Citations for
The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.
Thakur HC, Singh M, Nagel-Steger L, Kremer J, Prumbaum D, Fansa EK, Ezzahoini H, Nouri K, Gremer L, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.
J Biol Chem 289(1):74-88. doi: 10.1074/jbc.M113.532333. Epub 2013 Nov 22. 2014
Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division.
Thakur HC, Singh M, Nagel-Steger L, Prumbaum D, Kalawy Fansa E, Gremer L, Ezzahoini H, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.
Biol Chem iol Chem. 2013 Jun 20. doi:pii: /j/bchm.just-accepted/hsz-2013-0184/hsz-2013-0184.xml. 10.1515/hsz-2013-0184. [Epub ahead of pri 2013
TACC3 promotes epithelial-mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways.
Ha GH, Park JS, Breuer EK.
Cancer Lett 332(1):63-73. doi: 10.1016/j.canlet.2013.01.013. Epub 2013 Jan 21. 2013
Aurora A kinase and its substrate TACC3 are required for central spindle assembly.
Lioutas A, Vernos I.
EMBO Rep 14(9):829-36. doi: 10.1038/embor.2013.109. Epub 2013 Jul 26. 2013
Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly.
Fu W, Chen H, Wang G, Luo J, Deng Z, Xin G, Xu N, Guo X, Lei J, Jiang Q, Zhang C.
Proc Natl Acad Sci U S A 110(38):15295-300. doi: 10.1073/pnas.1312382110. Epub 2013 Sep 3. 2013
DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.
Yang YT, Wang CL, Van Aelst L.
Nat Neurosci 15(9):1201-10. doi: 10.1038/nn.3171. Epub 2012 Jul 29. 2012
Disruption of Tacc3 function leads to in vivo tumor regression.
Yao R, Natsume Y, Saiki Y, Shioya H, Takeuchi K, Yamori T, Toki H, Aoki I, Saga T, Noda T.
Oncogene 31(2):135-48. doi: 10.1038/onc.2011.235. Epub 2011 Jun 20. 2012
Transforming fusions of FGFR and TACC genes in human glioblastoma.
Singh D, Chan JM, Zoppoli P, Niola F, Sullivan R, Castano A, Liu EM, Reichel J, Porrati P, Pellegatta S, Qiu K, Gao Z, Ceccarelli M, Riccardi R, Brat DJ, Guha A, Aldape K, Golfinos JG, Zagzag D, Mikkelsen T, Finocchiaro G, Lasorella A, Rabadan R, Iavarone A.
Science 337(6099):1231-5. doi: 10.1126/science.1220834. 2012
A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells.
Fielding AB, Lim S, Montgomery K, Dobreva I, Dedhar S.
Oncogene 30(5):521-34. Epub 2010 Sep 13. 2011
A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging.
Booth DG, Hood FE, Prior IA, Royle SJ.
EMBO J 30(5):906-19. Epub 2011 Feb 4. 2011
Pulling it together: The mitotic function of TACC3.
Hood FE, Royle SJ.
Bioarchitecture 1(3):105-109. 2011
Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats.
Bargo S, Raafat A, McCurdy D, Amirjazil I, Shu Y, Traicoff J, Plant J, Vonderhaar BK, Callahan R.
Biochem Biophys Res Commun 400(4):606-12. Epub 2010 Sep 6. 2010
Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment.
Fu W, Tao W, Zheng P, Fu J, Bian M, Jiang Q, Clarke PR, Zhang C.
J Cell Sci 123(Pt 21):3645-51. doi: 10.1242/jcs.075911. Epub 2010 Oct 5. 2010
Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18 positive cervical carcinoma cells.
Yim EK, Tong SY, Ho EM, Bae JH, Um SJ, Park JS.
Oncol Rep 21(2):549-57. 2009
TOGp regulates microtubule assembly and density during mitosis and contributes to chromosome directional instability.
Cassimeris L, Becker B, Carney B.
Cell Motil Cytoskeleton 66(8):535-45. 2009
The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival.
Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Wetzel W, Schulze-Osthoff K, Nurnberg B, Piekorz RP.
J Biol Chem 282(40):29273-83. Epub 2007 Aug 5. 2007
Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues.
Ulisse S, Baldini E, Toller M, Delcros JG, Guého A, Curcio F, De Antoni E, Giacomelli L, Ambesi-Impiombato FS, Bocchini S, D'Armiento M, Arlot-Bonnemains Y.
Endocr Relat Cancer 14(3):827-37. 2007
Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity.
LeRoy PJ, Hunter JJ, Hoar KM, Burke KE, Shinde V, Ruan J, Bowman D, Galvin K, Ecsedy JA.
Cancer Res 67(11):5362-70. 2007
19AFTPH, ANKRD52, ANKRD57, ANKZF1, C10orf11, C17orf49, C21orf70, C9orf16, ERC1, KLC4, TACC3, TAF6, XTP13, ZNF740
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP.
Nat Biotechnol 24(10):1285-92. Epub 2006 Sep 10. 2006
Correlation of TACC3, FGFR3, MMSET and p21 expression with the t(4;14)(p16.3;q32) in multiple myeloma.
Stewart JP, Thompson A, Santra M, Barlogie B, Lappin TR, Shaughnessy J Jr.
Br J Haematol 126(1):72-6. 2004
The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells.
Gergely F, Draviam VM, Raff JW.
Genes Dev 17(3):336-41. 2003
Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus.
Steadman BT, Schmidt PH, Shanks RA, Lapierre LA, Goldenring JR.
J Biol Chem 277(33):30165-76. Epub 2002 May 15. 2002
Characterization and localization of expression of an erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid precursor cells.
McKeveney PJ, Hodges VM, Mullan RN, Maxwell P, Simpson D, Thompson A, Winter PC, Lappin TR, Maxwell AP.
Br J Haematol 112(4):1016-24. 2001
The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines.
Still IH, Vince P, Cowell JK.
Genomics 58(2):165-70. 1999