Citations for
1SYT1
Expanding the genotype and phenotype spectrum of SYT1-associated neurodevelopmental disorder.
Melland H, Bumbak F, Kolesnik-Taylor A, Ng-Cordell E, John A, Constantinou P, Joss S, Larsen M, Fagerberg C, Laulund LW, Thies J, Emslie F, Willemsen M, Kleefstra T, Pfundt R, Barrick R, Chang R, Loong L, Alfadhel M, van der Smagt J, Nizon M, Kurian M, Scott DJ, Ziarek JJ, Gordon SL, Baker K.
Genet Med. Jan 28:S1098-3600(21)05421-6. doi: 10.1016/j.gim.2021.12.002. Epub ahead of print. 2022
2STIM2, SYT1
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress
Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET.
Neuron. Apr 21;109(8):1314-1332.e5. doi: 10.1016/j.neuron.2021.02.023. Epub 2021 Mar 11. 2021
3SYT1
Synaptotagmin 1 oligomerization via the juxtamembrane linker regulates spontaneous and evoked neurotransmitter release
Courtney KC, Vevea JD, Li Y, Wu Z, Zhang Z, Chapman ER.
Proc Natl Acad Sci U S A. Nov 30;118(48):e2113859118. doi: 10.1073/pnas.2113859118. 2021
4SYT1
Synaptotagmin-1: A Multi-Functional Protein that Mediates Vesicle Docking, Priming, and Fusion.
Ullah N, Maaiden EE, Uddin MS, Ashraf GM.
Curr Protein Pept Sci. 22(6):470-478. doi: 10.2174/1389203722666210325110231. 2021
5SYT1
Synaptotagmin 1 oligomers clamp and regulate different modes of neurotransmitter release.
Tagliatti E, Bello OD, Mendonça PRF, Kotzadimitriou D, Nicholson E, Coleman J, Timofeeva Y, Rothman JE, Krishnakumar SS, Volynski KE.
Proc Natl Acad Sci U S A. Feb 18;117(7):3819-3827. doi: 10.1073/pnas.1920403117. Epub 2020 Feb 3. 2020
6NEDIMAE, SYT1
Molecular Basis for Synaptotagmin-1-Associated Neurodevelopmental Disorder.
Bradberry MM, Courtney NA, Dominguez MJ, Lofquist SM, Knox AT, Sutton RB, Chapman ER.
Neuron. Jul 8;107(1):52-64.e7. doi: 10.1016/j.neuron.2020.04.003. Epub 2020 May 1. 2020
7SYT1
Ca2+ sensor synaptotagmin-1 mediates exocytosis in mammalian photoreceptors.
Grassmeyer JJ, Cahill AL, Hays CL, Barta C, Quadros RM, Gurumurthy CB, Thoreson WB.
Elife. Jun 7;8:e45946. doi: 10.7554/eLife.45946. 2019
8NEDIMAE, SYT1
SYT1-associated neurodevelopmental disorder: a case series.
Baker K, Gordon SL, Melland H, Bumbak F, Scott DJ, Jiang TJ, Owen D, Turner BJ, Boyd SG, Rossi M, Al-Raqad M, Elpeleg O, Peck D, Mancini GMS, Wilke M, Zollino M, Marangi G, Weigand H, Borggraefe I, Haack T, Stark Z, Sadedin S; Broad Center for Mendelian Genomics, Tan TY, Jiang Y, Gibbs RA, Ellingwood S, Amaral M, Kelley W, Kurian MA, Cousin MA, Raymond FL.
Brain. Sep 1;141(9):2576-2591. doi: 10.1093/brain/awy209. 2018
9SYT1
Models of synaptotagmin-1 to trigger Ca2+ -dependent vesicle fusion.2018 PMID:
Park Y, Ryu JK.
FEBS Lett. Nov;592(21):3480-3492. doi: 10.1002/1873-3468.13193. Epub 2018 Jul 30. 2018
10SYT1, SYT2
Synaptotagmin2 (Syt2) Drives Fast Release Redundantly with Syt1 at the Output Synapses of Parvalbumin-Expressing Inhibitory Neurons
Bouhours B, Gjoni E, Kochubey O, Schneggenburger R.
