1 | TDG
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| Thymine DNA glycosylase modulates DNA damage response and gene expression by base excision repair-dependent and independent mechanisms.
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| Nakamura T, Murakami K, Tada H, Uehara Y, Nogami J, Maehara K, Ohkawa Y, Saitoh H, Nishitani H, Ono T, Nishi R, Yokoi M, Sakai W, Sugasawa K.
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| Genes Cells 22(4):392-405. doi: 10.1111/gtc.12481. Epub 2017 Mar 20.
2017
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2 | EP300, TDG
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| Interaction with the DNA Repair Protein Thymine DNA Glycosylase Regulates Histone Acetylation by p300.
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| Henry RA, Mancuso P, Kuo YM, Tricarico R, Tini M, Cole PA, Bellacosa A, Andrews AJ.
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| Biochemistry 55(49):6766-6775. Epub 2016 Dec 1.
2016
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3 | TDG
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| Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo.
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| McLaughlin D, Coey CT, Yang WC, Drohat AC, Matunis MJ.
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| J Biol Chem 291(17):9014-24. doi: 10.1074/jbc.M115.706325. Epub 2016 Feb 25.
2016
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4 | TDG
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| Characterizing Requirements for Small Ubiquitin-like Modifier (SUMO) Modification and Binding on Base Excision Repair Activity of Thymine-DNA Glycosylase in Vivo.
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| McLaughlin D, Coey CT, Yang WC, Drohat AC, Matunis MJ.
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| J Biol Chem 291(17):9014-24. doi: 10.1074/jbc.M115.706325. Epub 2016 Feb 25.
2016
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5 | NEIL1, NEIL2, TDG
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| Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation.
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| Schomacher L, Han D, Musheev MU, Arab K, Kienhöfer S, von Seggern A, Niehrs C.
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| Nat Struct Mol Biol 23(2):116-24. doi: 10.1038/nsmb.3151. Epub 2016 Jan 11.
2016
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6 | HRAS, ING4, TDG
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| Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance.
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| Sun J, Shen Q, Lu H, Jiang Z, Xu W, Feng L, Li L, Wang X, Cai X, Jin H.
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| Oncotarget 6(39):41997-2007. doi: 10.18632/oncotarget.6015.
2015
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7 | TDG
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| Thymine DNA glycosylase is a CRL4Cdt2 substrate.
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| Slenn TJ, Morris B, Havens CG, Freeman RM Jr, Takahashi TS, Walter JC.
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| J Biol Chem 289(33):23043-55. doi: 10.1074/jbc.M114.574194. Epub 2014 Jun 19.
2014
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8 | CREBBP, CTNNB1, TDG
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| Thymine DNA glycosylase promotes transactivation of β-catenin/TCFs by cooperating with CBP.
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| Jia Y, Nie F, Du A, Chen Z, Qin Y, Huang T, Song X, Li L.
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| J Mol Cell Biol 6(3):231-9. doi: 10.1093/jmcb/mju014. Epub 2014 Apr 18.
2014
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9 | SIRT1, TDG
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| Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase.
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| Madabushi A, Hwang BJ, Jin J, Lu AL.
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| Biochem J 456(1):89-98. doi: 10.1042/BJ20130670.
2013
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10 | CDKN2B, MBD4, TDG, ZNF217
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| TGF-β-dependent active demethylation and expression of the p15ink4b tumor suppressor are impaired by the ZNF217/CoREST complex.
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| Thillainadesan G, Chitilian JM, Isovic M, Ablack JN, Mymryk JS, Tini M, Torchia J.
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| Mol Cell 46(5):636-49. doi: 10.1016/j.molcel.2012.03.027. Epub 2012 May 3.
2012
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11 | TDG
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| Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.
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| Zhang L, Lu X, Lu J, Liang H, Dai Q, Xu GL, Luo C, Jiang H, He C.
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| Nat Chem Biol 8(4):328-30. doi: 10.1038/nchembio.914.
2012
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12 | TDG
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| Embryonic lethality in mice lacking mismatch-specific thymine DNA glycosylase is partially prevented by DOPS, a precursor of noradrenaline.
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| Saito Y, Ono T, Takeda N, Nohmi T, Seki M, Enomoto T, Noda T, Uehara Y.
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| Tohoku J Exp Med 226(1):75-83.
2012
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13 | TDG
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| Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.
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| Cortellino S, Xu J, Sannai M, Moore R, Caretti E, Cigliano A, Le Coz M, Devarajan K, Wessels A, Soprano D, Abramowitz LK, Bartolomei MS, Rambow F, Bassi MR, Bruno T, Fanciulli M, Renner C, Klein-Szanto AJ, Matsumoto Y, Kobi D, Davidson I, Alberti C, Larue L, Bellacosa A.
