| 1 | BHLHE40, TBX21
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| Transcriptional regulator Bhlhe40 works as a cofactor of T-bet in the regulation of IFN-γ production in iNKT cells.
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| Kanda M, Yamanaka H, Kojo S, Usui Y, Honda H, Sotomaru Y, Harada M, Taniguchi M, Suzuki N, Atsumi T, Wada H, Baghdadi M, Seino KI.
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| Proc Natl Acad Sci U S A roc Natl Acad Sci U S A. 2016 May 25. pii: 201604178. [Epub ahead of print]
2016
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| 2 | TBX21
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| T-bet Promotes Acute Graft-versus-Host Disease by Regulating Recipient Hematopoietic Cells in Mice.
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| Fu J, Wu Y, Nguyen H, Heinrichs J, Schutt S, Liu Y, Liu C, Jin J, Anasetti C, Yu XZ.
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| J Immunol 196(7):3168-79. doi: 10.4049/jimmunol.1501020.
2016
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| 3 | TBX21
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| T-bet Regulates Natural Regulatory T Cell Afferent Lymphatic Migration and Suppressive Function.
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| Xiong Y, Ahmad S, Iwami D, Brinkman CC, Bromberg JS.
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| J Immunol 196(6):2526-40. doi: 10.4049/jimmunol.1502537.
2016
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| 4 | GATA3, TBX21
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| Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance.
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| Yu F, Sharma S, Edwards J, Feigenbaum L, Zhu J.
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| Nat Immunol 16(2):197-206. doi: 10.1038/ni.3053. Epub 2014 Dec 15.
2015
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| 5 | RUNX3, TBX21
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| Aberrant expression of RUNX3 in patients with immune thrombocytopenia.
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| Qiao J, Liu Y, Wu Y, Li X, Zhu F, Xia Y, Yao H, Chu P, Li H, Ma P, Li D, Li Z, Xu K, Zeng L.
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| Int Immunopharmacol 28(1):252-6. doi: 10.1016/j.intimp.2015.06.008.
2015
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| 6 | FOXO1, TBX21
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| Transcription factor Foxo1 is a negative regulator of natural killer cell maturation and function.
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| Deng Y, Kerdiles Y, Chu J, Yuan S, Wang Y, Chen X, Mao H, Zhang L, Zhang J, Hughes T, Deng Y, Zhang Q, Wang F, Zou X, Liu CG, Freud AG, Li X, Caligiuri MA, Vivier E, Yu J.
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| Immunity 42(3):457-70. doi: 10.1016/j.immuni.2015.02.006.
2015
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| 7 | TBX21
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| T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung.
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| Iriguchi S, Kikuchi N, Kaneko S, Noguchi E, Morishima Y, Matsuyama M, Yoh K, Takahashi S, Nakauchi H, Ishii Y.
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| Blood 125(2):370-82. doi: 10.1182/blood-2014-05-575225.
2015
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| 8 | BCR, TBX21, TLR9
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| T-bet is a new synergistic meeting point for the BCR and TLR9 signaling cascades.
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| Kövesdi D, Angyal A, Huber K, Szili D, Sármay G.
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| Eur J Immunol 44(3):887-93. doi: 10.1002/eji.201343841. Epub 2013 Dec 16.
2014
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| 9 | IFNG, TBX21
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| NK cells gain higher IFN-γ competence during terminal differentiation.
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| Luetke-Eversloh M, Cicek BB, Siracusa F, Thom JT, Hamann A, Frischbutter S, Baumgrass R, Chang HD, Thiel A, Dong J, Romagnani C.
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| Eur J Immunol 44(7):2074-84. doi: 10.1002/eji.201344072. Epub 2014 May 19.
2014
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| 10 | RUNX3, TBX21
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| Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation.
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| Reis BS, Hoytema van Konijnenburg DP, Grivennikov SI, Mucida D.
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| Immunity 41(2):244-56. doi: 10.1016/j.immuni.2014.06.017.
