Citations for
1AURKA, CKAP5, TACC3
The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.
Thakur HC, Singh M, Nagel-Steger L, Kremer J, Prumbaum D, Fansa EK, Ezzahoini H, Nouri K, Gremer L, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.
J Biol Chem 289(1):74-88. doi: 10.1074/jbc.M113.532333. Epub 2013 Nov 22. 2014
2TACC3
Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division.
Thakur HC, Singh M, Nagel-Steger L, Prumbaum D, Kalawy Fansa E, Gremer L, Ezzahoini H, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.
Biol Chem iol Chem. 2013 Jun 20. doi:pii: /j/bchm.just-accepted/hsz-2013-0184/hsz-2013-0184.xml. 10.1515/hsz-2013-0184. [Epub ahead of pri 2013
3TACC3
TACC3 promotes epithelial-mesenchymal transition (EMT) through the activation of PI3K/Akt and ERK signaling pathways.
Ha GH, Park JS, Breuer EK.
Cancer Lett 332(1):63-73. doi: 10.1016/j.canlet.2013.01.013. Epub 2013 Jan 21. 2013
4AURKA, TACC3
Aurora A kinase and its substrate TACC3 are required for central spindle assembly.
Lioutas A, Vernos I.
EMBO Rep 14(9):829-36. doi: 10.1038/embor.2013.109. Epub 2013 Jul 26. 2013
5RAN, TACC3
Self-assembly and sorting of acentrosomal microtubules by TACC3 facilitate kinetochore capture during the mitotic spindle assembly.
Fu W, Chen H, Wang G, Luo J, Deng Z, Xin G, Xu N, Guo X, Lei J, Jiang Q, Zhang C.
Proc Natl Acad Sci U S A 110(38):15295-300. doi: 10.1073/pnas.1312382110. Epub 2013 Sep 3. 2013
6DOCK7, TACC3
DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.
Yang YT, Wang CL, Van Aelst L.
Nat Neurosci 15(9):1201-10. doi: 10.1038/nn.3171. Epub 2012 Jul 29. 2012
7TACC3
Disruption of Tacc3 function leads to in vivo tumor regression.
Yao R, Natsume Y, Saiki Y, Shioya H, Takeuchi K, Yamori T, Toki H, Aoki I, Saga T, Noda T.
Oncogene 31(2):135-48. doi: 10.1038/onc.2011.235. Epub 2011 Jun 20. 2012
8FGFR1, FGFR3, TACC1, TACC3
Transforming fusions of FGFR and TACC genes in human glioblastoma.
Singh D, Chan JM, Zoppoli P, Niola F, Sullivan R, Castano A, Liu EM, Reichel J, Porrati P, Pellegatta S, Qiu K, Gao Z, Ceccarelli M, Riccardi R, Brat DJ, Guha A, Aldape K, Golfinos JG, Zagzag D, Mikkelsen T, Finocchiaro G, Lasorella A, Rabadan R, Iavarone A.
Science 337(6099):1231-5. doi: 10.1126/science.1220834. 2012
9CKAP5, ILK, TACC3
A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells.
Fielding AB, Lim S, Montgomery K, Dobreva I, Dedhar S.
Oncogene 30(5):521-34. Epub 2010 Sep 13. 2011
10CKAP5, TACC3
A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging.
Booth DG, Hood FE, Prior IA, Royle SJ.
EMBO J 30(5):906-19. Epub 2011 Feb 4. 2011
11TACC3
Pulling it together: The mitotic function of TACC3.
Hood FE, Royle SJ.
Bioarchitecture 1(3):105-109. 2011
12NOTCH4, TACC3
Transforming acidic coiled-coil protein-3 (Tacc3) acts as a negative regulator of Notch signaling through binding to CDC10/Ankyrin repeats.
Bargo S, Raafat A, McCurdy D, Amirjazil I, Shu Y, Traicoff J, Plant J, Vonderhaar BK, Callahan R.
Biochem Biophys Res Commun 400(4):606-12. Epub 2010 Sep 6. 2010
13CLTC, TACC3
Clathrin recruits phosphorylated TACC3 to spindle poles for bipolar spindle assembly and chromosome alignment.
Fu W, Tao W, Zheng P, Fu J, Bian M, Jiang Q, Clarke PR, Zhang C.
J Cell Sci 123(Pt 21):3645-51. doi: 10.1242/jcs.075911. Epub 2010 Oct 5. 2010
14TACC3
Anticancer effects on TACC3 by treatment of paclitaxel in HPV-18 positive cervical carcinoma cells.
Yim EK, Tong SY, Ho EM, Bae JH, Um SJ, Park JS.
Oncol Rep 21(2):549-57. 2009
15CKAP5, TACC3
TOGp regulates microtubule assembly and density during mitosis and contributes to chromosome directional instability.
Cassimeris L, Becker B, Carney B.
Cell Motil Cytoskeleton 66(8):535-45. 2009
16TACC3
The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival.
Schneider L, Essmann F, Kletke A, Rio P, Hanenberg H, Wetzel W, Schulze-Osthoff K, Nurnberg B, Piekorz RP.
J Biol Chem 282(40):29273-83. Epub 2007 Aug 5. 2007
17AURKA, TACC3
Transforming acidic coiled-coil 3 and Aurora-A interact in human thyrocytes and their expression is deregulated in thyroid cancer tissues.
Ulisse S, Baldini E, Toller M, Delcros JG, Guého A, Curcio F, De Antoni E, Giacomelli L, Ambesi-Impiombato FS, Bocchini S, D'Armiento M, Arlot-Bonnemains Y.
Endocr Relat Cancer 14(3):827-37. 2007
18AURKA, TACC3
Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity.
LeRoy PJ, Hunter JJ, Hoar KM, Burke KE, Shinde V, Ruan J, Bowman D, Galvin K, Ecsedy JA.
Cancer Res 67(11):5362-70. 2007
19AFTPH, ANKRD52, ANKRD57, ANKZF1, C10orf11, C17orf49, C21orf70, C9orf16, ERC1, KLC4, TACC3, TAF6, XTP13, ZNF740
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP.
Nat Biotechnol 24(10):1285-92. Epub 2006 Sep 10. 2006
20WHSC1, TACC3, FGFR3
Correlation of TACC3, FGFR3, MMSET and p21 expression with the t(4;14)(p16.3;q32) in multiple myeloma.
Stewart JP, Thompson A, Santra M, Barlogie B, Lappin TR, Shaughnessy J Jr.
Br J Haematol 126(1):72-6. 2004
21CKAP5, TACC3
The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells.
Gergely F, Draviam VM, Raff JW.
Genes Dev 17(3):336-41. 2003
22AKAP9, TACC3
Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus.
Steadman BT, Schmidt PH, Shanks RA, Lapierre LA, Goldenring JR.
J Biol Chem 277(33):30165-76. Epub 2002 May 15. 2002
23TACC3
Characterization and localization of expression of an erythropoietin-induced gene, ERIC-1/TACC3, identified in erythroid precursor cells.
McKeveney PJ, Hodges VM, Mullan RN, Maxwell P, Simpson D, Thompson A, Winter PC, Lappin TR, Maxwell AP.
Br J Haematol 112(4):1016-24. 2001
24TACC3
The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines.
Still IH, Vince P, Cowell JK.
Genomics 58(2):165-70. 1999