J Neurosci. Apr 26;37(17):4604-4617. doi: 10.1523/JNEUROSCI.3736-16.2017. Epub 2017 Mar 31 2017
11SYT1
Replicated association of Synaptotagmin (SYT1) with ADHD and its broader influence in externalizing behaviors
Cupertino RB, Schuch JB, Bandeira CE, da Silva BS, Rovaris DL, Kappel DB, Contini V, Salatino-Oliveira A, Vitola ES, Karam RG, Hutz MH, Rohde LA, Grevet EH, Bau CHD, Mota NR.
Eur Neuropsychopharmacol. Mar;27(3):239-247. doi: 10.1016/j.euroneuro.2017.01.007. Epub 2017 Jan 24. 2017
12PSEN1, SYT1
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta.
Kuzuya A, Zoltowska KM, Post KL, Arimon M, Li X, Svirsky S, Maesako M, Muzikansky A, Gautam V, Kovacs D, Hyman BT, Berezovska O.
BMC Biol 14:25. doi: 10.1186/s12915-016-0248-3. 2016
13STXBP1, SYT1
Synaptotagmin-1 is an antagonist for Munc18-1 in SNARE zippering.
Lou X, Shin J, Yang Y, Kim J, Shin YK.
J Biol Chem 290(16):10535-43. doi: 10.1074/jbc.M114.631341. 2015
14NEDIMAE, SYT1
Identification of a human synaptotagmin-1 mutation that perturbs synaptic vesicle cycling.
Baker K, Gordon SL, Grozeva D, van Kogelenberg M, Roberts NY, Pike M, Blair E, Hurles ME, Chong WK, Baldeweg T, Kurian MA, Boyd SG, Cousin MA, Raymond FL.
J Clin Invest. Apr;125(4):1670-8. doi: 10.1172/JCI79765. Epub 2015 Feb 23. 2015
15SYT1
Synaptotagmin 1 is required for vesicular Ca²⁺/H⁺-antiport activity.
Cordeiro JM, Boda B, Gonçalves PP, Dunant Y.
J Neurochem. Jul;126(1):37-46. doi: 10.1111/jnc.12278. Epub 2013 May 15. 2013
16SYT1
Synaptotagmin 1 is necessary for the Ca2+ dependence of clathrin-mediated endocytosis.
Yao LH, Rao Y, Varga K, Wang CY, Xiao P, Lindau M, Gong LW.
J Neurosci 32(11):3778-85. doi: 10.1523/JNEUROSCI.3540-11.2012. 2012
17SYT1
Cis- and trans-membrane interactions of synaptotagmin-1.
Vennekate W, Schröder S, Lin CC, van den Bogaart G, Grunwald M, Jahn R, Walla PJ.
Proc Natl Acad Sci U S A 109(27):11037-42. doi: 10.1073/pnas.1116326109. Epub 2012 Jun 18. 2012
18SYT1
Molecular level interaction of inositol hexaphosphate with the C2B domain of human synaptotagmin I.
Joung MJ, Mohan SK, Yu C.
Biochemistry 51(17):3675-83. doi: 10.1021/bi300005w. Epub 2012 Apr 18. 2012
19SYT1
Synaptotagmin1 is required for spindle stability and metaphase-to-anaphase transition in mouse oocytes.
Zhu XL, Qi ST, Liu J, Chen L, Zhang C, Yang SW, Ouyang YC, Hou Y, Schatten H, Song YL, Xing FQ, Sun QY.
Cell Cycle 11(4):818-26. doi: 10.4161/cc.11.4.19329. Epub 2012 Feb 15. 2012
20SYT1
The importance of an asymmetric distribution of acidic lipids for synaptotagmin 1 function as a Ca2+ sensor.
Lai Y, Shin YK.
Biochem J 443(1):223-9. doi: 10.1042/BJ20112044. 2012
21SYT1
Ca(2+)-independent syntaxin binding to the C(2)B effector region of synaptotagmin.
Masumoto T, Suzuki K, Ohmori I, Michiue H, Tomizawa K, Fujimura A, Nishiki T, Matsui H.
Mol Cell Neurosci 49(1):1-8. doi: 10.1016/j.mcn.2011.09.007. Epub 2011 Oct 8. 2012
22CPLX1, SYT1
Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release.
