1 | SYT1
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| Expanding the genotype and phenotype spectrum of SYT1-associated neurodevelopmental disorder.
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| Melland H, Bumbak F, Kolesnik-Taylor A, Ng-Cordell E, John A, Constantinou P, Joss S, Larsen M, Fagerberg C, Laulund LW, Thies J, Emslie F, Willemsen M, Kleefstra T, Pfundt R, Barrick R, Chang R, Loong L, Alfadhel M, van der Smagt J, Nizon M, Kurian M, Scott DJ, Ziarek JJ, Gordon SL, Baker K.
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| Genet Med. Jan 28:S1098-3600(21)05421-6. doi: 10.1016/j.gim.2021.12.002. Epub ahead of print. 2022
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2 | STIM2, SYT1
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| Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress
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| Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET.
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| Neuron. Apr 21;109(8):1314-1332.e5. doi: 10.1016/j.neuron.2021.02.023. Epub 2021 Mar 11. 2021
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3 | SYT1
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| Synaptotagmin 1 oligomerization via the juxtamembrane linker regulates spontaneous and evoked neurotransmitter release
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| Courtney KC, Vevea JD, Li Y, Wu Z, Zhang Z, Chapman ER.
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| Proc Natl Acad Sci U S A. Nov 30;118(48):e2113859118. doi: 10.1073/pnas.2113859118. 2021
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4 | SYT1
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| Synaptotagmin-1: A Multi-Functional Protein that Mediates Vesicle Docking, Priming, and Fusion.
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| Ullah N, Maaiden EE, Uddin MS, Ashraf GM.
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| Curr Protein Pept Sci. 22(6):470-478. doi: 10.2174/1389203722666210325110231. 2021
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5 | SYT1
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| Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release.
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| Tagliatti E, Bello OD, Mendonça PRF, Kotzadimitriou D, Nicholson E, Coleman J, Timofeeva Y, Rothman JE, Krishnakumar SS, Volynski KE.
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| Proc Natl Acad Sci U S A. Feb 18;117(7):3819-3827. doi: 10.1073/pnas.1920403117. Epub 2020 Feb 3. 2020
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6 | NEDIMAE, SYT1
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| Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder.
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| Bradberry MM, Courtney NA, Dominguez MJ, Lofquist SM, Knox AT, Sutton RB, Chapman ER.
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| Neuron. Jul 8;107(1):52-64.e7. doi: 10.1016/j.neuron.2020.04.003. Epub 2020 May 1. 2020
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7 | SYT1
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| Ca2+ sensor synaptotagmin-1 mediates exocytosis in mammalian photoreceptors.
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| Grassmeyer JJ, Cahill AL, Hays CL, Barta C, Quadros RM, Gurumurthy CB, Thoreson WB.
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| Elife. Jun 7;8:e45946. doi: 10.7554/eLife.45946. 2019
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8 | NEDIMAE, SYT1
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| SYT1-associated neurodevelopmental disorder: a case series.
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| Baker K, Gordon SL, Melland H, Bumbak F, Scott DJ, Jiang TJ, Owen D, Turner BJ, Boyd SG, Rossi M, Al-Raqad M, Elpeleg O, Peck D, Mancini GMS, Wilke M, Zollino M, Marangi G, Weigand H, Borggraefe I, Haack T, Stark Z, Sadedin S; Broad Center for Mendelian Genomics, Tan TY, Jiang Y, Gibbs RA, Ellingwood S, Amaral M, Kelley W, Kurian MA, Cousin MA, Raymond FL.
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| Brain. Sep 1;141(9):2576-2591. doi: 10.1093/brain/awy209. 2018
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9 | SYT1
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| Models of synaptotagmin-1 to trigger Ca2+ -dependent vesicle fusion.2018 PMID:
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| Park Y, Ryu JK.
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| FEBS Lett. Nov;592(21):3480-3492. doi: 10.1002/1873-3468.13193. Epub 2018 Jul 30. 2018
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10 | SYT1, SYT2
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| Synaptotagmin2 (Syt2) Drives Fast Release Redundantly with Syt1 at the Output Synapses of Parvalbumin-Expressing Inhibitory Neurons
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| Bouhours B, Gjoni E, Kochubey O, Schneggenburger R.
