| 1 | EMD, LMNA, SUN1, SUN2, SYNE1
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| Spatiotemporal Mislocalization of Nuclear Membrane-Associated Proteins in γ-Irradiation-Induced Senescent Cells.
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| Alena SK, Eva B, Aleš K, Emilie L.
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| Cells 9(4). pii: E999. doi: 10.3390/cells9040999.
2020
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| 2 | SUN1, SUN2, SYNE1
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| SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells.
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| Porter L, Minaisah RM, Ahmed S, Ali S, Norton R, Zhang Q, Ferraro E, Molenaar C, Holt M, Cox S, Fountain S, Shanahan C, Warren D.
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| Cells 9(1). pii: E132. doi: 10.3390/cells9010132.
2020
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| 3 | EMD, PRO1, SUN1, SUN2, SYNE1, SYNE2
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| Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging.
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| Chang W, Wang Y, Luxton GWG, Östlund C, Worman HJ, Gundersen GG.
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| Proc Natl Acad Sci U S A 116(9):3578-3583. doi: 10.1073/pnas.1809683116. Epub 2019 Feb 11.
2019
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| 4 | SUN2, SYNE1, SYNE2
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| A molecular model for LINC complex regulation: activation of SUN2 for KASH binding.
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| Jahed Z, Vu UT, Fadavi D, Ke H, Rathish A, Kim SCJ, Feng W, Mofrad MRK.
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| Mol Biol Cell 29(16):2012-2023. doi: 10.1091/mbc.E18-04-0266. Epub 2018 Jul 11.
2018
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| 5 | EMD4, SYNE1
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| Dominant muscular dystrophy with a novel SYNE1 gene mutation.
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| Fanin M, Savarese M, Nascimbeni AC, Di Fruscio G, Pastorello E, Tasca E, Trevisan CP, Nigro V, Angelini C.
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| Muscle Nerve 51(1):145-7. doi: 10.1002/mus.24357. Epub 2014 Nov 24. No abstract available.
2015
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| 6 | SYNE1
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| Mammalian microtubule P-body dynamics are mediated by nesprin-1.
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| Rajgor D, Mellad JA, Soong D, Rattner JB, Fritzler MJ, Shanahan CM.
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| J Cell Biol 205(4):457-75. doi: 10.1083/jcb.201306076.
2014
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| 7 | SUN1, SUN2, SYNE1, SYNE2
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| SUN proteins facilitate the removal of membranes from chromatin during nuclear envelope breakdown.
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| Turgay Y, Champion L, Balazs C, Held M, Toso A, Gerlich DW, Meraldi P, Kutay U.
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| J Cell Biol 204(7):1099-109. doi: 10.1083/jcb.201310116. Epub 2014 Mar 24.
2014
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| 8 | SCAR8, SYNE1
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| SYNE1 mutations in autosomal recessive cerebellar ataxia.
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| Noreau A, Bourassa CV, Szuto A, Levert A, Dobrzeniecka S, Gauthier J, Forlani S, Durr A, Anheim M, Stevanin G, Brice A, Bouchard JP, Dion PA, Dupré N, Rouleau GA.
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| JAMA Neurol 70(10):1296-31.
2013
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| 9 | SYNE1
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| Nesprin-1 plays an important role in the proliferation and apoptosis of mesenchymal stem cells.
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| Yang W, Zheng H, Wang Y, Lian F, Hu Z, Xue S.
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| Int J Mol Med 32(4):805-12. doi: 10.3892/ijmm.2013.1445. Epub 2013 Jul 16.
2013
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| 10 | BCORL1, CRTRD, DDHD2, IDBDD, MCM3AP, PNRIID, PTPRT, SLC6A8, SPG54, SYNE1, ZNF528
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| Identification of pathogenic gene variants in small families with intellectually disabled siblings by exome sequencing.