Malsam J, Parisotto D, Bharat TA, Scheutzow A, Krause JM, Briggs JA, Söllner TH.
EMBO J 31(15):3270-81. doi: 10.1038/emboj.2012.164. Epub 2012 Jun 15. 2012
23SYT1
Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles.
Yao J, Kwon SE, Gaffaney JD, Dunning FM, Chapman ER.
Nat Neurosci 15(2):243-9. doi: 10.1038/nn.3013. 2011
24SYT1
Synaptotagmin 1 modulates lipid acyl chain order in lipid bilayers by demixing phosphatidylserine.
Lai AL, Tamm LK, Ellena JF, Cafiso DS.
J Biol Chem 286(28):25291-300. doi: 10.1074/jbc.M111.258848. Epub 2011 May 24. 2011
25SYT1, SYT7
Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.
Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J.
PLoS One 5(9). pii: e12544. 2010
26STXBP5, SYT1
Tomosyn inhibits synaptotagmin-1-mediated step of Ca2+-dependent neurotransmitter release through its N-terminal WD40 repeats.
Yamamoto Y, Mochida S, Miyazaki N, Kawai K, Fujikura K, Kurooka T, Iwasaki K, Sakisaka T.
J Biol Chem 285(52):40943-55. Epub 2010 Oct 26. 2010
27SLC9A3, SYT1
Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1.
Musch MW, Arvans DL, Wang Y, Nakagawa Y, Solomaha E, Chang EB.
Am J Physiol Gastrointest Liver Physiol 298(2):G203-11. doi: 10.1152/ajpgi.00379.2009. Epub 2009 Nov 19. 2010
28CPLX1, CPLX2, SYT1
Binding of the complexin N terminus to the SNARE complex potentiates synaptic-vesicle fusogenicity.
Xue M, Craig TK, Xu J, Chao HT, Rizo J, Rosenmund C.
Nat Struct Mol Biol 17(5):568-75. doi: 10.1038/nsmb.1791. Epub 2010 Apr 18. 2010
29SYT1
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release.
Xu J, Pang ZP, Shin OH, Südhof TC.
Nature Neurosci 12(6):759-66. 2009
30AREG, ARHGAP, BDNF, EPHA4, GFPT2, GRIA3, NEFM, PENK, PMCH, SLC16A6, SYT1
Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells.
Tondreau T, Dejeneffe M, Meuleman N, Stamatopoulos B, Delforge A, Martiat P, Bron D, Lagneaux L.
BMC Genomics 9:166.PMID: 18405367 2008
31SYT1
How synaptotagmin promotes membrane fusion.
Martens S, Kozlov MM, McMahon HT.
Science. 316(5828):1205-8. 2007
32SYT1, SYT2
Synaptotagmin I and II are present in distinct subsets of central synapses.
Fox MA, Sanes JR.
J Comp Neurol 503(2):280-96. 2007
33SYT1
A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis.
Pang ZP, Shin OH, Meyer AC, Rosenmund C, Südhof TC.
J Neurosci 26(48):12556-65. 2006
34SYT1
Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release.
Maximov A, Südhof TC.
Neuron. 48(4):547-54. 2005
35SYT9, SYT1
Unexpected Ca2+-binding properties of synaptotagmin 9.
Shin OH, Maximov A, Lim BK, Rizo J, Sudhof TC.
Proc Natl Acad Sci U S A 101(8):2554-9. 2004
36DLG4, PSD95, SYT1, ZDHHC17
Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins.
Huang K, Yanai A, Kang R, Arstikaitis P, Singaraja RR, Metzler M, Mullard A, Haigh B, Gauthier-Campbell C, Gutekunst CA, Hayden MR, El-Husseini A.
Neuron 44(6):977-86. 2004
37SV2B, SYT1
SV2B regulates synaptotagmin 1 by direct interaction.
Lazzell DR, Belizaire R, Thakur P, Sherry DM, Janz R.
J Biol Chem 279(50):52124-31. Epub 2004 Oct 5. 2004
38SYT1, SSX1, PLK3, GDF15, MSH2
Gene expression profile by blocking the SYT-SSX fusion gene in synovial sarcoma cells. Identification of XRCC4 as a putative SYT-SSX target gene.
