Citations for
1TCF7L2
Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm
Roychowdhury T, Lu H, Hornsby WE, Crone B, Wang GT, Guo DC, Sendamarai AK, Devineni P, Lin M, Zhou W, Graham SE, Wolford BN, Surakka I, Wang Z, Chang L, Zhang J, Mathis M, Brummett CM, Melendez TL, Shea MJ, Kim KM, Deeb GM, Patel HJ, Eliason J, Eagle KA, Yang B, Ganesh SK, Brumpton B, Åsvold BO, Skogholt AH, Hveem K; VA Million Veteran Program, Pyarajan S, Klarin D, Tsao PS, Damrauer SM, Leal SM, Milewicz DM, Chen YE, Garcia-Barrio MT, Willer CJ.
Am J Hum Genet. Sep 2;108(9):1578-1589. doi: 10.1016/j.ajhg.2021.06.016. Epub 2021 Jul 14 2021
2FRMD5, TCF7L2
Identification of FERM domain-containing protein 5 as a novel target of β-catenin/TCF7L2 complex
Zhu C, Yamaguchi K, Ohsugi T, Terakado Y, Noguchi R, Ikenoue T, Furukawa Y.
Cancer Sci. Apr;108(4):612-619. doi: 10.1111/cas.13174. Epub 2017 Apr 20. 2017
3CTNNB1, TCF7L2
A Critical Role for β-Catenin in Modulating Levels of Insulin Secretion from β-Cells by Regulating Actin Cytoskeleton and Insulin Vesicle Localization.
Sorrenson B, Cognard E, Lee KL, Dissanayake WC, Fu Y, Han W, Hughes WE, Shepherd PR.
J Biol Chem 291(50):25888-25900. 2016
4TCF7L2
Transcription Factor 7-Like 2 (TCF7L2) rs7903146 Polymorphism as a Risk Factor for Gestational Diabetes Mellitus: A Meta-Analysis.
Lin PC, Lin WT, Yeh YH, Wung SF.
PLoS One 11(4):e0153044. doi: 10.1371/journal.pone.0153044. 2016
5SOX10, TCF7L2, ZBTB33
Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation.
Zhao C, Deng Y, Liu L, Yu K, Zhang L, Wang H, He X, Wang J, Lu C, Wu LN, Weng Q, Mao M, Li J, van Es JH, Xin M, Parry L, Goldman SA, Clevers H, Lu QR.
Nat Commun 7:10883. doi: 10.1038/ncomms10883. 2016
6TCF7L2
Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population.
Yang Y, Xu JR, Wang YJ, Liu XM.
Genet Mol Res 14(3):10064-71. doi: 10.4238/2015.August.21.13. 2015
7TCF7L2
Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice.
Bailey KA, Savic D, Zielinski M, Park SY, Wang LJ, Witkowski P, Brady M, Hara M, Bell GI, Nobrega MA.
Hum Mol Genet 24(6):1646-54. doi: 10.1093/hmg/ddu577. 2015
8TCF7L2
Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.
Mitchell RK, Mondragon A, Chen L, Mcginty JA, French PM, Ferrer J, Thorens B, Hodson DJ, Rutter GA, Da Silva Xavier G.
Hum Mol Genet 24(5):1390-9. doi: 10.1093/hmg/ddu553. 2015
9TCF7L2, WWC1
Tissue-specific differences in the regulation of KIBRA gene expression involve transcription factor TCF7L2 and a complex alternative promoter system.
Guske K, Schmitz B, Schelleckes M, Duning K, Kremerskothen J, Pavenstädt HJ, Brand SM, Brand E.
J Mol Med (Berl) 92(2):185-96. doi: 10.1007/s00109-013-1089-y. 2014
10TCF7L2
Tcf7l2 is required for left-right asymmetric differentiation of habenular neurons.
Hüsken U, Stickney HL, Gestri G, Bianco IH, Faro A, Young RM, Roussigne M, Hawkins TA, Beretta CA, Brinkmann I, Paolini A, Jacinto R, Albadri S, Dreosti E, Tsalavouta M, Schwarz Q, Cavodeassi F, Barth AK, Wen L, Zhang B, Blader P, Yaksi E, Poggi L, Zigman M, Lin S, Wilson SW, Carl M.
