Citations for
The Roles of T-Box Genes in Vertebrate Limb Development.
Sheeba CJ, Logan MP.
Curr Top Dev Biol 122:355-381. doi: 10.1016/bs.ctdb.2016.08.009. Epub 2016 Oct 5. 2017
2TBX1, TBX18, TBX2, TBX20, TBX3
T-Box Genes in the Kidney and Urinary Tract.
Kispert A.
Curr Top Dev Biol 122:245-278. doi: 10.1016/bs.ctdb.2016.06.002. Epub 2016 Jul 27. 2017
Tbx3 represses bmp4 expression and with Pax6 is required and sufficient for retina formation.
Motahari Z, Martinez-De Luna RI, Viczian AS, Zuber ME.
Development evelopment. 2016 Aug 30. pii: dev.130955. [Epub ahead of print] 2016
Development of a subset of forelimb muscles and their attachment sites requires the ulnar-mammary syndrome gene Tbx3.
Colasanto MP, Eyal S, Mohassel P, Bamshad M, Bonnemann C, Zelzer E, Moon AM, Kardon G.
Dis Model Mech is Model Mech. 2016 Aug 4. pii: dmm.025874. [Epub ahead of print] 2016
The T-box transcription factor TBX3 drives proliferation by direct repression of the p21(WAF1) cyclin-dependent kinase inhibitor.
Willmer T, Hare S, Peres J, Prince S.
Cell Div 11:6. doi: 10.1186/s13008-016-0019-0. eCollection 2016. 2016
T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number.
Emechebe U, Kumar P P, Rozenberg JM, Moore B, Firment A, Mirshahi T, Moon AM.
Elife 5. pii: e07897. doi: 10.7554/eLife.07897. 2016
The T-Box factor TBX3 is important in S-phase and is regulated by c-Myc and cyclin A-CDK2.
Willmer T, Peres J, Mowla S, Abrahams A, Prince S.
Cell Cycle 14(19):3173-83. doi: 10.1080/15384101.2015.1080398. 2015
Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm.
Waghray A, Saiz N, Jayaprakash AD, Freire AG, Papatsenko D, Pereira CF, Lee DF, Brosh R, Chang B, Darr H, Gingold J, Kelley K, Schaniel C, Hadjantonakis AK, Lemischka IR.
Stem Cell Reports 5(1):97-110. doi: 10.1016/j.stemcr.2015.05.009. Epub 2015 Jun 18. 2015
Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium.
Kunasegaran K, Ho V, Chang TH, De Silva D, Bakker ML, Christoffels VM, Pietersen AM.
PLoS One 9(10):e110191. doi: 10.1371/journal.pone.0110191. eCollection 2014. 2014
TBX3, a downstream target of TGF-β1, inhibits mesangial cell apoptosis.
Wensing LA, Campos AH.
Exp Cell Res 328(2):340-50. doi: 10.1016/j.yexcr.2014.08.022. Epub 2014 Aug 23. 2014
TBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome.
Kumar P P, Franklin S, Emechebe U, Hu H, Moore B, Lehman C, Yandell M, Moon AM.
PLoS Genet 10(3):e1004247. doi: 10.1371/journal.pgen.1004247. eCollection 2014 Mar. 2014
Tbx3 isoforms are involved in pluripotency maintaining through distinct regulation of Nanog transcriptional activity.
Zhao D, Wu Y, Chen K.
Biochem Biophys Res Commun 444(3):411-4. doi: 10.1016/j.bbrc.2014.01.093. Epub 2014 Jan 25. 2014
13CSF1, JDP2, TBX3
The transcription factor T-box 3 regulates colony-stimulating factor 1-dependent Jun dimerization protein 2 expression and plays an important role in osteoclastogenesis.
Yao C, Yao GQ, Sun BH, Zhang C, Tommasini SM, Insogna K.
J Biol Chem 289(10):6775-90. doi: 10.1074/jbc.M113.499210. Epub 2014 Jan 6. 2014
Roles for Tbx3 in regulation of two-cell state and telomere elongation in mouse ES cells.
Dan J, Li M, Yang J, Li J, Okuka M, Ye X, Liu L.
Sci Rep 3:3492. doi: 10.1038/srep03492. 2013
The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion.
Peres J, Prince S.
Mol Cancer 12(1):117. doi: 10.1186/1476-4598-12-117. 2013
Genetic analysis of the TBX3 gene promoter in ventricular septal defects.
Chen D, Qiao Y, Meng H, Pang S, Huang W, Zhang H, Yan B.
Gene 512(2):185-8. doi: 10.1016/j.gene.2012.10.066. Epub 2012 Oct 29. 2013
TBX3 promotes human embryonic stem cell proliferation and neuroepithelial differentiation in a differentiation stage-dependent manner.
Esmailpour T, Huang T.
Stem Cells 30(10):2152-63. doi: 10.1002/stem.1187. 2012
Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis.
Frank DU, Carter KL, Thomas KR, Burr RM, Bakker ML, Coetzee WA, Tristani-Firouzi M, Bamshad MJ, Christoffels VM, Moon AM.
Proc Natl Acad Sci U S A 109(3):E154-63. doi: 10.1073/pnas.1115165109. Epub 2011 Dec 27. 2012
The ulnar-mammary syndrome gene, Tbx3, is a direct target of the retinoic acid signaling pathway, which regulates its expression during mouse limb development.
Ballim RD, Mendelsohn C, Papaioannou VE, Prince S.
Mol Biol Cell 23(12):2362-72. doi: 10.1091/mbc.E11-09-0790. Epub 2012 Apr 25. 2012
20TBX20, TBX3, TBX5
Alternative splicing of T-box transcription factor genes.