Xie Y, Tornkvist M, Aalto Y, Nilsson G, Girnita L, Nagy B, Knuutila S, Larsson O.
Oncogene 22(48):7628-31. 2003
39SYT1
Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo.
Poskanzer KE, Marek KW, Sweeney ST, Davis GW.
Nature 426(6966):559-63. 2003
40SYT1
The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.
Mackler JM, Drummond JA, Loewen CA, Robinson IM, Reist NE.
Nature 418(6895):340-4. 2002
41SYT1
Synaptotagmin I functions as a calcium regulator of release probability.
Fernandez-Chacon R, Konigstorfer A, Gerber SH, Garcia J, Matos MF, Stevens CF, Brose N, Rizo J, Rosenmund C, Sudhof TC.
Nature 410(6824):41-9. 2001
42ESYT2, ESYT3, SYT1, SYT10, SYT11, SYT12, SYT13, SYT15, SYT16, SYT2, SYT3, SYT4, SYT5, SYT6, SYT7, SYT8, SYT9
Genomic analysis of synaptotagmin genes.
Craxton M.
Genomics 77(1-2):43-9. 2001
43SYT1
Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress.
Landriscina M, Bagalá C, Mandinova A, Soldi R, Micucci I, Bellum S, Prudovsky I, Maciag T.
J Biol Chem. 276(27):25549-57. 2001
44SYT1, SYT2, SYT3, SYT5, SYT7
Role of the conserved WHXL motif in the C terminus of synaptotagmin in synaptic vesicle docking
Fukuda M, Moreira JE, Liu V, Sugimori M, Mikoshiba K, Llinas RR.
Proc Natl Acad Sci U S A 97(26):14715-9. 2000
45FGF1, SYT1
Synaptotagmin-1 is required for fibroblast growth factor-1 release.
LaVallee TM, et al.
J Biol Chem 273 : 22217-22223. 1998
46FGF1, S100A13, SYT1
S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro.
Mouta Carreira C, LaVallee TM, Tarantini F, Jackson A, Lathrop JT, Hampton B, Burgess WH, Maciag T.
J Biol Chem. 273(35):22224-31. 1998
47SYT1
Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch.
Shao X, Li C, Fernandez I, Zhang X, Südhof TC, Rizo J.
Neuron. 18(1):133-42. 1997
48CACNA1A, SYT1
Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel.
Charvin N, L'evêque C, Walker D, Berton F, Raymond C, Kataoka M, Shoji-Kasai Y, Takahashi M, De Waard M, Seagar MJ
EMBO J. 16(15):4591-6. 1997
49SYT1, SYT2, SYT3, SYT5
Synaptotagmins: C2-domain proteins that regulate membrane traffic.
Sudhof TC, et al.
Neuron 17(3):379-88. Review. No abstract available 1996
50SYT1, SYT2, SYT3
Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19.
Jones JM, et al.
Mamm Genome 6 : 212-213. 1995
51SYT1
Synaptotagmin I is a high affinity receptor for clathrin AP-2 : implications for membrane recycling.
Zhang JZ, et al.
Cell 78 : 751-760. 1994
52SYT1
Synaptotagmin I : a major Ca2+ sensor for transmitter release at a central synapse.
Geppert M, et al.
Cell 79 : 717-727. 1994
53SYT1
Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling.
Zhang JZ, Davletov BA, Südhof TC, Anderson RG.
Cell 78(5):751-60. 1994
54SYT1
Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants.
Littleton JT, Stern M, Perin M, Bellen HJ.
Proc Natl Acad Sci U S A. 91(23):10888-92. 1994
55SYT1
Synaptotagmin: a calcium sensor on the synaptic vesicle surface.
Brose N, Petrenko AG, Südhof TC, Jahn R.
Science. 256(5059):1021-5. 1992
56SYT1
Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans.
Perin MS, et al.
J Biol Chem 266 : 615-622. 1991
57SYT1, SYT2, SYT3, SYT5
Domain structure of synaptotagmin.
Perin MS, et al.
J Biol Chem 266(1):623-9. 1991
58SYT1
Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C.
Perin MS, et al.
Nature 345(6272):260-3. 1990