1 | HMGA1, KIFC1, TCF4
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| KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity.
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| Teng K, Wei S, Zhang C, Chen J, Chen J, Xiao K, Liu J, Dai M, Guan X, Yun J, Xie D.
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| J Exp Clin Cancer Res 38(1):329. doi: 10.1186/s13046-019-1331-8. Erratum in: J Exp Clin Cancer Res. 2019 Oct 31;38(1):442.
2019
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2 | CTNNB1, TCF4, ZNF433
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| ZNF433 positively regulates the beta-catenin/ TCF pathway in prostate cancer and enhances the tumorigenicity of cancer cells
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| Gu S, Hou P, Liu K, Niu X, Wei B, Mao F, Xu Z.
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| Onco Targets Ther. Feb 1;12:1031-1039. doi: 10.2147/OTT.S178150. 2019
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3 | FECD3, TCF4
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| Antisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity.
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| Zarouchlioti C, Sanchez-Pintado B, Hafford Tear NJ, Klein P, Liskova P, Dulla K, Semo M, Vugler AA, Muthusamy K, Dudakova L, Levis HJ, Skalicka P, Hysi P, Cheetham ME, Tuft SJ, Adamson P, Hardcastle AJ, Davidson AE.
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| Am J Hum Genet 102(4):528-539. doi: 10.1016/j.ajhg.2018.02.010. Epub 2018 Mar 8.
2018
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4 | SPIN1, SPIN2A, SPIN2B, SPIN3, SPIN4, SPINDOC, TCF4
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| A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1.
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| Bae N, Gao M, Li X, Premkumar T, Sbardella G, Chen J, Bedford MT.
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| J Biol Chem 292(51):20808-20817. doi: 10.1074/jbc.M117.814913. Epub 2017 Oct 23.
2017
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5 | TCF3, TCF4
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| Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development.
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| Wöhner M, Tagoh H, Bilic I, Jaritz M, Poliakova DK, Fischer M, Busslinger M.
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| J Exp Med 213(7):1201-21. doi: 10.1084/jem.20152002. Epub 2016 Jun 3.
2016
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6 | BACH1, TCF4
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| Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis.
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| Jiang L, Yin M, Wei X, Liu J, Wang X, Niu C, Kang X, Xu J, Zhou Z, Sun S, Wang X, Zheng X, Duan S, Yao K, Qian R, Sun N, Chen A, Wang R, Zhang J, Chen S, Meng D.
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| Circ Res 117(4):364-75. doi: 10.1161/CIRCRESAHA.115.306829. Epub 2015 Jun 29. Erratum in: Circ Res. 2015 Oct 9;117(9):e79.
2015
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7 | CD36, PPARG, TCF4, WNT1
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| Wnt1 positively regulates CD36 expression via TCF4 and PPAR-γ in macrophages.
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| Wang S, Sun Z, Zhang X, Li Z, Wu M, Zhao W, Wang H, Chen T, Yan H, Zhu J.
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| Cell Physiol Biochem 35(4):1289-302. doi: 10.1159/000373951.
2015
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8 | TCF3, TCF4
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| A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells.
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| Shah M, Rennoll SA, Raup-Konsavage WM, Yochum GS.
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| Cell Cycle 14(3):323-32. doi: 10.4161/15384101.2014.980643.
2015
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9 | PLAGL1, TCF4
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| Zac1 regulates cell cycle arrest in neuronal progenitors via Tcf4.
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| Schmidt-Edelkraut U, Daniel G, Hoffmann A, Spengler D.
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| Mol Cell Biol ol Cell Biol. 2014 Jan 6. [Epub ahead of print]
2014
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10 | TCF4
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| Comprehensive assessment of genetic variants within TCF4 in Fuchs' endothelial corneal dystrophy.
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| Wieben ED, Aleff RA, Eckloff BW, Atkinson EJ, Baheti S, Middha S, Brown WL, Patel SV, Kocher JP, Baratz KH.
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| Invest Ophthalmol Vis Sci 55(9):6101-7. doi: 10.1167/iovs.14-14958.
2014
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11 | AGBL1, FECD8, TCF4
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| Mutations in AGBL1 cause dominant late-onset Fuchs corneal dystrophy and alter protein-protein interaction with TCF4.
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| Riazuddin SA, Vasanth S, Katsanis N, Gottsch JD.
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| Am J Hum Genet 93(4):758-64. doi: 10.1016/j.ajhg.2013.08.010. 2013
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12 | TCF4
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| Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation.
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| Forrest MP, Waite AJ, Martin-Rendon E, Blake DJ.
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| PLoS One 8(8):e73169. doi: 10.1371/journal.pone.0073169. eCollection 2013.
