Citations for
1RAB27A, STXBP1, SYTL4
STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a.
van Breevoort D, Snijders AP, Hellen N, Weckhuysen S, van Hooren KW, Eikenboom J, Valentijn K, Fernandez-Borja M, Ceulemans B, De Jonghe P, Voorberg J, Hannah M, Carter T, Bierings R.
Blood 123(20):3185-94. doi: 10.1182/blood-2013-10-535831. 2014
2RAB27A, SYTL1, SYTL4
The Rab27a effector exophilin7 promotes fusion of secretory granules that have not been docked to the plasma membrane.
Wang H, Ishizaki R, Xu J, Kasai K, Kobayashi E, Gomi H, Izumi T.
Mol Biol Cell 24(3):319-30. doi: 10.1091/mbc.E12-04-0265. Epub 2012 Dec 5. 2013
3RAB8A, SYTL1, SYTL4
Synaptotagmin-like protein 4 and Rab8 interact and increase dense granule release in platelets.
Hampson A, O'Connor A, Smolenski A.
J Thromb Haemost 11(1):161-8. doi: 10.1111/jth.12068. 2013
4STX1A, SYTL4
Loss of granuphilin and loss of syntaxin-1A cause differential effects on insulin granule docking and fusion.
Wang H, Ishizaki R, Kobayashi E, Fujiwara T, Akagawa K, Izumi T.
J Biol Chem 286(37):32244-50. Epub 2011 Jul 18. 2011
5EXPH5, RAB27A, RAB27B, SYTL4
Rab27a and Rab27b control different steps of the exosome secretion pathway.
Ostrowski M, Carmo NB, Krumeich S, Fanget I, Raposo G, Savina A, Moita CF, Schauer K, Hume AN, Freitas RP, Goud B, Benaroch P, Hacohen N, Fukuda M, Desnos C, Seabra MC, Darchen F, Amigorena S, Moita LF, Thery C.
Nat Cell Biol 12(1):19-30; sup pp 1-13. doi: 10.1038/ncb2000. Epub 2009 Dec 6. 2010
6STXBP1, SYTL4
Munc 18-1 and granuphilin collaborate during insulin granule exocytosis.
Tomas A, Meda P, Regazzi R, Pessin JE, Halban PA.
Traffic 9(5):813-32. Epub 2008 Jan 19. 2008
7SYTL4
MicroRNA-9 controls the expression of Granuphilin/Slp4 and the secretory response of insulin-producing cells.
Plaisance V, Abderrahmani A, Perret-Menoud V, Jacquemin P, Lemaigre F, Regazzi R.
J Biol Chem 281(37):26932-42. Epub 2006 Jul 10. 2006
8SREBF1, SYTL4
Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice.
Kato T, Shimano H, Yamamoto T, Yokoo T, Endo Y, Ishikawa M, Matsuzaka T, Nakagawa Y, Kumadaki S, Yahagi N, Takahashi A, Sone H, Suzuki H, Toyoshima H, Hasty AH, Takahashi S, Gomi H, Izumi T, Yamada N.
Cell Metab 4(2):143-54. 2006
9SYTL4
Slp4-a/granuphilin-a interacts with syntaxin-2/3 in a Munc18-2-dependent manner.
Fukuda M, Imai A, Nashida T, Shimomura H.
J Biol Chem 280(47):39175-84. Epub 2005 Sep 26. 2005
10EXPH5,MLPH,MYRIP,SYTL1,SYTL2,SYTL3,SYTL4,SYTL5
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
Kuroda TS, Fukuda M, Ariga H, Mikoshiba K.
J Biol Chem 277(11):9212-8. Epub 2001 Dec 31. 2002
11MLPH,SYTL1,SYTL2,SYTL3,SYTL4
Novel splicing isoforms of synaptotagmin-like proteins 2 and 3: identification of the Slp homology domain.
Fukuda M, Saegusa C, Mikoshiba K.
Biochem Biophys Res Commun 283(2):513-9. 2001
12SYTL4
Novel rabphilin-3-like protein associates with insulin-containing granules in pancreatic beta cells.
Wang J, Takeuchi T, Yokota H, Izumi T.
J Biol Chem 274(40):28542-8. 1999