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| J Neurosci. Apr 26;37(17):4604-4617. doi: 10.1523/JNEUROSCI.3736-16.2017. Epub 2017 Mar 31 2017
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11 | SYT1
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| Replicated association of Synaptotagmin (SYT1) with ADHD and its broader influence in externalizing behaviors
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| Cupertino RB, Schuch JB, Bandeira CE, da Silva BS, Rovaris DL, Kappel DB, Contini V, Salatino-Oliveira A, Vitola ES, Karam RG, Hutz MH, Rohde LA, Grevet EH, Bau CHD, Mota NR.
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| Eur Neuropsychopharmacol. Mar;27(3):239-247. doi: 10.1016/j.euroneuro.2017.01.007. Epub 2017 Jan 24. 2017
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12 | PSEN1, SYT1
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| Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta.
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| Kuzuya A, Zoltowska KM, Post KL, Arimon M, Li X, Svirsky S, Maesako M, Muzikansky A, Gautam V, Kovacs D, Hyman BT, Berezovska O.
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| BMC Biol 14:25. doi: 10.1186/s12915-016-0248-3.
2016
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13 | STXBP1, SYT1
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| Synaptotagmin-1 is an antagonist for Munc18-1 in SNARE zippering.
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| Lou X, Shin J, Yang Y, Kim J, Shin YK.
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| J Biol Chem 290(16):10535-43. doi: 10.1074/jbc.M114.631341.
2015
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14 | NEDIMAE, SYT1
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| Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cycling.
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| Baker K, Gordon SL, Grozeva D, van Kogelenberg M, Roberts NY, Pike M, Blair E, Hurles ME, Chong WK, Baldeweg T, Kurian MA, Boyd SG, Cousin MA, Raymond FL.
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| J Clin Invest. Apr;125(4):1670-8. doi: 10.1172/JCI79765. Epub 2015 Feb 23. 2015
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15 | SYT1
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| Synaptotagmin 1 is required for vesicular Ca²⁺/H⁺-antiport activity.
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| Cordeiro JM, Boda B, Gonçalves PP, Dunant Y.
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| J Neurochem. Jul;126(1):37-46. doi: 10.1111/jnc.12278. Epub 2013 May 15. 2013
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16 | SYT1
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| Synaptotagmin 1 is necessary for the Ca2+ dependence of clathrin-mediated endocytosis.
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| Yao LH, Rao Y, Varga K, Wang CY, Xiao P, Lindau M, Gong LW.
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| J Neurosci 32(11):3778-85. doi: 10.1523/JNEUROSCI.3540-11.2012.
2012
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17 | SYT1
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| Cis- and trans-membrane interactions of synaptotagmin-1.
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| Vennekate W, Schröder S, Lin CC, van den Bogaart G, Grunwald M, Jahn R, Walla PJ.
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| Proc Natl Acad Sci U S A 109(27):11037-42. doi: 10.1073/pnas.1116326109. Epub 2012 Jun 18.
2012
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18 | SYT1
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| Molecular level interaction of inositol hexaphosphate with the C2B domain of human synaptotagmin I.
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| Joung MJ, Mohan SK, Yu C.
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| Biochemistry 51(17):3675-83. doi: 10.1021/bi300005w. Epub 2012 Apr 18.
2012
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19 | SYT1
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| Synaptotagmin1 is required for spindle stability and metaphase-to-anaphase transition in mouse oocytes.
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| Zhu XL, Qi ST, Liu J, Chen L, Zhang C, Yang SW, Ouyang YC, Hou Y, Schatten H, Song YL, Xing FQ, Sun QY.
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| Cell Cycle 11(4):818-26. doi: 10.4161/cc.11.4.19329. Epub 2012 Feb 15.
2012
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20 | SYT1
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| The importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensor.
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| Lai Y, Shin YK.
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| Biochem J 443(1):223-9. doi: 10.1042/BJ20112044.
2012
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21 | SYT1
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| Ca(2+)-independent syntaxin binding to the C(2)B effector region of synaptotagmin.
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| Masumoto T, Suzuki K, Ohmori I, Michiue H, Tomizawa K, Fujimura A, Nishiki T, Matsui H.
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| Mol Cell Neurosci 49(1):1-8. doi: 10.1016/j.mcn.2011.09.007. Epub 2011 Oct 8.
2012
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22 | CPLX1, SYT1
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| Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release.
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| Malsam J, Parisotto D, Bharat TA, Scheutzow A, Krause JM, Briggs JA, Söllner TH.
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| EMBO J 31(15):3270-81. doi: 10.1038/emboj.2012.164. Epub 2012 Jun 15.