2013
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13 | SOX9, TCF4
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| SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt/β-catenin activation in breast cancer.
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| Wang H, He L, Ma F, Regan MM, Balk SP, Richardson AL, Yuan X.
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| J Biol Chem 288(9):6478-87. doi: 10.1074/jbc.M112.419184. Epub 2013 Jan 10.
2013
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14 | DEL18QD, TCF4
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| Mosaic 18q21.2 deletions including the TCF4 gene: A clinical report.
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| Rossi M, Labalme A, Cordier MP, Till M, Blanchard G, Dubois R, Guibaud L, Heissat S, Javouhey E, Lachaux A, Mure PY, Ville D, Edery P, Sanlaville D.
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| Am J Med Genet A m J Med Genet A. 2012 Nov 19. doi: 10.1002/ajmg.a.35588. [Epub ahead of print]
2012
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15 | PTHS, TCF4
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| Novel comprehensive diagnostic strategy in Pitt-Hopkins syndrome: clinical score and further delineation of the TCF4 mutational spectrum.
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| Whalen S, Héron D, Gaillon T, Moldovan O, Rossi M, Devillard F, Giuliano F, Soares G, Mathieu-Dramard M, Afenjar A, Charles P, Mignot C, Burglen L, Van Maldergem L, Piard J, Aftimos S, Mancini G, Dias P, Philip N, Goldenberg A, Le Merrer M, Rio M, Josifova D, Van Hagen JM, Lacombe D, Edery P, Dupuis-Girod S, Putoux A, Sanlaville D, Fischer R, Drévillon L, Briand-Suleau A, Metay C, Goossens M, Amiel J, Jacquette A, Giurgea I.
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| Hum Mutat 33(1):64-72. doi: 10.1002/humu.21639. Epub 2011 Nov 23.
2012
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16 | PTHS, TCF4
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| Pitt-Hopkins syndrome-associated mutations in TCF4 lead to variable impairment of the transcription factor function ranging from hypomorphic to dominant-negative effects.
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| Sepp M, Pruunsild P, Timmusk T.
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| Hum Mol Genet 21(13):2873-88. doi: 10.1093/hmg/dds112. Epub 2012 Mar 28.
2012
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17 | CLU, TCF4
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| Association of TCF4 and CLU polymorphisms with Fuchs' endothelial dystrophy and implication of CLU and TGFBI proteins in the disease process.
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| Kuot A, Hewitt AW, Griggs K, Klebe S, Mills R, Jhanji V, Craig JE, Sharma S, Burdon KP.
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| Eur J Hum Genet 20(6):632-8. doi: 10.1038/ejhg.2011.248. Epub 2012 Jan 11.
2012
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18 | PTHS, TCF4
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| The Pitt-Hopkins syndrome: report of 16 new patients and clinical diagnostic criteria.
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| Marangi G, Ricciardi S, Orteschi D, Lattante S, Murdolo M, Dallapiccola B, Biscione C, Lecce R, Chiurazzi P, Romano C, Greco D, Pettinato R, Sorge G, Pantaleoni C, Alfei E, Toldo I, Magnani C, Bonanni P, Martinez F, Serra G, Battaglia D, Lettori D, Vasco G, Baroncini A, Daolio C, Zollino M.
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| Am J Med Genet A 155A(7):1536-45. doi: 10.1002/ajmg.a.34070. Epub 2011 Jun 10.
2011
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19 | DEL18QD, TCF4
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| The role of the TCF4 gene in the phenotype of individuals with 18q segmental deletions.
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| Hasi M, Soileau B, Sebold C, Hill A, Hale DE, O'Donnell L, Cody JD.
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| Hum Genet 130(6):777-87. Epub 2011 Jun 14.
2011
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20 | DEFA5, FGFR3, TCF4
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| Fibroblast growth factor receptor-3 (FGFR-3) regulates expression of paneth cell lineage-specific genes in intestinal epithelial cells through both TCF4/beta-catenin-dependent and -independent signaling pathways.
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| Brodrick B, Vidrich A, Porter E, Bradley L, Buzan JM, Cohn SM.
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| J Biol Chem 286(21):18515-25. Epub 2011 Mar 9.
2011
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21 | TCF4
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| Association of TCF4 gene polymorphisms with Fuchs' corneal dystrophy in the Chinese.
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| Thalamuthu A, Khor CC, Venkataraman D, Koh LW, Tan DT, Aung T, Mehta JS, Vithana EN.
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| Invest Ophthalmol Vis Sci. 52(8):5573-8. 2011
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22 | CTNNB1, TCF4, ZEB1
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| β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness.
