Citations for
1CLPTM1L, NKX2-4, TERT
Functional characterization of 5p15.33 risk locus in uveal melanoma reveals rs452384 as a functional variant and NKX2.4 as an allele-specific interactor.
Derrien AC, Houy A, Ganier O, Dingli F, Ningarhari M, Mobuchon L, Espejo DÝaz MI, Loew D, Cassoux N, Cussenot O, Cancel-Tassin G, Margueron R, Noirel J, Zucman-Rossi J, Rodrigues M, Stern MH.
Am J Hum Genet. Dec 1;109(12):2196-2209. doi: 10.1016/j.ajhg.2022.11.004. 2022
2RBM10, TERT
RBM10 regulates human TERT gene splicing and inhibits pancreatic cancer progression
Xiao W, Chen X, Li X, Deng K, Liu H, Ma J, Wang Z, Hu Y, Hou J.
Am J Cancer Res. Jan 1;11(1):157-170. 2021
3NOVA1, PTBP1, TERT
NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells.
Sayed ME, Yuan L, Robin JD, Tedone E, Batten K, Dahlson N, Wright WE, Shay JW, Ludlow AT.
Oncogene 38(16):2937-2952. doi: 10.1038/s41388-018-0639-8. Epub 2018 Dec 19. 2019
4CPSF4, TERT
Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT.
Yang Q, Fan W, Zheng Z, Lin S, Liu C, Wang R, Li W, Zuo Y, Sun Y, Hu S, Chen M, Guo P, Pan J, Tian C, Zhu T, Diao C, Hao J, Yu W, Li L, Li Y, Guo W, Deng W, Wu X.
Biochim Biophys Acta Mol Cell Res 1866(10):1533-1543. doi: 10.1016/j.bbamcr.2019.07.001. Epub 2019 Jul 10. 2019
5CLPTM1L, TERT
The interaction effects of polycyclic aromatic hydrocarbons exposure and TERT- CLPTM1L variants on longitudinal telomere length shortening: A prospective cohort study.
Fu W, Chen Z, Bai Y, Wu X, Li G, Chen W, Wang G, Wang S, Li X, He M, Zhang X, Wu T, Guo H.
Environ Pollut. Nov;242(Pt B):2100-2110. doi: 10.1016/j.envpol.2018.05.026. Epub 2018 Aug 7. 2018
6KLF2, TERT
KrŘppel-like factor 2 represses transcription of the telomerase catalytic subunit human telomerase reverse transcriptase (hTERT) in human T cells.
Hara T, Mizuguchi M, Fujii M, Nakamura M.
J Biol Chem 290(14):8758-63. doi: 10.1074/jbc.M114.610386. Epub 2015 Feb 18. 2015
7TERC, TERT
Triallelic and epigenetic-like inheritance in human disorders of telomerase.
Collopy LC, Walne AJ, Cardoso S, de la Fuente J, Mohamed M, Toriello H, Tamary H, Ling AJ, Lloyd T, Kassam R, Tummala H, Vulliamy TJ, Dokal I.
Blood 126(2):176-84. doi: 10.1182/blood-2015-03-633388. Epub 2015 May 29. 2015
8TERT, TPP1
The Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner.
Chu TW, D'Souza Y, Autexier C.
Mol Cell Biol 36(1):210-22. doi: 10.1128/MCB.00746-15. 2015
9PINX1, TERT
Increased Stability of Nucleolar PinX1 in the Presence of TERT.
Keo P, Choi JS, Bae J, Shim YH, Oh BK.
Mol Cells 38(9):814-20. doi: 10.14348/molcells.2015.0144. Epub 2015 Jul 21. 2015
10CLPTM1L, TERT
Common variants modify the age of onset for basal cell carcinomas in Gorlin syndrome
Yasar B, Byers HJ, Smith MJ, Lear J, Oudit D, Bholah Z, Roberts SA, Newman WG, Evans DG.
Eur J Hum Genet. May;23(5):708-10. doi: 10.1038/ejhg.2014.167. Epub 2014 Aug 27 2015
11MCRS1, SCYL1, TERT
The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF).
