| 1 | EMD, PRO1, SUN1, SUN2, SYNE1, SYNE2
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| Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging.
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| Chang W, Wang Y, Luxton GWG, Östlund C, Worman HJ, Gundersen GG.
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| Proc Natl Acad Sci U S A 116(9):3578-3583. doi: 10.1073/pnas.1809683116. Epub 2019 Feb 11.
2019
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| 2 | SUN2, SYNE1, SYNE2
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| A molecular model for LINC complex regulation: activation of SUN2 for KASH binding.
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| Jahed Z, Vu UT, Fadavi D, Ke H, Rathish A, Kim SCJ, Feng W, Mofrad MRK.
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| Mol Biol Cell 29(16):2012-2023. doi: 10.1091/mbc.E18-04-0266. Epub 2018 Jul 11.
2018
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| 3 | SMC2, SMC4, SYNE2
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| Nesprin-2 Interacts with Condensin Component SMC2.
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| Xing X, Mroß C, Hao L, Munck M, Herzog A, Mohr C, Unnikannan CP, Kelkar P, Noegel AA, Eichinger L, Neumann S.
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| Int J Cell Biol 2017:8607532. doi: 10.1155/2017/8607532. Epub 2017 Dec 27.
2017
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| 4 | FSCN1, SYNE2
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| Fascin Regulates Nuclear Movement and Deformation in Migrating Cells.
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| Jayo A, Malboubi M, Antoku S, Chang W, Ortiz-Zapater E, Groen C, Pfisterer K, Tootle T, Charras G, Gundersen GG, Parsons M.
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| Dev Cell. Aug 22;38(4):371-83. doi: 10.1016/j.devcel.2016.07.021 2016
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| 5 | FHOD1, SYNE2
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| FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement.
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| Kutscheidt S, Zhu R, Antoku S, Luxton GW, Stagljar I, Fackler OT, Gundersen GG.
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| Nat Cell Biol at Cell Biol. 2014 Jun 1. doi: 10.1038/ncb2981. [Epub ahead of print]
2014
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| 6 | SUN1, SUN2, SYNE1, SYNE2
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| SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown.
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| Turgay Y, Champion L, Balazs C, Held M, Toso A, Gerlich DW, Meraldi P, Kutay U.
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| J Cell Biol 204(7):1099-109. doi: 10.1083/jcb.201310116. Epub 2014 Mar 24.
2014
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| 7 | SYNE1, SYNE2
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| Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.
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| Rajgor D, Mellad JA, Autore F, Zhang Q, Shanahan CM.
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| PLoS One 7(7):e40098. doi: 10.1371/journal.pone.0040098. Epub 2012 Jul 2.
2012
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| 8 | SUN1, SUN2, SYNE1, SYNE2
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| KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
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| Yu J, Lei K, Zhou M, Craft CM, Xu G, Xu T, Zhuang Y, Xu R, Han M.
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| Hum Mol Genet 20(6):1061-73. Epub 2010 Dec 21. 2011
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| 9 | SYNE2
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| Nesprin-2 epsilon: a novel nesprin isoform expressed in human ovary and Ntera-2 cells.
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| Lam le T, Böhm SV, Roberts RG, Morris GE.
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| Biochem Biophys Res Commun 412(2):291-5. Epub 2011 Jul 28.
2011
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| 10 | SUN1, SUN2, SUN3, SYNE2
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| Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes.
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| Haque F, Mazzeo D, Patel JT, Smallwood DT, Ellis JA, Shanahan CM, Shackleton S.
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| J Biol Chem 285(5):3487-98. Epub 2009 Nov 21.PMID: 19933576 2010
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| 11 | SYNE2
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| Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.
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| Randles KN, Lam le T, Sewry CA, Puckelwartz M, Furling D, Wehnert M, McNally EM, Morris GE.
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| Dev Dyn 239(3):998-1009.
2010
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| 12 | EMD, SYNE2
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| Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope.
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| Neumann S, Schneider M, Daugherty RL, Gottardi CJ, Eming SA, Beijer A, Noegel AA, Karakesisoglou I.
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| J Biol Chem 285(45):34932-8. Epub 2010 Aug 26.
2010
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| 13 | SYNE1, SYNE2
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| Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.
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| Randles KN, Lam le T, Sewry CA, Puckelwartz M, Furling D, Wehnert M, McNally EM, Morris GE.
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| Dev Dyn 239(3):998-1009. doi: 10.1002/dvdy.22229.