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| Sánchez-Tilló E, de Barrios O, Siles L, Cuatrecasas M, Castells A, Postigo A.
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| Proc Natl Acad Sci U S A 108(48):19204-9. doi: 10.1073/pnas.1108977108. Epub 2011 Nov 11. 2011
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23 | CIAO2B, TCF4
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| Interference of E2-2-mediated effect in endothelial cells by FAM96B through its limited expression of E2-2.
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| Yang W, Itoh F, Ohya H, Kishimoto F, Tanaka A, Nakano N, Itoh S, Kato M.
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| Cancer Sci 102(10):1808-14. doi: 10.1111/j.1349-7006.2011.02022.x. Epub 2011 Aug 2. 2011
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24 | TCF4
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| Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing.
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| Sepp M, Kannike K, Eesmaa A, Urb M, Timmusk T.
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| PLoS One 6(7):e22138. doi: 10.1371/journal.pone.0022138. Epub 2011 Jul 15.
2011
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25 | FECD3, TCF4
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| Replication of TCF4 through association and linkage studies in late-onset Fuchs endothelial corneal dystrophy.
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| Li YJ, Minear MA, Rimmler J, Zhao B, Balajonda E, Hauser MA, Allingham RR, Eghrari AO, Riazuddin SA, Katsanis N, Gottsch JD, Gregory SG, Klintworth GK, Afshari NA.
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| PLoS One 6(4):e18044. doi: 10.1371/journal.pone.0018044.
2011
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26 | DEL18QD, PHS, PTHS, TCF4
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| Mosaic microdeletion 18q21 as a cause of mental retardation.
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| Stavropoulos DJ, Macgregor DL, Yoon G.
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| Eur J Med Genet 53(6):396-399. Epub 2010 Sep 21.PMID: 20813211 2010
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27 | CDX2, TCF4
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| TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions.
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| Verzi MP, Hatzis P, Sulahian R, Philips J, Schuijers J, Shin H, Freed E, Lynch JP, Dang DT, Brown M, Clevers H, Liu XS, Shivdasani RA.
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| Proc Natl Acad Sci U S A 107(34):15157-62. Epub 2010 Aug 9.PMID: 20696899 2010
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28 | DEL18QD, FBXO15, NETO1, TCF4
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| Genetic determinants of autism in individuals with deletions of 18q.
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| O'Donnell L, Soileau B, Heard P, Carter E, Sebold C, Gelfond J, Hale DE, Cody JD.
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| Hum Genet 128(2):155-64. Epub 2010 May 25.PMID: 20499253 2010
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29 | TCF4
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| The transcription factor ITF-2A induces cell cycle arrest via p21(Cip1).
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| Herbst A, Helferich S, Behrens A, Göke B, Kolligs FT.
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| Biochem Biophys Res Commun 387(4):736-40. Epub 2009 Jul 25.
2009
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30 | NRGN, TCF4
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| Common variants conferring risk of schizophrenia.
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| Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietiläinen OP, Mors O, Mortensen PB, Sigurdsson E, Gustafsson O, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Suvisaari J, Lonnqvist J, Paunio T, Børglum AD, Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Böttcher Y, Olesen J, Breuer R, Möller HJ, Giegling I, Rasmussen HB, Timm S, Mattheisen M, Bitter I, Réthelyi JM, Magnusdottir BB, Sigmundsson T, Olason P, Masson G, Gulcher JR, Haraldsson M, Fossdal R, Thorgeirsson TE, Thorsteinsdottir U, Ruggeri M, Tosato S, Franke B, Strengman E, Kiemeney LA; Genetic Risk and Outcome in Psychosis (GROUP), Melle I, Djurovic S, Abramova L, Kaleda V, Sanjuan J, de Frutos R, Bramon E, Vassos E, Fraser G, Ettinger U, Picchioni M, Walker N, Toulopoulou T, Need AC, Ge D, Yoon JL, Shianna KV, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Carracedo A, Arango C, Costas J, Jönsson EG, Terenius L, Agartz I, Petursson H, Nöthen MM, Rietschel M, Matthews PM, Muglia P, Peltonen L, St Clair D, Goldstein DB, Stefansson K, Collier DA.
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| Nature 460(7256):744-7. Epub 2009 Jul 1.
2009
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31 | LEF1, TCF3, TCF4
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| Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia.
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| Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM, Pasolli HA, Fuchs E.
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| Nat Genet 41(10):1068-75. Epub 2009 Aug 30.PMID: 19718027 2009
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32 | CHD6, TCF4
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| Disruption of the TCF4 gene in a girl with mental retardation but without the classical Pitt-Hopkins syndrome.
