1 | NR2C2, RNF4, TAB1, TAB2, TAB3
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| RNF4 negatively regulates NF-κB signaling by down-regulating TAB2.
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| Tan B, Mu R, Chang Y, Wang YB, Wu M, Tu HQ, Zhang YC, Guo SS, Qin XH, Li T, Li WH, Zhang XM, Li AL, Li HY.
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| FEBS Lett 589(19 Pt B):2850-8. doi: 10.1016/j.febslet.2015.07.051. Epub 2015 Aug 20.
2015
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2 | MAP3K7, TAB2
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| TAK1 binding protein 2 is essential for liver protection from stressors.
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| Ikeda Y, Morioka S, Matsumoto K, Ninomiya-Tsuji J.
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| PLoS One 9(2):e88037. doi: 10.1371/journal.pone.0088037. eCollection 2014.
2014
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3 | TAB2, TAF5, TRAF6
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| TRAF5 negatively regulates TLR signaling in B lymphocytes.
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| Buchta CM, Bishop GA.
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| J Immunol 192(1):145-50. doi: 10.4049/jimmunol.1301901. Epub 2013 Nov 20.
2014
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4 | NR2C2, TAB2, TAB3
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| Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs.
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| Ori D, Kato H, Sanjo H, Tartey S, Mino T, Akira S, Takeuchi O.
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| J Immunol 190(8):4037-45. doi: 10.4049/jimmunol.1300173. Epub 2013 Mar 15.
2013
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5 | SIK1, SIK3, TAB2, TLR4, TRAF6
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| Salt-inducible kinases 1 and 3 negatively regulate Toll-like receptor 4-mediated signal.
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| Yong Kim S, Jeong S, Chah KH, Jung E, Baek KH, Kim ST, Shim JH, Chun E, Lee KY.
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| Mol Endocrinol 27(11):1958-68. doi: 10.1210/me.2013-1240. Epub 2013 Sep 23. 2013
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6 | ATG13, NR2C2, TAB2, TAB3, ULK1
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| TGFβ-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy.
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| Takaesu G, Kobayashi T, Yoshimura A.
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| J Biochem 151(2):157-66. doi: 10.1093/jb/mvr123. Epub 2011 Oct 5.
2012
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7 | NR2C2, TAB2, TAB3
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| Inhibition of autophagy by TAB2 and TAB3.
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| Criollo A, Niso-Santano M, Malik SA, Michaud M, Morselli E, Mariño G, Lachkar S, Arkhipenko AV, Harper F, Pierron G, Rain JC, Ninomiya-Tsuji J, Fuentes JM, Lavandero S, Galluzzi L, Maiuri MC, Kroemer G.
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| EMBO J 30(24):4908-20. doi: 10.1038/emboj.2011.413.
2011
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8 | MAP3K7, NLK, TAB2
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| TAB2 scaffolds TAK1 and NLK in repressing canonical Wnt signaling.
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| Li M, Wang H, Huang T, Wang J, Ding Y, Li Z, Zhang J, Li L.
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| J Biol Chem 285(18):13397-404. Epub 2010 Mar 1.
2010
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9 | DEL6Q25, TAB2
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| Haploinsufficiency of TAB2 causes congenital heart defects in humans.
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| Thienpont B, Zhang L, Postma AV, Breckpot J, Tranchevent LC, Van Loo P, Møllgård K, Tommerup N, Bache I, Tümer Z, van Engelen K, Menten B, Mortier G, Waggoner D, Gewillig M, Moreau Y, Devriendt K, Larsen LA.
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| Am J Hum Genet 86(6):839-49. Epub 2010 May 20.PMID: 20493459 2010
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10 | MAP3K7, TAB1, TAB2
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| Constitutive association of TGF-beta-activated kinase 1 with the IkappaB kinase complex in the nucleus and cytoplasm of human neutrophils and its impact on downstream processes.
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| Ear T, Fortin CF, Simard FA, McDonald PP.
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| J Immunol 184(7):3897-906. Epub 2010 Mar 3.
2010
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11 | TAB2
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| Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain.
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| Kulathu Y, Akutsu M, Bremm A, Hofmann K, Komander D.
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| Nat Struct Mol Biol 16(12):1328-30. Epub 2009 Nov 22.PMID: 19935683 2009
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12 | TAB2, TAB3
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| Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3.
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| Sato Y, Yoshikawa A, Yamashita M, Yamagata A, Fukai S.
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| EMBO J 28(24):3903-9. Epub .PMID: 19927120 2009
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13 | NUMBL, TAB2
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| NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation.
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| Ma Q, Zhou L, Shi H, Huo K.
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| Cell Signal 20(6):1044-51. Epub 2008 Jan 31. 2008
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14 | IDDM5, SUMO4, TAB2
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| Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population.
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| Noso S, Fujisawa T, Kawabata Y, Asano K, Hiromine Y, Fukai A, Ogihara T, Ikegami H.
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| J Clin Endocrinol Metab 92(6):2358-62. Epub 2007 Mar 20. 2007
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15 | TAB2, TAB3
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| TAK1-dependent signaling requires functional interaction with TAB2/TAB3.
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| Besse A, Lamothe B, Campos AD, Webster WK, Maddineni U, Lin SC, Wu H, Darnay BG.
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| J Biol Chem 282(6):3918-28. Epub 2006 Dec 8. 2007
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16 | EDAR, EDARADD, MAP3K7, TAB2, TRAF6
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| TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.
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| Morlon A, Munnich A, Smahi A.
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| Hum Mol Genet 14(23):3751-7. Epub 2005 Oct 26. 2005
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17 | SUMO1, TAB2
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| A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes.
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| Owerbach D, Pina L, Gabbay KH.
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| Diabetes 53(7):1890-3. 2004
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18 | TAB2
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| TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling.
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| Sanjo H, Takeda K, Tsujimura T, Ninomiya-Tsuji J, Matsumoto K, Akira S.
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| Mol Cell Biol 23(4):1231-8.
2003
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19 | TAB2
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| Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway.
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| Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K.
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| Mol Cell Biol 21(7):2475-84. 2001
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20 | TAB2
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| TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
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| Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K.
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| Mol Cell 5(4):649-58. 2000
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