Citations for
1EMD, LMNA, SUN1, SUN2, SYNE1
Spatiotemporal Mislocalization of Nuclear Membrane-Associated Proteins in γ-Irradiation-Induced Senescent Cells.
Alena SK, Eva B, Aleš K, Emilie L.
Cells 9(4). pii: E999. doi: 10.3390/cells9040999. 2020
2SUN1, SUN2, SYNE1
SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
Porter L, Minaisah RM, Ahmed S, Ali S, Norton R, Zhang Q, Ferraro E, Molenaar C, Holt M, Cox S, Fountain S, Shanahan C, Warren D.
Cells 9(1). pii: E132. doi: 10.3390/cells9010132. 2020
3EMD, PRO1, SUN1, SUN2, SYNE1, SYNE2
Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging.
Chang W, Wang Y, Luxton GWG, Östlund C, Worman HJ, Gundersen GG.
Proc Natl Acad Sci U S A 116(9):3578-3583. doi: 10.1073/pnas.1809683116. Epub 2019 Feb 11. 2019
4SUN2, SYNE1, SYNE2
A molecular model for LINC complex regulation: activation of SUN2 for KASH binding.
Jahed Z, Vu UT, Fadavi D, Ke H, Rathish A, Kim SCJ, Feng W, Mofrad MRK.
Mol Biol Cell 29(16):2012-2023. doi: 10.1091/mbc.E18-04-0266. Epub 2018 Jul 11. 2018
5EMD4, SYNE1
Dominant muscular dystrophy with a novel SYNE1 gene mutation.
Fanin M, Savarese M, Nascimbeni AC, Di Fruscio G, Pastorello E, Tasca E, Trevisan CP, Nigro V, Angelini C.
Muscle Nerve 51(1):145-7. doi: 10.1002/mus.24357. Epub 2014 Nov 24. No abstract available. 2015
6SYNE1
Mammalian microtubule P-body dynamics are mediated by nesprin-1.
Rajgor D, Mellad JA, Soong D, Rattner JB, Fritzler MJ, Shanahan CM.
J Cell Biol 205(4):457-75. doi: 10.1083/jcb.201306076. 2014
7SUN1, SUN2, SYNE1, SYNE2
SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown.
Turgay Y, Champion L, Balazs C, Held M, Toso A, Gerlich DW, Meraldi P, Kutay U.
J Cell Biol 204(7):1099-109. doi: 10.1083/jcb.201310116. Epub 2014 Mar 24. 2014
8SCAR8, SYNE1
SYNE1 mutations in autosomal recessive cerebellar ataxia.
Noreau A, Bourassa CV, Szuto A, Levert A, Dobrzeniecka S, Gauthier J, Forlani S, Durr A, Anheim M, Stevanin G, Brice A, Bouchard JP, Dion PA, Dupré N, Rouleau GA.
JAMA Neurol 70(10):1296-31. 2013
9SYNE1
Nesprin-1 plays an important role in the proliferation and apoptosis of mesenchymal stem cells.
Yang W, Zheng H, Wang Y, Lian F, Hu Z, Xue S.
Int J Mol Med 32(4):805-12. doi: 10.3892/ijmm.2013.1445. Epub 2013 Jul 16. 2013
10BCORL1, CRTRD, DDHD2, IDBDD, MCM3AP, PNRIID, PTPRT, SLC6A8, SPG54, SYNE1, ZNF528
Identification of pathogenic gene variants in small families with intellectually disabled siblings by exome sequencing.
Schuurs-Hoeijmakers JH, Vulto-van Silfhout AT, Vissers LE, van de Vondervoort II, van Bon BW, de Ligt J, Gilissen C, Hehir-Kwa JY, Neveling K, del Rosario M, Hira G, Reitano S, Vitello A, Failla P, Greco D, Fichera M, Galesi O, Kleefstra T, Greally MT, Ockeloen CW, Willemsen MH, Bongers EM, Janssen IM, Pfundt R, Veltman JA, Romano C, Willemsen MA, van Bokhoven H, Brunner HG, de Vries BB, de Brouwer AP.
J Med Genet. Dec;50(12):802-11. doi: 10.1136/jmedgenet-2013-101644. Epub 2013 Oct 11. 2013
11EMD4, SYNE1
Role of nesprin-1 in nuclear deformation in endothelial cells under static and uniaxial stretching conditions.
Anno T, Sakamoto N, Sato M.
Biochem Biophys Res Commun 424(1):94-9. doi: 10.1016/j.bbrc.2012.06.073. Epub 2012 Jun 21. 2012
12SYNE1, SYNE2
Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.
Rajgor D, Mellad JA, Autore F, Zhang Q, Shanahan CM.
PLoS One 7(7):e40098. doi: 10.1371/journal.pone.0040098. Epub 2012 Jul 2. 2012
13SUN1, SUN2, SYNE1, SYNE2
KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
Yu J, Lei K, Zhou M, Craft CM, Xu G, Xu T, Zhuang Y, Xu R, Han M.
Hum Mol Genet 20(6):1061-73. Epub 2010 Dec 21. 2011
14SYNE1
Nesprin 1 is critical for nuclear positioning and anchorage.
Zhang J, Felder A, Liu Y, Guo LT, Lange S, Dalton ND, Gu Y, Peterson KL, Mizisin AP, Shelton GD, Lieber RL, Chen J.