2014
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| 11 | TBX21, TOX, TOX2
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| TOX2 regulates human natural killer cell development by controlling T-BET expression.
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| Vong QP, Leung WH, Houston J, Li Y, Rooney B, Holladay M, Oostendorp RA, Leung W.
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| Blood 124(26):3905-13. doi: 10.1182/blood-2014-06-582965.
2014
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| 12 | TBX21
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| The role of protein modifications of T-bet in cytokine production and differentiation of T helper cells.
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| Oh S, Hwang ES.
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| J Immunol Res 2014:589672. doi: 10.1155/2014/589672. Review.
2014
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| 13 | TBX21
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| T-bet is essential for Th1-mediated, but not Th17-mediated, CNS autoimmune disease.
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| O'Connor RA, Cambrook H, Huettner K, Anderton SM.
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| Eur J Immunol 43(11):2818-23. doi: 10.1002/eji.201343689.
2013
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| 14 | IL21, TBX21
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| IL-21 promotes CD8+ CTL activity via the transcription factor T-bet.
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| Sutherland AP, Joller N, Michaud M, Liu SM, Kuchroo VK, Grusby MJ.
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| J Immunol 190(8):3977-84. doi: 10.4049/jimmunol.1201730.
2013
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| 15 | EOMES, TBX21
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| The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation.
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| Gordon SM, Chaix J, Rupp LJ, Wu J, Madera S, Sun JC, Lindsten T, Reiner SL.
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| Immunity 36(1):55-67. Epub 2012 Jan 18.
2012
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| 16 | IL36G, TBX21
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| IL-36γ/IL-1F9, an innate T-bet target in myeloid cells.
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| Bachmann M, Scheiermann P, Härdle L, Pfeilschifter J, Mühl H.
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| J Biol Chem 287(50):41684-96. doi: 10.1074/jbc.M112.385443. Epub 2012 Oct 24.
2012
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| 17 | TBX21
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| The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns.
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| Oestreich KJ, Huang AC, Weinmann AS.
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| J Exp Med 208(5):1001-13. doi: 10.1084/jem.20102144.
2011
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| 18 | TBX21
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| A common promoter variant of TBX21 is associated with allele specific binding to Yin-Yang 1 and reduced gene expression.
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| Li JR, Li JG, Deng GH, Zhao WL, Dan YJ, Wang YM, Chen S.
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| Scand J Immunol 73(5):449-58. doi: 10.1111/j.1365-3083.2011.02520.x.
2011
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| 19 | IFNG, TBX21
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| Ikaros silences T-bet expression and interferon-gamma production during T helper 2 differentiation.
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| Thomas RM, Chen C, Chunder N, Ma L, Taylor J, Pearce EJ, Wells AD.
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| J Biol Chem 285(4):2545-53. Epub 2009 Nov 18.PMID: 19923223 2010
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| 20 | HAVCR2, TBX21
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| T-bet, a Th1 transcription factor regulates the expression of Tim-3.
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| Anderson AC, Lord GM, Dardalhon V, Lee DH, Sabatos-Peyton CA, Glimcher LH, Kuchroo VK.
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| Eur J Immunol 40(3):859-66. doi: 10.1002/eji.200939842.
2010
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| 21 | TBX21
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| Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines.
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| Gourh P, Agarwal SK, Divecha D, Assassi S, Paz G, Arora-Singh RK, Reveille JD, Shete S, Mayes MD, Arnett FC, Tan FK.
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| Arthritis Rheum 60(12):3794-806.PMID: 19950257 2009
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| 22 | TBX21
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| Association of TBX21 T-1993C polymorphism with viral persistence but not disease progression in hepatitis B virus carriers.
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| Chen S, Zhao W, Tan W, Xu B, Dan Y, Mao Q, Kuang X, Wang Y, Deng G.