2010
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| 14 | C19orf46, EDMD2, EDMD3, LMNA, SUN1, SUN2, SYNE1, SYNE2, SYNE3
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| Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice.
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| Puckelwartz MJ, Kessler E, Zhang Y, Hodzic D, Randles KN, Morris G, Earley JU, Hadhazy M, Holaska JM, Mewborn SK, Pytel P, McNally EM.
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| Hum Mol Genet 18(4):607-20. Epub 2008 Nov 13. 2009
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| 15 | SYNE2
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| SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.
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| Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, Xu R, Han M.
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| Neuron 64(2):173-87.
2009
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| 16 | SYNE1, SYNE2, TOR1A
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| TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.
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| Nery FC, Zeng J, Niland BP, Hewett J, Farley J, Irimia D, Li Y, Wiche G, Sonnenberg A, Breakefield XO.
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| J Cell Sci 121(Pt 20):3476-86. Epub 2008 Sep 30.
2008
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| 17 | SYNE2
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| Nesprin-2 Giant (NUANCE) maintains nuclear envelope architecture and composition in skin.
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| Lüke Y, Zaim H, Karakesisoglou I, Jaeger VM, Sellin L, Lu W, Schneider M, Neumann S, Beijer A, Munck M, Padmakumar VC, Gloy J, Walz G, Noegel AA.
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| J Cell Sci 121(Pt 11):1887-98. Epub 2008 May 13.PMID: 18477613 2008
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| 18 | EMD4, EMD5, SUN1, SUN2, SYNE1, SYNE2
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| Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.
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| Zhang Q, Bethmann C, Worth NF, Davies JD, Wasner C, Feuer A, Ragnauth CD, Yi Q, Mellad JA, Warren DT, Wheeler MA, Ellis JA, Skepper JN, Vorgerd M, Schlotter-Weigel B, Weissberg PL, Roberts RG, Wehnert M, Shanahan CM.
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| Hum Mol Genet 16(23):2816-33. Epub 2007 Aug 29. 2007
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| 19 | SYNE1, SYNE2
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| Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.
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| Wheeler MA, Davies JD, Zhang Q, Emerson LJ, Hunt J, Shanahan CM, Ellis JA.
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| Exp Cell Res 313(13):2845-57. Epub 2007 Mar 30. 2007
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| 20 | SYNE2
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| Nesprin-2 giant safeguards nuclear envelope architecture in LMNA S143F progeria cells.
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| Kandert S, Lüke Y, Kleinhenz T, Neumann S, Lu W, Jaeger VM, Munck M, Wehnert M, Müller CR, Zhou Z, Noegel AA, Dabauvalle MC, Karakesisoglou I.
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| Hum Mol Genet 16(23):2944-59. Epub 2007 Sep 19. Erratum in: Hum Mol Genet. 2008 Feb 1;17(3):468. PMID: 17881656 2007
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| 21 | SYNE2
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| The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope.
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| Padmakumar VC, Libotte T, Lu W, Zaim H, Abraham S, Noegel AA, Gotzmann J, Foisner R, Karakesisoglou I.
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| J Cell Sci 118(Pt 15):3419-30. 2005
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| 22 | LMNA, SYNE2, EMD
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| Lamin A/C-dependent localization of Nesprin-2, a giant scaffolder at the nuclear envelope.
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| Libotte T, Zaim H, Abraham S, Padmakumar VC, Schneider M, Lu W, Munck M, Hutchison C, Wehnert M, Fahrenkrog B, Sauder U, Aebi U, Noegel AA, Karakesisoglou I.
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| Mol Biol Cell 16(7):3411-24. Epub 2005 Apr 20. 2005
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| 23 | SUN1, SUN2, SYNE1, SYNE2
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| Role of ANC-1 in tethering nuclei to the actin cytoskeleton.
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| Starr DA, Han M.
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| Science 298(5592):406-9. 2002
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| 24 | SYNE1, SYNE2
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| The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.
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| Zhang Q, Ragnauth C, Greener MJ, Shanahan CM, Roberts RG.
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| Genomics 80(5):473-81. 2002
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| 25 | SYNE1, SYNE2
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| Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.
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| Zhang Q, Skepper JN, Yang F, Davies JD, Hegyi L, Roberts RG, Weissberg PL, Ellis JA, Shanahan CM.
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| J Cell Sci 114(Pt 24):4485-98. 2001
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| 26 | SYNE1, SYNE2
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| Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.
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| Apel ED, Lewis RM, Grady RM, Sanes JR.
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| J Biol Chem 275(41):31986-95. 2000
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