Citations for
1NR2C2, RNF4, TAB1, TAB2, TAB3
RNF4 negatively regulates NF-κB signaling by down-regulating TAB2.
Tan B, Mu R, Chang Y, Wang YB, Wu M, Tu HQ, Zhang YC, Guo SS, Qin XH, Li T, Li WH, Zhang XM, Li AL, Li HY.
FEBS Lett 589(19 Pt B):2850-8. doi: 10.1016/j.febslet.2015.07.051. Epub 2015 Aug 20. 2015
2MAP3K7, TAB2
TAK1 binding protein 2 is essential for liver protection from stressors.
Ikeda Y, Morioka S, Matsumoto K, Ninomiya-Tsuji J.
PLoS One 9(2):e88037. doi: 10.1371/journal.pone.0088037. eCollection 2014. 2014
3TAB2, TAF5, TRAF6
TRAF5 negatively regulates TLR signaling in B lymphocytes.
Buchta CM, Bishop GA.
J Immunol 192(1):145-50. doi: 10.4049/jimmunol.1301901. Epub 2013 Nov 20. 2014
4NR2C2, TAB2, TAB3
Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs.
Ori D, Kato H, Sanjo H, Tartey S, Mino T, Akira S, Takeuchi O.
J Immunol 190(8):4037-45. doi: 10.4049/jimmunol.1300173. Epub 2013 Mar 15. 2013
5SIK1, SIK3, TAB2, TLR4, TRAF6
Salt-inducible kinases 1 and 3 negatively regulate Toll-like receptor 4-mediated signal.
Yong Kim S, Jeong S, Chah KH, Jung E, Baek KH, Kim ST, Shim JH, Chun E, Lee KY.
Mol Endocrinol 27(11):1958-68. doi: 10.1210/me.2013-1240. Epub 2013 Sep 23. 2013
6ATG13, NR2C2, TAB2, TAB3, ULK1
TGFβ-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy.
Takaesu G, Kobayashi T, Yoshimura A.
J Biochem 151(2):157-66. doi: 10.1093/jb/mvr123. Epub 2011 Oct 5. 2012
7NR2C2, TAB2, TAB3
Inhibition of autophagy by TAB2 and TAB3.
Criollo A, Niso-Santano M, Malik SA, Michaud M, Morselli E, Mariño G, Lachkar S, Arkhipenko AV, Harper F, Pierron G, Rain JC, Ninomiya-Tsuji J, Fuentes JM, Lavandero S, Galluzzi L, Maiuri MC, Kroemer G.
EMBO J 30(24):4908-20. doi: 10.1038/emboj.2011.413. 2011
8MAP3K7, NLK, TAB2
TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling.
Li M, Wang H, Huang T, Wang J, Ding Y, Li Z, Zhang J, Li L.
J Biol Chem 285(18):13397-404. Epub 2010 Mar 1. 2010
9DEL6Q25, TAB2
Haploinsufficiency of TAB2 causes congenital heart defects in humans.
Thienpont B, Zhang L, Postma AV, Breckpot J, Tranchevent LC, Van Loo P, Møllgård K, Tommerup N, Bache I, Tümer Z, van Engelen K, Menten B, Mortier G, Waggoner D, Gewillig M, Moreau Y, Devriendt K, Larsen LA.
Am J Hum Genet 86(6):839-49. Epub 2010 May 20.PMID: 20493459 2010
10MAP3K7, TAB1, TAB2
Constitutive association of TGF-beta-activated kinase 1 with the IkappaB kinase complex in the nucleus and cytoplasm of human neutrophils and its impact on downstream processes.
Ear T, Fortin CF, Simard FA, McDonald PP.
J Immunol 184(7):3897-906. Epub 2010 Mar 3. 2010
11TAB2
Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain.
Kulathu Y, Akutsu M, Bremm A, Hofmann K, Komander D.
Nat Struct Mol Biol 16(12):1328-30. Epub 2009 Nov 22.PMID: 19935683 2009
12TAB2, TAB3
Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3.
Sato Y, Yoshikawa A, Yamashita M, Yamagata A, Fukai S.
EMBO J 28(24):3903-9. Epub .PMID: 19927120 2009
13NUMBL, TAB2
NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation.
Ma Q, Zhou L, Shi H, Huo K.
Cell Signal 20(6):1044-51. Epub 2008 Jan 31. 2008
14IDDM5, SUMO4, TAB2
Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population.
Noso S, Fujisawa T, Kawabata Y, Asano K, Hiromine Y, Fukai A, Ogihara T, Ikegami H.
J Clin Endocrinol Metab 92(6):2358-62. Epub 2007 Mar 20. 2007
15TAB2, TAB3
TAK1-dependent signaling requires functional interaction with TAB2/TAB3.
Besse A, Lamothe B, Campos AD, Webster WK, Maddineni U, Lin SC, Wu H, Darnay BG.
J Biol Chem 282(6):3918-28. Epub 2006 Dec 8. 2007
16EDAR, EDARADD, MAP3K7, TAB2, TRAF6
TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.
Morlon A, Munnich A, Smahi A.
Hum Mol Genet 14(23):3751-7. Epub 2005 Oct 26. 2005
17SUMO1, TAB2
A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes.
Owerbach D, Pina L, Gabbay KH.
Diabetes 53(7):1890-3. 2004
18TAB2
TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling.
Sanjo H, Takeda K, Tsujimura T, Ninomiya-Tsuji J, Matsumoto K, Akira S.
Mol Cell Biol 23(4):1231-8. 2003
19TAB2
Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway.
Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K.
Mol Cell Biol 21(7):2475-84. 2001
20TAB2
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K.
Mol Cell 5(4):649-58. 2000