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| Cell 146(1):67-79. doi: 10.1016/j.cell.2011.06.020. Epub 2011 Jun 30.
2011
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14 | TDG
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| Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability.
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| Cortázar D, Kunz C, Selfridge J, Lettieri T, Saito Y, MacDougall E, Wirz A, Schuermann D, Jacobs AL, Siegrist F, Steinacher R, Jiricny J, Bird A, Schär P.
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| Nature 470(7334):419-23. doi: 10.1038/nature09672. Epub 2011 Jan 30.
2011
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15 | NCOA3, TDG
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| The interaction between thymine DNA glycosylase and nuclear receptor coactivator 3 is required for the transcriptional activation of nuclear hormone receptors.
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| Chiang S, Burch T, Van Domselaar G, Dick K, Radziwon A, Brusnyk C, Edwards MR, Piper J, Cutts T, Cao J, Li X, He R.
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| Mol Cell Biochem 333(1-2):221-32. doi: 10.1007/s11010-009-0223-1. Epub 2009 Aug 4.
2010
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16 | TDG
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| Thymine-DNA glycosylase interacts with and functions as a coactivator of p53 family proteins.
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| Kim EJ, Um SJ.
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| Biochem Biophys Res Commun 377(3):838-42. Epub 2008 Oct 23.
2008
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17 | TDG
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| Thymine DNA glycosylase represses myocardin-induced smooth muscle cell differentiation by competing with serum response factor for myocardin binding.
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| Zhou J, Blue EK, Hu G, Herring BP.
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| J Biol Chem 283(51):35383-92. doi: 10.1074/jbc.M805489200. Epub 2008 Oct 21.
2008
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18 | HUS1, TDG
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| The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase.
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| Guan X, Madabushi A, Chang DY, Fitzgerald ME, Shi G, Drohat AC, Lu AL.
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| Nucleic Acids Res 35(18):6207-18. Epub 2007 Sep 12.
2007
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19 | NEIL1, NEIL2, SMUG1, UNG, TDG, MPG
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| Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition.
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| Broderick P, Bagratuni T, Vijayakrishnan J, Lubbe S, Chandler I, Houlston RS.
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| BMC Cancer 6:243. 2006
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20 | TDG, XPC
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| Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase.
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| Shimizu Y, Iwai S, Hanaoka F, Sugasawa K.
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| EMBO J 22(1):164-73. 2003
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21 | TDG
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| The main role of human thymine-DNA glycosylase is removal of thymine produced by deamination of 5-methylcytosine and not removal of ethenocytosine.
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| Abu M, Waters TR.
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| J Biol Chem 278(10):8739-44. Epub 2002 Dec 18. 2003
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22 | TDG
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| Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22-q24.1 in human pancreatic ductal adenocarcinoma.
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| Yatsuoka T, et al.
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| Int J Pancreatol 25(2):97-102. 1999
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23 | TDG
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| A 55-kDa protein isolated from human cells shows DNA glycosylase activity toward 3,N4-ethenocytosine and the G/T mismatch.
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| Hang B, et al.
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| Proc Natl Acad Sci U S A 95 : 13561-13566. 1998
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24 | TDG
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| 3,N4-ethenocytosine, a highly mutagenic adduct, is a primary substrate for Escherichia coli double-stranded uracil-DNA glycosylase and human mismatch-specific thymine-DNA glycosylase.
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| Saparbaev M, et al.
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| Proc Natl Acad Sci U S A 95 : 8508-8513. 1998
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25 | TDG
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| Human thymine-DNA glycosylase maps at chromosome 12q22-q24.1: a region of high loss of heterozygosity in gastric cancer.
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| Schmutte C, Baffa R, Veronese LM, Murakumo Y, Fishel R.
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| Cancer Res 57(14):3010-5. 1997
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26 | TDG, TDGRL11, TDGRL12
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| Chromosomal localizations and molecular analysis of TDG gene-related sequences.
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| Sard L, Tornielli S, Gallinari P, Minoletti F, Jiricny J, Lettieri T, Pierotti MA, Sozzi G, Radice P.
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| Genomics 44(2):222-6. 1997
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27 | TDG
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| Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase.
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| Neddermann P, et al.
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| J Biol Chem 271 : 12767-12774. 1996
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28 | TDG
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| DNA repair in eukaryotes.
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| Wood RD.
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| Annu Rev Biochem 65 : 135-167. 1996
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