Hsu CC, Chen CH, Hsu TI, Hung JJ, Ko JL, Zhang B, Lee YC, Chen HK, Chang WC, Lin DY.
Biochim Biophys Acta 1843(3):565-79. 2014
12TERT
TERT promoter mutation status as an independent prognostic factor in cutaneous melanoma.
Griewank KG, Murali R, Puig-Butille JA, Schilling B, Livingstone E, Potrony M, Carrera C, Schimming T, M÷ller I, Schwamborn M, Sucker A, Hillen U, Badenas C, Malvehy J, Zimmer L, Scherag A, Puig S, Schadendorf D.
J Natl Cancer Inst 106(9). pii: dju246. doi: 10.1093/jnci/dju246. Print 2014 Sep. 2014
13TERT
Dual roles of c-Myc in the regulation of hTERT gene.
Zhao Y, Cheng D, Wang S, Zhu J.
Nucleic Acids Res 42(16):10385-98. doi: 10.1093/nar/gku721. Epub 2014 Aug 28. 2014
14DKC1, TERT
Dyskeratosis congenita caused by a novel TERT point mutation in siblings with pancytopenia and exudative retinopathy.
Sharma A, Myers K, Ye Z, D'Orazio J.
Pediatr Blood Cancer 61(12):2302-4. doi: 10.1002/pbc.25161. Epub 2014 Jul 25. 2014
15FOXO3, SIRT1, TERT
FOXO3a potentiates hTERT gene expression by activating c-MYC and extends the replicative life-span of human fibroblast.
Yamashita S, Ogawa K, Ikei T, Fujiki T, Katakura Y.
PLoS One 9(7):e101864. doi: 10.1371/journal.pone.0101864. eCollection 2014. 2014
16TERT
TERT attenuated ER stress-induced cell death.
Hosoi T, Inoue Y, Nakatsu K, Matsushima N, Kiyose N, Shimamoto A, Tahara H, Ozawa K.
Biochem Biophys Res Commun 447(2):378-82. doi: 10.1016/j.bbrc.2014.04.034. Epub 2014 Apr 16. 2014
17TERT
Telomerase enzymatic component hTERT shortens long telomeres in human cells.
Zheng YL, Zhang F, Sun B, Du J, Sun C, Yuan J, Wang Y, Tao L, Kota K, Liu X, Schlegel R, Yang Q.
Cell Cycle 13(11):1765-76. doi: 10.4161/cc.28705. Epub 2014 Apr 10. 2014
18TERT
TERT promoter mutations in cancer development.
Heidenreich B, Rachakonda PS, Hemminki K, Kumar R.
Curr Opin Genet Dev 24:30-7. doi: 10.1016/j.gde.2013.11.005. Epub 2013 Dec 20. Review. 2014
19PTTG1, TERT, XRCC6
Changes in PTTG1 by human TERT gene expression modulate the self-renewal of placenta-derived mesenchymal stem cells.
Lee HJ, Choi JH, Jung J, Kim JK, Lee SS, Kim GJ.
Cell Tissue Res 357(1):145-57. doi: 10.1007/s00441-014-1874-0. Epub 2014 May 11. 2014
20PINX1, TERF1, TERT
PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles.
Yoo JE, Park YN, Oh BK.
J Biol Chem 289(10):6886-98. doi: 10.1074/jbc.M113.506006. Epub 2014 Jan 10. 2014
21DEK, TERT
Chromatin redistribution of the DEK oncoprotein represses hTERT transcription in leukemias.
Karam M, Thenoz M, Capraro V, Robin JP, Pinatel C, Lancon A, Galia P, Sibon D, Thomas X, Ducastelle-Lepretre S, Nicolini F, El-Hamri M, Chelghoun Y, Wattel E, Mortreux F.
Neoplasia 16(1):21-30. 2014
22CPSF4, TERT
CPSF4 activates telomerase reverse transcriptase and predicts poor prognosis in human lung adenocarcinomas.
