Citations for
1TET2
Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases
Cochran JN, Geier EG, Bonham LW, Newberry JS, Amaral MD, Thompson ML, Lasseigne BN, Karydas AM, Roberson ED, Cooper GM, Rabinovici GD, Miller BL, Myers RM, Yokoyama JS
Am J Hum Genet. May 7;106(5):632-645. doi: 10.1016/j.ajhg.2020.03.010. Epub 2020 Apr 23 2020
2TET2, TET3
Loss of TET2 and TET3 in regulatory T cells unleashes effector function.
Yue X, Lio CJ, Samaniego-Castruita D, Li X, Rao A.
Nat Commun 10(1):2011. doi: 10.1038/s41467-019-09541-y. 2019
3CXXC5, POU5F1, TET1, TET2
Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells.
Ravichandran M, Lei R, Tang Q, Zhao Y, Lee J, Ma L, Chrysanthou S, Lorton BM, Cvekl A, Shechter D, Zheng D, Dawlaty MM.
Cell Rep 28(8):1993-2003.e5. doi: 10.1016/j.celrep.2019.07.080. 2019
4EZH2, SIN3A, TET1, TET2
Specific functions of TET1 and TET2 in regulating mesenchymal cell lineage determination
Cakouros D, Hemming S, Gronthos K, Liu R, Zannettino A, Shi S, Gronthos S.
Epigenetics Chromatin. Jan 3;12(1):3. doi: 10.1186/s13072-018-0247-4. 2019
5TET2
The Loss of TET2 Promotes CD8+ T Cell Memory Differentiation.
Carty SA, Gohil M, Banks LB, Cotton RM, Johnson ME, Stelekati E, Wells AD, Wherry EJ, Koretzky GA, Jordan MS.
J Immunol 200(1):82-91. doi: 10.4049/jimmunol.1700559. Epub 2017 Nov 17. 2018
6P2RX7, TET1, TET2
Tet1 and Tet2 maintain mesenchymal stem cell homeostasis via demethylation of the P2rX7 promoter. 2018
Yang R, Yu T, Kou X, Gao X, Chen C, Liu D, Zhou Y, Shi S
Nat Commun. Jun 1;9(1):2143. doi: 10.1038/s41467-018-04464-6 2018
7SETD1A, TET2
TET2- and TDG-mediated changes are required for the acquisition of distinct histone modifications in divergent terminal differentiation of myeloid cells.
Garcia-Gomez A, Li T, Kerick M, Català-Moll F, Comet NR, Rodríguez-Ubreva J, de la Rica L, Branco MR, Martín J, Ballestar E.
Nucleic Acids Res 45(17):10002-10017. doi: 10.1093/nar/gkx666. 2017
8TET2
Tet2 restrains inflammatory gene expression in macrophages.
Cull AH, Snetsinger B, Buckstein R, Wells RA, Rauh MJ.
Exp Hematol 55:56-70.e13. doi: 10.1016/j.exphem.2017.08.001. Epub 2017 Aug 18. 2017
9TET2
The protective role of TET2 in erythroid iron homeostasis against oxidative stress and erythropoiesis.
Guo S, Jiang X, Wang Y, Chen L, Li H, Li X, Jia Y.
Cell Signal 38:106-115. doi: 10.1016/j.cellsig.2017.07.002. Epub 2017 Jul 8. 2017
10RHOA, TET2
Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis.
Zang S, Li J, Yang H, Zeng H, Han W, Zhang J, Lee M, Moczygemba M, Isgandarova S, Yang Y, Zhou Y, Rao A, You MJ, Sun D, Huang Y.
J Clin Invest 127(8):2998-3012. doi: 10.1172/JCI92026. Epub 2017 Jul 10. 2017
11TET2
TET2 mutations in B cells of patients affected by angioimmunoblastic T-cell lymphoma.
Schwartz FH, Cai Q, Fellmann E, Hartmann S, Mäyränpää MI, Karjalainen-Lindsberg ML, Sundström C, Scholtysik R, Hansmann ML, Küppers R.
J Pathol 242(2):129-133. doi: 10.1002/path.4898. Epub 2017 May 3. 2017
12TET2
Impact of TET2 deficiency on iron metabolism in erythroblasts.
Inokura K, Fujiwara T, Saito K, Iino T, Hatta S, Okitsu Y, Fukuhara N, Onishi Y, Ishizawa K, Shimoda K, Harigae H.
