| 1 | CLPTM1L, NKX2-4, TERT
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| Functional characterization of 5p15.33 risk locus in uveal melanoma reveals rs452384 as a functional variant and NKX2.4 as an allele-specific interactor.
|
| Derrien AC, Houy A, Ganier O, Dingli F, Ningarhari M, Mobuchon L, Espejo Díaz MI, Loew D, Cassoux N, Cussenot O, Cancel-Tassin G, Margueron R, Noirel J, Zucman-Rossi J, Rodrigues M, Stern MH.
|
| Am J Hum Genet. Dec 1;109(12):2196-2209. doi: 10.1016/j.ajhg.2022.11.004. 2022
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| 2 | RBM10, TERT
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| RBM10 regulates human TERT gene splicing and inhibits pancreatic cancer progression
|
| Xiao W, Chen X, Li X, Deng K, Liu H, Ma J, Wang Z, Hu Y, Hou J.
|
| Am J Cancer Res. Jan 1;11(1):157-170. 2021
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| 3 | NOVA1, PTBP1, TERT
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| NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells.
|
| Sayed ME, Yuan L, Robin JD, Tedone E, Batten K, Dahlson N, Wright WE, Shay JW, Ludlow AT.
|
| Oncogene 38(16):2937-2952. doi: 10.1038/s41388-018-0639-8. Epub 2018 Dec 19.
2019
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| 4 | CPSF4, TERT
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| Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT.
|
| Yang Q, Fan W, Zheng Z, Lin S, Liu C, Wang R, Li W, Zuo Y, Sun Y, Hu S, Chen M, Guo P, Pan J, Tian C, Zhu T, Diao C, Hao J, Yu W, Li L, Li Y, Guo W, Deng W, Wu X.
|
| Biochim Biophys Acta Mol Cell Res 1866(10):1533-1543. doi: 10.1016/j.bbamcr.2019.07.001. Epub 2019 Jul 10.
2019
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| 5 | PES1, TERT
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| PES1 is a critical component of telomerase assembly and regulates cellular senescence
|
| Cheng L, Yuan B, Ying S, Niu C, Mai H, Guan X, Yang X, Teng Y, Lin J, Huang J, Jin R, Wu J, Liu B, Chang S, Wang E, Zhang C, Hou N, Cheng X, Xu D, Yang X, Gao S, Ye Q.
|
| Sci Adv. May 15;5(5):eaav1090. doi: 10.1126/sciadv.aav1090 2019
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| 6 | CLPTM1L, TERT
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| The interaction effects of polycyclic aromatic hydrocarbons exposure and TERT- CLPTM1L variants on longitudinal telomere length shortening: A prospective cohort study.
|
| Fu W, Chen Z, Bai Y, Wu X, Li G, Chen W, Wang G, Wang S, Li X, He M, Zhang X, Wu T, Guo H.
|
| Environ Pollut. Nov;242(Pt B):2100-2110. doi: 10.1016/j.envpol.2018.05.026. Epub 2018 Aug 7. 2018
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| 7 | KLF2, TERT
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| Krüppel-like factor 2 represses transcription of the telomerase catalytic subunit human telomerase reverse transcriptase (hTERT) in human T cells.
|
| Hara T, Mizuguchi M, Fujii M, Nakamura M.
|
| J Biol Chem 290(14):8758-63. doi: 10.1074/jbc.M114.610386. Epub 2015 Feb 18.
2015
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| 8 | TERC, TERT
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| Triallelic and epigenetic-like inheritance in human disorders of telomerase.
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| Collopy LC, Walne AJ, Cardoso S, de la Fuente J, Mohamed M, Toriello H, Tamary H, Ling AJ, Lloyd T, Kassam R, Tummala H, Vulliamy TJ, Dokal I.
|
| Blood 126(2):176-84. doi: 10.1182/blood-2015-03-633388. Epub 2015 May 29.
2015
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| 9 | TERT, TPP1
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| The Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner.
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| Chu TW, D'Souza Y, Autexier C.
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| Mol Cell Biol 36(1):210-22. doi: 10.1128/MCB.00746-15.
2015
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| 10 | PINX1, TERT
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| Increased Stability of Nucleolar PinX1 in the Presence of TERT.
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| Keo P, Choi JS, Bae J, Shim YH, Oh BK.
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| Mol Cells 38(9):814-20. doi: 10.14348/molcells.2015.0144. Epub 2015 Jul 21.
2015
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| 11 | CLPTM1L, TERT
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| Common variants modify the age of onset for basal cell carcinomas in Gorlin syndrome
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| Yasar B, Byers HJ, Smith MJ, Lear J, Oudit D, Bholah Z, Roberts SA, Newman WG, Evans DG.