Chen W, Qin L, Wang S, Li M, Shi D, Tian Y, Wang J, Fu L, Li Z, Guo W, Yu W, Yuan Y, Kang T, Huang W, Deng W.
Mol Oncol 8(3):704-16. doi: 10.1016/j.molonc.2014.02.001. Epub 2014 Feb 14. 2014
23ATF7IP, BAK1, DMRT1, KITLG, SPRY4, TERT
Investigation of six testicular germ cell tumor susceptibility genes suggests a parent-of-origin effect in SPRY4.
Karlsson R, Andreassen KE, Kristiansen W, Aschim EL, Bremnes RM, Dahl O, Fossň SD, Klepp O, Langberg CW, Solberg A, Tretli S, Magnusson PK, Adami HO, Haugen TB, Grotmol T, Wiklund F.
Hum Mol Genet 22(16):3373-80. doi: 10.1093/hmg/ddt188. Epub 2013 May 2. 2013
24DDB1, DYRK2, TERT, UBR5, VPRBP
Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation.
Jung HY, Wang X, Jun S, Park JI.
J Biol Chem 288(10):7252-62. doi: 10.1074/jbc.M112.416792. Epub 2013 Jan 28. 2013
25TERT
Highly recurrent TERT promoter mutations in human melanoma.
Huang FW, Hodis E, Xu MJ, Kryukov GV, Chin L, Garraway LA.
Science 339(6122):957-9. doi: 10.1126/science.1229259. Epub 2013 Jan 24. 2013
26TERT
TERT promoter mutations in familial and sporadic melanoma.
Horn S, Figl A, Rachakonda PS, Fischer C, Sucker A, Gast A, Kadel S, Moll I, Nagore E, Hemminki K, Schadendorf D, Kumar R.
Science 339(6122):959-61. doi: 10.1126/science.1230062. Epub 2013 Jan 24. 2013
27TERT
Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells.
Mazumdar T, Sandhu R, Qadan M, DeVecchio J, Magloire V, Agyeman A, Li B, Houghton JA.
PLoS One 8(9):e75253. doi: 10.1371/journal.pone.0075253. eCollection 2013. 2013
28TERT
Physiological and pathological significance of human telomerase reverse transcriptase splice variants.
Bollmann FM.
Biochimie 95(11):1965-70. doi: 10.1016/j.biochi.2013.07.031. Epub 2013 Aug 9. Review. 2013
29TERT
Many disease-associated variants of hTERT retain high telomerase enzymatic activity.
Zaug AJ, Crary SM, Jesse Fioravanti M, Campbell K, Cech TR.
Nucleic Acids Res 41(19):8969-78. doi: 10.1093/nar/gkt653. Epub 2013 Jul 30. 2013
30TERT
Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-κB-dependent transcription.
Ding D, Xi P, Zhou J, Wang M, Cong YS.
FASEB J 27(11):4375-83. doi: 10.1096/fj.13-230904. Epub 2013 Jul 24. 2013
31TERC, TERT
The roles of telomerase in the generation of polyploidy during neoplastic cell growth.
Christodoulidou A, Raftopoulou C, Chiourea M, Papaioannou GK, Hoshiyama H, Wright WE, Shay JW, Gagos S.
Neoplasia 15(2):156-68. 2013
32TERT
Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis.
Singhapol C, Pal D, Czapiewski R, Porika M, Nelson G, Saretzki GC.
PLoS One 8(1):e52989. doi: 10.1371/journal.pone.0052989. Epub 2013 Jan 9. 2013
33NVL, TERT
The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly.
Her J, Chung IK.
Biochem Biophys Res Commun 417(3):1086-92. doi: 10.1016/j.bbrc.2011.12.101. Epub 2011 Dec 27. 2012
34AKT1, TERT
Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation.
Chung J, Khadka P, Chung IK.
J Cell Sci 125(Pt 11):2684-97. doi: 10.1242/jcs.099267. Epub 2012 Feb 24. 2012
35DKC1, TERT
The accumulation and not the specific activity of telomerase ribonucleoprotein determines telomere maintenance deficiency in X-linked dyskeratosis congenita.