Exp Hematol 49:56-67.e5. doi: 10.1016/j.exphem.2017.01.002. Epub 2017 Feb 5. 2017
13TET2
Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress.
Zhang YW, Wang Z, Xie W, Cai Y, Xia L, Easwaran H, Luo J, Yen RC, Li Y, Baylin SB.
Mol Cell 65(2):323-335. doi: 10.1016/j.molcel.2016.12.013. 2017
14TET2, TET3
Distinct roles for TET family proteins in regulating human erythropoiesis.
Yan H, Wang Y, Qu X, Li J, Hale J, Huang Y, An C, Papoin J, Guo X, Chen L, Kang Q, Li W, Schulz VP, Gallagher PG, Hillyer CD, Mohandas N, An X.
Blood 129(14):2002-2012. doi: 10.1182/blood-2016-08-736587. Epub 2017 Feb 6. 2017
15TET1, TET2, ZNF281
Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States.
Fidalgo M, Huang X, Guallar D, Sanchez-Priego C, Valdes VJ, Saunders A, Ding J, Wu WS, Clavel C, Wang J.
Cell Stem Cell 19(3):355-69. doi: 10.1016/j.stem.2016.05.025. Epub 2016 Jun 23. 2016
16DNMT3A, TET2
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells.
Zhang X, Su J, Jeong M, Ko M, Huang Y, Park HJ, Guzman A, Lei Y, Huang YH, Rao A, Li W, Goodell MA.
Nat Genet 48(9):1014-23. doi: 10.1038/ng.3610. Epub 2016 Jul 18. 2016
17TET2
TET2 Regulates Mast Cell Differentiation and Proliferation through Catalytic and Non-catalytic Activities.
Montagner S, Leoni C, Emming S, Della Chiara G, Balestrieri C, Barozzi I, Piccolo V, Togher S, Ko M, Rao A, Natoli G, Monticelli S.
Cell Rep 15(7):1566-1579. doi: 10.1016/j.celrep.2016.04.044. Epub 2016 May 5. 2016
18TET1, TET2, TET3
Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling.
Li X, Yue X, Pastor WA, Lin L, Georges R, Chavez L, Evans SM, Rao A.
Proc Natl Acad Sci U S A 113(51):E8267-E8276. doi: 10.1073/pnas.1617802113. Epub 2016 Dec 5. 2016
19FOXP3, TET2, TET3
Control of Foxp3 stability through modulation of TET activity.
Yue X, Trifari S, Äijö T, Tsagaratou A, Pastor WA, Zepeda-Martínez JA, Lio CW, Li X, Huang Y, Vijayanand P, Lähdesmäki H, Rao A.
J Exp Med 213(3):377-97. doi: 10.1084/jem.20151438. Epub 2016 Feb 22. 2016
20ASXL1, TET2
Mutations of ASXL1 and TET2 in aplastic anemia.
Huang J, Ge M, Lu S, Shi J, Li X, Zhang J, Wang M, Yu W, Shao Y, Huang Z, Zhang J, Nie N, Zheng Y.
Haematologica 100(5):e172-5. doi: 10.3324/haematol.2014.120931. No abstract available. 2015
21TET2
TET2 Mutation in Adult T-Cell Leukemia/Lymphoma.
Shimoda K, Shide K, Kameda T, Hidaka T, Kubuki Y, Kamiunten A, Sekine M, Akizuki K, Shimoda H, Yamaji T, Nakamura K, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Kitanaka A.
J Clin Exp Hematop 55(3):145-9. doi: 10.3960/jslrt.55.145. 2015
22TET1, TET2
Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice.
Zhao Z, Chen L, Dawlaty MM, Pan F, Weeks O, Zhou Y, Cao Z, Shi H, Wang J, Lin L, Chen S, Yuan W, Qin Z, Ni H, Nimer SD, Yang FC, Jaenisch R, Jin P, Xu M.
Cell Rep 13(8):1692-704. doi: 10.1016/j.celrep.2015.10.037. Epub 2015 Nov 12. 2015
23TET2
A Novel Function of TET2 in CNS: Sustaining Neuronal Survival.
Mi Y, Gao X, Dai J, Ma Y, Xu L, Jin W.
Int J Mol Sci 16(9):21846-57. doi: 10.3390/ijms160921846. 2015
24PRDM14, TET1, TET2
PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation.
Okashita N, Sakashita N, Ito K, Mitsuya A, Suwa Y, Seki Y.