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| Schuurs-Hoeijmakers JH, Vulto-van Silfhout AT, Vissers LE, van de Vondervoort II, van Bon BW, de Ligt J, Gilissen C, Hehir-Kwa JY, Neveling K, del Rosario M, Hira G, Reitano S, Vitello A, Failla P, Greco D, Fichera M, Galesi O, Kleefstra T, Greally MT, Ockeloen CW, Willemsen MH, Bongers EM, Janssen IM, Pfundt R, Veltman JA, Romano C, Willemsen MA, van Bokhoven H, Brunner HG, de Vries BB, de Brouwer AP.
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| J Med Genet. Dec;50(12):802-11. doi: 10.1136/jmedgenet-2013-101644. Epub 2013 Oct 11. 2013
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| 11 | EMD4, SYNE1
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| Role of nesprin-1 in nuclear deformation in endothelial cells under static and uniaxial stretching conditions.
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| Anno T, Sakamoto N, Sato M.
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| Biochem Biophys Res Commun 424(1):94-9. doi: 10.1016/j.bbrc.2012.06.073. Epub 2012 Jun 21.
2012
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| 12 | SYNE1, SYNE2
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| Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds.
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| Rajgor D, Mellad JA, Autore F, Zhang Q, Shanahan CM.
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| PLoS One 7(7):e40098. doi: 10.1371/journal.pone.0040098. Epub 2012 Jul 2.
2012
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| 13 | SUN1, SUN2, SYNE1, SYNE2
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| KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
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| Yu J, Lei K, Zhou M, Craft CM, Xu G, Xu T, Zhuang Y, Xu R, Han M.
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| Hum Mol Genet 20(6):1061-73. Epub 2010 Dec 21. 2011
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| 14 | SYNE1
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| Nesprin 1 is critical for nuclear positioning and anchorage.
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| Zhang J, Felder A, Liu Y, Guo LT, Lange S, Dalton ND, Gu Y, Peterson KL, Mizisin AP, Shelton GD, Lieber RL, Chen J.
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| Hum Mol Genet 19(2):329-41. Epub 2009 Oct 28.PMID: 19864491 2010
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| 15 | SYNE1, SYNE2
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| Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development.
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| Randles KN, Lam le T, Sewry CA, Puckelwartz M, Furling D, Wehnert M, McNally EM, Morris GE.
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| Dev Dyn 239(3):998-1009. doi: 10.1002/dvdy.22229.
2010
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| 16 | C19orf46, EDMD2, EDMD3, LMNA, SUN1, SUN2, SYNE1, SYNE2, SYNE3
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| Disruption of nesprin-1 produces an Emery Dreifuss muscular dystrophy-like phenotype in mice.
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| Puckelwartz MJ, Kessler E, Zhang Y, Hodzic D, Randles KN, Morris G, Earley JU, Hadhazy M, Holaska JM, Mewborn SK, Pytel P, McNally EM.
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| Hum Mol Genet 18(4):607-20. Epub 2008 Nov 13. 2009
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| 17 | AMCN3, SYNE1
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| Mutation of SYNE-1, encoding an essential component of the nuclear lamina, is responsible for autosomal recessive arthrogryposis.
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| Attali R, Warwar N, Israel A, Gurt I, McNally E, Puckelwartz M, Glick B, Nevo Y, Ben-Neriah Z, Melki J.
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| Hum Mol Genet 18(18):3462-9. Epub 2009 Jun 19.PMID: 19542096 2009
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| 18 | SYNE1, SYNE2, TOR1A
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| TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.
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| Nery FC, Zeng J, Niland BP, Hewett J, Farley J, Irimia D, Li Y, Wiche G, Sonnenberg A, Breakefield XO.
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| J Cell Sci 121(Pt 20):3476-86. Epub 2008 Sep 30.
2008
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| 19 | SCAR8,SYNE1
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| Mutations in SYNE1 lead to a newly discovered form of autosomal recessive cerebellar ataxia.
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| Gros-Louis F, Dupre N, Dion P, Fox MA, Laurent S, Verreault S, Sanes JR, Bouchard JP, Rouleau GA.
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| Nat Genet 39(1):80-5. Epub 2006 Dec 10. 2007
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| 20 | EMD4, EMD5, SUN1, SUN2, SYNE1, SYNE2
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| Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity.