Zeng XL, Thumati NR, Fleisig HB, Hukezalie KR, Savage SA, Giri N, Alter BP, Wong JM.
Hum Mol Genet 21(4):721-9. doi: 10.1093/hmg/ddr504. Epub 2011 Nov 4. 2012
36TERC, TERT
Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes.
Aubert G, Baerlocher GM, Vulto I, Poon SS, Lansdorp PM.
PLoS Genet 8(5):e1002696. doi: 10.1371/journal.pgen.1002696. Epub 2012 May 17. 2012
37TERT
Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/β-catenin pathway in human cancer.
Zhang Y, Toh L, Lau P, Wang X.
J Biol Chem 287(39):32494-511. 2012
38RUVBL2, TERT
RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer.
Flavin P, Redmond A, McBryan J, Cocchiglia S, Tibbitts P, Fahy-Browne P, Kay E, Treumann A, Perrem K, McIlroy M, Hill AD, Young LS.
FEBS Lett 585(15):2537-44. Epub 2011 Jul 13. 2011
39TERT
Dual roles of a variable number of tandem repeat polymorphism in the TERT gene in lung cancer.
Jin G, Yoo SS, Cho S, Jeon HS, Lee WK, Kang HG, Choi YY, Choi JE, Cha SI, Lee EB, Kim CH, Jung TH, Kim YT, Park JY.
Cancer Sci 102(1):144-9. doi: 10.1111/j.1349-7006.2010.01782.x. Epub 2010 Nov 18.PMID: 21083788 2011
40TERT
Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis.
Alder JK, Cogan JD, Brown AF, Anderson CJ, Lawson WE, Lansdorp PM, Phillips JA 3rd, Loyd JE, Chen JJ, Armanios M.
PLoS Genet 7(3):e1001352. Epub 2011 Mar 31. 2011
41TERT
Direct involvement of the TEN domain at the active site of human telomerase.
Jurczyluk J, Nouwens AS, Holien JK, Adams TE, Lovrecz GO, Parker MW, Cohen SB, Bryan TM.
Nucleic Acids Res 39(5):1774-88. Epub 2010 Nov 3. 2011
42FEN1, TERT
Mapping the FEN1 interaction domain with hTERT.
Sampathi S, Chai W.
Biochem Biophys Res Commun 407(1):34-8. Epub 2011 Feb 21. 2011
43ACD, TERT
Functional interaction between telomere protein TPP1 and telomerase.
Zaug AJ, Podell ER, Nandakumar J, Cech TR.
Genes Dev 24(6):613-22.PMID: 20231318 2010
44CLPTM1L, TERT
Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck.
Liu Z, Li G, Wei S, Niu J, Wang LE, Sturgis EM, Wei Q.
Carcinogenesis 31(11):1977-81. Epub 2010 Aug 28.PMID: 20802237 2010
45TERT
Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines.
Tsai CC, Chen CL, Liu HC, Lee YT, Wang HW, Hou LT, Hung SC.
J Biomed Sci 17:64.PMID: 20670406 2010
46TERT
KrŘppel-like transcription factor 4 contributes to maintenance of telomerase activity in stem cells.
Wong CW, Hou PS, Tseng SF, Chien CL, Wu KJ, Chen HF, Ho HN, Kyo S, Teng SC.
Stem Cells 28(9):1510-7.PMID: 20629177 2010
47TERT
Human chromosome 5 carries a transcriptional regulator of human telomerase reverse transcriptase (hTERT).
Qi DL, Ohhira T, Oshimura M, Kugoh H.
Biochem Biophys Res Commun 398(4):695-701. Epub 2010 Jul 16.PMID: 20621064 2010
48TERT
Variation at the TERT locus and predisposition for cancer.
Baird DM.
Expert Rev Mol Med 12:e16. Review.PMID: 20478107 2010
49PINX1, TERF1, TERT
C-terminal amino acids 290-328 of LPTS/PinX1 confer telomerase inhibition.
Chen G, Da L, Xu Y, Xu M, Song L, Li T, Zhao M.