2012
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23 | SYT1
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| Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles.
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| Yao J, Kwon SE, Gaffaney JD, Dunning FM, Chapman ER.
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| Nat Neurosci 15(2):243-9. doi: 10.1038/nn.3013.
2011
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24 | SYT1
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| Synaptotagmin 1 modulates lipid acyl chain order in lipid bilayers by demixing phosphatidylserine.
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| Lai AL, Tamm LK, Ellena JF, Cafiso DS.
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| J Biol Chem 286(28):25291-300. doi: 10.1074/jbc.M111.258848. Epub 2011 May 24.
2011
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25 | SYT1, SYT7
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| Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
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| Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J.
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| PLoS One 5(9). pii: e12544.
2010
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26 | STXBP5, SYT1
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| Tomosyn inhibits synaptotagmin-1-mediated step of Ca2+-dependent neurotransmitter release through its N-terminal WD40 repeats.
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| Yamamoto Y, Mochida S, Miyazaki N, Kawai K, Fujikura K, Kurooka T, Iwasaki K, Sakisaka T.
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| J Biol Chem 285(52):40943-55. Epub 2010 Oct 26.
2010
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27 | SLC9A3, SYT1
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| Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1.
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| Musch MW, Arvans DL, Wang Y, Nakagawa Y, Solomaha E, Chang EB.
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| Am J Physiol Gastrointest Liver Physiol 298(2):G203-11. doi: 10.1152/ajpgi.00379.2009. Epub 2009 Nov 19.
2010
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28 | CPLX1, CPLX2, SYT1
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| Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.
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| Xue M, Craig TK, Xu J, Chao HT, Rizo J, Rosenmund C.
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| Nat Struct Mol Biol 17(5):568-75. doi: 10.1038/nsmb.1791. Epub 2010 Apr 18.
2010
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29 | SYT1
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| Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release.
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| Xu J, Pang ZP, Shin OH, Südhof TC.
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| Nature Neurosci 12(6):759-66. 2009
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30 | AREG, ARHGAP, BDNF, EPHA4, GFPT2, GRIA3, NEFM, PENK, PMCH, SLC16A6, SYT1
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| Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells.
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| Tondreau T, Dejeneffe M, Meuleman N, Stamatopoulos B, Delforge A, Martiat P, Bron D, Lagneaux L.
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| BMC Genomics 9:166.PMID: 18405367 2008
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31 | SYT1
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| How synaptotagmin promotes membrane fusion.
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| Martens S, Kozlov MM, McMahon HT.
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| Science. 316(5828):1205-8. 2007
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32 | SYT1, SYT2
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| Synaptotagmin I and II are present in distinct subsets of central synapses.
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| Fox MA, Sanes JR.
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| J Comp Neurol 503(2):280-96.
2007
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33 | SYT1
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| A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.
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| Pang ZP, Shin OH, Meyer AC, Rosenmund C, Südhof TC.
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| J Neurosci 26(48):12556-65.
2006
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34 | SYT1
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| Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release.
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| Maximov A, Südhof TC.
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| Neuron. 48(4):547-54. 2005
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35 | SYT9, SYT1
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| Unexpected Ca2+-binding properties of synaptotagmin 9.
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| Shin OH, Maximov A, Lim BK, Rizo J, Sudhof TC.
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| Proc Natl Acad Sci U S A 101(8):2554-9. 2004
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36 | DLG4, PSD95, SYT1, ZDHHC17
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| Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.
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| Huang K, Yanai A, Kang R, Arstikaitis P, Singaraja RR, Metzler M, Mullard A, Haigh B, Gauthier-Campbell C, Gutekunst CA, Hayden MR, El-Husseini A.
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| Neuron 44(6):977-86. 2004
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37 | SV2B, SYT1
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| SV2B regulates synaptotagmin 1 by direct interaction.
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| Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R.
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| J Biol Chem 279(50):52124-31. Epub 2004 Oct 5. 2004
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38 | SYT1, SSX1, PLK3, GDF15, MSH2
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| Gene expression profile by blocking the SYT-SSX fusion gene in synovial sarcoma cells. Identification of XRCC4 as a putative SYT-SSX target gene.
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| Xie Y, Tornkvist M, Aalto Y, Nilsson G, Girnita L, Nagy B, Knuutila S, Larsson O.
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| Oncogene 22(48):7628-31. 2003
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39 | SYT1
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| Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo.
|
| Poskanzer KE, Marek KW, Sweeney ST, Davis GW.