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| Eur J Hum Genet. May;23(5):708-10. doi: 10.1038/ejhg.2014.167. Epub 2014 Aug 27 2015
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| 12 | IRX2, TERT
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| Activation of human telomerase reverse transcriptase through gene fusion in clear cell sarcoma of the kidney.
|
| Karlsson J, Lilljebjörn H, Holmquist Mengelbier L, Valind A, Rissler M, Øra I, Fioretos T, Gisselsson D
|
| Cancer Lett. Feb 28;357(2):498-501. doi: 10.1016/j.canlet.2014.11.057. Epub 2014 Dec 3. 2015
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| 13 | MCRS1, SCYL1, TERT
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| The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF).
|
| Hsu CC, Chen CH, Hsu TI, Hung JJ, Ko JL, Zhang B, Lee YC, Chen HK, Chang WC, Lin DY.
|
| Biochim Biophys Acta 1843(3):565-79.
2014
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| 14 | TERT
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| TERT promoter mutation status as an independent prognostic factor in cutaneous melanoma.
|
| Griewank KG, Murali R, Puig-Butille JA, Schilling B, Livingstone E, Potrony M, Carrera C, Schimming T, Möller I, Schwamborn M, Sucker A, Hillen U, Badenas C, Malvehy J, Zimmer L, Scherag A, Puig S, Schadendorf D.
|
| J Natl Cancer Inst 106(9). pii: dju246. doi: 10.1093/jnci/dju246. Print 2014 Sep.
2014
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| 15 | TERT
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| Dual roles of c-Myc in the regulation of hTERT gene.
|
| Zhao Y, Cheng D, Wang S, Zhu J.
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| Nucleic Acids Res 42(16):10385-98. doi: 10.1093/nar/gku721. Epub 2014 Aug 28.
2014
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| 16 | DKC1, TERT
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| Dyskeratosis congenita caused by a novel TERT point mutation in siblings with pancytopenia and exudative retinopathy.
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| Sharma A, Myers K, Ye Z, D'Orazio J.
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| Pediatr Blood Cancer 61(12):2302-4. doi: 10.1002/pbc.25161. Epub 2014 Jul 25.
2014
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| 17 | FOXO3, SIRT1, TERT
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| FOXO3a potentiates hTERT gene expression by activating c-MYC and extends the replicative life-span of human fibroblast.
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| Yamashita S, Ogawa K, Ikei T, Fujiki T, Katakura Y.
|
| PLoS One 9(7):e101864. doi: 10.1371/journal.pone.0101864. eCollection 2014.
2014
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| 18 | TERT
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| TERT attenuated ER stress-induced cell death.
|
| Hosoi T, Inoue Y, Nakatsu K, Matsushima N, Kiyose N, Shimamoto A, Tahara H, Ozawa K.
|
| Biochem Biophys Res Commun 447(2):378-82. doi: 10.1016/j.bbrc.2014.04.034. Epub 2014 Apr 16.
2014
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| 19 | TERT
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| Telomerase enzymatic component hTERT shortens long telomeres in human cells.
|
| Zheng YL, Zhang F, Sun B, Du J, Sun C, Yuan J, Wang Y, Tao L, Kota K, Liu X, Schlegel R, Yang Q.
|
| Cell Cycle 13(11):1765-76. doi: 10.4161/cc.28705. Epub 2014 Apr 10.
2014
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| 20 | TERT
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| TERT promoter mutations in cancer development.
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| Heidenreich B, Rachakonda PS, Hemminki K, Kumar R.
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| Curr Opin Genet Dev 24:30-7. doi: 10.1016/j.gde.2013.11.005. Epub 2013 Dec 20. Review.
2014
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| 21 | PTTG1, TERT, XRCC6
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| Changes in PTTG1 by human TERT gene expression modulate the self-renewal of placenta-derived mesenchymal stem cells.
|
| Lee HJ, Choi JH, Jung J, Kim JK, Lee SS, Kim GJ.
|
| Cell Tissue Res 357(1):145-57. doi: 10.1007/s00441-014-1874-0. Epub 2014 May 11.
2014
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| 22 | PINX1, TERF1, TERT
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| PinX1, a telomere repeat-binding factor 1 (TRF1)-interacting protein, maintains telomere integrity by modulating TRF1 homeostasis, the process in which human telomerase reverse Transcriptase (hTERT) plays dual roles.
|
| Yoo JE, Park YN, Oh BK.
|
| J Biol Chem 289(10):6886-98. doi: 10.1074/jbc.M113.506006. Epub 2014 Jan 10.
2014
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| 23 | DEK, TERT
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| Chromatin redistribution of the DEK oncoprotein represses hTERT transcription in leukemias.
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| Karam M, Thenoz M, Capraro V, Robin JP, Pinatel C, Lancon A, Galia P, Sibon D, Thomas X, Ducastelle-Lepretre S, Nicolini F, El-Hamri M, Chelghoun Y, Wattel E, Mortreux F.
|
| Neoplasia 16(1):21-30.
