| 1 | PADI4, SYVN1
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| Inhibitory effects of ubiquitination of synoviolin by PADI4
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| Aratani S, Fujita H, Yagishita N, Yamano Y, Okubo Y, Nishioka K, Nakajima T.
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| Mol Med Rep. 2017 Dec;16(6):9203-9209. doi: 10.3892/mmr.2017.7764. Epub 2017 Oct 11. 2017
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| 2 | SYVN1, USP19
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| USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase.
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| Harada K, Kato M, Nakamura N.
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| Int J Mol Sci 17(11). pii: E1829.
2016
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| 3 | STXBP5L, SYVN1
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| Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion.
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| Bhatnagar S, Soni MS, Wrighton LS, Hebert AS, Zhou AS, Paul PK, Gregg T, Rabaglia ME, Keller MP, Coon JJ, Attie AD.
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| J Biol Chem 289(36):25276-86. doi: 10.1074/jbc.M114.575985. Epub 2014 Jul 7.
2014
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| 4 | DERL2, HEY1, HEY2, SEL1L, SYVN1
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| Role of HERP and a HERP-related protein in HRD1-dependent protein degradation at the endoplasmic reticulum.
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| Huang CH, Chu YR, Ye Y, Chen X.
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| J Biol Chem 289(7):4444-54. doi: 10.1074/jbc.M113.519561. Epub 2013 Dec 23.
2014
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| 5 | ABCG5, ABCG8, RNF5, SYVN1
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| Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter.
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| Suzuki S, Shuto T, Sato T, Kaneko M, Takada T, Suico MA, Cyr DM, Suzuki H, Kai H.
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| Sci Rep 4:4258. doi: 10.1038/srep04258.
2014
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| 6 | SYVN1, USP25
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| Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation.
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| Blount JR, Burr AA, Denuc A, Marfany G, Todi SV.
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| PLoS One 7(5):e36542. doi: 10.1371/journal.pone.0036542. Epub 2012 May 9.
2012
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| 7 | SYVN1, UBE2J1
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| HRD1 and UBE2J1 target misfolded MHC class I heavy chains for endoplasmic reticulum-associated degradation.
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| Burr ML, Cano F, Svobodova S, Boyle LH, Boname JM, Lehner PJ.
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| Proc Natl Acad Sci U S A 108(5):2034-9. Epub 2011 Jan 18.
2011
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| 8 | SEL1L, SYVN1
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| SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates.
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| Iida Y, Fujimori T, Okawa K, Nagata K, Wada I, Hosokawa N.
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| J Biol Chem 286(19):16929-39. Epub 2011 Mar 24.
2011
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| 9 | HERPUD1, SYVN1
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| Herp regulates Hrd1-mediated ubiquitylation in a ubiquitin-like domain-dependent manner.
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| Kny M, Standera S, Hartmann-Petersen R, Kloetzel PM, Seeger M.
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| J Biol Chem 286(7):5151-6. Epub 2010 Dec 13.
2011
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| 10 | BTRC, NRF1, SYVN1
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| Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms.
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| Tsuchiya Y, Morita T, Kim M, Iemura S, Natsume T, Yamamoto M, Kobayashi A.
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| Mol Cell Biol 31(22):4500-12. doi: 10.1128/MCB.05663-11. Epub 2011 Sep 12. 2011
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| 11 | SYVN1
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| E3 ubiquitin ligase synoviolin is involved in liver fibrogenesis.
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| Hasegawa D, Fujii R, Yagishita N, Matsumoto N, Aratani S, Izumi T, Azakami K, Nakazawa M, Fujita H, Sato T, Araya N, Koike J, Tadokoro M, Suzuki N, Nagata K, Senoo H, Friedman SL, Nishioka K, Yamano Y, Itoh F, Nakajima T.
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| PLoS One 5(10):e13590.
2010
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| 12 | SYVN1
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| Loss of HRD1-mediated protein degradation causes amyloid precursor protein accumulation and amyloid-beta generation.
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| Kaneko M, Koike H, Saito R, Kitamura Y, Okuma Y, Nomura Y.
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| J Neurosci 30(11):3924-32.
2010
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| 13 | SYVN1
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| Correlation between decrease in protein levels of ubiquitin ligase HRD1 and amyloid-beta production.
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| Saito R, Kaneko M, Okuma Y, Nomura Y.
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| J Pharmacol Sci 113(3):285-8. Epub 2010 Jul 1.
2010
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| 14 | NCSTN, SYVN1
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| An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein.
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| Maeda T, Marutani T, Zou K, Araki W, Tanabe C, Yagishita N, Yamano Y, Amano T, Michikawa M, Nakajima T, Komano H.
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| FEBS J 276(20):5832-40. Epub 2009 Sep 2.
2009
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| 15 | ERLEC1, SEL1L, SYVN1
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| Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP.
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| Hosokawa N, Wada I, Nagasawa K, Moriyama T, Okawa K, Nagata K.
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| J Biol Chem 283(30):20914-24. Epub 2008 May 23. 2008
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| 16 | SYVN1
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| Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds.
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| Yamamoto K, Suzuki N, Wada T, Okada T, Yoshida H, Kaufman RJ, Mori K.
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| J Biochem 144(4):477-86. Epub 2008 Jul 29.
2008
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| 17 | GPR37, SYVN1
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| A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.
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| Omura T, Kaneko M, Okuma Y, Orba Y, Nagashima K, Takahashi R, Fujitani N, Matsumura S, Hata A, Kubota K, Murahashi K, Uehara T, Nomura Y.
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| J Neurochem 99(6):1456-69. Epub 2006 Oct 24.PMID: 17059562 2006
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| 18 | SYVN1
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| Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum.
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| Kikkert M, Doolman R, Dai M, Avner R, Hassink G, van Voorden S, Thanedar S, Roitelman J, Chau V, Wiertz E.
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| J Biol Chem 279(5):3525-34. Epub 2003 Oct 30. 2004
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| 19 | SYVN1
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| A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1.
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| Nadav E, Shmueli A, Barr H, Gonen H, Ciechanover A, Reiss Y.
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| Biochem Biophys Res Commun 303(1):91-7. 2003
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| 20 | SYVN1
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| Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation.
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| Kaneko M, Ishiguro M, Niinuma Y, Uesugi M, Nomura Y.
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| FEBS Lett 532(1-2):147-52. 2002
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| 21 | ABLIM2, ACSS1, ATCAY, ATP13A1, BRSK1, CAPRIN2, CCDC132, CDH23, CHAMP1, COL27A1, EHMT1, FBN3, FNDC1, GMPPB, GPR123, GPS2, HHIPL1, IRF2BPL, JPH4, KBTBD8, KIAA1841, KIRREL3, KIRREL3, MEGF10, MEGF11, MLK4, NTNG2, PHF17, PHYHIPL, RANGAP1, SEMA6C, SLX4, SPIRE2, SRRM4, ST6GAL2, SYVN1, TTBK1, VCPIP1, WDR22, ZNF286A, ZNF333, ZNF512, ZNF528
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| Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
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| Nagase T, Nakayama M, Nakajima D, Kikuno R, Ohara O.
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| DNA Res 8(2):85-95. 2001
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