Citations for
Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.
Pichler I, Minelli C, Sanna S, Tanaka T, Schwienbacher C, Naitza S, Porcu E, Pattaro C, Busonero F, Zanon A, Maschio A, Melville SA, Grazia Piras M, Longo DL, Guralnik J, Hernandez D, Bandinelli S, Aigner E, Murphy AT, Wroblewski V, Marroni F, Theurl I, Gnewuch C, Schadt E, Mitterer M, Schlessinger D, Ferrucci L, Witcher DR, Hicks AA, Weiss G, Uda M, Pramstaller PP.
Hum Mol Genet 20(6):1232-40. Epub 2010 Dec 28. 2011
Highly Elevated Serum Hepcidin in Patients with Acute Myeloid Leukemia prior to and after Allogeneic Hematopoietic Cell Transplantation: Does This Protect from Excessive Parenchymal Iron Loading?
Eisfeld AK, Westerman M, Krahl R, Leiblein S, Liebert UG, Hehme M, Teupser D, Niederwieser D, Al-Ali HK.
Adv Hematol 2011:491058. Epub 2011 May 5. 2011
Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis.
Forejtnikovŕ H, Vieillevoye M, Zermati Y, Lambert M, Pellegrino RM, Guihard S, Gaudry M, Camaschella C, Lacombe C, Roetto A, Mayeux P, Verdier F.
Blood 116(24):5357-67. Epub 2010 Sep 8. 2010
Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation.
Poli M, Luscieti S, Gandini V, Maccarinelli F, Finazzi D, Silvestri L, Roetto A, Arosio P.
Haematologica 95(11):1832-40. Epub 2010 Jul 15. 2010
Comparison of 3 Tfr2-deficient murine models suggests distinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.
Roetto A, Di Cunto F, Pellegrino RM, Hirsch E, Azzolino O, Bondi A, Defilippi I, Carturan S, Miniscalco B, Riondato F, Cilloni D, Silengo L, Altruda F, Camaschella C, Saglio G.
Blood 115(16):3382-9. Epub 2010 Feb 23. 2010
Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.
Gao J, Chen J, De Domenico I, Koeller DM, Harding CO, Fleming RE, Koeberl DD, Enns CA.
Blood 115(16):3374-81. Epub 2010 Feb 22. 2010
Characterization of the interaction between diferric transferrin and transferrin receptor 2 by functional assays and atomic force microscopy.
Ikuta K, Yersin A, Ikai A, Aisen P, Kohgo Y.
J Mol Biol 397(2):375-84. Epub 2010 Jan 22. 2010
The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells.
Herbison CE, Thorstensen K, Chua AC, Graham RM, Leedman P, Olynyk JK, Trinder D.
Am J Physiol Cell Physiol 297(6):C1567-75. Epub 2009 Oct 14. 2009
Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression.
Gao J, Chen J, Kramer M, Tsukamoto H, Zhang AS, Enns CA.
Cell Metab 9(3):217-27. 2009
10TF, TFR2
A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease.
Mastroberardino PG, Hoffman EK, Horowitz MP, Betarbet R, Taylor G, Cheng D, Na HM, Gutekunst CA, Gearing M, Trojanowski JQ, Anderson M, Chu CT, Peng J, Greenamyre JT.
Neurobiol Dis 34(3):417-31. Epub 2009 Feb 26. 2009
HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron.
Waheed A, Britton RS, Grubb JH, Sly WS, Fleming RE.
Arch Biochem Biophys 474(1):193-7. Epub 2008 Mar 7. 2008
Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron.
Graham RM, Reutens GM, Herbison CE, Delima RD, Chua AC, Olynyk JK, Trinder D.
J Hepatol 48(2):327-34. Epub 2007 Nov 26. 2008
Transferrin receptor 2: evidence for ligand-induced stabilization and redirection to a recycling pathway.
Johnson MB, Chen J, Murchison N, Green FA, Enns CA.
Mol Biol Cell 18(3):743-54. Epub 2006 Dec 20. 2007
14HFE2, TFR2
Localization of the iron-regulatory proteins hemojuvelin and transferrin receptor 2 to the basolateral membrane domain of hepatocytes.
Merle U, Theilig F, Fein E, Gehrke S, Kallinowski B, Riedel HD, Bachmann S, Stremmel W, Kulaksiz H.
Histochem Cell Biol 127(2):221-6. Epub 2006 Aug 25. 2007
Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing.
Goswami T, Andrews NC.
J Biol Chem 281(39):28494-8. Epub 2006 Aug 7. 2006
Hepcidin is decreased in TFR2 hemochromatosis.
Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C.
Blood 105(4):1803-6. Epub 2004 Oct 14. 2005
17HFE3, TFR2
Clinical and pathologic findings in hemochromatosis type 3 due to a novel mutation in transferrin receptor 2 gene.
Girelli D, Bozzini C, Roetto A, Alberti F, Daraio F, Colombari R, Olivieri O, Corrocher R, Camaschella C.
Gastroenterology 122(5):1295-302. 2002
18HFE3, TFR2
The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.
Camaschella C, Roetto A, Cali A, De Gobbi M, Garozzo G, Carella M, Majorano N, Totaro A, Gasparini P.
Nat Genet 25(1):14-5. 2000
Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor.
Bennett MJ, Lebron JA, Bjorkman PJ.
Nature 403(6765):46-53. 2000
Transferrin receptor is negatively modulated by the hemochromatosis protein HFE: implications for cellular iron homeostasis.
Salter-Cid L, et al.
Proc Natl Acad Sci U S A 96(10):5434-9. 1999
Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family.
Kawabata H, et al.
J Biol Chem 274(30):20826-32 1999
Large-scale sequencing of two regions in human chromosome 7q22 : analysis of 650kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.
Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A.
Genome Res 8 : 1060-1073. 1998