DeBenedittis P, Jiao K.
Biochem Biophys Res Commun 412(4):513-7. Epub 2011 Aug 11. Review. 2011
Basal transcription of the human TBX3 gene, a key developmental regulator which is overexpressed in several cancers, requires functional NF-Y and Sp1 sites.
Smith J, Mowla S, Prince S.
Gene 486(1-2):41-6. doi: 10.1016/j.gene.2011.07.013. Epub 2011 Jul 20. 2011
22SOX4, TBX3
Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43.
Boogerd CJ, Wong LY, van den Boogaard M, Bakker ML, Tessadori F, Bakkers J, 't Hoen PA, Moorman AF, Christoffels VM, Barnett P.
Cell Mol Life Sci 68(23):3949-61. doi: 10.1007/s00018-011-0693-7. Epub 2011 May 3. 2011
Tbx3 improves the germ-line competency of induced pluripotent stem cells.
Han J, Yuan P, Yang H, Zhang J, Soh BS, Li P, Lim SL, Cao S, Tay J, Orlov YL, Lufkin T, Ng HH, Tam WL, Lim B.
Nature 463(7284):1096-100. Epub 2010 Feb 7.PMID: 20139965 2010
PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration.
Mowla S, Pinnock R, Leaner VD, Goding CR, Prince S.
Biochem J 433(1):145-53. 2010
Ulnar Mammary syndrome and TBX3: expanding the phenotype.
Linden H, Williams R, King J, Blair E, Kini U.
Am J Med Genet A 149A(12):2809-12.PMID: 19938096 2009
26TBX2, TBX3
Expression and requirement of T-box transcription factors Tbx2 and Tbx3 during secondary palate development in the mouse.
Zirzow S, Lüdtke TH, Brons JF, Petry M, Christoffels VM, Kispert A.
Dev Biol 336(2):145-55. Epub 2009 Sep 19.PMID: 19769959 2009
27TBX2, TBX3
Tbx3 represses E-cadherin expression and enhances melanoma invasiveness.
Rodriguez M, Aladowicz E, Lanfrancone L, Goding CR.
Cancer Res 68(19):7872-81. 2008
TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases.
Yarosh W, Barrientos T, Esmailpour T, Lin L, Carpenter PM, Osann K, Anton-Culver H, Huang T.
Cancer Res 68(3):693-9.PMID: 18245468 2008
Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression.
Suzuki A, Sekiya S, Büscher D, Izpisúa Belmonte JC, Taniguchi H.
Development 135(9):1589-95. Epub 2008 Mar 20.PMID: 18356246 2008
Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system.
Bakker ML, Boukens BJ, Mommersteeg MT, Brons JF, Wakker V, Moorman AF, Christoffels VM.
Circ Res 102(11):1340-9. Epub 2008 May 8.PMID: 18467625 2008
Tbx3 is required for outflow tract development.
Mesbah K, Harrelson Z, Théveniau-Ruissy M, Papaioannou VE, Kelly RG.
Circ Res 103(7):743-50. Epub 2008 Aug 21. 2008
Tbx3, a transcriptional factor, involves in proliferation and osteogenic differentiation of human adipose stromal cells.
Lee HS, Cho HH, Kim HK, Bae YC, Baik HS, Jung JS.
Mol Cell Biochem 296(1-2):129-36. Epub 2006 Sep 6. 2007
33TBX3, TBX5, RBM19
Contiguous hemizygous deletion of TBX5, TBX3, and RBM19 resulting in a combined phenotype of Holt-Oram and ulnar-mammary syndromes.
Borozdin W, Bravo-Ferrer Acosta AM, Seemanova E, Leipoldt M, Bamshad MJ, Unger S, Kohlhase J.
Am J Med Genet A 140(17):1880-6. No abstract available. 2006
Ulnar-mammary syndrome with dysmorphic facies and mental retardation caused by a novel 1.28 Mb deletion encompassing the TBX3 gene.
Klopocki E, Neumann LM, Tonnies H, Ropers HH, Mundlos S, Ullmann R.
Eur J Hum Genet 14(12):1274-9. Epub 2006 Aug 9. 2006
T-box genes and congenital heart/limb malformations.
Isphording D, Leylek AM, Yeung J, Mischel A, Simon HG.
Clin Genet 66(4):253-64. 2004
36TBX19, TBX2, TBX22, TBX3, TBX5
T-box genes in human disorders.
Packham EA, Brook JD.
Hum Mol Genet 12(Suppl 1):R37-44. 2003
TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence.
Brummelkamp TR, Kortlever RM, Lingbeek M, Trettel F, MacDonald ME, van Lohuizen M, Bernards R.
J Biol Chem 277(8):6567-72. Epub 2001 Dec 17. 2002
The spectrum of mutations in TBX3: Genotype/Phenotype relationship in ulnar-mammary syndrome.
Bamshad M, et al.
Am J Hum Genet 64(6):1550-62. 1999
39HOS1, TBX3, TBX5
Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family.
Li QY, et al.
Nat Genet 15 : 21-29. 1997
Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome.
Bamshad M, Lin RC, Law DJ, Watkins WC, Krakowiak PA, Moore ME, Franceschini P, Lala R, Holmes LB, Gebuhr TC, Bruneau BG, Schinzel A, Seidman JG, Seidman CE, Jorde LB.
Nat Genet 16(3):311-5. 1997
41TBX3, TBX5
Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity.
Gibson-Brown JJ, et al.
Mech Dev 56(1-2):93-101. 1996