Biochem Biophys Res Commun 398(4):683-9. Epub 2010 Jul 8.PMID: 20620128 2010
50DKC1, DKC2, DKC3, DKC4, DKC5, DKC6, NHP2, NOP10, TERC, TERT, TINF2
Dyskeratosis congenita.
Bessler M, Wilson DB, Mason PJ.
FEBS Lett 584(17):3831-8. Epub 2010 May 21.PMID: 20493861 2010
51MBD2, TERT
Specific association between the methyl-CpG-binding domain protein 2 and the hypermethylated region of the human telomerase reverse transcriptase promoter in cancer cells.
Chatagnon A, Bougel S, Perriaud L, Lachuer J, Benhattar J, Dante R.
Carcinogenesis 30(1):28-34. Epub 2008 Oct 24. 2009
52TERT
Differential repression of human and mouse TERT genes during cell differentiation.
Wang S, Zhao Y, Hu C, Zhu J.
Nucleic Acids Res 37(8):2618-29. Epub 2009 Mar 6. 2009
53SMARCA4, TERT
Telomerase modulates Wnt signalling by association with target gene chromatin.
Park JI, Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, Chang W, Meng Z, Cheung P, Ji H, McLaughlin M, Veenstra TD, Nusse R, McCrea PD, Artandi SE.
Nature 460(7251):66-72. 2009
54RMRP, TERT
An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA.
Maida Y, Yasukawa M, Furuuchi M, Lassmann T, Possemato R, Okamoto N, Kasim V, Hayashizaki Y, Hahn WC, Masutomi K.
Nature 461(7261):230-5. Epub 2009 Aug 23. 2009
55TERT
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
Landi MT, Chatterjee N, Yu K, Goldin LR, Goldstein AM, Rotunno M, Mirabello L, Jacobs K, Wheeler W, Yeager M, Bergen AW, Li Q, Consonni D, Pesatori AC, Wacholder S, Thun M, Diver R, Oken M, Virtamo J, Albanes D, Wang Z, Burdette L, Doheny KF, Pugh EW, Laurie C, Brennan P, Hung R, Gaborieau V, McKay JD, Lathrop M, McLaughlin J, Wang Y, Tsao MS, Spitz MR, Wang Y, Krokan H, Vatten L, Skorpen F, Arnesen E, Benhamou S, Bouchard C, Metsapalu A, Vooder T, Nelis M, Vńlk K, Field JK, Chen C, Goodman G, Sulem P, Thorleifsson G, Rafnar T, Eisen T, Sauter W, Rosenberger A, Bickeb÷ller H, Risch A, Chang-Claude J, Wichmann HE, Stefansson K, Houlston R, Amos CI, Fraumeni JF Jr, Savage SA, Bertazzi PA, Tucker MA, Chanock S, Caporaso NE.
Am J Hum Genet 85(5):679-91. Epub 2009 Oct 15.PMID: 19836008 2009
56NHP2, NOL10, TERC, TERT
Exogenous TERC alone can enhance proliferative potential, telomerase activity and telomere length in lymphocytes from dyskeratosis congenita patients.
Kirwan M, Beswick R, Vulliamy T, Nathwani AC, Walne AJ, Casimir C, Dokal I.
Br J Haematol 144(5):771-81. Epub 2008 Nov 20.PMID: 19036115 2009
57PRKCD, TERT
Protein kinase C delta plays a key role in cellular senescence programs of human normal diploid cells.
Katakura Y, Udono M, Katsuki K, Nishide H, Tabira Y, Ikei T, Yamashita M, Fujiki T, Shirahata S.
J Biochem 146(1):87-93. Epub 2009 Mar 11.PMID: 19279193 2009
58TERT
Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population.
Jin G, Xu L, Shu Y, Tian T, Liang J, Xu Y, Wang F, Chen J, Dai J, Hu Z, Shen H.
Carcinogenesis 30(6):987-90. Epub 2009 Apr 15.PMID: 19369581 2009
59PTGES3, TERT
A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function.
Woo SH, An S, Lee HC, Jin HO, Seo SK, Yoo DH, Lee KH, Rhee CH, Choi EJ, Hong SI, Park IC.