Curr Biol 24(19):2217-27. doi: 10.1016/j.cub.2014.08.006. 2014
11TCF7L2
TCF7L2 is a master regulator of insulin production and processing.
Zhou Y, Park SY, Su J, Bailey K, Ottosson-Laakso E, Shcherbina L, Oskolkov N, Zhang E, Thevenin T, Fadista J, Bennet H, Vikman P, Wierup N, Fex M, Rung J, Wollheim C, Nobrega M, Renström E, Groop L, Hansson O.
Hum Mol Genet 23(24):6419-31. doi: 10.1093/hmg/ddu359. 2014
12TCF7L2
Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility.
Meinhardt G, Haider S, Haslinger P, Proestling K, Fiala C, Pollheimer J, Knöfler M.
Endocrinology 155(5):1908-20. doi: 10.1210/en.2013-2042. 2014
13TCF7L2
Alternative human liver transcripts of TCF7L2 bind to the gluconeogenesis regulator HNF4α at the protein level.
Neve B, Le Bacquer O, Caron S, Huyvaert M, Leloire A, Poulain-Godefroy O, Lecoeur C, Pattou F, Staels B, Froguel P.
Diabetologia 57(4):785-96. doi: 10.1007/s00125-013-3154-z. 2014
14AES, TCF7L2
GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos.
Costa AM, Pereira-Castro I, Ricardo E, Spencer F, Fisher S, da Costa LT.
PLoS One 8(7):e67694. doi: 10.1371/journal.pone.0067694. 2013
15TCF7L2
Loss of exon 4 in a human T-cell factor-4 isoform promotes hepatic tumourigenicity.
Tomimaru Y, Xu CQ, Nambotin SB, Yan T, Wands JR, Kim M.
Liver Int 33(10):1536-48. doi: 10.1111/liv.12189. 2013
16TCF7L2
Acetylation of human TCF4 (TCF7L2) proteins attenuates inhibition by the HBP1 repressor and induces a conformational change in the TCF4::DNA complex.
Elfert S, Weise A, Bruser K, Biniossek ML, Jägle S, Senghaas N, Hecht A.
PLoS One 8(4):e61867. doi: 10.1371/journal.pone.0061867. 2013
17TCF7L2
T cell factor 4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating nuclear factor κB signaling.
Ma B, Zhong L, van Blitterswijk CA, Post JN, Karperien M.
J Biol Chem 288(24):17552-8. doi: 10.1074/jbc.M113.453985. 2013
18TCF7L2
Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain.
Nagalski A, Irimia M, Szewczyk L, Ferran JL, Misztal K, Kuznicki J, Wisniewska MB.
Brain Struct Funct 218(6):1531-49. doi: 10.1007/s00429-012-0474-6. 2013
19TCF7L2
Adipose tissue TCF7L2 splicing is regulated by weight loss and associates with glucose and fatty acid metabolism.
Kaminska D, Kuulasmaa T, Venesmaa S, Käkelä P, Vaittinen M, Pulkkinen L, Pääkkönen M, Gylling H, Laakso M, Pihlajamäki J.
Diabetes 61(11):2807-13. doi: 10.2337/db12-0239. 2012
20TCF7L2
TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver.
Oh KJ, Park J, Kim SS, Oh H, Choi CS, Koo SH.
PLoS Genet 8(9):e1002986. doi: 10.1371/journal.pgen.1002986. 2012
21TCF7L2
Impact of transcription factor 7-like 2 (TCF7L2) on pancreatic islet function and morphology in mice and men.
Renström E.
Diabetologia 55(10):2559-61. doi: 10.1007/s00125-012-2659-1. 2012
22TCF7L2
Tcf7l2 is tightly controlled during myelin formation.
Fu H, Kesari S, Cai J.