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| Nature 426(6966):559-63. 2003
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40 | SYT1
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| The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.
|
| Mackler JM, Drummond JA, Loewen CA, Robinson IM, Reist NE.
|
| Nature 418(6895):340-4. 2002
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41 | SYT1
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| Synaptotagmin I functions as a calcium regulator of release probability.
|
| Fernandez-Chacon R, Konigstorfer A, Gerber SH, Garcia J, Matos MF, Stevens CF, Brose N, Rizo J, Rosenmund C, Sudhof TC.
|
| Nature 410(6824):41-9. 2001
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42 | ESYT2, ESYT3, SYT1, SYT10, SYT11, SYT12, SYT13, SYT15, SYT16, SYT2, SYT3, SYT4, SYT5, SYT6, SYT7, SYT8, SYT9
|
| Genomic analysis of synaptotagmin genes.
|
| Craxton M.
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| Genomics 77(1-2):43-9. 2001
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43 | SYT1
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| Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress.
|
| Landriscina M, Bagalá C, Mandinova A, Soldi R, Micucci I, Bellum S, Prudovsky I, Maciag T.
|
| J Biol Chem. 276(27):25549-57. 2001
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44 | SYT1, SYT2, SYT3, SYT5, SYT7
|
| Role of the conserved WHXL motif in the C terminus of synaptotagmin in synaptic vesicle docking
|
| Fukuda M, Moreira JE, Liu V, Sugimori M, Mikoshiba K, Llinas RR.
|
| Proc Natl Acad Sci U S A 97(26):14715-9. 2000
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45 | FGF1, SYT1
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| Synaptotagmin-1 is required for fibroblast growth factor-1 release.
|
| LaVallee TM, et al.
|
| J Biol Chem 273 : 22217-22223. 1998
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46 | FGF1, S100A13, SYT1
|
| S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro.
|
| Mouta Carreira C, LaVallee TM, Tarantini F, Jackson A, Lathrop JT, Hampton B, Burgess WH, Maciag T.
|
| J Biol Chem. 273(35):22224-31. 1998
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47 | SYT1
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| Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch.
|
| Shao X, Li C, Fernandez I, Zhang X, Südhof TC, Rizo J.
|
| Neuron. 18(1):133-42. 1997
|
48 | CACNA1A, SYT1
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| Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel.
|
| Charvin N, L'evêque C, Walker D, Berton F, Raymond C, Kataoka M, Shoji-Kasai Y, Takahashi M, De Waard M, Seagar MJ
|
| EMBO J. 16(15):4591-6. 1997
|
49 | SYT1, SYT2, SYT3, SYT5
|
| Synaptotagmins: C2-domain proteins that regulate membrane traffic.
|
| Sudhof TC, et al.
|
| Neuron 17(3):379-88. Review. No abstract available 1996
|
50 | SYT1, SYT2, SYT3
|
| Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19.
|
| Jones JM, et al.
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| Mamm Genome 6 : 212-213. 1995
|
51 | SYT1
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| Synaptotagmin I is a high affinity receptor for clathrin AP-2 : implications for membrane recycling.
|
| Zhang JZ, et al.
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| Cell 78 : 751-760. 1994
|
52 | SYT1
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| Synaptotagmin I : a major Ca2+ sensor for transmitter release at a central synapse.
|
| Geppert M, et al.
|
| Cell 79 : 717-727. 1994
|
53 | SYT1
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| Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling.
|
| Zhang JZ, Davletov BA, Südhof TC, Anderson RG.
|
| Cell 78(5):751-60. 1994
|
54 | SYT1
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| Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants.
|
| Littleton JT, Stern M, Perin M, Bellen HJ.
|
| Proc Natl Acad Sci U S A. 91(23):10888-92. 1994
|
55 | SYT1
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| Synaptotagmin: a calcium sensor on the synaptic vesicle surface.
|
| Brose N, Petrenko AG, Südhof TC, Jahn R.
|
| Science. 256(5059):1021-5. 1992
|
56 | SYT1
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| Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans.
|
| Perin MS, et al.
|
| J Biol Chem 266 : 615-622. 1991
|
57 | SYT1, SYT2, SYT3, SYT5
|
| Domain structure of synaptotagmin.
|
| Perin MS, et al.
|
| J Biol Chem 266(1):623-9. 1991
|
58 | SYT1
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| Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C.
|
| Perin MS, et al.
|
| Nature 345(6272):260-3. 1990
|