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| Hepatol Res 39(7):716-23. Epub 2009 Mar 15.PMID: 19473434 2009
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| 23 | TBX21
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| T-bet expression is regulated by EGR1-mediated signaling in activated T cells.
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| Shin HJ, Lee JB, Park SH, Chang J, Lee CW.
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| Clin Immunol 131(3):385-94.PMID: 19307156 2009
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| 24 | TBX21
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| pSTAT1, pSTAT3, and T-bet as markers of disease activity in chronic inflammatory demyelinating polyradiculoneuropathy.
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| Madia F, Frisullo G, Nociti V, Conte A, Luigetti M, Del Grande A, Patanella AK, Iorio R, Tonali PA, Batocchi AP, Sabatelli M.
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| J Peripher Nerv Syst 14(2):107-17.PMID: 19691533 2009
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| 25 | TBX21
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| T-box 21 transcription factor is responsible for distorted T(H)2 differentiation in human peripheral CD4+ T cells.
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| Kaminuma O, Kitamura F, Miyatake S, Yamaoka K, Miyoshi H, Inokuma S, Tatsumi H, Nemoto S, Kitamura N, Mori A, Hiroi T.
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| J Allergy Clin Immunol 123(4):813-23.e3.PMID: 19348920 2009
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| 26 | GATA3, TBX21
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| Cyclic regulation of T-Bet and GATA-3 in human endometrium.
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| Inman D, Kawana K, Schust D, Lininger R, Young S.
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| Reprod Sci 15(1):83-90.PMID: 18212358 2008
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| 27 | ONECUT2, TBX21
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| Onecut transcription factor OC2 is a direct target of T-bet in type-1 T-helper cells.
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| Furuno K, Ikeda K, Hamano S, Fukuyama K, Sonoda M, Hara T, Sasazuki T, Yamamoto K.
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| Genes Immun 9(4):302-8. doi: 10.1038/gene.2008.18. Epub 2008 Apr 17.
2008
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| 28 | TBX21
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| Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13.
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| Aliprantis AO, Wang J, Fathman JW, Lemaire R, Dorfman DM, Lafyatis R, Glimcher LH.
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| Proc Natl Acad Sci U S A [Epub ahead of print] 2007
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| 29 | TBX21
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| T-box proteins differentially activate the expression of the endogenous interferon gamma gene versus transfected reporter genes in non-immune cells.
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| Butz NV, Gronostajski RM, Campbell CE.
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| Gene [Epub ahead of print] 2006
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| 30 | TBX21
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| Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.
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| Akahoshi M, Obara K, Hirota T, Matsuda A, Hasegawa K, Takahashi N, Shimizu M, Nakashima K, Cheng L, Doi S, Fujiwara H, Miyatake A, Fujita K, Higashi N, Taniguchi M, Enomoto T, Mao XQ, Nakashima H, Adra CN, Nakamura Y, Tamari M, Shirakawa T.
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| Hum Genet 117(1):16-26. Epub 2005 Apr 2. 2005
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| 31 | TBX21, IFNG
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| Identification of a novel type 1 diabetes susceptibility gene, T-bet.
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| Sasaki Y, Ihara K, Matsuura N, Kohno H, Nagafuchi S, Kuromaru R, Kusuhara K, Takeya R, Hoey T, Sumimoto H, Hara T.
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| Hum Genet 115(3):177-84. Epub 2004 Jul 06. 2004
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| 32 | TBX21
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| TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids.
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| Tantisira KG, Hwang ES, Raby BA, Silverman ES, Lake SL, Richter BG, Peng SL, Drazen JM, Glimcher LH, Weiss ST.
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| Proc Natl Acad Sci U S A 101(52):18099-104. Epub 2004 Dec 16. 2004
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| 33 | TBX21
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| Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.
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| Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH.
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| Science 295(5553):338-42. 2002
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| 34 | TBX21
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| Cloning and characterization of a new member of the T-box gene family.
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| Zhang WX, Yang SY.
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| Genomics 70(1):41-8. 2000
|