2014
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| 24 | CPSF4, TERT
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| CPSF4 activates telomerase reverse transcriptase and predicts poor prognosis in human lung adenocarcinomas.
|
| Chen W, Qin L, Wang S, Li M, Shi D, Tian Y, Wang J, Fu L, Li Z, Guo W, Yu W, Yuan Y, Kang T, Huang W, Deng W.
|
| Mol Oncol 8(3):704-16. doi: 10.1016/j.molonc.2014.02.001. Epub 2014 Feb 14.
2014
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| 25 | ATF7IP, BAK1, DMRT1, KITLG, SPRY4, TERT
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| Investigation of six testicular germ cell tumor susceptibility genes suggests a parent-of-origin effect in SPRY4.
|
| Karlsson R, Andreassen KE, Kristiansen W, Aschim EL, Bremnes RM, Dahl O, Fosså SD, Klepp O, Langberg CW, Solberg A, Tretli S, Magnusson PK, Adami HO, Haugen TB, Grotmol T, Wiklund F.
|
| Hum Mol Genet 22(16):3373-80. doi: 10.1093/hmg/ddt188. Epub 2013 May 2.
2013
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| 26 | DDB1, DYRK2, TERT, UBR5, VPRBP
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| Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation.
|
| Jung HY, Wang X, Jun S, Park JI.
|
| J Biol Chem 288(10):7252-62. doi: 10.1074/jbc.M112.416792. Epub 2013 Jan 28.
2013
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| 27 | TERT
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| Highly recurrent TERT promoter mutations in human melanoma.
|
| Huang FW, Hodis E, Xu MJ, Kryukov GV, Chin L, Garraway LA.
|
| Science 339(6122):957-9. doi: 10.1126/science.1229259. Epub 2013 Jan 24.
2013
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| 28 | TERT
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| TERT promoter mutations in familial and sporadic melanoma.
|
| Horn S, Figl A, Rachakonda PS, Fischer C, Sucker A, Gast A, Kadel S, Moll I, Nagore E, Hemminki K, Schadendorf D, Kumar R.
|
| Science 339(6122):959-61. doi: 10.1126/science.1230062. Epub 2013 Jan 24.
2013
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| 29 | TERT
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| Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells.
|
| Mazumdar T, Sandhu R, Qadan M, DeVecchio J, Magloire V, Agyeman A, Li B, Houghton JA.
|
| PLoS One 8(9):e75253. doi: 10.1371/journal.pone.0075253. eCollection 2013.
2013
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| 30 | TERT
|
| Physiological and pathological significance of human telomerase reverse transcriptase splice variants.
|
| Bollmann FM.
|
| Biochimie 95(11):1965-70. doi: 10.1016/j.biochi.2013.07.031. Epub 2013 Aug 9. Review.
2013
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| 31 | TERT
|
| Many disease-associated variants of hTERT retain high telomerase enzymatic activity.
|
| Zaug AJ, Crary SM, Jesse Fioravanti M, Campbell K, Cech TR.
|
| Nucleic Acids Res 41(19):8969-78. doi: 10.1093/nar/gkt653. Epub 2013 Jul 30.
2013
|
| 32 | TERT
|
| Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-κB-dependent transcription.
|
| Ding D, Xi P, Zhou J, Wang M, Cong YS.
|
| FASEB J 27(11):4375-83. doi: 10.1096/fj.13-230904. Epub 2013 Jul 24.
2013
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| 33 | TERC, TERT
|
| The roles of telomerase in the generation of polyploidy during neoplastic cell growth.
|
| Christodoulidou A, Raftopoulou C, Chiourea M, Papaioannou GK, Hoshiyama H, Wright WE, Shay JW, Gagos S.
|
| Neoplasia 15(2):156-68.
2013
|
| 34 | TERT
|
| Mitochondrial telomerase protects cancer cells from nuclear DNA damage and apoptosis.
|
| Singhapol C, Pal D, Czapiewski R, Porika M, Nelson G, Saretzki GC.
|
| PLoS One 8(1):e52989. doi: 10.1371/journal.pone.0052989. Epub 2013 Jan 9.
2013
|
| 35 | NVL, TERT
|
| The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly.
|
| Her J, Chung IK.
|
| Biochem Biophys Res Commun 417(3):1086-92. doi: 10.1016/j.bbrc.2011.12.101. Epub 2011 Dec 27.
2012
|
| 36 | AKT1, TERT
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| Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation.
|
| Chung J, Khadka P, Chung IK.
|
| J Cell Sci 125(Pt 11):2684-97. doi: 10.1242/jcs.099267. Epub 2012 Feb 24.