J Biol Chem 284(45):30871-80. Epub 2009 Sep 9. 2009
60DKC1, DKC2, TERC, DKC3, TERT
Dyskeratosis congenita: a genetic disorder of many faces.
Kirwan M, Dokal I.
Clin Genet 73(2):103-12. Epub 2007 Nov 14. Review. 2008
61DKC, DKC1, DKC2, DKC3, DKC4, DKC5, TERC, TERT, TINF2
Dyskeratosis congenita: the diverse clinical presentation of mutations in the telomerase complex.
Vulliamy TJ, Dokal I.
Biochimie 90(1):122-30. Epub 2007 Jul 31. Review. 2008
62TERT
A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis.
Mushiroda T, Wattanapokayakit S, Takahashi A, Nukiwa T, Kudoh S, Ogura T, Taniguchi H, Kubo M, Kamatani N, Nakamura Y; Pirfenidone Clinical Study Group.
J Med Genet 45(10):654-6. 2008
63CLPTM1L, TERT
Lung cancer susceptibility locus at 5p15.33.
McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, Byrnes G, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, McLaughlin J, Shepherd F, Montpetit A, Narod S, Krokan HE, Skorpen F, Elvestad MB, Vatten L, Nj°lstad I, Axelsson T, Chen C, Goodman G, Barnett M, Loomis MM, Lubi˝ski J, Matyjasik J, Lener M, Oszutowska D, Field J, Liloglou T, Xinarianos G, Cassidy A; EPIC Study, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, Gonzßlez CA, Ramˇn Quirˇs J, MartÝnez C, Navarro C, Ardanaz E, Larra˝aga N, Kham KT, Key T, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tj°nneland A, Kumle M, Riboli E, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P.
Nat Genet 40(12):1404-6. Epub 2008 Nov 2. 2008
64NFX1, SIN3A, TERT
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA.
Mol Cell Biol 28(15):4819-28. Epub 2008 May 27. 2008
65TERT
Functional genomics of hTERT gene in leukemic myelopoiesis.
Kaul D, Gautam A, Varma S, Ahlawat A.
Mol Cell Biochem 314(1-2):19-23. Epub 2008 Apr 13.PMID: 1840903 2008
66TERT
Nucleolar localization of TERT is unrelated to telomerase function in human cells.
Lin J, Jin R, Zhang B, Chen H, Bai YX, Yang PX, Han SW, Xie YH, Huang PT, Huang C, Huang JJ.
J Cell Sci 121(Pt 13):2169-76. Epub 2008 Jun 3.PMID: 18522991 2008
67PINX1, TERT, SOCS1
Characterization of a novel effect of hPinX1 on hTERT nucleolar localization.
Lin J, Jin R, Zhang B, Yang PX, Chen H, Bai YX, Xie Y, Huang C, Huang J.
Biochem Biophys Res Commun 353(4):946-52. Epub 2006 Dec 22. 2007
68TERT
A novel peptide-nucleotide dual vaccine of human telomerase reverse transcriptase induces a potent cytotoxic T-cell response in vivo.
Guo H, Hao J, Wu C, Shi Y, Zhao XY, Fang DC.
Biochem Biophys Res Commun 357(4):1090-5. Epub 2007 Apr 19. 2007
69TERT
hTERT inhibits the Epstein-Barr virus lytic cycle and promotes the proliferation of primary B lymphocytes: implications for EBV-driven lymphomagenesis.
Terrin L, Dolcetti R, Corradini I, Indraccolo S, Col JD, Bertorelle R, Bonaldi L, Esposito G, De Rossi A.
Int J Cancer 121(3):576-87. 2007
70ZBTB16, TP53INP1, TERT, ID3, ID1
Identification of apoptosis-related PLZF target genes.
Bernardo MV, Yelo E, Gimeno L, Campillo JA, Parrado A.
Biochem Biophys Res Commun 359(2):317-22. Epub 2007 May 24. 2007
71SMYD3, TERT
The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3.