Cell Mol Neurobiol 32(3):345-52. doi: 10.1007/s10571-011-9778-y. 2012
23TCF7L2
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.
Boj SF, van Es JH, Huch M, Li VS, José A, Hatzis P, Mokry M, Haegebarth A, van den Born M, Chambon P, Voshol P, Dor Y, Cuppen E, Fillat C, Clevers H.
Cell 151(7):1595-607. doi: 10.1016/j.cell.2012.10.053. 2012
24TCF7L2
Identification of T-cell factor-4 isoforms that contribute to the malignant phenotype of hepatocellular carcinoma cells.
Tsedensodnom O, Koga H, Rosenberg SA, Nambotin SB, Carroll JJ, Wands JR, Kim M.
Exp Cell Res 317(7):920-31. Epub 2011 Jan 20. 2011
25TCF7L2, VTI1A
Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.
Bass AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y, Cibulskis K, Sougnez C, Voet D, Saksena G, Sivachenko A, Jing R, Parkin M, Pugh T, Verhaak RG, Stransky N, Boutin AT, Barretina J, Solit DB, Vakiani E, Shao W, Mishina Y, Warmuth M, Jimenez J, Chiang DY, Signoretti S, Kaelin WG, Spardy N, Hahn WC, Hoshida Y, Ogino S, Depinho RA, Chin L, Garraway LA, Fuchs CS, Baselga J, Tabernero J, Gabriel S, Lander ES, Getz G, Meyerson M.
Nat Genet 43(10):964-8. doi: 10.1038/ng.936. 2011
26PMEPA1, TCF7L2
Requirement of TCF7L2 for TGF-beta-dependent transcriptional activation of the TMEPAI gene.
Nakano N, Itoh S, Watanabe Y, Maeyama K, Itoh F, Kato M.
J Biol Chem 285(49):38023-33. Epub 2010 Sep 30. 2010
27MAD2L2, TCF7L2
MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation.
Hong CF, Chou YT, Lin YS, Wu CW.
J Biol Chem 284(29):19613-22. Epub 2009 May 14. 2009
28TCF7L2
Tissue-specific alternative splicing of TCF7L2.
Prokunina-Olsson L, Welch C, Hansson O, Adhikari N, Scott LJ, Usher N, Tong M, Sprau A, Swift A, Bonnycastle LL, Erdos MR, He Z, Saxena R, Harmon B, Kotova O, Hoffman EP, Altshuler D, Groop L, Boehnke M, Collins FS, Hall JL.
Hum Mol Genet 18(20):3795-804. Epub 2009 Jul 14. 2009
29TCF7L2
Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2.
Biyasheva A, Legro RS, Dunaif A, Urbanek M.
J Clin Endocrinol Metab 94(7):2617-25. Epub 2009 Apr 7. 2009
30AXIN2, TCF7L2
Frameshift mutations of Wnt pathway genes AXIN2 and TCF7L2 in gastric carcinomas with high microsatellite instability.
Kim MS, Kim SS, Ahn CH, Yoo NJ, Lee SH.
Hum Pathol 40(1):58-64. Epub 2008 Aug 27.PMID: 18755497 2009
31TCF7L2
Expression of the transcription factor 7-like 2 gene (TCF7L2) in human adipocytes is down regulated by insulin.
Ahlzen M, Johansson LE, Cervin C, Tornqvist H, Groop L, Ridderstrale M.
Biochem Biophys Res Commun 370(1):49-52. Epub 2008 Mar 13. 2008
32TCF7L2
TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta-cells.
Loder MK, da Silva Xavier G, McDonald A, Rutter GA.
Biochem Soc Trans 36(Pt 3):357-9.PMID: 18481957 2008
33TCF7L2
Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort.
van Vliet-Ostaptchouk JV, Shiri-Sverdlov R, Zhernakova A, Strengman E, van Haeften TW, Hofker MH, Wijmenga C.
Diabetologia 50(1):59-62. Epub 2006 Oct 10. 2007
34TCF7L2
TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden.
Mayans S, Lackovic K, Lindgren P, Ruikka K, Agren A, Eliasson M, Holmberg D.