Biochem Biophys Res Commun 466(1):138-45. doi: 10.1016/j.bbrc.2015.08.122. Epub 2015 Aug 29. 2015
25TET2, TET3
Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells.
Putiri EL, Tiedemann RL, Thompson JJ, Liu C, Ho T, Choi JH, Robertson KD.
Genome Biol 15(6):R81. doi: 10.1186/gb-2014-15-6-r81. 2014
26OGT, TET2, TET3
Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).
Zhang Q, Liu X, Gao W, Li P, Hou J, Li J, Wong J.
J Biol Chem 289(9):5986-96. doi: 10.1074/jbc.M113.524140. Epub 2014 Jan 6. 2014
27PRDM14, TET1, TET2
PRDM14 promotes active DNA demethylation through the ten-eleven translocation (TET)-mediated base excision repair pathway in embryonic stem cells.
Okashita N, Kumaki Y, Ebi K, Nishi M, Okamoto Y, Nakayama M, Hashimoto S, Nakamura T, Sugasawa K, Kojima N, Takada T, Okano M, Seki Y.
Development 141(2):269-80. doi: 10.1242/dev.099622. Epub 2013 Dec 11. 2014
28OGT, TET.3, TET2
TET2 promotes histone O-GlcNAcylation during gene transcription.
Chen Q, Chen Y, Bian C, Fujiki R, Yu X.
Nature 493(7433):561-4. doi: 10.1038/nature11742. Epub 2012 Dec 9. 2013
29TET2
Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters.
Lemonnier F, Couronné L, Parrens M, Jaïs JP, Travert M, Lamant L, Tournillac O, Rousset T, Fabiani B, Cairns RA, Mak T, Bastard C, Bernard OA, de Leval L, Gaulard P.
Blood 120(7):1466-9. Epub 2012 Jul 3. 2012
30PARP1, TET2
Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2.
Doege CA, Inoue K, Yamashita T, Rhee DB, Travis S, Fujita R, Guarnieri P, Bhagat G, Vanti WB, Shih A, Levine RL, Nik S, Chen EI, Abeliovich A.
Nature 488(7413):652-5. doi: 10.1038/nature11333. 2012
31TET2
TET2 is essential for survival and hematopoietic stem cell homeostasis.
Shide K, Kameda T, Shimoda H, Yamaji T, Abe H, Kamiunten A, Sekine M, Hidaka T, Katayose K, Kubuki Y, Yamamoto S, Miike T, Iwakiri H, Hasuike S, Nagata K, Marutsuka K, Iwama A, Matsuda T, Kitanaka A, Shimoda K.
Leukemia 26(10):2216-23. doi: 10.1038/leu.2012.94. Epub 2012 Apr 3. 2012
32TET2
Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia.
Yamazaki J, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Shen L, Kantarjian HM, Estecio MR, Jelinek J, Godley LA, Issa JP.
Epigenetics 7(2):201-7. doi: 10.4161/epi.7.2.19015. 2012
33TET2
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis.
Busque L, Patel JP, Figueroa ME, Vasanthakumar A, Provost S, Hamilou Z, Mollica L, Li J, Viale A, Heguy A, Hassimi M, Socci N, Bhatt PK, Gonen M, Mason CE, Melnick A, Godley LA, Brennan CW, Abdel-Wahab O, Levine RL.
Nat Genet 44(11):1179-81. doi: 10.1038/ng.2413. Epub 2012 Sep 23. 2012
34ASXL1, TET2
Role of TET2 and ASXL1 mutations in the pathogenesis of myeloproliferative neoplasms.
Abdel-Wahab O, Tefferi A, Levine RL.
Hematol Oncol Clin North Am 26(5):1053-64. doi: 10.1016/j.hoc.2012.07.006. Review. 2012
35TET1, TET2, TET3
Emerging roles of TET proteins and 5-hydroxymethylcytosines in active DNA demethylation and beyond.
Guo JU, Su Y, Zhong C, Ming GL, Song H.
Cell Cycle 10(16):2662-8. Epub 2011 Aug 15. Review. 2011
36TET2
TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics.
Chou WC, Chou SC, Liu CY, Chen CY, Hou HA, Kuo YY, Lee MC, Ko BS, Tang JL, Yao M, Tsay W, Wu SJ, Huang SY, Hsu SC, Chen YC, Chang YC, Kuo YY, Kuo KT, Lee FY, Liu MC, Liu CW, Tseng MH, Huang CF, Tien HF.