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| Zhang Q, Bethmann C, Worth NF, Davies JD, Wasner C, Feuer A, Ragnauth CD, Yi Q, Mellad JA, Warren DT, Wheeler MA, Ellis JA, Skepper JN, Vorgerd M, Schlotter-Weigel B, Weissberg PL, Roberts RG, Wehnert M, Shanahan CM.
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| Hum Mol Genet 16(23):2816-33. Epub 2007 Aug 29. 2007
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| 21 | SYNE1, SYNE2
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| Distinct functional domains in nesprin-1alpha and nesprin-2beta bind directly to emerin and both interactions are disrupted in X-linked Emery-Dreifuss muscular dystrophy.
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| Wheeler MA, Davies JD, Zhang Q, Emerson LJ, Hunt J, Shanahan CM, Ellis JA.
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| Exp Cell Res 313(13):2845-57. Epub 2007 Mar 30. 2007
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| 22 | SYNE1
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| Syne proteins anchor muscle nuclei at the neuromuscular junction.
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| Grady RM, Starr DA, Ackerman GL, Sanes JR, Han M.
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| Proc Natl Acad Sci U S A 102(12):4359-64. Epub 2005 Mar 4. 2005
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| 23 | SYNE1
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| Golgi localization of Syne-1.
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| Gough LL, Fan J, Chu S, Winnick S, Beck KA.
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| Mol Biol Cell 14(6):2410-24. Epub 2003 Mar 07. 2003
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| 24 | SUN1, SUN2, SYNE1, SYNE2
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| Role of ANC-1 in tethering nuclei to the actin cytoskeleton.
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| Starr DA, Han M.
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| Science 298(5592):406-9. 2002
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| 25 | SYNE1
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| Myne-1, a spectrin repeat transmembrane protein of the myocyte inner nuclear membrane, interacts with lamin A/C.
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| Mislow JM, Kim MS, Davis DB, McNally EM.
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| J Cell Sci 115(Pt 1):61-70. 2002
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| 26 | SYNE1, SYNE2
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| The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300.
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| Zhang Q, Ragnauth C, Greener MJ, Shanahan CM, Roberts RG.
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| Genomics 80(5):473-81. 2002
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| 27 | SYNE1, SYNE2
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| Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues.
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| Zhang Q, Skepper JN, Yang F, Davies JD, Hegyi L, Roberts RG, Weissberg PL, Ellis JA, Shanahan CM.
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| J Cell Sci 114(Pt 24):4485-98. 2001
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| 28 | SYNE1, SYNE2
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| Syne-1, a dystrophin- and Klarsicht-related protein associated with synaptic nuclei at the neuromuscular junction.
|
| Apel ED, Lewis RM, Grady RM, Sanes JR.
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| J Biol Chem 275(41):31986-95. 2000
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| 29 | ADGRL2, ADGRL3, ADNP, AKAP9, ANGEL1, ARHGAP32, ATP10B, ATP1A2, BAG5, BAIAP3, CAMKK2, CLCC1, CLSTN3, DDHD2, DDN, DDX46, DDX46, DGKB, DIP, DOCK4, DST, EIF5B, EPM2AIP1, FAM131B, FAM153A, FARP2, FCHSD2, GPR116, HDAC9, IPO13, KBTBD11, KIAA0748, KIAA0753, KIAA0754, KIAA0802, KLHL18, LARP1, LRIG2, MAST2, MTUS2, MYO10, MYO1D, NFASC, NRXN3, NUP155, OSBPL2, PCNX, PHF14, PPP1R13B, RAD54L2, RBM12, RHOBTB1, RHOBTB2, RIMS2, SACS, SASH1, SEC24A, SEC24B, SEC24C, SEC24D, SENP6, SLC4A8, SNRNP200, SNX13, SORBS2, SPATA2, SPON1, SUPT7L, SV2A, SV2B, SYNE1, TBKBP1, TCAF1, TMCC1, TMEM63A, TOMM70A, TSPYL4, UBXN7, ULK1, USP34, VPRBP, VPS39, VPS8, WSCD2, XPO7, ZBED1, ZBED1Y, ZNF294, ZNF423, ZNF432
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| Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
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| Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O.
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| DNA Res 5(5):277-86. 1998
|