| 1 | EOMES, T, TBX1, TBX15, TBX18, TBX2, TBX3, TBX4, TBX5
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| The Roles of T-Box Genes in Vertebrate Limb Development.
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| Sheeba CJ, Logan MP.
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| Curr Top Dev Biol 122:355-381. doi: 10.1016/bs.ctdb.2016.08.009. Epub 2016 Oct 5.
2017
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| 2 | TBX1, TBX18, TBX2, TBX20, TBX3
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| T-Box Genes in the Kidney and Urinary Tract.
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| Kispert A.
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| Curr Top Dev Biol 122:245-278. doi: 10.1016/bs.ctdb.2016.06.002. Epub 2016 Jul 27.
2017
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| 3 | BMP4, TBX3
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| Tbx3 represses bmp4 expression and with Pax6 is required and sufficient for retina formation.
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| Motahari Z, Martinez-De Luna RI, Viczian AS, Zuber ME.
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| Development evelopment. 2016 Aug 30. pii: dev.130955. [Epub ahead of print]
2016
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| 4 | TBX3
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| Development of a subset of forelimb muscles and their attachment sites requires the ulnar-mammary syndrome gene Tbx3.
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| Colasanto MP, Eyal S, Mohassel P, Bamshad M, Bonnemann C, Zelzer E, Moon AM, Kardon G.
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| Dis Model Mech is Model Mech. 2016 Aug 4. pii: dmm.025874. [Epub ahead of print]
2016
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| 5 | CDKN1A, TBX3
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| The T-box transcription factor TBX3 drives proliferation by direct repression of the p21(WAF1) cyclin-dependent kinase inhibitor.
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| Willmer T, Hare S, Peres J, Prince S.
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| Cell Div 11:6. doi: 10.1186/s13008-016-0019-0. eCollection 2016.
2016
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| 6 | GLI3, TBX3
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| T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number.
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| Emechebe U, Kumar P P, Rozenberg JM, Moore B, Firment A, Mirshahi T, Moon AM.
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| Elife 5. pii: e07897. doi: 10.7554/eLife.07897.
2016
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| 7 | TBX3
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| The T-Box factor TBX3 is important in S-phase and is regulated by c-Myc and cyclin A-CDK2.
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| Willmer T, Peres J, Mowla S, Abrahams A, Prince S.
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| Cell Cycle 14(19):3173-83. doi: 10.1080/15384101.2015.1080398.
2015
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| 8 | DPPA3, TBX3
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| Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm.
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| Waghray A, Saiz N, Jayaprakash AD, Freire AG, Papatsenko D, Pereira CF, Lee DF, Brosh R, Chang B, Darr H, Gingold J, Kelley K, Schaniel C, Hadjantonakis AK, Lemischka IR.
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| Stem Cell Reports 5(1):97-110. doi: 10.1016/j.stemcr.2015.05.009. Epub 2015 Jun 18.
2015
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| 9 | TBX3
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| Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium.
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| Kunasegaran K, Ho V, Chang TH, De Silva D, Bakker ML, Christoffels VM, Pietersen AM.
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| PLoS One 9(10):e110191. doi: 10.1371/journal.pone.0110191. eCollection 2014.
2014
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| 10 | TBX3
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| TBX3, a downstream target of TGF-β1, inhibits mesangial cell apoptosis.
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| Wensing LA, Campos AH.
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| Exp Cell Res 328(2):340-50. doi: 10.1016/j.yexcr.2014.08.022. Epub 2014 Aug 23.
2014
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| 11 | TBX3, UMS
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| TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome.
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| Kumar P P, Franklin S, Emechebe U, Hu H, Moore B, Lehman C, Yandell M, Moon AM.
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| PLoS Genet 10(3):e1004247. doi: 10.1371/journal.pgen.1004247. eCollection 2014 Mar.
2014
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| 12 | TBX3
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| Tbx3 isoforms are involved in pluripotency maintaining through distinct regulation of Nanog transcriptional activity.
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| Zhao D, Wu Y, Chen K.
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| Biochem Biophys Res Commun 444(3):411-4. doi: 10.1016/j.bbrc.2014.01.093. Epub 2014 Jan 25.
2014
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| 13 | CSF1, JDP2, TBX3
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| The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis.