2012
|
| 37 | DKC1, TERT
|
| The accumulation and not the specific activity of telomerase ribonucleoprotein determines telomere maintenance deficiency in X-linked dyskeratosis congenita.
|
| Zeng XL, Thumati NR, Fleisig HB, Hukezalie KR, Savage SA, Giri N, Alter BP, Wong JM.
|
| Hum Mol Genet 21(4):721-9. doi: 10.1093/hmg/ddr504. Epub 2011 Nov 4.
2012
|
| 38 | TERC, TERT
|
| Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes.
|
| Aubert G, Baerlocher GM, Vulto I, Poon SS, Lansdorp PM.
|
| PLoS Genet 8(5):e1002696. doi: 10.1371/journal.pgen.1002696. Epub 2012 May 17.
2012
|
| 39 | TERT
|
| Human telomerase reverse transcriptase (hTERT) is a novel target of the Wnt/β-catenin pathway in human cancer.
|
| Zhang Y, Toh L, Lau P, Wang X.
|
| J Biol Chem 287(39):32494-511.
2012
|
| 40 | RUVBL2, TERT
|
| RuvBl2 cooperates with Ets2 to transcriptionally regulate hTERT in colon cancer.
|
| Flavin P, Redmond A, McBryan J, Cocchiglia S, Tibbitts P, Fahy-Browne P, Kay E, Treumann A, Perrem K, McIlroy M, Hill AD, Young LS.
|
| FEBS Lett 585(15):2537-44. Epub 2011 Jul 13.
2011
|
| 41 | TERT
|
| Dual roles of a variable number of tandem repeat polymorphism in the TERT gene in lung cancer.
|
| Jin G, Yoo SS, Cho S, Jeon HS, Lee WK, Kang HG, Choi YY, Choi JE, Cha SI, Lee EB, Kim CH, Jung TH, Kim YT, Park JY.
|
| Cancer Sci 102(1):144-9. doi: 10.1111/j.1349-7006.2010.01782.x. Epub 2010 Nov 18.PMID: 21083788 2011
|
| 42 | TERT
|
| Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis.
|
| Alder JK, Cogan JD, Brown AF, Anderson CJ, Lawson WE, Lansdorp PM, Phillips JA 3rd, Loyd JE, Chen JJ, Armanios M.
|
| PLoS Genet 7(3):e1001352. Epub 2011 Mar 31.
2011
|
| 43 | TERT
|
| Direct involvement of the TEN domain at the active site of human telomerase.
|
| Jurczyluk J, Nouwens AS, Holien JK, Adams TE, Lovrecz GO, Parker MW, Cohen SB, Bryan TM.
|
| Nucleic Acids Res 39(5):1774-88. Epub 2010 Nov 3.
2011
|
| 44 | FEN1, TERT
|
| Mapping the FEN1 interaction domain with hTERT.
|
| Sampathi S, Chai W.
|
| Biochem Biophys Res Commun 407(1):34-8. Epub 2011 Feb 21.
2011
|
| 45 | ACD, TERT
|
| Functional interaction between telomere protein TPP1 and telomerase.
|
| Zaug AJ, Podell ER, Nandakumar J, Cech TR.
|
| Genes Dev 24(6):613-22.PMID: 20231318 2010
|
| 46 | CLPTM1L, TERT
|
| Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck.
|
| Liu Z, Li G, Wei S, Niu J, Wang LE, Sturgis EM, Wei Q.
|
| Carcinogenesis 31(11):1977-81. Epub 2010 Aug 28.PMID: 20802237 2010
|
| 47 | TERT
|
| Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines.
|
| Tsai CC, Chen CL, Liu HC, Lee YT, Wang HW, Hou LT, Hung SC.
|
| J Biomed Sci 17:64.PMID: 20670406 2010
|
| 48 | TERT
|
| Krüppel-like transcription factor 4 contributes to maintenance of telomerase activity in stem cells.
|
| Wong CW, Hou PS, Tseng SF, Chien CL, Wu KJ, Chen HF, Ho HN, Kyo S, Teng SC.
|
| Stem Cells 28(9):1510-7.PMID: 20629177 2010
|
| 49 | TERT
|
| Human chromosome 5 carries a transcriptional regulator of human telomerase reverse transcriptase (hTERT).
|
| Qi DL, Ohhira T, Oshimura M, Kugoh H.
|
| Biochem Biophys Res Commun 398(4):695-701. Epub 2010 Jul 16.PMID: 20621064 2010
|
| 50 | TERT
|
| Variation at the TERT locus and predisposition for cancer.
|
| Baird DM.
|
| Expert Rev Mol Med 12:e16. Review.PMID: 20478107 2010
|
| 51 | PINX1, TERF1, TERT
|
| C-terminal amino acids 290-328 of LPTS/PinX1 confer telomerase inhibition.
|
| Chen G, Da L, Xu Y, Xu M, Song L, Li T, Zhao M.