Blood 118(14):3803-10. doi: 10.1182/blood-2011-02-339747. Epub 2011 Aug 9. 2011
37TET2
Decreased TET2 gene expression during chronic myeloid leukemia progression.
Albano F, Anelli L, Zagaria A, Coccaro N, Minervini A, Rossi AR, Specchia G.
Leuk Res 35(11):e220-2. doi: 10.1016/j.leukres.2011.07.013. Epub 2011 Jul 27. 2011
38TET2
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.
Moran-Crusio K, Reavie L, Shih A, Abdel-Wahab O, Ndiaye-Lobry D, Lobry C, Figueroa ME, Vasanthakumar A, Patel J, Zhao X, Perna F, Pandey S, Madzo J, Song C, Dai Q, He C, Ibrahim S, Beran M, Zavadil J, Nimer SD, Melnick A, Godley LA, Aifantis I, Levine RL.
Cancer Cell 20(1):11-24. doi: 10.1016/j.ccr.2011.06.001. Epub 2011 Jun 30. 2011
39TET2
New TET2 gene mutations in patients with myeloproliferative neoplasms and splanchnic vein thrombosis.
Colaizzo D, Tiscia GL, Pisanelli D, Bafunno V, Amitrano L, Grandone E, Guardascione MA, Margaglione M.
J Thromb Haemost 8(5):1142-4. doi: 10.1111/j.1538-7836.2010.03810.x. Epub 2010 Feb 12. No abstract available. 2010
40TET2
TET2 mutations in myelodysplasia and myeloid malignancies.
Mullighan CG.
Nat Genet 41(7):766-7. 2009
41TET2
TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs).
Kosmider O, Gelsi-Boyer V, Cheok M, Grabar S, Della-Valle V, Picard F, Viguié F, Quesnel B, Beyne-Rauzy O, Solary E, Vey N, Hunault-Berger M, Fenaux P, Mansat-De Mas V, Delabesse E, Guardiola P, Lacombe C, Vainchenker W, Preudhomme C, Dreyfus F, Bernard OA, Birnbaum D, Fontenay M; Groupe Francophone des Myélodysplasies.
Blood 114(15):3285-91. Epub 2009 Aug 7. 2009
42TET2
Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms.
Saint-Martin C, Leroy G, Delhommeau F, Panelatti G, Dupont S, James C, Plo I, Bordessoule D, Chomienne C, Delannoy A, Devidas A, Gardembas-Pain M, Isnard F, Plumelle Y, Bernard O, Vainchenker W, Najman A, Bellanné-Chantelot C; French Group of Familial Myeloproliferative Disorders.
Blood 114(8):1628-32. Epub 2009 Jun 29. 2009
43TET2
TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis.
Tefferi A, Pardanani A, Lim KH, Abdel-Wahab O, Lasho TL, Patel J, Gangat N, Finke CM, Schwager S, Mullally A, Li CY, Hanson CA, Mesa R, Bernard O, Delhommeau F, Vainchenker W, Gilliland DG, Levine RL.
Leukemia 23(5):905-11. Epub 2009 Mar 5. 2009
44TET2
Acquired mutations in TET2 are common in myelodysplastic syndromes.
Langemeijer SM, Kuiper RP, Berends M, Knops R, Aslanyan MG, Massop M, Stevens-Linders E, van Hoogen P, van Kessel AG, Raymakers RA, Kamping EJ, Verhoef GE, Verburgh E, Hagemeijer A, Vandenberghe P, de Witte T, van der Reijden BA, Jansen JH.
Nat Genet 41(7):838-42. Epub 2009 May 31. 2009
45TET1, TET2, TET3
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies.
Abdel-Wahab O, Mullally A, Hedvat C, Garcia-Manero G, Patel J, Wadleigh M, Malinge S, Yao J, Kilpivaara O, Bhat R, Huberman K, Thomas S, Dolgalev I, Heguy A, Paietta E, Le Beau MM, Beran M, Tallman MS, Ebert BL, Kantarjian HM, Stone RM, Gilliland DG, Crispino JD, Levine RL.
Blood 114(1):144-7. Epub 2009 May 6. 2009
46CXXC10, CXXC4, TET2
Identification and characterization of human CXXC10 gene in silico.
Katoh M, Katoh M.
Int J Oncol 25(4):1193-9. 2004
47TET1, TET2
TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).
Lorsbach RB, Moore J, Mathew S, Raimondi SC, Mukatira ST, Downing JR.
Leukemia 17(3):637-41. No abstract available. 2003