Liu C, Fang X, Ge Z, Jalink M, Kyo S, Bj÷rkholm M, Gruber A, Sj÷berg J, Xu D.
Cancer Res 67(6):2626-31. 2007
72SMAD3, TERT
Mechanisms of action of TGF-beta in cancer: evidence for Smad3 as a repressor of the hTERT gene.
Li H, Liu JP.
Ann N Y Acad Sci 1114:56-68. Epub 2007 Oct 12. Review. 2007
73TERT
Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis.
Santos JH, Meyer JN, Van Houten B.
Hum Mol Genet 15(11):1757-68. Epub 2006 Apr 13. 2006
74TERT
A major role of PKC theta and NFkappaB in the regulation of hTERT in human T lymphocytes.
Sheng WY, Chen YR, Wang TC.
FEBS Lett 580(30):6819-24. Epub 2006 Nov 27. 2006
75NHP2, TERT
Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia.
Yamaguchi H, Calado RT, Ly H, Kajigaya S, Baerlocher GM, Chanock SJ, Lansdorp PM, Young NS.
N Engl J Med 352(14):1413-24. 2005
76TERT
Effects of telomerase and telomere length on epidermal stem cell behavior.
Flores I, Cayuela ML, Blasco MA.
Science 309(5738):1253-6. Epub 2005 Jul 21. 2005
77TERT, DKC3
Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita.
Armanios M, Chen JL, Chang YP, Brodsky RA, Hawkins A, Griffin CA, Eshleman JR, Cohen AR, Chakravarti A, Hamosh A, Greider CW.
Proc Natl Acad Sci U S A 102(44):15960-4. Epub 2005 Oct 24. 2005
78TERT
Role of hTERT in apoptosis of cervical cancer induced by histone deacetylase inhibitor.
Wu P, Meng L, Wang H, Zhou J, Xu G, Wang S, Xi L, Chen G, Wang B, Zhu T, Lu Y, Ma D.
Biochem Biophys Res Commun 335(1):36-44. 2005
79TP73, TP53, TERT
C-terminal p73 isoforms repress transcriptional activity of the human telomerase reverse transcriptase (hTERT) promoter.
Racek T, Mise N, Li Z, Stoll A, Putzer BM.
J Biol Chem 280(49):40402-5. Epub 2005 Oct 17. 2005
80CTCF, TERT
CTCF binds the proximal exonic region of hTERT and inhibits its transcription.
Renaud S, Loukinov D, Bosman FT, Lobanenkov V, Benhattar J.
Nucleic Acids Res 33(21):6850-60. Print 2005. 2005
81TERT
Human chromosome 5 carries a putative telomerase repressor gene
Kugoh H, Shigenami K, Funaki K, Barrett JC, Oshimura M.
Genes Chromosomes Cancer 36(1):37-47. 2003
82FRK, GEMIN2, MAD1L1, TERT
Multiple tumor suppressor pathways negatively regulate telomerase.
Lin SY, Elledge SJ.
Cell 113(7):881-9. 2003
83TERT
Telomerase maintains telomere structure in normal human cells.
Masutomi K, Yu EY, Khurts S, Ben-Porath I, Currier JL, Metz GB, Brooks MW, Kaneko S, Murakami S, DeCaprio JA, Weinberg RA, Stewart SA, Hahn WC.
Cell 114(2):241-53. 2003
84TERT, EREG
Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene.
Lindvall C, Hou M, Komurasaki T, Zheng C, Henriksson M, Sedivy JM, Bjorkholm M, Teh BT, Nordenskjold M, Xu D.
Cancer Res 63(8):1743-7. 2003
85BIRC5, TERT
Co-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma.
Wurl P, Kappler M, Meye A, Bartel F, Kohler T, Lautenschlager C, Bache M, Schmidt H, Taubert H.
Lancet 359(9310):943-5. 2002
86TERT
Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomas.
Zhang A, Zheng C, Hou M, Lindvall C, Wallin KL, Angstrom T, Yang X, Hellstrom AC, Blennow E, Bjorkholm M, Zetterberg A, Gruber A, Xu D.