|
| Biochem Biophys Res Commun 398(4):683-9. Epub 2010 Jul 8.PMID: 20620128 2010
|
| 52 | DKC1, DKC2, DKC3, DKC4, DKC5, DKC6, NHP2, NOP10, TERC, TERT, TINF2
|
| Dyskeratosis congenita.
|
| Bessler M, Wilson DB, Mason PJ.
|
| FEBS Lett 584(17):3831-8. Epub 2010 May 21.PMID: 20493861 2010
|
| 53 | MBD2, TERT
|
| Specific association between the methyl-CpG-binding domain protein 2 and the hypermethylated region of the human telomerase reverse transcriptase promoter in cancer cells.
|
| Chatagnon A, Bougel S, Perriaud L, Lachuer J, Benhattar J, Dante R.
|
| Carcinogenesis 30(1):28-34. Epub 2008 Oct 24.
2009
|
| 54 | TERT
|
| Differential repression of human and mouse TERT genes during cell differentiation.
|
| Wang S, Zhao Y, Hu C, Zhu J.
|
| Nucleic Acids Res 37(8):2618-29. Epub 2009 Mar 6.
2009
|
| 55 | SMARCA4, TERT
|
| Telomerase modulates Wnt signalling by association with target gene chromatin.
|
| Park JI, Venteicher AS, Hong JY, Choi J, Jun S, Shkreli M, Chang W, Meng Z, Cheung P, Ji H, McLaughlin M, Veenstra TD, Nusse R, McCrea PD, Artandi SE.
|
| Nature 460(7251):66-72.
2009
|
| 56 | RMRP, TERT
|
| An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA.
|
| Maida Y, Yasukawa M, Furuuchi M, Lassmann T, Possemato R, Okamoto N, Kasim V, Hayashizaki Y, Hahn WC, Masutomi K.
|
| Nature 461(7261):230-5. Epub 2009 Aug 23.
2009
|
| 57 | TERT
|
| A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.
|
| Landi MT, Chatterjee N, Yu K, Goldin LR, Goldstein AM, Rotunno M, Mirabello L, Jacobs K, Wheeler W, Yeager M, Bergen AW, Li Q, Consonni D, Pesatori AC, Wacholder S, Thun M, Diver R, Oken M, Virtamo J, Albanes D, Wang Z, Burdette L, Doheny KF, Pugh EW, Laurie C, Brennan P, Hung R, Gaborieau V, McKay JD, Lathrop M, McLaughlin J, Wang Y, Tsao MS, Spitz MR, Wang Y, Krokan H, Vatten L, Skorpen F, Arnesen E, Benhamou S, Bouchard C, Metsapalu A, Vooder T, Nelis M, Välk K, Field JK, Chen C, Goodman G, Sulem P, Thorleifsson G, Rafnar T, Eisen T, Sauter W, Rosenberger A, Bickeböller H, Risch A, Chang-Claude J, Wichmann HE, Stefansson K, Houlston R, Amos CI, Fraumeni JF Jr, Savage SA, Bertazzi PA, Tucker MA, Chanock S, Caporaso NE.
|
| Am J Hum Genet 85(5):679-91. Epub 2009 Oct 15.PMID: 19836008 2009
|
| 58 | NHP2, NOL10, TERC, TERT
|
| Exogenous TERC alone can enhance proliferative potential, telomerase activity and telomere length in lymphocytes from dyskeratosis congenita patients.
|
| Kirwan M, Beswick R, Vulliamy T, Nathwani AC, Walne AJ, Casimir C, Dokal I.
|
| Br J Haematol 144(5):771-81. Epub 2008 Nov 20.PMID: 19036115 2009
|
| 59 | PRKCD, TERT
|
| Protein kinase C delta plays a key role in cellular senescence programs of human normal diploid cells.
|
| Katakura Y, Udono M, Katsuki K, Nishide H, Tabira Y, Ikei T, Yamashita M, Fujiki T, Shirahata S.
|
| J Biochem 146(1):87-93. Epub 2009 Mar 11.PMID: 19279193 2009
|
| 60 | TERT
|
| Common genetic variants on 5p15.33 contribute to risk of lung adenocarcinoma in a Chinese population.
|
| Jin G, Xu L, Shu Y, Tian T, Liang J, Xu Y, Wang F, Chen J, Dai J, Hu Z, Shen H.
|
| Carcinogenesis 30(6):987-90. Epub 2009 Apr 15.PMID: 19369581 2009
|
| 61 | PTGES3, TERT
|
| A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function.
|
| Woo SH, An S, Lee HC, Jin HO, Seo SK, Yoo DH, Lee KH, Rhee CH, Choi EJ, Hong SI, Park IC.
|
| J Biol Chem 284(45):30871-80. Epub 2009 Sep 9.