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| Yao C, Yao GQ, Sun BH, Zhang C, Tommasini SM, Insogna K.
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| J Biol Chem 289(10):6775-90. doi: 10.1074/jbc.M113.499210. Epub 2014 Jan 6.
2014
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| 14 | TBX3
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| Roles for Tbx3 in regulation of two-cell state and telomere elongation in mouse ES cells.
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| Dan J, Li M, Yang J, Li J, Okuka M, Ye X, Liu L.
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| Sci Rep 3:3492. doi: 10.1038/srep03492.
2013
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| 15 | TBX3
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| The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion.
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| Peres J, Prince S.
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| Mol Cancer 12(1):117. doi: 10.1186/1476-4598-12-117.
2013
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| 16 | TBX3
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| Genetic analysis of the TBX3 gene promoter in ventricular septal defects.
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| Chen D, Qiao Y, Meng H, Pang S, Huang W, Zhang H, Yan B.
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| Gene 512(2):185-8. doi: 10.1016/j.gene.2012.10.066. Epub 2012 Oct 29.
2013
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| 17 | TBX3
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| TBX3 promotes human embryonic stem cell proliferation and neuroepithelial differentiation in a differentiation stage-dependent manner.
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| Esmailpour T, Huang T.
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| Stem Cells 30(10):2152-63. doi: 10.1002/stem.1187.
2012
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| 18 | TBX3
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| Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis.
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| Frank DU, Carter KL, Thomas KR, Burr RM, Bakker ML, Coetzee WA, Tristani-Firouzi M, Bamshad MJ, Christoffels VM, Moon AM.
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| Proc Natl Acad Sci U S A 109(3):E154-63. doi: 10.1073/pnas.1115165109. Epub 2011 Dec 27.
2012
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| 19 | TBX3
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| The ulnar-mammary syndrome gene, Tbx3, is a direct target of the retinoic acid signaling pathway, which regulates its expression during mouse limb development.
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| Ballim RD, Mendelsohn C, Papaioannou VE, Prince S.
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| Mol Biol Cell 23(12):2362-72. doi: 10.1091/mbc.E11-09-0790. Epub 2012 Apr 25.
2012
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| 20 | TBX20, TBX3, TBX5
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| Alternative splicing of T-box transcription factor genes.
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| DeBenedittis P, Jiao K.
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| Biochem Biophys Res Commun 412(4):513-7. Epub 2011 Aug 11. Review.
2011
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| 21 | TBX3
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| Basal transcription of the human TBX3 gene, a key developmental regulator which is overexpressed in several cancers, requires functional NF-Y and Sp1 sites.
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| Smith J, Mowla S, Prince S.
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| Gene 486(1-2):41-6. doi: 10.1016/j.gene.2011.07.013. Epub 2011 Jul 20.
2011
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| 22 | SOX4, TBX3
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| Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43.
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| Boogerd CJ, Wong LY, van den Boogaard M, Bakker ML, Tessadori F, Bakkers J, 't Hoen PA, Moorman AF, Christoffels VM, Barnett P.
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| Cell Mol Life Sci 68(23):3949-61. doi: 10.1007/s00018-011-0693-7. Epub 2011 May 3.
2011
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| 23 | TBX3
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| Tbx3 improves the germ-line competency of induced pluripotent stem cells.
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| Han J, Yuan P, Yang H, Zhang J, Soh BS, Li P, Lim SL, Cao S, Tay J, Orlov YL, Lufkin T, Ng HH, Tam WL, Lim B.
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| Nature 463(7284):1096-100. Epub 2010 Feb 7.PMID: 20139965 2010
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| 24 | TBX3
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| PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration.
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| Mowla S, Pinnock R, Leaner VD, Goding CR, Prince S.
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| Biochem J 433(1):145-53.
2010
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| 25 | TBX3, UMS
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| Ulnar Mammary syndrome and TBX3: expanding the phenotype.
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| Linden H, Williams R, King J, Blair E, Kini U.
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| Am J Med Genet A 149A(12):2809-12.PMID: 19938096 2009
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| 26 | TBX2, TBX3
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| Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse.
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| Zirzow S, Lüdtke TH, Brons JF, Petry M, Christoffels VM, Kispert A.
