1 | SLC2A4, TBC1D4
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| Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney.
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| Di Chiara M, Glaudemans B, Loffing-Cueni D, Odermatt A, Al-Hasani H, Devuyst O, Faresse N, Loffing J.
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| Am J Physiol Renal Physiol 309(9):F779-90. doi: 10.1152/ajprenal.00139.2015. Epub 2015 Sep 2.
2015
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2 | CIDEC, RAB8A, TBC1D4
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| Rab8a-AS160-MSS4 regulatory circuit controls lipid droplet fusion and growth.
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| Wu L, Xu D, Zhou L, Xie B, Yu L, Yang H, Huang L, Ye J, Deng H, Yuan YA, Chen S, Li P.
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| Dev Cell 30(4):378-93. doi: 10.1016/j.devcel.2014.07.005.
2014
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3 | TBC1D4
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| The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes.
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| Tan SX, Ng Y, Burchfield JG, Ramm G, Lambright DG, Stöckli J, James DE.
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| Mol Cell Biol 32(24):4946-59. doi: 10.1128/MCB.00761-12. Epub 2012 Oct 8.
2012
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4 | CLIP3, TBC1D4
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| The association of ClipR-59 protein with AS160 modulates AS160 protein phosphorylation and adipocyte Glut4 protein membrane translocation.
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| Ren W, Cheema S, Du K.
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| J Biol Chem 287(32):26890-900. doi: 10.1074/jbc.M112.357699. Epub 2012 Jun 11.
2012
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5 | SLC2A4, TBC1D4
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| The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes.
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| Tan SX, Ng Y, Burchfield JG, Ramm G, Lambright DG, Stöckli J, James DE.
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| Mol Cell Biol 32(24):4946-59. doi: 10.1128/MCB.00761-12. Epub 2012 Oct 8.
2012
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6 | TBC1D1, TBC1D4
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| Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation.
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| Park SY, Jin W, Woo JR, Shoelson SE.
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| J Biol Chem 286(20):18130-8. Epub 2011 Mar 23.
2011
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7 | AQP2, TBC1D4
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| Emerging role of Akt substrate protein AS160 in the regulation of AQP2 translocation.
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| Kim HY, Choi HJ, Lim JS, Park EJ, Jung HJ, Lee YJ, Kim SY, Kwon TH.
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| Am J Physiol Renal Physiol 301(1):F151-61. Epub 2011 Apr 20.
2011
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8 | ATIC, TBC1D4
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| AICAR reverses ketone body mediated insulin resistance in isolated oxidative muscle.
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| Ivarsson N, Zhang SJ, Katz A.
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| Biochem Biophys Res Commun 414(4):670-4. doi: 10.1016/j.bbrc.2011.09.122. Epub 2011 Oct 1.
2011
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9 | ATF3, PDX1, TBC1D4
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| ATF3 inhibits PDX-1-stimulated transactivation.
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| Kim WH, Jang MK, Kim CH, Shin HK, Jung MH.
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| Biochem Biophys Res Commun 414(4):681-7. doi: 10.1016/j.bbrc.2011.09.132. Epub 2011 Oct 2.
2011
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10 | SLC2A4, TBC1D4
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| Molecular basis of insulin-responsive GLUT4 trafficking systems revealed by single molecule imaging.
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| Hatakeyama H, Kanzaki M.
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| Traffic 12(12):1805-20. doi: 10.1111/j.1600-0854.2011.01279.x. Epub 2011 Oct 9.
2011
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11 | TBC1D4, WNK1
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| Protein kinase WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex.
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| Mendes AI, Matos P, Moniz S, Jordan P.
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| J Biol Chem 285(50):39117-26. Epub 2010 Oct 11.
2010
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12 | ANHI, TBC1D4
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| A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia.
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| Dash S, Sano H, Rochford JJ, Semple RK, Yeo G, Hyden CS, Soos MA, Clark J, Rodin A, Langenberg C, Druet C, Fawcett KA, Tung YC, Wareham NJ, Barroso I, Lienhard GE, O'Rahilly S, Savage DB.
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| Proc Natl Acad Sci U S A 106(23):9350-5. Epub 2009 May 22. 2009
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13 | TBC1D4
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| Identification of a novel AS160 splice variant that regulates GLUT4 translocation and glucose-uptake in rat muscle cells.
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| Baus D, Heermeier K, De Hoop M, Metz-Weidmann C, Gassenhuber J, Dittrich W, Welte S, Tennagels N.
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| Cell Signal 20(12):2237-46. Epub 2008 Aug 17.
2008
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14 | TBC1D4
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| Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells.
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| Bouzakri K, Ribaux P, Tomas A, Parnaud G, Rickenbach K, Halban PA.
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| Diabetes 57(5):1195-204. Epub 2008 Feb 14.
2008
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15 | RAB10, TBC1D4
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| Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane.
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| Sano H, Eguez L, Teruel MN, Fukuda M, Chuang TD, Chavez JA, Lienhard GE, McGraw TE.
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| Cell Metab 5(4):293-303.PMID: 17403373 2007
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16 | RAB11FIP5, TBC1D4
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| Rip11 is a Rab11- and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes.
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| Welsh GI, Leney SE, Lloyd-Lewis B, Wherlock M, Lindsay AJ, McCaffrey MW, Tavaré JM.
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| J Cell Sci 120(Pt 23):4197-208. Epub 2007 Nov 14.
2007
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17 | TBC1D4, SLC2A4
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| A role for 14-3-3 in insulin-stimulated GLUT4 translocation through its interaction with the RabGAP AS160.
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| Ramm G, Larance M, Guilhaus M, James DE.
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| J Biol Chem 281(39):29174-80. Epub 2006 Jul 31. 2006
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18 | TBC1D4
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| AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.
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| Mîinea CP, Sano H, Kane S, Sano E, Fukuda M, Peränen J, Lane WS, Lienhard GE.
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| Biochem J 391(Pt 1):87-93.
2005
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19 | TBC1D4
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| Upregulation of the transcript level of GTPase activating protein KIAA0603 in T cells from patients with atopic dermatitis.
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| Matsumoto Y, Imai Y, Lu Yoshida N, Sugita Y, Tanaka T, Tsujimoto G, Saito H, Oshida T.
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| FEBS Lett 572(1-3):135-40. 2004
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20 | COMMD6, TBC1D4, LMO7, UCHL3
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| Candidate genes required for embryonic development: a comparative analysis of distal mouse chromosome 14 and human chromosome 13q22.
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| Kurihara LJ, Semenova E, Miller W, Ingram RS, Guan XJ, Tilghman SM.
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| Genomics 79(2):154-61. 2002
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