Genes Chromosomes Cancer 34(3):269-75. 2002
87CLPTM1L, TERT
The human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphisms in intronic regions.
Leem SH, Londono-Vallejo JA, Kim JH, Bui H, Tubacher E, Solomon G, Park JE, Horikawa I, Kouprina N, Barrett JC, Larionov V.
Oncogene 21(5):769-77. 2002
88TERT, USF2
Variant forms of upstream stimulatory factors (USFs) control the promoter activity of hTERT, the human gene encoding the catalytic subunit of telomerase.
Yago M, Ohki R, Hatakeyama S, Fujita T, Ishikawa F.
FEBS Lett 520(1-3):40-6. 2002
89TERT
Methylation of the human telomerase gene CpG island.
Dessain SK, Yu H, Reddel RR, Beijersbergen RL, Weinberg RA.
Cancer Res 60(3):537-41. 2000
90TERT
Identification of Mad as a repressor of the human telomerase (hTERT) gene.
Oh S, Song YH, Yim J, Kim TK.
Oncogene 19(11):1485-90. 2000
91TERT
Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization.
Bryce LA, Morrison N, Hoare SF, Muir S, Keith WN.
Neoplasia 2(3):197-201. 2000
92TERT
Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1.
Gunes C, Lichtsteiner S, Vasserot AP, Englert C.
Cancer Res 60(8):2116-21. 2000
93DKC1, GAR1, NHP2, NOP10, SNHG3, SNORA73A, SNORA73B, TERC, TERT
In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs.
Dragon F, Pogacic V, Filipowicz W.
Mol Cell Biol 20(9):3037-48. 2000
94DKC1, GAR1, NHP2, NHP2L1, NOP10, SNHG3, SNORA73A, SNORA73B, TERC, TERT
Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10.
Pogacic V, Dragon F, Filipowicz W.
Mol Cell Biol 20(23):9028-40. 2000
95TERC, TERT
Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase.
Mitchell JR, Collins K.
Mol Cell 6(2):361-71. 2000
96TERT
The human telomerase catalytic subunit hTERT : organization of the gene and characterization of the promoter.
Cong YS, Wen J, Bacchetti S.
Hum Mol Genet 8 : 137-142. 1999
97ALB, CAD, CCNA2, CDC25A, CDK1, CEBPA, COL1A1, COL1A2, COL3A1, COL6A3, DHFR, DMTF1, GADD45A, JUN, LDHA, MXI1, MYC, ODC1, RCC1, SERPINE1, TERT, TK1, TK2, TP53
c-Myc target genes involved in cell growth, apoptosis, and metabolism.
Dang CV.
Mol Cell Biol 19(1):1-11. Review. No abstract available 1999
98TERT
Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells.
Takakura M, et al.
Cancer Res 59(3):551-7. 1999
99TERT
Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections.
Tahara H, et al.
Oncogene 18(8):1561-7. 1999
100TERT
Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT).
Wick M, et al.
Gene 232(1):97-106. 1999
101TERT
DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene.
Devereux TR, Horikawa I, Anna CH, Annab LA, Afshari CA, Barrett JC.
Cancer Res 59(24):6087-90. 1999
102TERT
Expression of TERT in early premalignant lesions and a subset of cells in normal tissues.
Kolquist KA, et al.
Nat Genet 19 : 182-186. 1998
103TERC, TERT
Essential role of mouse telomerase in highly proliferative organs.
Lee HW, Blasco MA, Gottlieb GJ, Horner JW 2nd, Greider CW, DePinho RA.
Nature 392(6676):569-74. 1998
104TERT
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.
Meyerson M, et al.
Cell 90 : 785-795. 1997
105TERT
Telomerase catalytic subunit homologs from fission yeast and human.
Nakamura TM, et al.
Science 277 : 955-959. 1997
106TERT
Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.
Kilian A, et al.
Hum Mol Genet 6 : 2011-2019. 1997
107TERT
Human telomerase contains evolutionarily conserved catalytic and structural subunits.
Harrington L, et al.
Genes Dev 11 : 3109-3115. 1997