Association of genetic variation of the transforming growth factor-alpha gene with cleft lip and palate.
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| Ardinger HH, et al.
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| Am J Hum Genet 45 : 348-353. 1989
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42 | TGFA
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| A Taq I polymorphism for the human transforming growth factor alpha gene (TGFA).
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| Hayward NK, et al.
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| Nucleic Acids Res 15 : 5503. 1987
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43 | TGFA
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| RFLPs for transforming growth factor alpha (TGFA) gene at 2p13.
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| Murray JC, et al.
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| Nucleic Acids Res 14 : 7136. 1986
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44 | TGFA
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| The gene for human transforming growth factor alpha is on the short arm of chromosome 2.
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| Tricoli JV, et al.
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| Cytogenet Cell Genet 42 : 94-98. 1986
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45 | TGFA
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| Assignment of the gene coding for human TGFalpha to chromosome 2p13.
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| Tricoli JV, et al.
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| (HGM8) Cytogenet Cell Genet 40 : 762. 1985
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46 | TGFA
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| Transforming growth factor alpha gene (TGFA) maps to human chromosome 2 close to the breakpoint of the t(2;8) variant translocation in Burkitt lymphoma.
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| Brissenden JE, et al.
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| (HGM8) Cytogenet Cell Genet 40 : 589. 1985
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47 | TGFA
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| Mapping of transforming growth factor alpha gene on human chromosome 2 close to the breakpoint of the Burkitt's lymphoma t(2;8) variant translocation.
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| Brissenden JE, et al.
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| Cancer Res 45 : 5593-5597. 1985
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