2009
|
| 62 | DKC1, DKC2, TERC, DKC3, TERT
|
| Dyskeratosis congenita: a genetic disorder of many faces.
|
| Kirwan M, Dokal I.
|
| Clin Genet 73(2):103-12. Epub 2007 Nov 14. Review. 2008
|
| 63 | DKC, DKC1, DKC2, DKC3, DKC4, DKC5, TERC, TERT, TINF2
|
| Dyskeratosis congenita: the diverse clinical presentation of mutations in the telomerase complex.
|
| Vulliamy TJ, Dokal I.
|
| Biochimie 90(1):122-30. Epub 2007 Jul 31. Review. 2008
|
| 64 | TERT
|
| A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis.
|
| Mushiroda T, Wattanapokayakit S, Takahashi A, Nukiwa T, Kudoh S, Ogura T, Taniguchi H, Kubo M, Kamatani N, Nakamura Y; Pirfenidone Clinical Study Group.
|
| J Med Genet 45(10):654-6.
2008
|
| 65 | CLPTM1L, TERT
|
| Lung cancer susceptibility locus at 5p15.33.
|
| McKay JD, Hung RJ, Gaborieau V, Boffetta P, Chabrier A, Byrnes G, Zaridze D, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, McLaughlin J, Shepherd F, Montpetit A, Narod S, Krokan HE, Skorpen F, Elvestad MB, Vatten L, Njølstad I, Axelsson T, Chen C, Goodman G, Barnett M, Loomis MM, Lubiñski J, Matyjasik J, Lener M, Oszutowska D, Field J, Liloglou T, Xinarianos G, Cassidy A; EPIC Study, Vineis P, Clavel-Chapelon F, Palli D, Tumino R, Krogh V, Panico S, González CA, Ramón Quirós J, Martínez C, Navarro C, Ardanaz E, Larrañaga N, Kham KT, Key T, Bueno-de-Mesquita HB, Peeters PH, Trichopoulou A, Linseisen J, Boeing H, Hallmans G, Overvad K, Tjønneland A, Kumle M, Riboli E, Zelenika D, Boland A, Delepine M, Foglio M, Lechner D, Matsuda F, Blanche H, Gut I, Heath S, Lathrop M, Brennan P.
|
| Nat Genet 40(12):1404-6. Epub 2008 Nov 2.
2008
|
| 66 | NFX1, SIN3A, TERT
|
| NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
|
| Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA.
|
| Mol Cell Biol 28(15):4819-28. Epub 2008 May 27.
2008
|
| 67 | TERT
|
| Functional genomics of hTERT gene in leukemic myelopoiesis.
|
| Kaul D, Gautam A, Varma S, Ahlawat A.
|
| Mol Cell Biochem 314(1-2):19-23. Epub 2008 Apr 13.PMID: 1840903 2008
|
| 68 | TERT
|
| Nucleolar localization of TERT is unrelated to telomerase function in human cells.
|
| Lin J, Jin R, Zhang B, Chen H, Bai YX, Yang PX, Han SW, Xie YH, Huang PT, Huang C, Huang JJ.
|
| J Cell Sci 121(Pt 13):2169-76. Epub 2008 Jun 3.PMID: 18522991 2008
|
| 69 | PINX1, TERT, SOCS1
|
| Characterization of a novel effect of hPinX1 on hTERT nucleolar localization.
|
| Lin J, Jin R, Zhang B, Yang PX, Chen H, Bai YX, Xie Y, Huang C, Huang J.
|
| Biochem Biophys Res Commun 353(4):946-52. Epub 2006 Dec 22. 2007
|
| 70 | TERT
|
| A novel peptide-nucleotide dual vaccine of human telomerase reverse transcriptase induces a potent cytotoxic T-cell response in vivo.
|
| Guo H, Hao J, Wu C, Shi Y, Zhao XY, Fang DC.
|
| Biochem Biophys Res Commun 357(4):1090-5. Epub 2007 Apr 19. 2007
|
| 71 | TERT
|
| hTERT inhibits the Epstein-Barr virus lytic cycle and promotes the proliferation of primary B lymphocytes: implications for EBV-driven lymphomagenesis.
|
| Terrin L, Dolcetti R, Corradini I, Indraccolo S, Col JD, Bertorelle R, Bonaldi L, Esposito G, De Rossi A.
|
| Int J Cancer 121(3):576-87. 2007
|
| 72 | ZBTB16, TP53INP1, TERT, ID3, ID1
|
| Identification of apoptosis-related PLZF target genes.
|
| Bernardo MV, Yelo E, Gimeno L, Campillo JA, Parrado A.
|
| Biochem Biophys Res Commun 359(2):317-22. Epub 2007 May 24. 2007
|
| 73 | SMYD3, TERT
|
| The telomerase reverse transcriptase (hTERT) gene is a direct target of the histone methyltransferase SMYD3.
|
| Liu C, Fang X, Ge Z, Jalink M, Kyo S, Björkholm M, Gruber A, Sjöberg J, Xu D.
|
| Cancer Res 67(6):2626-31.