Eur J Hum Genet 15(3):342-6. Epub 2007 Jan 24. 2007
35TCF7L2
Type 2 Diabetes TCF7L2 Risk Genotypes Alter Birth Weight: A Study of 24,053 Individuals.
Freathy RM, Weedon MN, Bennett A, Hypponen E, Relton CL, Knight B, Shields B, Parnell KS, Groves CJ, Ring SM, Pembrey ME, Ben-Shlomo Y, Strachan DP, Power C, Jarvelin MR, McCarthy MI, Davey Smith G, Hattersley AT, Frayling TM.
Am J Hum Genet 80(6):1150-61. Epub 2007 Apr 23. 2007
36PPARG, KCNJ11, TCF7L2, CDKAL1
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS; Wellcome Trust Case Control Consortium (WTCCC), Burton PR, Clayton DG, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Davison D, Easton D, Evans D, Leung HT, Spencer CC, Tobin MD, Attwood AP, Boorman JP, Cant B, Everson U, Hussey JM, Jolley JD, Knight AS, Koch K, Meech E, Nutland S, Prowse CV, Stevens HE, Taylor NC, Walters GR, Walker NM, Watkins NA, Winzer T, Jones RW, McArdle WL, Ring SM, Strachan DP, Pembrey M, Breen G, St Clair D, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green EK, Grozeva D, Hamshere ML, Holmans PA, Jones IR, Kirov G, Moskvina V, Nikolov I, O'donovan MC, Owen MJ, Collier DA, Elkin A, Farmer A, Williamson R, McGuffin P, Young AH, Ferrier IN, Ball SG, Balmforth AJ, Barrett JH, Bishop DT, Iles MM, Maqbool A, Yuldasheva N, Hall AS, Braund PS, Dixon RJ, Mangino M, Stevens S, Thompson JR, Bredin F, Tremelling M, Parkes M, Drummond H, Lees CW, Nimmo ER, Satsangi J, Fisher SA, Forbes A, Lewis CM, Onnie CM, Prescott NJ, Sanderson J, Mathew CG, Barbour J, Mohiuddin MK, Todhunter CE, Mansfield JC, Ahmad T, Cummings FR, Jewell DP, Webster J, Brown MJ, Lathrop GM, Connell J, Dominiczak A, Braga Marcano CA, Burke B, Dobson R, Gungadoo J, Lee KL, Munroe PB, Newhouse SJ, Onipinla A, Wallace C, Xue M, Caulfield M, Farrall M, Barton A, Bruce IN, Donovan H, Eyre S, Gilbert PD, Hider SL, Hinks AM, John SL, Potter C, Silman AJ, Symmons DP, Thomson W, Worthington J, Dunger DB, Widmer B, Newport M, Sirugo G, Lyons E, Vannberg F, Hill AV, Bradbury LA, Farrar C, Pointon JJ, Wordsworth P, Brown MA, Franklyn JA, Heward JM, Simmonds MJ, Gough SC, Seal S, Stratton MR, Rahman N, Ban M, Goris A, Sawcer SJ, Compston A, Conway D, Jallow M, Rockett KA, Bumpstead SJ, Chaney A, Downes K, Ghori MJ, Gwilliam R, Hunt SE, Inouye M, Keniry A, King E, McGinnis R, Potter S, Ravindrarajah R, Whittaker P, Widden C, Withers D, Cardin NJ, Ferreira T, Pereira-Gale J, Hallgrimsdottir IB, Howie BN, Su Z, Teo YY, Vukcevic D, Bentley D, Compston A, Ouwehand NJ, Samani MR, Isaacs JD, Morgan AW, Wilson GD, Ardern-Jones A, Berg J, Brady A, Bradshaw N, Brewer C, Brice G, Bullman B, Campbell J, Castle B, Cetnarsryj R, Chapman C, Chu C, Coates N, Cole T, Davidson R, Donaldson A, Dorkins H, Douglas F, Eccles D, Eeles R, Elmslie F, Evans DG, Goff S, Goodman S, Goudie D, Gray J, Greenhalgh L, Gregory H, Hodgson SV, Homfray T, Houlston RS, Izatt L, Jackson L, Jeffers L, Johnson-Roffey V, Kavalier F, Kirk C, Lalloo F, Langman C, Locke I, Longmuir M, Mackay J, Magee A, Mansour S, Miedzybrodzka Z, Miller J, Morrison P, Murday V, Paterson J, Pichert G, Porteous M, Rahman N, Rogers M, Rowe S, Shanley S, Saggar A, Scott G, Side L, Snadden L, Steel M, Thomas M, Thomas S, McCarthy MI, Hattersley AT.
