Citations for
1SYVN1, USP19
USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase.
Harada K, Kato M, Nakamura N.
Int J Mol Sci 17(11). pii: E1829. 2016
2STXBP5L, SYVN1
Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion.
Bhatnagar S, Soni MS, Wrighton LS, Hebert AS, Zhou AS, Paul PK, Gregg T, Rabaglia ME, Keller MP, Coon JJ, Attie AD.
J Biol Chem 289(36):25276-86. doi: 10.1074/jbc.M114.575985. Epub 2014 Jul 7. 2014
3DERL2, HEY1, HEY2, SEL1L, SYVN1
Role of HERP and a HERP-related protein in HRD1-dependent protein degradation at the endoplasmic reticulum.
Huang CH, Chu YR, Ye Y, Chen X.
J Biol Chem 289(7):4444-54. doi: 10.1074/jbc.M113.519561. Epub 2013 Dec 23. 2014
4ABCG5, ABCG8, RNF5, SYVN1
Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter.
Suzuki S, Shuto T, Sato T, Kaneko M, Takada T, Suico MA, Cyr DM, Suzuki H, Kai H.
Sci Rep 4:4258. doi: 10.1038/srep04258. 2014
5SYVN1, USP25
Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation.
Blount JR, Burr AA, Denuc A, Marfany G, Todi SV.
PLoS One 7(5):e36542. doi: 10.1371/journal.pone.0036542. Epub 2012 May 9. 2012
6SYVN1, UBE2J1
HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation.
Burr ML, Cano F, Svobodova S, Boyle LH, Boname JM, Lehner PJ.
Proc Natl Acad Sci U S A 108(5):2034-9. Epub 2011 Jan 18. 2011
7SEL1L, SYVN1
SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates.
Iida Y, Fujimori T, Okawa K, Nagata K, Wada I, Hosokawa N.
J Biol Chem 286(19):16929-39. Epub 2011 Mar 24. 2011
8HERPUD1, SYVN1
Herp regulates Hrd1-mediated ubiquitylation in a ubiquitin-like domain-dependent manner.
Kny M, Standera S, Hartmann-Petersen R, Kloetzel PM, Seeger M.
J Biol Chem 286(7):5151-6. Epub 2010 Dec 13. 2011
9BTRC, NRF1, SYVN1
Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms.
Tsuchiya Y, Morita T, Kim M, Iemura S, Natsume T, Yamamoto M, Kobayashi A.
Mol Cell Biol 31(22):4500-12. doi: 10.1128/MCB.05663-11. Epub 2011 Sep 12. 2011
10SYVN1
E3 ubiquitin ligase synoviolin is involved in liver fibrogenesis.
Hasegawa D, Fujii R, Yagishita N, Matsumoto N, Aratani S, Izumi T, Azakami K, Nakazawa M, Fujita H, Sato T, Araya N, Koike J, Tadokoro M, Suzuki N, Nagata K, Senoo H, Friedman SL, Nishioka K, Yamano Y, Itoh F, Nakajima T.
PLoS One 5(10):e13590. 2010
11SYVN1
Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation.
Kaneko M, Koike H, Saito R, Kitamura Y, Okuma Y, Nomura Y.
J Neurosci 30(11):3924-32. 2010
12SYVN1
Correlation between decrease in protein levels of ubiquitin ligase HRD1 and amyloid-beta production.
Saito R, Kaneko M, Okuma Y, Nomura Y.
J Pharmacol Sci 113(3):285-8. Epub 2010 Jul 1. 2010
13NCSTN, SYVN1
An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein.
Maeda T, Marutani T, Zou K, Araki W, Tanabe C, Yagishita N, Yamano Y, Amano T, Michikawa M, Nakajima T, Komano H.
FEBS J 276(20):5832-40. Epub 2009 Sep 2. 2009
14ERLEC1, SEL1L, SYVN1
Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.
Hosokawa N, Wada I, Nagasawa K, Moriyama T, Okawa K, Nagata K.
J Biol Chem 283(30):20914-24. Epub 2008 May 23. 2008
15SYVN1
Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds.
Yamamoto K, Suzuki N, Wada T, Okada T, Yoshida H, Kaufman RJ, Mori K.
J Biochem 144(4):477-86. Epub 2008 Jul 29. 2008
16GPR37, SYVN1
A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.
Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, Fujitani N, Matsumura S, Hata A, Kubota K, Murahashi K, Uehara T, Nomura Y.
J Neurochem 99(6):1456-69. Epub 2006 Oct 24.PMID: 17059562 2006
17SYVN1
Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum.
Kikkert M, Doolman R, Dai M, Avner R, Hassink G, van Voorden S, Thanedar S, Roitelman J, Chau V, Wiertz E.
J Biol Chem 279(5):3525-34. Epub 2003 Oct 30. 2004
18SYVN1
A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1.
Nadav E, Shmueli A, Barr H, Gonen H, Ciechanover A, Reiss Y.
Biochem Biophys Res Commun 303(1):91-7. 2003
19SYVN1
Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation.
Kaneko M, Ishiguro M, Niinuma Y, Uesugi M, Nomura Y.
FEBS Lett 532(1-2):147-52. 2002
20ABLIM2, ACSS1, ATCAY, ATP13A1, BRSK1, CAPRIN2, CCDC132, CDH23, CHAMP1, COL27A1, EHMT1, FBN3, FNDC1, GMPPB, GPR123, GPS2, HHIPL1, IRF2BPL, JPH4, KBTBD8, KIAA1841, KIRREL3, KIRREL3, MEGF10, MEGF11, MLK4, NTNG2, PHF17, PHYHIPL, RANGAP1, SEMA6C, SLX4, SPIRE2, SRRM4, ST6GAL2, SYVN1, TTBK1, VCPIP1, WDR22, ZNF286A, ZNF333, ZNF512, ZNF528
Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O.
DNA Res 8(2):85-95. 2001