2007
|
| 74 | SMAD3, TERT
|
| Mechanisms of action of TGF-beta in cancer: evidence for Smad3 as a repressor of the hTERT gene.
|
| Li H, Liu JP.
|
| Ann N Y Acad Sci 1114:56-68. Epub 2007 Oct 12. Review.
2007
|
| 75 | TERT
|
| Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis.
|
| Santos JH, Meyer JN, Van Houten B.
|
| Hum Mol Genet 15(11):1757-68. Epub 2006 Apr 13. 2006
|
| 76 | TERT
|
| A major role of PKC theta and NFkappaB in the regulation of hTERT in human T lymphocytes.
|
| Sheng WY, Chen YR, Wang TC.
|
| FEBS Lett 580(30):6819-24. Epub 2006 Nov 27. 2006
|
| 77 | NHP2, TERT
|
| Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia.
|
| Yamaguchi H, Calado RT, Ly H, Kajigaya S, Baerlocher GM, Chanock SJ, Lansdorp PM, Young NS.
|
| N Engl J Med 352(14):1413-24. 2005
|
| 78 | TERT
|
| Effects of telomerase and telomere length on epidermal stem cell behavior.
|
| Flores I, Cayuela ML, Blasco MA.
|
| Science 309(5738):1253-6. Epub 2005 Jul 21. 2005
|
| 79 | TERT, DKC3
|
| Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita.
|
| Armanios M, Chen JL, Chang YP, Brodsky RA, Hawkins A, Griffin CA, Eshleman JR, Cohen AR, Chakravarti A, Hamosh A, Greider CW.
|
| Proc Natl Acad Sci U S A 102(44):15960-4. Epub 2005 Oct 24. 2005
|
| 80 | TERT
|
| Role of hTERT in apoptosis of cervical cancer induced by histone deacetylase inhibitor.
|
| Wu P, Meng L, Wang H, Zhou J, Xu G, Wang S, Xi L, Chen G, Wang B, Zhu T, Lu Y, Ma D.
|
| Biochem Biophys Res Commun 335(1):36-44. 2005
|
| 81 | TP73, TP53, TERT
|
| C-terminal p73 isoforms repress transcriptional activity of the human telomerase reverse transcriptase (hTERT) promoter.
|
| Racek T, Mise N, Li Z, Stoll A, Putzer BM.
|
| J Biol Chem 280(49):40402-5. Epub 2005 Oct 17. 2005
|
| 82 | CTCF, TERT
|
| CTCF binds the proximal exonic region of hTERT and inhibits its transcription.
|
| Renaud S, Loukinov D, Bosman FT, Lobanenkov V, Benhattar J.
|
| Nucleic Acids Res 33(21):6850-60. Print 2005. 2005
|
| 83 | TERT
|
| Human chromosome 5 carries a putative telomerase repressor gene
|
| Kugoh H, Shigenami K, Funaki K, Barrett JC, Oshimura M.
|
| Genes Chromosomes Cancer 36(1):37-47. 2003
|
| 84 | FRK, GEMIN2, MAD1L1, TERT
|
| Multiple tumor suppressor pathways negatively regulate telomerase.
|
| Lin SY, Elledge SJ.
|
| Cell 113(7):881-9. 2003
|
| 85 | TERT
|
| Telomerase maintains telomere structure in normal human cells.
|
| Masutomi K, Yu EY, Khurts S, Ben-Porath I, Currier JL, Metz GB, Brooks MW, Kaneko S, Murakami S, DeCaprio JA, Weinberg RA, Stewart SA, Hahn WC.
|
| Cell 114(2):241-53. 2003
|
| 86 | TERT, EREG
|
| Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene.
|
| Lindvall C, Hou M, Komurasaki T, Zheng C, Henriksson M, Sedivy JM, Bjorkholm M, Teh BT, Nordenskjold M, Xu D.
|
| Cancer Res 63(8):1743-7. 2003
|
| 87 | BIRC5, TERT
|
| Co-expression of survivin and TERT and risk of tumour-related death in patients with soft-tissue sarcoma.
|
| Wurl P, Kappler M, Meye A, Bartel F, Kohler T, Lautenschlager C, Bache M, Schmidt H, Taubert H.
|
| Lancet 359(9310):943-5. 2002
|
| 88 | TERT
|
| Amplification of the telomerase reverse transcriptase (hTERT) gene in cervical carcinomas.
|
| Zhang A, Zheng C, Hou M, Lindvall C, Wallin KL, Angstrom T, Yang X, Hellstrom AC, Blennow E, Bjorkholm M, Zetterberg A, Gruber A, Xu D.
|
| Genes Chromosomes Cancer 34(3):269-75. 2002
|
| 89 | CLPTM1L, TERT
|
| The human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphisms in intronic regions.