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| Kalscheuer VM, Feenstra I, Van Ravenswaaij-Arts CM, Smeets DF, Menzel C, Ullmann R, Musante L, Ropers HH.
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| Am J Med Genet A 146A(16):2053-9.
2008
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33 | TCF4, PTHS, DEL18QD
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| Deletion 18q21.2q21.32 involving TCF4 in a boy diagnosed by CGH-array.
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| Andrieux J, Lepretre F, Cuisset JM, Goldenberg A, Delobel B, Manouvrier-Hanu S, Holder-Espinasse M.
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| Eur J Med Genet [Epub ahead of print] 2008
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34 | TCF4
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| A conserved domain in the transcription factor ITF-2B attenuates its activity.
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| Herbst A, Kolligs FT.
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| Biochem Biophys Res Commun 370(2):327-31. Epub 2008 Mar 25.
2008
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35 | PTHS, TCF4
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| TCF4 deletions in Pitt-Hopkins Syndrome.
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| Giurgea I, Missirian C, Cacciagli P, Whalen S, Fredriksen T, Gaillon T, Rankin J, Mathieu-Dramard M, Morin G, Martin-Coignard D, Dubourg C, Chabrol B, Arfi J, Giuliano F, Claude Lambert J, Philip N, Sarda P, Villard L, Goossens M, Moncla A.
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| Hum Mutat 29(11):E242-51.
2008
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36 | PTHS, TCF4
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| Further delineation of Pitt-Hopkins syndrome: phenotypic and genotypic description of 16 novel patients.
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| Zweier C, Sticht H, Bijlsma EK, Clayton-Smith J, Boonen SE, Fryer A, Greally MT, Hoffmann L, den Hollander NS, Jongmans M, Kant SG, King MD, Lynch SA, McKee S, Midro AT, Park SM, Ricotti V, Tarantino E, Wessels M, Peippo M, Rauch A.
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| J Med Genet 45(11):738-44. Epub 2008 Aug 26.
2008
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37 | SPIB, TCF4
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| E-box protein E2-2 is a crucial regulator of plasmacytoid DC development.
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| Esashi E, Liu YJ.
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| Eur J Immunol 38(9):2386-8.PMID: 18792016 2008
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38 | TCF4
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| Menin promotes the Wnt signaling pathway in pancreatic endocrine cells.
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| Chen G, A J, Wang M, Farley S, Lee LY, Lee LC, Sawicki MP.
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| Mol Cancer Res. 6(12):1894-907. 2008
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39 | PTHS, TCF4
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| Haploinsufficiency of TCF4 Causes Syndromal Mental Retardation with Intermittent Hyperventilation (Pitt-Hopkins Syndrome).
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| Zweier C, Peippo MM, Hoyer J, Sousa S, Bottani A, Clayton-Smith J, Reardon W, Saraiva J, Cabral A, Gohring I, Devriendt K, de Ravel T, Bijlsma EK, Hennekam RC, Orrico A, Cohen M, Dreweke A, Reis A, Nurnberg P, Rauch A.
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| Am J Hum Genet 80(5):994-1001. Epub 2007 Mar 23. 2007
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40 | PTHS, TCF4
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| Mutations in TCF4, Encoding a Class I Basic Helix-Loop-Helix Transcription Factor, Are Responsible for Pitt-Hopkins Syndrome, a Severe Epileptic Encephalopathy Associated with Autonomic Dysfunction.
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| Amiel J, Rio M, Pontual LD, Redon R, Malan V, Boddaert N, Plouin P, Carter NP, Lyonnet S, Munnich A, Colleaux L.
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| Am J Hum Genet 80(5):988-993. Epub 2007 Mar 23. 2007
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41 | TCF4, PTHS
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| Severe mental retardation with breathing abnormalities (Pitt-Hopkins syndrome) is caused by haploinsufficiency of the neuronal bHLH transcription factor TCF4.
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| Brockschmidt A, Todt U, Ryu S, Hoischen A, Landwehr C, Birnbaum S, Frenck W, Radlwimmer B, Lichter P, Engels H, Driever W, Kubisch C, Weber RG.
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| Hum Mol Genet 16(12):1488-94. Epub 2007 May 3. 2007
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42 | TCF4
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| The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors.
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| Flora A, Garcia JJ, Thaller C, Zoghbi HY.
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| Proc Natl Acad Sci U S A. 104(39):15382-7. 2007
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43 | HIC1, TCF4
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| HIC1 attenuates Wnt signaling by recruitment of TCF-4 and beta-catenin to the nuclear bodies.
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| Valenta T, Lukas J, Doubravska L, Fafilek B, Korinek V.