Science 316(5829):1336-41. Epub 2007 Apr 26. 2007
37HHEX, IGFBP2, TCF7L2, CDKAL1, SLC30A8, KCNJ11
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M.
Science 316(5829):1341-5. Epub 2007 Apr 26. 2007
38TCF7L2
TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children.
Korner A, Berndt J, Stumvoll M, Kiess W, Kovacs P.
J Clin Endocrinol Metab 92(5):1956-60. Epub 2007 Feb 20. 2007
39TCF7L2
Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort.
van Vliet-Ostaptchouk JV, Shiri-Sverdlov R, Zhernakova A, Strengman E, van Haeften TW, Hofker MH, Wijmenga C.
Diabetologia 50(1):59-62. Epub 2006 Oct 10. 2007
40TCF7L2
Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.
Chandak GR, Janipalli CS, Bhaskar S, Kulkarni SR, Mohankrishna P, Hattersley AT, Frayling TM, Yajnik CS.
Diabetologia 50(1):63-7. Epub 2006 Nov 9. 2007
41TCF7L2
A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus.
Shaat N, Lernmark A, Karlsson E, Ivarsson S, Parikh H, Berntorp K, Groop L.
Diabetologia 50(5):972-9. Epub 2007 Mar 7. 2007
42TCF7L2
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes.
Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K.
Nat Genet 38(3):320-3. Epub 2006 Jan 15. 2006
43AXIN1, AXIN2, TCF7L2
Colorectal cancer and genetic alterations in the Wnt pathway.
Segditsas S, Tomlinson I.
Oncogene 25(57):7531-7. Review. 2006
44TCF7L2
Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women.
Humphries SE, Gable D, Cooper JA, Ireland H, Stephens JW, Hurel SJ, Li KW, Palmen J, Miller MA, Cappuccio FP, Elkeles R, Godsland I, Miller GJ, Talmud PJ.
J Mol Med 84(12):1005-14. 2006
45IFRD1, SPP1, TCF7L2
TIS7 regulation of the beta-catenin/Tcf-4 target gene osteopontin (OPN) is histone deacetylase-dependent.
Vietor I, Kurzbauer R, Brosch G, Huber LA.
J Biol Chem 280(48):39795-801. Epub 2005 Oct 3. 2005
46TCF7L2
Assignment of the TCF-4 gene (TCF7L2) to human chromosome band 10q25.3.
Duval A, Busson-Leconiat M, Berger R, Hamelin R.
Cytogenet Cell Genet 88(3-4):264-5. No abstract available. 2000
47TCF7L2
The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines.
Duval A, Rolland S, Tubacher E, Bui H, Thomas G, Hamelin R.
Cancer Res 60(14):3872-9. 2000
48TCF7L2
Variable mutation frequencies in coding repeats of TCF-4 and other target genes in colon, gastric and endometrial carcinoma showing microsatellite instability.
Duval A, Iacopetta B, Ranzani GN, Lothe RA, Thomas G, Hamelin R.
Oncogene 18(48):6806-9. 1999
49APC, CTNNB1, TCF7L2, FAP
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
Korinek V, et al.
Science 275 : 1784-1787. 1997
50TCF7L2
A gene family of HMG-box transcription factors with homology to TCF-1.
Castrop J, van Norren K, Clevers H.
Nucleic Acids Res 20(3):611. No abstract available. 1992