|
| Leem SH, Londono-Vallejo JA, Kim JH, Bui H, Tubacher E, Solomon G, Park JE, Horikawa I, Kouprina N, Barrett JC, Larionov V.
|
| Oncogene 21(5):769-77. 2002
|
| 90 | TERT, USF2
|
| Variant forms of upstream stimulatory factors (USFs) control the promoter activity of hTERT, the human gene encoding the catalytic subunit of telomerase.
|
| Yago M, Ohki R, Hatakeyama S, Fujita T, Ishikawa F.
|
| FEBS Lett 520(1-3):40-6. 2002
|
| 91 | TERT
|
| Methylation of the human telomerase gene CpG island.
|
| Dessain SK, Yu H, Reddel RR, Beijersbergen RL, Weinberg RA.
|
| Cancer Res 60(3):537-41. 2000
|
| 92 | TERT
|
| Identification of Mad as a repressor of the human telomerase (hTERT) gene.
|
| Oh S, Song YH, Yim J, Kim TK.
|
| Oncogene 19(11):1485-90. 2000
|
| 93 | TERT
|
| Mapping of the gene for the human telomerase reverse transcriptase, hTERT, to chromosome 5p15.33 by fluorescence in situ hybridization.
|
| Bryce LA, Morrison N, Hoare SF, Muir S, Keith WN.
|
| Neoplasia 2(3):197-201. 2000
|
| 94 | TERT
|
| Expression of the hTERT gene is regulated at the level of transcriptional initiation and repressed by Mad1.
|
| Gunes C, Lichtsteiner S, Vasserot AP, Englert C.
|
| Cancer Res 60(8):2116-21. 2000
|
| 95 | DKC1, GAR1, NHP2, NOP10, SNHG3, SNORA73A, SNORA73B, TERC, TERT
|
| In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs.
|
| Dragon F, Pogacic V, Filipowicz W.
|
| Mol Cell Biol 20(9):3037-48. 2000
|
| 96 | DKC1, GAR1, NHP2, NHP2L1, NOP10, SNHG3, SNORA73A, SNORA73B, TERC, TERT
|
| Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10.
|
| Pogacic V, Dragon F, Filipowicz W.
|
| Mol Cell Biol 20(23):9028-40. 2000
|
| 97 | TERC, TERT
|
| Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase.
|
| Mitchell JR, Collins K.
|
| Mol Cell 6(2):361-71. 2000
|
| 98 | TERT
|
| The human telomerase catalytic subunit hTERT : organization of the gene and characterization of the promoter.
|
| Cong YS, Wen J, Bacchetti S.
|
| Hum Mol Genet 8 : 137-142. 1999
|
| 99 | ALB, CAD, CCNA2, CDC25A, CDK1, CEBPA, COL1A1, COL1A2, COL3A1, COL6A3, DHFR, DMTF1, GADD45A, JUN, LDHA, MXI1, MYC, ODC1, RCC1, SERPINE1, TERT, TK1, TK2, TP53
|
| c-Myc target genes involved in cell growth, apoptosis, and metabolism.
|
| Dang CV.
|
| Mol Cell Biol 19(1):1-11. Review. No abstract available 1999
|
| 100 | TERT
|
| Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells.
|
| Takakura M, et al.
|
| Cancer Res 59(3):551-7. 1999
|
| 101 | TERT
|
| Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections.
|
| Tahara H, et al.
|
| Oncogene 18(8):1561-7. 1999
|
| 102 | TERT
|
| Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT).
|
| Wick M, et al.
|
| Gene 232(1):97-106. 1999
|
| 103 | TERT
|
| DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene.
|
| Devereux TR, Horikawa I, Anna CH, Annab LA, Afshari CA, Barrett JC.
|
| Cancer Res 59(24):6087-90. 1999
|
| 104 | TERT
|
| Expression of TERT in early premalignant lesions and a subset of cells in normal tissues.
|
| Kolquist KA, et al.
|
| Nat Genet 19 : 182-186. 1998
|
| 105 | TERC, TERT
|
| Essential role of mouse telomerase in highly proliferative organs.
|
| Lee HW, Blasco MA, Gottlieb GJ, Horner JW 2nd, Greider CW, DePinho RA.
|
| Nature 392(6676):569-74. 1998
|
| 106 | TERT
|
| hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.
|
| Meyerson M, et al.
|
| Cell 90 : 785-795. 1997
|
| 107 | TERT
|
| Telomerase catalytic subunit homologs from fission yeast and human.
|
| Nakamura TM, et al.
|
| Science 277 : 955-959. 1997
|
| 108 | TERT
|
| Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.
|
| Kilian A, et al.
|
| Hum Mol Genet 6 : 2011-2019. 1997
|
| 109 | TERT
|
| Human telomerase contains evolutionarily conserved catalytic and structural subunits.
|
| Harrington L, et al.
|
| Genes Dev 11 : 3109-3115. 1997
|