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| EMBO J 25(11):2326-37. Epub 2006 May 25.
2006
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44 | TCF4, JUN
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| Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development.
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| Nateri AS, Spencer-Dene B, Behrens A.
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| Nature 437(7056):281-5. Epub 2005 Jul 10. 2005
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45 | TLE3, AES, TCF4, PROP1
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| TCF and Groucho-related genes influence pituitary growth and development.
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| Brinkmeier ML, Potok MA, Cha KB, Gridley T, Stifani S, Meeldijk J, Clevers H, Camper SA.
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| Mol Endocrinol 17(11):2152-61. Epub 2003 Aug 7. 2003
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46 | TCF4
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| Hot spots in Tcf4 for the interaction with beta-catenin.
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| Fasolini M, Wu X, Flocco M, Trosset JY, Oppermann U, Knapp S.
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| J Biol Chem. 278(23):21092-8. 2003
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47 | TCF4
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| Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation.
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| Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H.
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| J Biol Chem. 277(11):9118-26. 2002
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48 | TCF4
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| Involvement of ITF2 in the transcriptional regulation of melanogenic genes.
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| Furumura M, Potterf SB, Toyofuku K, Matsunaga J, Muller J, Hearing VJ.
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| J Biol Chem 276(30):28147-54. 2001
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49 | CALM1, CALM3, NEUROD1, TCF4
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| A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors.
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| Onions J, Hermann S, Grundstrom T.
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| Biochemistry 39(15):4366-74. 2000
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50 | TCF4
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| HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex.
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| Persson P, Jögi A, Grynfeld A, Påhlman S, Axelson H.
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| Biochem Biophys Res Commun. 274(1):22-31. 2000
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51 | ERDA1, ATXN3, ATXN1, ATXN2, ATXN7, TCF4
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| Cis-acting modifiers of expanded CAG/CTG triplet repeat expandability: associations with flanking GC content and proximity to CpG islands.
|
| Brock GJ, et al.
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| Hum Mol Genet 8(6):1061-7. 1999
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52 | ERDA1, SPAST, TCF4
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| CAG repeat expansion in autosomal dominant familial spastic paraparesis : novel expansion in a subset of patients.
|
| Benson KF, et al.
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| Hum Mol Genet 7 : 1779-1786. 1998
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53 | TCF4, PTHS
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| Mental retardation, coarse face, and hyperbreathing: confirmation of the Pitt-Hopkins syndrome.
|
| Van Balkom ID, Quartel S, Hennekam RC.
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| Am J Med Genet 75(3):273-6. Review. 1998
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54 | TCF4
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| A splice variant of E2-2 basic helix-loop-helix protein represses the brain-specific fibroblast growth factor 1 promoter through the binding to an imperfect E-box.
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| Liu Y, Ray SK, Yang XQ, Luntz-Leybman V, Chiu IM.
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| J Biol Chem. 273(30):19269-76. 1998
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55 | TCF4
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| A novel, heritable, expanding CTG repeat in an intron of the SEF2-1 gene on chromosome 18q21.1.
|
| Breschel TS, McInnis MG, Margolis RL, Sirugo G, Corneliussen B, Simpson SG, McMahon FJ, MacKinnon DF, Xu JF, Pleasant N, Huo Y, Ashworth RG, Grundstrom C, Grundstrom T, Kidd KK, DePaulo JR, Ross CA.
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| Hum Mol Genet 6(11):1855-63. 1997
|
56 | TCF12, TCF4
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| Differential interactions of Id proteins with basic-helix-loop-helix transcription factors.
|
| Langlands K, Yin X, Anand G, Prochownik EV.
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| J Biol Chem. 272(32):19785-93. 1997
|
57 | TCF4
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| B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes.
|
| Zhuang Y, et al.
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| Mol Cell Biol 16 : 2898-2905. 1996
|
58 | TCF4
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| The helix-loop-helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene.
|
| Pscherer A, Dorflinger U, Kirfel J, Gawlas K, Ruschoff J, Buettner R, Schule R.
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| EMBO J 15(23):6680-90. 1996
|
59 | TCF4
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| Determinants of helix-loop-helix dimerization affinity. Random mutational analysis of SCL/tal.
|
| Goldfarb AN, Lewandowska K, Shoham M.
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| J Biol Chem. 271(5):2683-8. 1996
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60 | TCF4
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| Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers.
|
| Corneliussen B, et al.
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| J Virol 65 : 6084-6093. 1991
|
61 | TCF3, TCF4
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| Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif.
|
| Henthorn P, Kiledjian M, Kadesch T.
|
| Science 247(4941):467-70. 1990
|