Hum Mol Genet 19(2):329-41. Epub 2009 Oct 28.PMID: 19864491 2010
15SYNE1, SYNE2
Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.
Randles KN, Lam le T, Sewry CA, Puckelwartz M, Furling D, Wehnert M, McNally EM, Morris GE.
Dev Dyn 239(3):998-1009. doi: 10.1002/dvdy.22229. 2010
16C19orf46, EDMD2, EDMD3, LMNA, SUN1, SUN2, SYNE1, SYNE2, SYNE3
Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice.
Puckelwartz MJ, Kessler E, Zhang Y, Hodzic D, Randles KN, Morris G, Earley JU, Hadhazy M, Holaska JM, Mewborn SK, Pytel P, McNally EM.
Hum Mol Genet 18(4):607-20. Epub 2008 Nov 13. 2009
17AMCN3, SYNE1
Mutation of SYNE-1, encoding an essential component of the nuclear lamina, is responsible for autosomal recessive arthrogryposis.
Attali R, Warwar N, Israel A, Gurt I, McNally E, Puckelwartz M, Glick B, Nevo Y, Ben-Neriah Z, Melki J.
Hum Mol Genet 18(18):3462-9. Epub 2009 Jun 19.PMID: 19542096 2009
18SYNE1, SYNE2, TOR1A
TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.
Nery FC, Zeng J, Niland BP, Hewett J, Farley J, Irimia D, Li Y, Wiche G, Sonnenberg A, Breakefield XO.
J Cell Sci 121(Pt 20):3476-86. Epub 2008 Sep 30. 2008
19SCAR8,SYNE1
Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia.
Gros-Louis F, Dupre N, Dion P, Fox MA, Laurent S, Verreault S, Sanes JR, Bouchard JP, Rouleau GA.
Nat Genet 39(1):80-5. Epub 2006 Dec 10. 2007
20EMD4, EMD5, SUN1, SUN2, SYNE1, SYNE2
Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.
Zhang Q, Bethmann C, Worth NF, Davies JD, Wasner C, Feuer A, Ragnauth CD, Yi Q, Mellad JA, Warren DT, Wheeler MA, Ellis JA, Skepper JN, Vorgerd M, Schlotter-Weigel B, Weissberg PL, Roberts RG, Wehnert M, Shanahan CM.
Hum Mol Genet 16(23):2816-33. Epub 2007 Aug 29. 2007
21SYNE1, SYNE2
Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.
Wheeler MA, Davies JD, Zhang Q, Emerson LJ, Hunt J, Shanahan CM, Ellis JA.
Exp Cell Res 313(13):2845-57. Epub 2007 Mar 30. 2007
22SYNE1
Syne proteins anchor muscle nuclei at the neuromuscular junction.
Grady RM, Starr DA, Ackerman GL, Sanes JR, Han M.
Proc Natl Acad Sci U S A 102(12):4359-64. Epub 2005 Mar 4. 2005
23SYNE1
Golgi localization of Syne-1.
Gough LL, Fan J, Chu S, Winnick S, Beck KA.
Mol Biol Cell 14(6):2410-24. Epub 2003 Mar 07. 2003
24SUN1, SUN2, SYNE1, SYNE2
Role of ANC-1 in tethering nuclei to the actin cytoskeleton.
Starr DA, Han M.
Science 298(5592):406-9. 2002
25SYNE1
Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C.
Mislow JM, Kim MS, Davis DB, McNally EM.
J Cell Sci 115(Pt 1):61-70. 2002
26SYNE1, SYNE2
The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.
Zhang Q, Ragnauth C, Greener MJ, Shanahan CM, Roberts RG.
Genomics 80(5):473-81. 2002
27SYNE1, SYNE2
Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.
Zhang Q, Skepper JN, Yang F, Davies JD, Hegyi L, Roberts RG, Weissberg PL, Ellis JA, Shanahan CM.
J Cell Sci 114(Pt 24):4485-98. 2001
28SYNE1, SYNE2
Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.
Apel ED, Lewis RM, Grady RM, Sanes JR.
J Biol Chem 275(41):31986-95. 2000
29ADGRL2, ADGRL3, ADNP, AKAP9, ANGEL1, ARHGAP32, ATP10B, ATP1A2, BAG5, BAIAP3, CAMKK2, CLCC1, CLSTN3, DDHD2, DDN, DDX46, DDX46, DGKB, DIP, DOCK4, DST, EIF5B, EPM2AIP1, FAM131B, FAM153A, FARP2, FCHSD2, GPR116, HDAC9, IPO13, KBTBD11, KIAA0748, KIAA0753, KIAA0754, KIAA0802, KLHL18, LARP1, LRIG2, MAST2, MTUS2, MYO10, MYO1D, NFASC, NRXN3, NUP155, OSBPL2, PCNX, PHF14, PPP1R13B, RAD54L2, RBM12, RHOBTB1, RHOBTB2, RIMS2, SACS, SASH1, SEC24A, SEC24B, SEC24C, SEC24D, SENP6, SLC4A8, SNRNP200, SNX13, SORBS2, SPATA2, SPON1, SUPT7L, SV2A, SV2B, SYNE1, TBKBP1, TCAF1, TMCC1, TMEM63A, TOMM70A, TSPYL4, UBXN7, ULK1, USP34, VPRBP, VPS39, VPS8, WSCD2, XPO7, ZBED1, ZBED1Y, ZNF294, ZNF423, ZNF432
Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O.
DNA Res 5(5):277-86. 1998