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| Dev Biol 336(2):145-55. Epub 2009 Sep 19.PMID: 19769959 2009
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| 27 | TBX2, TBX3
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| Tbx3 represses E-cadherin expression and enhances melanoma invasiveness.
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| Rodriguez M, Aladowicz E, Lanfrancone L, Goding CR.
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| Cancer Res 68(19):7872-81.
2008
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| 28 | TBX3
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| TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases.
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| Yarosh W, Barrientos T, Esmailpour T, Lin L, Carpenter PM, Osann K, Anton-Culver H, Huang T.
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| Cancer Res 68(3):693-9.PMID: 18245468 2008
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| 29 | TBX3
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| Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression.
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| Suzuki A, Sekiya S, Büscher D, Izpisúa Belmonte JC, Taniguchi H.
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| Development 135(9):1589-95. Epub 2008 Mar 20.PMID: 18356246 2008
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| 30 | TBX3
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| Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system.
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| Bakker ML, Boukens BJ, Mommersteeg MT, Brons JF, Wakker V, Moorman AF, Christoffels VM.
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| Circ Res 102(11):1340-9. Epub 2008 May 8.PMID: 18467625 2008
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| 31 | TBX3
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| Tbx3 is required for outflow tract development.
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| Mesbah K, Harrelson Z, Théveniau-Ruissy M, Papaioannou VE, Kelly RG.
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| Circ Res 103(7):743-50. Epub 2008 Aug 21.
2008
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| 32 | TBX3
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| Tbx3, a transcriptional factor, involves in proliferation and osteogenic differentiation of human adipose stromal cells.
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| Lee HS, Cho HH, Kim HK, Bae YC, Baik HS, Jung JS.
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| Mol Cell Biochem 296(1-2):129-36. Epub 2006 Sep 6.
2007
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| 33 | TBX3, TBX5, RBM19
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| Contiguous hemizygous deletion of TBX5, TBX3, and RBM19 resulting in a combined phenotype of Holt-Oram and ulnar-mammary syndromes.
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| Borozdin W, Bravo-Ferrer Acosta AM, Seemanova E, Leipoldt M, Bamshad MJ, Unger S, Kohlhase J.
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| Am J Med Genet A 140(17):1880-6. No abstract available. 2006
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| 34 | TBX3, UMS
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| Ulnar-mammary syndrome with dysmorphic facies and mental retardation caused by a novel 1.28 Mb deletion encompassing the TBX3 gene.
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| Klopocki E, Neumann LM, Tonnies H, Ropers HH, Mundlos S, Ullmann R.
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| Eur J Hum Genet 14(12):1274-9. Epub 2006 Aug 9. 2006
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| 35 | TBX1,TBX3, TBX4, TBX5
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| T-box genes and congenital heart/limb malformations.
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| Isphording D, Leylek AM, Yeung J, Mischel A, Simon HG.
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| Clin Genet 66(4):253-64. 2004
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| 36 | TBX19, TBX2, TBX22, TBX3, TBX5
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| T-box genes in human disorders.
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| Packham EA, Brook JD.
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| Hum Mol Genet 12(Suppl 1):R37-44. 2003
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| 37 | TBX3
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| TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.
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| Brummelkamp TR, Kortlever RM, Lingbeek M, Trettel F, MacDonald ME, van Lohuizen M, Bernards R.
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| J Biol Chem 277(8):6567-72. Epub 2001 Dec 17. 2002
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| 38 | UMS, TBX3
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| The spectrum of mutations in TBX3: Genotype/Phenotype relationship in ulnar-mammary syndrome.
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| Bamshad M, et al.
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| Am J Hum Genet 64(6):1550-62. 1999
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| 39 | HOS1, TBX3, TBX5
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| Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family.
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| Li QY, et al.
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| Nat Genet 15 : 21-29. 1997
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| 40 | TBX3, UMS
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| Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome.
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| Bamshad M, Lin RC, Law DJ, Watkins WC, Krakowiak PA, Moore ME, Franceschini P, Lala R, Holmes LB, Gebuhr TC, Bruneau BG, Schinzel A, Seidman JG, Seidman CE, Jorde LB.
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| Nat Genet 16(3):311-5. 1997
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| 41 | TBX3, TBX5
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| Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity.
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| Gibson-Brown JJ, et al.
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| Mech Dev 56(1-2):93-101. 1996
|